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3'-phosphoadenylyl sulfate + (heparan sulfate)-glucosamine
adenosine 3',5'-bisphosphate + (heparan sulfate)-N-sulfoglucosamine
NDST-1 plays a role in lung development and repair following injury due to its influence on the activity of fibroblast growth factor
-
-
?
3'-phosphoadenylyl sulfate + GlcA-GlcNAc-GlcA-GlcNS-GlcA-pNP
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + heparosan
adenosine 3',5'-bisphosphate + heparosan sulfate
3'-phosphoadenylyl sulfate + N-deacetylase K5-polysaccharide
?
3'-phosphoadenylyl sulfate + N-desulfated heparin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
3'-phosphoadenylylsulfate + chondroitin 4-sulfate
?
-
weak activity
-
-
?
3'-phosphoadenylylsulfate + de-N-sulfated heparin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + dermatan sulfate
?
3'-phosphoadenylylsulfate + desulfated N-acetylated heparan sulfate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + heparan sulfate
adenosine 3',5'-bisphosphate + N-sulfoheparan sulfate
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
3'-phosphoadenylylsulfate + N,O-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + O-desulfated heparan sulfate
3'-phosphoadenylylsulfate + N,O-desulfoheparan sulfate tetrasaccharide
?
-
-
-
-
?
3'-phosphoadenylylsulfate + N,O-desulfoheparan sulfate tetrasaccharides with the nonreducing terminus occupied by glucuronic acid
?
3'-phosphoadenylylsulfate + N-acetyl heparosan
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-acetylated heparan sulfate
?
3'-phosphoadenylylsulfate + N-deacetylated K5 polysaccharide
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-deacetylated K5-polysaccharide
?
3'-phosphoadenylylsulfate + N-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + heparan sulfate
3'-phosphoadenylylsulfate + N-desulfated heparin
?
3'-phosphoadenylylsulfate + N-desulfated, N-acetylated heparin
adenosine 3',5'-bisphosphate + ?
-
poor substrate
-
-
?
3'-phosphoadenylylsulfate + N-desulfoheparan sulfate
adenosine 3',5'-bisphosphate + heparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + N-desulfoheparin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + oligosaccharides derived from N-desulfoheparan sulfate
?
-
-
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + heparosan
adenosine 3',5'-bisphosphate + heparosan sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + heparosan
adenosine 3',5'-bisphosphate + heparosan sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + N-deacetylase K5-polysaccharide
?
-
-
-
?
3'-phosphoadenylyl sulfate + N-deacetylase K5-polysaccharide
?
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
-
product structure analysis, overview
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
in livers of wild-type and NDST mutant mice, overview
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
r
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
enzyme is present in embryonic tracheal tissue, which does not synthesize heparin
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
substrate needs to be deacetylated
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
NDST1 is able to partially sulfate exogenous substrate in the absence of NDST2 but not vice versa
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
substrate needs to be deacetylated
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
substrate needs to be deacetylated
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
recombinant bifunctional enzyme overexpressed in human kidney cells shows 2.5fold increase in N-sulfation and 8fold increase of N-deacetylation of glucosaminyl residues of human heparan sulfate in vivo
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
structural analysis of substrate and product
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
may be involved in biosynthesis of heparin and not of heparan sulfate
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
isozyme regulation, developmental importance in different tissues
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
cerebral hypoplasia and craniofacial defects are detected in mice lacking heparan sulfate Ndst1 gene function. Ndst1 is a crucial regulator of mammalian forebrain and facial development. Properly modified heparan sulfate is necessary for neuronal, glia and neural crest development
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
expression of heparan sulfate sulfotransferase genes is spatiotemporally regulated in the developing brain, suggesting that the structure of heparan sulfate changes dynamically for the regulation of various biological processes. Posttranscriptional regulation also plays a critical role
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of heparin is initiated by the NDST enzymes, which catalyze the N-deacetylation and subsequent N-sulfation of selected GlcNAc residues of the [GlcUA-GlcNAc] polymer
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of heparin is initiated by the NDST enzymes, which catalyze the N-deacetylation and subsequent N-sulfation of selected GlcNAc residues of the [GlcUA-GlcNAc] polymer
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
substrate needs to be deacetylated
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
N-sulfated residues of heparan sulfate participate in the binding of this polymer to proteins as basic fibroblast growth factor
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of the nitrogen of glucosamine in heparan sulfate is an obligatory step for subsequent epimerization of D-glucuronic to L-iduronic acid and of O-sulfation of the sugar chains
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
important role of the enzyme in heparan sulfate assembly in glomerula basement membrane and glomerular epithelial cells and in the pathogenesis of proteinuria in puromycin aminonucleoside nephrosis
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the enzyme initiates the N-sulfation of heparan sulfate
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
isozyme regulation, developmental importance in different tissues
-
?
3'-phosphoadenylylsulfate + dermatan sulfate
?
-
-
-
-
?
3'-phosphoadenylylsulfate + dermatan sulfate
?
-
weak activity
-
-
?
3'-phosphoadenylylsulfate + heparan sulfate
adenosine 3',5'-bisphosphate + N-sulfoheparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + heparan sulfate
adenosine 3',5'-bisphosphate + N-sulfoheparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + heparan sulfate
adenosine 3',5'-bisphosphate + N-sulfoheparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + heparan sulfate
adenosine 3',5'-bisphosphate + N-sulfoheparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
-
-
-
-
?
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
-
-
?
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
-
-
-
?
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
-
-
-
-
?
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
-
-
-
-
?
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
-
-
-
-
?
3'-phosphoadenylylsulfate + N,O-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + O-desulfated heparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + N,O-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + O-desulfated heparan sulfate
-
no activity with
-
-
?
3'-phosphoadenylylsulfate + N,O-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + O-desulfated heparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + N,O-desulfoheparan sulfate tetrasaccharides with the nonreducing terminus occupied by glucuronic acid
?
-
not iduronic acid
-
-
?
3'-phosphoadenylylsulfate + N,O-desulfoheparan sulfate tetrasaccharides with the nonreducing terminus occupied by glucuronic acid
?
-
the enzyme transfers sulfate to the 2-amino groups and to the 6-hydroxy groups of glucosamine units of the acceptor substrate, the ratio of the N/O-sulfation ranges between 3:1 and 2:1
-
-
?
3'-phosphoadenylylsulfate + N-acetylated heparan sulfate
?
-
no activity with
-
-
?
3'-phosphoadenylylsulfate + N-acetylated heparan sulfate
?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-deacetylated K5-polysaccharide
?
-
-
-
?
3'-phosphoadenylylsulfate + N-deacetylated K5-polysaccharide
?
-
from E. coli K5-derived capsular polysaccharide
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + heparan sulfate
-
chemically de-N-sulfated heparan sulfate is a better substrate than heparan sulfate
-
?
3'-phosphoadenylylsulfate + N-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + heparan sulfate
-
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparan sulfate
adenosine 3',5'-bisphosphate + heparan sulfate
-
best substrate
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
much poorer substrate than N-desulfated heparan sulfate
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
best substrate
-
-
?
additional information
?
-
-
poor acceptors: N-desulfo-N-acetylheparan, heparin, N-desulfoheparin
-
-
?
additional information
?
-
-
hyaluronic acid is no acceptor
-
-
?
additional information
?
-
-
heparin is no acceptor
-
-
?
additional information
?
-
-
chondroitin sulfate is no acceptor
-
-
?
additional information
?
-
-
no activity with N-acetylated substrates
-
-
?
additional information
?
-
-
substrate binding structures, overview
-
-
-
additional information
?
-
-
NDST1 and NDST2 have no redundant activities but rather have complementary activities in making N-sulfated heparan sulfate motifs with cyclophilin B-binding properties. Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases
-
-
?
additional information
?
-
NDST-1 is a bifunctional enzyme that displays N-deacetylase and N-sulfotransferase activities to convert an N-acetylated glucosamine residue to an N-sulfoglucosamine residue
-
-
?
additional information
?
-
substrate specificity of recombinant NDST-1 (rNDST-1), full-length enzyme and individual N-deacetylase and N-sulfotransferase domains, with model oligosaccharides, detailed overview. Saccharides N-sulfated by NDST-1 are highly ordered, alternately containing N-S domains and N-Ac domains. Domain cooperation plays an essential role in NDST-1 production of HS with specific structures, and N-deacetylation is the limiting step. Recombinant NDST-1 clearly displayed bifunctional activity, it shows N-deacetylase and N-sulfotransferase activity, and the minimum-sized substrate for the bifunctional activity is a hexasaccharide
-
-
-
additional information
?
-
substrate specificity of recombinant NDST-1 (rNDST-1), full-length enzyme and individual N-deacetylase and N-sulfotransferase domains, with model oligosaccharides, detailed overview. Saccharides N-sulfated by NDST-1 are highly ordered, alternately containing N-S domains and N-Ac domains. Domain cooperation plays an essential role in NDST-1 production of HS with specific structures, and N-deacetylation is the limiting step. Recombinant NDST-1 clearly displayed bifunctional activity, it shows N-deacetylase and N-sulfotransferase activity, and the minimum-sized substrate for the bifunctional activity is a hexasaccharide
-
-
-
additional information
?
-
-
substrate specificity of recombinant NDST-1 (rNDST-1), full-length enzyme and individual N-deacetylase and N-sulfotransferase domains, with model oligosaccharides, detailed overview. Saccharides N-sulfated by NDST-1 are highly ordered, alternately containing N-S domains and N-Ac domains. Domain cooperation plays an essential role in NDST-1 production of HS with specific structures, and N-deacetylation is the limiting step. Recombinant NDST-1 clearly displayed bifunctional activity, it shows N-deacetylase and N-sulfotransferase activity, and the minimum-sized substrate for the bifunctional activity is a hexasaccharide
-
-
-
additional information
?
-
substrate specificity of recombinant NDST-4 (rNDST-4) with model oligosaccharides, detailed overview. Full-length rNDST-4 lacks obvious N-deacetylase activity, and displays only N-sulfotransferase activity. NDST-4 does not show directional N-sulfotransferase activity and the N-deacetylase domain is inactive. rNDST-4 modified heparosan only contained below 5% disaccharide units with the structure of GlcA-GlcNS. rNDST-4 displays low N-deacetylase activity toward polysaccharide. rNDST-4 is not active with a heptasaccharide substrate or smaller
-
-
-
additional information
?
-
substrate specificity of recombinant NDST-4 (rNDST-4) with model oligosaccharides, detailed overview. Full-length rNDST-4 lacks obvious N-deacetylase activity, and displays only N-sulfotransferase activity. NDST-4 does not show directional N-sulfotransferase activity and the N-deacetylase domain is inactive. rNDST-4 modified heparosan only contained below 5% disaccharide units with the structure of GlcA-GlcNS. rNDST-4 displays low N-deacetylase activity toward polysaccharide. rNDST-4 is not active with a heptasaccharide substrate or smaller
-
-
-
additional information
?
-
-
substrate specificity of recombinant NDST-4 (rNDST-4) with model oligosaccharides, detailed overview. Full-length rNDST-4 lacks obvious N-deacetylase activity, and displays only N-sulfotransferase activity. NDST-4 does not show directional N-sulfotransferase activity and the N-deacetylase domain is inactive. rNDST-4 modified heparosan only contained below 5% disaccharide units with the structure of GlcA-GlcNS. rNDST-4 displays low N-deacetylase activity toward polysaccharide. rNDST-4 is not active with a heptasaccharide substrate or smaller
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST3 has relatively higher N-deacetylase activity and lower sulfotransferase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST3 has relatively higher N-deacetylase activity and lower sulfotransferase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST3 has relatively higher N-deacetylase activity and lower sulfotransferase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST3 has relatively higher N-deacetylase activity and lower sulfotransferase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST4 has relatively higher sulfotransferase activity and lower N-deacetylase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST4 has relatively higher sulfotransferase activity and lower N-deacetylase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST4 has relatively higher sulfotransferase activity and lower N-deacetylase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. Isozyme NDST4 has relatively higher sulfotransferase activity and lower N-deacetylase activity
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. The catalytic mechanism of NDST1 is responsible for determining the distribution of GlcNS residues in the heparan sulfate (HS) chains. NDST1 binds to its substrates in a random manner, but the processes catalyzed by this enzyme are nonrandom, leading to the formation of specific products in different regions of the chains. During this process, NDST1 can bind to any of the internal GlcNAc residues on the chain. Once the sulfation process has been initiated, NDST1 can then convert the GlcNAc residues to GlcNS residues in sequence from the nonreducing to the reducing end of the chain until it reaches a GlcNS residue located five units away from the reducing end. The establishment of this catalytic model for NDST1 provides direct proof that NDST1 plays a decisive role in the distribution of GlcNS residues
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. The catalytic mechanism of NDST1 is responsible for determining the distribution of GlcNS residues in the heparan sulfate (HS) chains. NDST1 binds to its substrates in a random manner, but the processes catalyzed by this enzyme are nonrandom, leading to the formation of specific products in different regions of the chains. During this process, NDST1 can bind to any of the internal GlcNAc residues on the chain. Once the sulfation process has been initiated, NDST1 can then convert the GlcNAc residues to GlcNS residues in sequence from the nonreducing to the reducing end of the chain until it reaches a GlcNS residue located five units away from the reducing end. The establishment of this catalytic model for NDST1 provides direct proof that NDST1 plays a decisive role in the distribution of GlcNS residues
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. The catalytic mechanism of NDST1 is responsible for determining the distribution of GlcNS residues in the heparan sulfate (HS) chains. NDST1 binds to its substrates in a random manner, but the processes catalyzed by this enzyme are nonrandom, leading to the formation of specific products in different regions of the chains. During this process, NDST1 can bind to any of the internal GlcNAc residues on the chain. Once the sulfation process has been initiated, NDST1 can then convert the GlcNAc residues to GlcNS residues in sequence from the nonreducing to the reducing end of the chain until it reaches a GlcNS residue located five units away from the reducing end. The establishment of this catalytic model for NDST1 provides direct proof that NDST1 plays a decisive role in the distribution of GlcNS residues
-
-
-
additional information
?
-
the enzyme NDST removes the acetyl group from the GlcNAc residue and transfers a sulfate group to the primary amine forming a GlcNS substitute. The catalytic mechanism of NDST1 is responsible for determining the distribution of GlcNS residues in the heparan sulfate (HS) chains. NDST1 binds to its substrates in a random manner, but the processes catalyzed by this enzyme are nonrandom, leading to the formation of specific products in different regions of the chains. During this process, NDST1 can bind to any of the internal GlcNAc residues on the chain. Once the sulfation process has been initiated, NDST1 can then convert the GlcNAc residues to GlcNS residues in sequence from the nonreducing to the reducing end of the chain until it reaches a GlcNS residue located five units away from the reducing end. The establishment of this catalytic model for NDST1 provides direct proof that NDST1 plays a decisive role in the distribution of GlcNS residues
-
-
-
additional information
?
-
-
p-nitrophenol is no acceptor
-
-
?
additional information
?
-
-
heparin is no acceptor
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
-
heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development, disruption of heparan sulfate synthesis in vertebrate development causes malformations that are composites of those caused by mutations of multiple heparan sulfate binding growth factors and morphogens, overview, molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, overview
-
-
?
additional information
?
-
-
no acceptors: tyrosine-containing tripeptides, N-acetylated heparan sulfate, N-acetylated heparin, chondroitin
-
-
?
additional information
?
-
-
chondroitin sulfate is no acceptor
-
-
?
additional information
?
-
-
key enzyme in hepatic heparan sulfate biosynthesis.Diabetes substantially suppresses hepatic N-deacetylase/N-sulfotransferase-1 mRNA, protein and enzymatic activity. Suppression of hepatic N-deacetylase/N-sulfotransferase-1 may contribute to diabetic dyslipidemia. Stimulation of N-deacetylase/N-sulfotransferase-1 activity by AngII inhibitors may provide cardiovascular protection
-
-
?
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3'-phosphoadenylyl sulfate + (heparan sulfate)-glucosamine
adenosine 3',5'-bisphosphate + (heparan sulfate)-N-sulfoglucosamine
NDST-1 plays a role in lung development and repair following injury due to its influence on the activity of fibroblast growth factor
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
3'-phosphoadenylylsulfate + N-desulfoheparin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
in livers of wild-type and NDST mutant mice, overview
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
enzyme is present in embryonic tracheal tissue, which does not synthesize heparin
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
NDST1 is able to partially sulfate exogenous substrate in the absence of NDST2 but not vice versa
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
may be involved in biosynthesis of heparin and not of heparan sulfate
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
isozyme regulation, developmental importance in different tissues
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
cerebral hypoplasia and craniofacial defects are detected in mice lacking heparan sulfate Ndst1 gene function. Ndst1 is a crucial regulator of mammalian forebrain and facial development. Properly modified heparan sulfate is necessary for neuronal, glia and neural crest development
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of heparin is initiated by the NDST enzymes, which catalyze the N-deacetylation and subsequent N-sulfation of selected GlcNAc residues of the [GlcUA-GlcNAc] polymer
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of heparin is initiated by the NDST enzymes, which catalyze the N-deacetylation and subsequent N-sulfation of selected GlcNAc residues of the [GlcUA-GlcNAc] polymer
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
N-sulfated residues of heparan sulfate participate in the binding of this polymer to proteins as basic fibroblast growth factor
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of the nitrogen of glucosamine in heparan sulfate is an obligatory step for subsequent epimerization of D-glucuronic to L-iduronic acid and of O-sulfation of the sugar chains
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
isozyme regulation, developmental importance in different tissues
-
?
additional information
?
-
-
NDST1 and NDST2 have no redundant activities but rather have complementary activities in making N-sulfated heparan sulfate motifs with cyclophilin B-binding properties. Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases
-
-
?
additional information
?
-
-
heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development, disruption of heparan sulfate synthesis in vertebrate development causes malformations that are composites of those caused by mutations of multiple heparan sulfate binding growth factors and morphogens, overview, molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, overview
-
-
?
additional information
?
-
-
key enzyme in hepatic heparan sulfate biosynthesis.Diabetes substantially suppresses hepatic N-deacetylase/N-sulfotransferase-1 mRNA, protein and enzymatic activity. Suppression of hepatic N-deacetylase/N-sulfotransferase-1 may contribute to diabetic dyslipidemia. Stimulation of N-deacetylase/N-sulfotransferase-1 activity by AngII inhibitors may provide cardiovascular protection
-
-
?
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Albuminuria
Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis.
Amyotrophic Lateral Sclerosis
NDST3 deacetylates ?-tubulin and suppresses V-ATPase assembly and lysosomal acidification.
Anophthalmos
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.
Asthma
Endothelial and leukocyte heparan sulfates regulate the development of allergen-induced airway remodeling in a mouse model.
Ataxia
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Breast Neoplasms
Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer.
Carcinoma
Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.
Carcinoma
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
Carcinoma
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
Carcinoma
IDUA, NDST1, SAP30L, CRYBA4, and SI as novel prognostic signatures clear cell renal cell carcinoma.
Carcinoma
MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803.
Carcinoma, Lewis Lung
Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.
Carcinoma, Lewis Lung
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
Carcinoma, Renal Cell
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
Carcinoma, Renal Cell
IDUA, NDST1, SAP30L, CRYBA4, and SI as novel prognostic signatures clear cell renal cell carcinoma.
Colorectal Neoplasms
Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
Colorectal Neoplasms
NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer.
Coronary Disease
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
Cranial Nerve Diseases
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Craniofacial Abnormalities
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Demyelinating Diseases
Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production.
Double Outlet Right Ventricle
Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.
Embolic Stroke
Integrative Analysis Identified IRF6 and NDST1 as Potential Causal Genes for Ischemic Stroke.
Encephalitis, Japanese
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.
Frontotemporal Dementia
NDST3 deacetylates ?-tubulin and suppresses V-ATPase assembly and lysosomal acidification.
Glioblastoma
MiRNA-191 functions as an oncogene in primary glioblastoma by directly targeting NDST1.
Heart Septal Defects, Ventricular
Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.
Hernias, Diaphragmatic, Congenital
Down-regulation of N-deacetylase-N-sulfotransferase-1 signaling in the developing diaphragmatic vasculature of nitrofen-induced congenital diaphragmatic hernia.
Holoprosencephaly
Integrated clinical and omics approach to rare diseases: novel genes and oligogenic inheritance in holoprosencephaly.
Infections
Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor.
Infections
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.
Intellectual Disability
NDST1 missense mutations in autosomal recessive intellectual disability.
Intellectual Disability
Two Cases of Recessive Intellectual Disability Caused by NDST1 and METTL23 Variants.
Ischemic Stroke
Integrative Analysis Identified IRF6 and NDST1 as Potential Causal Genes for Ischemic Stroke.
Mastocytoma
3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction.
Mastocytoma
cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.
Mastocytoma
Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line.
Melanoma
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy.
Melanoma
Epac1 promotes melanoma metastasis via modification of heparan sulfate.
Mucopolysaccharidoses
NDST1 Preferred Promoter Confirmation and Identification of Corresponding Transcriptional Inhibitors as Substrate Reduction Agents for Multiple Mucopolysaccharidosis Disorders.
Neoplasm Metastasis
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
Neoplasms
Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
Neoplasms
Cell surface heparan sulfate promotes replication of Toxoplasma gondii.
Neoplasms
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.
Neoplasms
Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.
Neoplasms
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
Neoplasms
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
Neoplasms
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
Neoplasms
Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer.
Neoplasms
NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer.
Neoplasms
Transcriptional Activity of Heparan Sulfate Biosynthetic Machinery is Specifically Impaired in Benign Prostate Hyperplasia and Prostate Cancer.
Nephrosis
Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis.
Neurodegenerative Diseases
NDST3 deacetylates ?-tubulin and suppresses V-ATPase assembly and lysosomal acidification.
Oligodendroglioma
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.
Paralysis
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Perinatal Death
Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice.
Proteinuria
Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis.
Pulmonary Atelectasis
Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice.
Respiratory Distress Syndrome, Newborn
Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice.
Respiratory Insufficiency
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Thrombosis
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
Truncus Arteriosus, Persistent
Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.
Vascular System Injuries
Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling.
Yellow Fever
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
Lymphatic endothelial heparan sulfate deficiency results in altered growth responses to VEGF-C.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.
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Cheung, W.F.; Eriksson, I.; Kusche-Gulberg, M.; Lindahl, U.; Kjellen, L.
Expression of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase in human kidney 293 cells results in increased N-sulfation of heparan sulfate
Biochemistry
35
5250-5256
1996
Mus musculus
brenda
Suzuki, S.; Trenn, R.H.; Strominger, J.L.
Separation of specific mucopolysaccharide sulfotransferases
Biochim. Biophys. Acta
50
169-170
1961
Gallus gallus
-
brenda
Hiroshi, M.; Isemura, M.; Yosizawa, Z.
Effects of female hormones on the activity of 3-phosphoadenylylsulphate: desulphated heparan sulphate sulphotransferase in the endometrium of rabbit uterus
Int. J. Biochem.
17
1077-1083
1985
Oryctolagus cuniculus
brenda
Ghler, D.; Niemann, R.; Buddecke, E.
Purification and characterization of 3-phosphoadenylylsulfate: N-desulfoheparan sulfate sulfotransferase from arterial tissue
Eur. J. Biochem.
138
301-308
1984
Bos taurus
brenda
Wei, Z.; Swiedler, S.J.; Ishihara, M.; Orellana, A.; Hirschberg, C.B.
A single protein catalyzes both N-deacetylation and N-sulfation during the biosynthesis of heparan sulfate
Proc. Natl. Acad. Sci. USA
90
3885-3888
1993
Rattus norvegicus
brenda
Hashimoto, Y.; Orellana, A.; Gil, G.; Hirschberg, C.B.
Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase
J. Biol. Chem.
267
15744-15750
1992
Rattus norvegicus
brenda
Mandon, E.; Kempner, E.S.; Ishihara, M.; Hirschberg, C.B.
A monomeric protein in the Golgi membrane catalyzes both N-deacetylation and N-sulfation of heparan sulfate
J. Biol. Chem.
269
11729-11733
1994
Rattus norvegicus
brenda
Brandan, E.; Hirschberg, C.B.
Purification of rat liver N-heparan-sulfate sulfotransferase
J. Biol. Chem.
263
2417-2422
1988
Rattus norvegicus
brenda
Orellana, A.; Hirschberg, C.B.; Wei, Z.; Swiedler, S.J.; Ishihara, M.
Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line
J. Biol. Chem.
269
2270-2276
1994
Mus musculus
brenda
Johnson, A.H.; Baker, J.R.
The enzymatic sulphation of heparan sulphate by hens uterus
Biochim. Biophys. Acta
320
341-351
1973
Gallus gallus
brenda
Eisenman, R.A.; Balasubramanian, A.S.; Marx, W.
3-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction
Arch. Biochem. Biophys.
119
387-397
1967
Mus musculus
brenda
Jansson, L.; Hk, M.; Wasteson, A.; Lindahl, U.
Biosynthesis of heparin. Solubilization and partial characterization of N- and O-sulphotransferases
Biochem. J.
149
49-55
1975
Mus musculus
brenda
Foley, T.; Baker, J.R.
A heparan sulphate sulphotransferase from ox lung
Biochem. J.
124
25P-26P
1971
Bos taurus
brenda
Sueyoshi, T.; Kakuta, Y.; Pedersen, L.C.; Wall, F.E.; Pedersen, L.G.; Negishi, M.
A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase
FEBS Lett.
433
211-214
1998
Homo sapiens
brenda
Toma, L.; Berninsone, P.; Hirschberg, C.B.
The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cells
J. Biol. Chem.
273
22458-22465
1998
Bos taurus (O97583), Bos taurus
brenda
Kusche-Gullberg, M.; Eriksson, I.; Pikas, D.S.; Kjellen, L.
Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes
J. Biol. Chem.
273
11902-11907
1998
Rattus norvegicus, Mus musculus (Q3UHN9), Mus musculus
brenda
Kakuta, Y.; Sueyoshi, T.; Negishi, M.; Pedersen, L.C.
Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/N-sulfotransferase 1
J. Biol. Chem.
274
10673-10676
1999
Homo sapiens
brenda
Aikawa, J.; Esko, J.D.
Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/N-sulfotransferase family
J. Biol. Chem.
274
2690-2695
1999
Cricetulus griseus, Homo sapiens (O95803), Homo sapiens
brenda
Gorokhov, A.; Perera, L.; Darden, T.A.; Negishi, M.; Pedersen, L.C.; Pedersen, L.G.
Heparan sulfate biosynthesis: a theoretical study of the initial sulfation step by N-deacetylase/N-sulfotransferase
Biophys. J.
79
2909-2917
2000
Homo sapiens
brenda
Aikawa, J.; Grobe, K.; Tsujimoto, M.; Esko, J.D.
Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4
J. Biol. Chem.
276
5876-5882
2001
Homo sapiens (O95803), Homo sapiens (Q9H3R1), Homo sapiens, Mus musculus (P52850), Mus musculus (Q3UHN9), Mus musculus (Q9EQH7), Mus musculus (Q9EQW8), Mus musculus
brenda
Grobe, K.; Ledin, J.; Ringvall, M.; Holmborn, K.; Forsberg, E.; Esko, J.D.; Kjellen, L.
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
Biochim. Biophys. Acta
1573
209-215
2002
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Homo sapiens (O95803), Homo sapiens (Q9H3R1), Mus musculus, Mus musculus (Q9EQW8), vertebrata
brenda
Duncan, M.B.; Liu, M.; Fox, C.; Liu, J.
Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2
Biochem. Biophys. Res. Commun.
339
1232-1237
2006
Homo sapiens
brenda
Grobe, K.; Inatani, M.; Pallerla, S.R.; Castagnola, J.; Yamaguchi, Y.; Esko, J.D.
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
Development
132
3777-3786
2005
Mus musculus
brenda
Williams, K.J.; Liu, M.L.; Zhu, Y.; Xu, X.; Davidson, W.R.; McCue, P.; Sharma, K.
Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II
Diabetes
54
1116-1122
2005
Rattus norvegicus
brenda
Saribas, A.S.; Mobasseri, A.; Pristatsky, P.; Chen, X.; Barthelson, R.; Hakes, D.; Wang, J.
Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1)
Glycobiology
14
1217-1228
2004
Rattus norvegicus
brenda
Yabe, T.; Hata, T.; He, J.; Maeda, N.
Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain
Glycobiology
15
982-993
2005
Mus musculus
brenda
Bishop, J.R.; Crawford, B.E.; Esko, J.D.
Cell surface heparan sulfate promotes replication of Toxoplasma gondii
Infect. Immun.
73
5395-5401
2005
Toxoplasma gondii
brenda
Nakayama, K.; Natori, Y.; Sato, T.; Kimura, T.; Sugiura, A.; Sato, H.; Saito, T.; Ito, S.
Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis
J. Lab. Clin. Med.
143
106-114
2004
Rattus norvegicus
brenda
Pallerla, S.R.; Pan, Y.; Zhang, X.; Esko, J.D.; Grobe, K.
Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development
Dev. Dyn.
236
556-563
2007
Mus musculus
brenda
Pan, Y.; Woodbury, A.; Esko, J.D.; Grobe, K.; Zhang, X.
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
Development
133
4933-4944
2006
Mus musculus
brenda
Ledin, J.; Ringvall, M.; Thuveson, M.; Eriksson, I.; Wilen, M.; Kusche-Gullberg, M.; Forsberg, E.; Kjellen, L.
Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation
J. Biol. Chem.
281
35727-35734
2006
Mus musculus
brenda
Newman, D.R.; Walsh, E.; Apparao, K.B.; Sannes, P.L.
Fibroblast growth factor-binding protein and N-deacetylase/N-sulfotransferase-1 expression in type II cells is modulated by heparin and extracellular matrix
Am. J. Physiol. Lung Cell Mol. Physiol.
293
1314-1320
2007
Rattus norvegicus (Q02353)
brenda
Deligny, A.; Denys, A.; Marcant, A.; Melchior, A.; Mazurier, J.; van Kuppevelt, T.H.; Allain, F.
Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases
J. Biol. Chem.
285
1701-1715
2010
Homo sapiens
brenda
Duelli, A.; Roennberg, E.; Waern, I.; Ringvall, M.; Kolset, S.O.; Pejler, G.
Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases
J. Immunol.
183
7073-7083
2009
Mus musculus
brenda
Jiang, Z.; Michal, J.J.; Wu, X.L.; Pan, Z.; MacNeil, M.D.
The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition
Int. J. Biol. Sci.
7
659-663
2011
Bos taurus
brenda
Sheng, J.; Liu, R.; Xu, Y.; Liu, J.
The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate
J. Biol. Chem.
286
19768-19776
2011
Rattus norvegicus
brenda
Holley, R.J.; Deligny, A.; Wei, W.; Watson, H.A.; Ninonuevo, M.R.; Dagaelv, A.; Leary, J.A.; Bigger, B.W.; Kjellen, L.; Merry, C.L.
Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking alpha-L-iduronidase
J. Biol. Chem.
286
37515-37524
2011
Mus musculus
brenda
Gesteira, T.F.; Coulson-Thomas, V.J.; Taunay-Rodrigues, A.; Oliveira, V.; Thacker, B.E.; Juliano, M.A.; Pasqualini, R.; Arap, W.; Tersariol, I.L.; Nader, H.B.; Esko, J.D.; Pinhal, M.A.
Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1
J. Biol. Chem.
286
5338-5346
2011
Mus musculus
brenda
Bush, K.T.; Crawford, B.E.; Garner, O.B.; Nigam, K.B.; Esko, J.D.; Nigam, S.K.
N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland
J. Biol. Chem.
287
42064-42070
2012
Mus musculus
brenda
Dou, W.; Xu, Y.; Pagadala, V.; Pedersen, L.C.; Liu, J.
Role of deacetylase activity of N-deacetylase/n-sulfotransferase 1 in forming n-sulfated domain in heparan sulfate
J. Biol. Chem.
290
20427-20437
2015
Homo sapiens (P52848)
brenda
Deligny, A.; Dierker, T.; Dagaelv, A.; Lundequist, A.; Eriksson, I.; Nairn, A.V.; Moremen, K.W.; Merry, C.L.; Kjellen, L.
NDST2 (N-deacetylase/N-sulfotransferase-2) enzyme regulates heparan sulfate chain length
J. Biol. Chem.
291
18600-18607
2016
Mus musculus (P52850), Mus musculus
brenda
Kero, D.; Bilandzija, T.; Arapovic, L.; Vukojevic, K.; Saraga-Babic, M.
Syndecans and enzymes involved in heparan sulfate biosynthesis and degradation are differentially expressed during human dontogenesis
Front. Physiol.
9
732
2018
Homo sapiens (P52848), Homo sapiens (P52849), Homo sapiens
brenda
Ushakov, V.; Tsidulko, A.; De La Bourdonnaye, G.; Kazanskaya, G.; Volkov, A.; Kiselev, R.; Kobozev, V.; Kostromskaya, D.; Gaytan, A.; Krivoshapkin, A.; Aidagulova, S.; Grigorieva, E.
Heparan sulfate biosynthetic system is inhibited in human glioma due to EXT1/2 and HS6ST1/2 down-regulation
Int. J. Mol. Sci.
18
2301
2017
Homo sapiens (P52848), Homo sapiens (P52849)
brenda
Li, Y.J.; Yin, F.X.; Zhang, X.K.; Yu, J.; Zheng, S.; Song, X.L.; Wang, F.S.; Sheng, J.Z.
Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates
Biochim. Biophys. Acta
1862
547-556
2018
Homo sapiens (P52848), Homo sapiens (Q9H3R1), Homo sapiens
brenda
Zhang, X.; Wang, F.; Sheng, J.
''Coding'' and ''Decoding'' hypothesis for the regulatory mechanism involved in heparan sulfate biosynthesis
Carbohydr. Res.
428
1-7
2016
Homo sapiens (O95803), Homo sapiens (P52848), Homo sapiens (P52849), Homo sapiens (Q9H3R1)
brenda
Gesteira, T.F.; Coulson-Thomas, V.J.
Structural basis of oligosaccharide processing by glycosaminoglycan sulfotransferases
Glycobiology
28
885-897
2018
Homo sapiens
brenda
Chen, H.; Ambadapadi, S.; Wakefield, D.; Bartee, M.; Yaron, J.R.; Zhang, L.; Archer-Hartmann, S.A.; Azadi, P.; Burgin, M.; Borges, C.; Zheng, D.; Ergle, K.; Muppala, V.; Morshed, S.; Rand, K.; Clapp, W.; Proudfoot, A.; Lucas, A.
Selective deletion of heparan sulfotransferase enzyme, Ndst1, in donor endothelial and myeloid precursor cells significantly decreases acute allograft rejection
Sci. Rep.
8
13433
2018
Mus musculus (Q3UHN9), Mus musculus C57BL/6 (Q3UHN9)
brenda