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CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
CTP + alpha-D-xylose 1-phosphate
diphosphate + CDPxylose
-
poor substrate
-
?
CTP + D-glucosamine 1-phosphate
diphosphate + CDPglucosamine
CTP + D-glucose 1-phosphate
?
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-glucose
-
the structure of the enzyme with bound MgCTP reveals that the binding pocket for the nucleotide is contained within one subunit rather than shared between two. Key side chains involved in nucleotide binding include Thr14, Arg15, Lys25, and Arg111
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-glucose
-
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
highly specific
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dATP, dGTP, dCTP, D-ribitol 5-phosphate, L-glycerol 3-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: GDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
highly specific
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
best substrates
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
catalyzes bimolecular group transfer reaction
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: UDPgalactose, UDP-D-mannose, UDP-N-acetyl-D-glucosamine, dTDP-L-rhamnose
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: D-ribose 1-phosphate
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the reverse reaction: CDPparatose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
specific for base and sugar
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: GTP and D-mannose 1-phosphate
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrates in the reverse reaction: GDPglucose
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
specific for CTP and alpha-D-glucose 1-phosphate
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
specific for CTP and alpha-D-glucose 1-phosphate
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: ATP, GTP
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
-
no substrate in the forward reaction: TTP
-
-
?
CTP + D-glucosamine 1-phosphate
diphosphate + CDPglucosamine
-
reaction at about 25% the rate with glucose 1-phosphate
-
-
?
CTP + D-glucosamine 1-phosphate
diphosphate + CDPglucosamine
-
reaction at about 15% the rate with glucose 1-phosphate
-
?
CTP + D-glucose 1-phosphate
?
-
first of five enzymes committed to CDP-D-abequose biosynthesis
-
-
r
CTP + D-glucose 1-phosphate
?
-
branch-point in glucose 1-phosphate anabolism
-
-
r
CTP + D-glucose 1-phosphate
?
first step in biosynthesis of CDP-ascarylose
-
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
-
-
-
?
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
poor substrate
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
?
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CDP-2-O-methyldeoxyaldose
-
-
-
CDP-4-keto-6-deoxy-D-glucose
-
-
CDP-ascarylose
-
synonym: 3,6-dideoxy-L-mannose, strong, kinetics
CDP-D-fucose/CDP-6-deoxy-D-glucose mixture
-
-
CDPabequose
-
synonym: 3,6-dideoxy-D-galactose, strong
CDPparatose
-
synonym: 3,6-dideoxy-D-glucose, feed-back inhibition, CDPglucose partially reverses, maximal inhibition at 0.6 mM
dTTP
-
strong, competitive with CTP, kinetics
CDPglucose
-
product inhibition, competitive with respect to CTP, kinetics
CDPglucose
-
product inhibition, competitive with respect to CTP, kinetics
diphosphate
-
product inhibition, kinetics
diphosphate
-
product inhibition, kinetics
additional information
-
little or no inhibition by CDPethanolamine, CDPcholine, dTTPglucose, UDP-D-glucosamine, dCTP, dCDP, dTMP, dAMP, dGMP, dCMP, dTDP-L-rhamnose, dTDP-4-amino-4,6-dideoxy-D-glucose and its N-acetyl-derivative, UDP-D-galactose, UDP-D-glucuronic acid, UDP-N-acetyl-D-glucosamine, GDP-D-mannose, D-glucose 6-phosphate, D-glucose 1,6-diphosphate, D-galactose 1-phosphate, D-glucosamine 1-phosphate, D-mannose 1-phosphate, N-acetyl-D-glucosamine 1-phosphate, D-fructose 6-phosphate, D-fructose 1,6-diphosphate, D-ribitol 5-phosphate, L-glycerol 3-phosphate, phosphoenolpyruvate, pyruvate, ADP, AMP, GMP, UMP, beta-NAD+ or beta-NADP+; little or no inhibition by CMP, GDPglucose, UDPglucose, dTDPglucose
-
additional information
-
little or no inhibition by CMP, GDPglucose, UDPglucose, dTDPglucose; no inhibition by NaF, diphosphatase, 2-mercaptoethanol, paratose, CTP
-
additional information
-
no inhibition by abequose
-
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Mayer, R.M.; Ginsburg, V.
Purification and properties of cytidine diphosphate D-glucose pyrophosphorylase from Salmonella paratyphi A
J. Biol. Chem.
240
1900-1904
1965
Salmonella enterica subsp. enterica serovar Paratyphi A
brenda
Kimata, K.; Suzuki, S.
Studies on cytidine diphosphate glucose pyrophosphorylase and related enzymes of Azotobacter vinelandii
J. Biol. Chem.
241
1099-1113
1966
Azotobacter vinelandii, Azotobacter vinelandii O
brenda
Rubenstein, P.A.; Strominger, J.L.
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexosis. IX. Purification and properties of the cytidine diphosphate-D-glucose pyrophosphorylase from Pasteurella pseudotuberculosis. type V
J. Biol. Chem.
249
3789-3796
1974
Yersinia pseudotuberculosis
brenda
Lindqvist, L.; Kaiser, R.; Reeves, P.R.; Lindberg, A.A.
Purification, characterization, and high performance liquid chromatography assay of Salmonella glucose-1-phosphate cytidylyltransferase from the cloned rfbF gene
J. Biol. Chem.
269
122-126
1994
Salmonella enterica
brenda
Beyer, S.; Mayer, G.; Piepersberg, W.
The StrQ protein encoded in the gene cluster for 5'-hydroxystreptomycin of Streptomyces glaucescens GLA.0 is a alpha-D-glucose-1-phosphate cytidylyltransferase (CDP-D-glucose synthase)
Eur. J. Biochem.
258
1059-1067
1998
no activity in Streptomyces griseus, Streptomyces glaucescens, Streptomyces glaucescens GLA.0
brenda
Thorson, J.S.; Kelly, T.M.; Liu, H.W.
Cloning, sequencing, and overexpression in Escherichia coli of the alpha-D-glucose-1-phosphate cytidylyltransferase gene isolated from Yersinia pseudotuberculosis
J. Bacteriol.
176
1840-1849
1994
Yersinia pseudotuberculosis (Q57430), Yersinia pseudotuberculosis
brenda
Koropatkin, N.M.; Holden, H.M.
Molecular structure of alpha-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhi
J. Biol. Chem.
279
44023-44029
2004
Salmonella enterica subsp. enterica serovar Typhi
brenda
Koropatkin, N.M.; Cleland, W.W.; Holden, H.M.
Kinetic and structural analysis of alpha-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhi
J. Biol. Chem.
280
10774-10780
2005
Salmonella enterica subsp. enterica serovar Typhi
brenda
Qi, X.Q.; Sun, Q.L.; Bai, L.P.; Shan, J.J.; Zhang, Y.; Zhang, R.; Li, Y.
Identification of alpha-D-glucose-1-phosphate cytidylyltransferase involved in Ebosin biosynthesis of Streptomyces sp. 139
Appl. Microbiol. Biotechnol.
83
361-368
2009
Streptomyces sp. 139 (Q8KN04)
brenda