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adenosine 5'-phosphorofluoridate + NH3
adenosine 5'-phosphoramidate + F-
-
-
-
?
adenosine 5'-phosphosulfate + NH3
adenosine 5'-phosphoramidate + SO42- + H+
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
ApppA + NH3
adenosine 5'-phosphoramidate + ppA
-
-
-
?
cytidine 5'-phosphosulfate + NH3
cytidine 5'-phosphoramidate + SO42- + H+
91% of the rate with adenosine 5'-phosphosulfate
-
-
?
guanosine 5'-phosphosulfate + NH3
guanosine 5'-phosphoramidate + SO42- + H+
47% of the rate with adenosine 5'-phosphosulfate
-
-
?
uridine 5'-phosphosulfate + NH3
uridine 5'-phosphoramidate + SO42- + H+
56% of the rate with adenosine 5'-phosphosulfate
-
-
?
additional information
?
-
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
a large variety of ammonia analogs such as amines, amides etc. can not replace ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
Microorganisms
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
additional information
?
-
enzyme catalyses ammonolysis of adenosine 5'-phosphosulfate, which results in the formation of adenosine 5'-phosphoramidate. The mechanism for Fhit-catalysed ammonolysis of these substrates most probably involves attack by NH3 on the covalent histidine-bound enzyme-nucleosidyl intermediate. No substrate: adenosine 5'-phosphosulfate-3-phosphate
-
-
?
additional information
?
-
-
enzyme catalyses ammonolysis of adenosine 5'-phosphosulfate, which results in the formation of adenosine 5'-phosphoramidate. The mechanism for Fhit-catalysed ammonolysis of these substrates most probably involves attack by NH3 on the covalent histidine-bound enzyme-nucleosidyl intermediate. No substrate: adenosine 5'-phosphosulfate-3-phosphate
-
-
?
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adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
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Frankhauser, H.; Schiff, J.A.
Further purification and properties of adenylyl sulfate (APS): ammonia adenylyl transferase (APSAT) from Chlorella
Plant Physiol.
65S
17
1979
Chlorella sp.
-
brenda
Frankhauser, H.; Garber, L.; Schiff, J.A.
Adenylyl sulfate (APS): ammonia adenylyl transferase (APSAT) forming adenosine 5'phosphoamidate (APA) from APS and ammonia
Plant Physiol.
63S
162
1979
Embryophyta, Microorganisms
-
brenda
Frankhauser, H.; Schiff, J.A.; Garber, L.J.; Saidha, T.
Adenylylsulfate-ammonia adenylyltransferase from Chlorella
Methods Enzymol.
143
354-361
1987
Auxenochlorella pyrenoidosa, Dictyostelium discoideum, Escherichia coli, Euglena sp., Hordeum vulgare, Spinacia oleracea
-
brenda
Frankhauser, H.; Schiff, J.A.; Garber, L.J.
Purification and properties of adenylyl sulphate:ammonia adenylyltransferase from Chlorella catalysing the formation of adenosine 5 -phosphoramidate from adenosine 5 -phosphosulphate and ammonia
Biochem. J.
195
545-560
1981
Auxenochlorella pyrenoidosa, Dictyostelium discoideum, Escherichia coli, Euglena gracilis var. bacillaris, Hordeum vulgare, Spinacia oleracea
brenda
Wojdyla-Mamori, A.M.; Guranowski, A.
Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins
Biosci. Rep.
35
e00235
2015
Homo sapiens (O00298), Homo sapiens
brenda