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Information on EC 2.7.7.38 - 3-deoxy-manno-octulosonate cytidylyltransferase and Organism(s) Pseudomonas aeruginosa
for references in articles please use BRENDA:EC2.7.7.38
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EC Tree 2 Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
- 2.7.7.38
- lipopolysaccharide
- medicine
-
3-deoxy-d-manno-2-octulosonate
-
2-deoxy
- capsular
-
cytidylytransferase
- agriculture
- analysis
Reaction Schemes
showSynonyms
cmp-kdo synthetase, 3-deoxy-manno-octulosonate cytidylyltransferase, 3-deoxy-d-manno-octulosonate cytidylyltransferase, ctp:cmp-3-deoxy-d-manno-octulosonate cytidylyltransferase, l-cks, cmp/kdo synthase, cmp:kdo synthase, 2-keto-3-deoxy-d-manno-octulosonate cytidylyltransferase, more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-keto-3-deoxyoctonate cytidylyltransferase
-
-
-
-
3-deoxy-D-manno-octulosonate cytidylyltransferase
-
-
-
-
CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase
-
-
-
-
CMP-3-deoxy-D-manno-octulosonate synthetase
-
-
-
-
CMP-KDO synthetase
-
-
-
-
CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase
-
-
-
-
cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase
-
-
-
-
cytidine monophospho-3-deoxy-D-manno-octulosonate synthetase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
CMP-3-deoxy-D-manno-octulosonate biosynthesis
SYSTEMATIC NAME
IUBMB Comments
CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY
37278-28-7
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
Substrates: -
Products: -
Products: -
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
Substrates: -
Products: -
Products: -
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
Substrates: -
Products: -
Products: -
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
Substrates: -
Products: -
Products: -
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
Rose Bengal, competitive with 2-keto-3-deoxy-D-manno-octulosonate but non-competitive against CTP
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.01466
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
Pseudomonas aeruginosa
at pH 7.5 and 25°C
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksUNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0ABD7K4A6_PSEAI
254
0
27533
TrEMBL
Secretory Pathway (Reliability: 2)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bravo, I.G.; Reglero, A.
The cytidyltransferases family: Properties, kinetics, genomic and phylogeny
Recent Res. Devel. Biochem.
4
224-254
2003
Aquifex aeolicus, Arabidopsis thaliana (Q9C920), Caulobacter vibrioides (Q9A4A3), Chlamydia muridarum, Chlamydia pneumoniae, Chlamydia trachomatis, Escherichia coli, Escherichia coli (P42216), Haemophilus influenzae, Helicobacter pylori, Mesorhizobium loti (Q98BN3), Neisseria meningitidis, Neisseria meningitidis (Q9K0D6), Neisseria meningitidis MC58 (Q9K0D6), Pasteurella multocida, Pseudomonas aeruginosa, Rickettsia conorii (Q92I96), Rickettsia prowazekii, Salmonella enterica subsp. enterica serovar Typhimurium, Sinorhizobium meliloti (Q92SX6), Vibrio cholerae (Q9KQX2), Xylella fastidiosa (Q9PB46), Zea mays, Zea mays (Q9M4D3), Zea mays (Q9M4G3)
-
Kim, S.; Jo, S.; Kim, M.S.; Shin, D.H.
A study of Rose Bengal against a 2-keto-3-deoxy-D-manno-octulosonate cytidylyltransferase as an antibiotic candidate
J. Enzyme Inhib. Med. Chem.
35
1414-1421
2020
Burkholderia pseudomallei (Q63WL5), Burkholderia pseudomallei, Burkholderia pseudomallei K96243 (Q63WL5), Burkholderia thailandensis, Chlamydia psittaci (A0A2D2D9V4), Chlamydia psittaci, Pseudomonas aeruginosa (A0A0C7D0B2), Pseudomonas aeruginosa
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