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Information on EC 2.7.7.69 - GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase

for references in articles please use BRENDA:EC2.7.7.69

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IUBMB Comments

This plant enzyme catalyses the conversion of GDP-β-L-galactose and GDP-α-D-glucose to β-L-galactose 1-phosphate and α-D-glucose 1-phosphate, respectively. The enzyme can use inorganic phosphate as the co-substrate, but several hexose 1-phosphates, including α-D-mannose 1-phosphate, α-D-glucose 1-phosphate, and α-D-galactose 1-phosphate, are better guanylyl acceptors. The enzyme's activity on GDP-β-L-galactose is crucial for the biosynthesis of L-ascorbate.

The enzyme appears in viruses and cellular organisms

Synonyms
gdp-l-galactose phosphorylase, slggp1, osggp, slggp, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose
show the reaction diagram
(2)
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GDP-beta-L-galactose + alpha-D-mannose 1-phosphate = beta-L-galactose 1-phosphate + GDP-alpha-D-mannose
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
extended VTC2 cycle, L-ascorbate biosynthesis I (plants, L-galactose pathway), VTC2 cycle
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