Reference on EC 2.7.7.31 - DNA nucleotidylexotransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Krakow, J.S.; Coutsogeorgopoulos, C.; Canellakis, E.S.
Studies on the incorporation of deoxyribonucleotides and ribonucleotides into deoxyribonucleic acid
Biochim. Biophys. Acta
55
639-650
1962
Bos taurus
Gottesman, M.E.; Canellakis, E.S.
The terminal nucleotidyltransferases of calf thymus nuclei
J. Biol. Chem.
241
4339-4352
1966
Bos taurus
Chang, L.M.S.; Bollum, F.J.
Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase
J. Biol. Chem.
246
909-916
1971
Bos taurus
Pandey, V.; Modak, M.J.
Purification of high molecular mass species of calf thymus terminal deoxynucleotidyltransferase
Prep. Biochem.
17
359-377
1987
Bos taurus
Matthes, E.; Lehman, C.; Drescher, B.; Buettner, W.; Langen, P.
3-Deoxy-3-fluorothymidinetriphosphate: inhibitor and terminator of DNA synthesis catalysed by DNA polymerase beta, terminal deoxynucleotidyl transferase and DNA polymerase I
Biomed. Biochim. Acta
44
K63-K73
1985
Bos taurus
Deibel, M.R.; Coleman, M.S.; Hutton, J.J.
Purification and characterization of multiple forms of terminal transferase from human leukemic cells
Adv. Exp. Med. Biol.
145
37-60
1982
Homo sapiens
Penit, C.; Gelabert, M.J.; Transy, C.; Rouget, P.
Purification and properties of chick terminal deoxynucleotidyl transferase (TdT)
Adv. Exp. Med. Biol.
145
61-73
1982
Gallus gallus
Deibel, M.R.; Coleman, M.S.; Acree, K.; Hutton, J.J.
Biochemical and immunological properties of human terminal deoxynucleotidyl transferase purified from blasts of acute lymphoblastic and chronic myelogenous leukemia
J. Clin. Invest.
67
725-734
1981
Bos taurus, Homo sapiens
Grosse, F.; Manns, A.
Terminal deoxyribonucleotidyl transferase
Methods Mol. Biol.
16
95-105
1993
Homo sapiens
Ratliff, R.L.
Terminal deoxyribonucleotidyl transferase
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
14
105-118
1981
Bos taurus, Homo sapiens, Mus musculus
-
Bollum, F.J.
Terminal deoxyribonucleotidyl transferase
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
10
145-171
1974
Bos taurus
-
Bollum, F.J.
Terminal deoxynucleotidyl transferase: biological studies
Adv. Enzymol. Relat. Areas Mol. Biol.
47
347-374
1978
Bos taurus
Kaneda, T.; Kuroda, S.; Koiwai, O.; Yoshida, S.
Purification of terminal deoxynucleotidyl transferase from pig thymus: identification of 42,000 and 57,000 dalton species
J. Biochem.
90
1421-1427
1981
Sus scrofa
Mller, W.E.G.; Zahn, R.K.; Arendes, J.
Differential mode of inhibition of terminal deoxynucleotidyl transferase by 3-dATP, ATP, betaaraATP and alphaaraATP
FEBS Lett.
94
47-50
1978
Bos taurus
DiCioccio, R.A.; Sahai Srivastava, B.I.S.
Inhibition of deoxyribonucleic acid polymerases from human cells and from simian sarcoma virus by pyran
Biochem. J.
175
519-524
1978
Homo sapiens
Brodniewicz-Proba, T.; Buchowicz, J.
Properties of a terminal deoxyribonucleotidyltransferase isolated from wheat germ
Biochem. J.
191
139-145
1980
Triticum aestivum
Coleman, M.S.
Terminal deoxynucleotidyl transferase: characterization of extraction and assay conditions from human and calf tissue
Arch. Biochem. Biophys.
182
525-532
1977
Bos taurus, Homo sapiens
Ashley, R.L.; Cardiff, R.D.; Manning, J.S.
Characterization of a terminal deoxynucleotidyl transferase activity in mouse mammary tumor virus
Virology
77
367-375
1977
mouse mammary tumor virus
DiCioccio, R.A.; Srivastava, B.I.S.
Selective inhibition of terminal deoxynucleotidyl transferase from leukemic cells by streptolydigin
Biochem. Biophys. Res. Commun.
72
1343-1349
1976
Homo sapiens
Ono, K.; Nakane, H.; Colla, L.; De Clercq, E.
Inhibition of terminal deoxyribonucleotidyltransferase by (E)-5-(2-bromovinyl)-2-deoxyuridine 5-triphosphate
Nucleic Acids Res.
12
123-126
1983
Bos taurus
-
Ono, K.; Iwata, Y.; Nakamura, H.; Matsukage, A.
Selective inhibition of terminal deoxynucleotidyl transferase by diadenosine 5,5-P1,P4-tetraphosphate
Biochem. Biophys. Res. Commun.
95
34-40
1980
Bos taurus
Fuller, S.A.; Philips, A.; Coleman, M.S.
Affinity purification and refined structural characterization of terminal deoxynucleotidyltransferase
Biochem. J.
231
105-113
1985
Bos taurus
Ono, K.
Inhibitory effects of various 2,3-dideoxynucleoside 5-triphosphates on the utilization of 2-deoxynucleoside 5-triphosphates by terminal deoxynucleotidyltransferase from calf thymus
Biochim. Biophys. Acta
1049
15-20
1990
Bos taurus
Pandey, V.N.; Amrute, S.B.; Satav, J.G.; Modak, M.J.
Inhibition of terminal deoxynucleotidyl trasnferase by adenine dinucleotides
FEBS Lett.
213
205-208
1987
Bos taurus
-
Lee, A.; Hsu, E.
Isolation and characterization of the Xenopus terminal deoxynucleotidyl transferase
J. Immunol.
152
4500-4507
1994
Xenopus sp.
Srivastava, A.; Modak, M.J.
Biochemistry of terminal deoxynucleotidyltransferase: identification, characterization, requirements, and active-site involvement in the catalysis of associated pyrophosphate exchange and pyrophosphorolytic activity
Biochemistry
19
3270-3275
1980
Bos taurus
Modak, M.J.
Biochemistry of terminal deoxynucleotidyltransferase. Mechanism of manganese-dependent inhibition by deoxyadenosine 5-triphosphate and biological implications
Biochemistry
18
2679-2684
1979
Bos taurus
Nakamura, H.; Tanabe, K.; Yoshida, S.; Morita, T.
Terminal deoxynucleotidyltransferase of 60,000 daltons from mouse, rat, and calf thymus. Purification by immunoadsorbent chromatography and comparison of peptide structures
J. Biol. Chem.
256
8745-8751
1981
Bos taurus, Mus musculus, Rattus norvegicus
Okamura, S.; Crane, F.; Messner, H.A.; Mak, T.W.
Purification of terminal deoxynucleotidyltransferase by oligonucleotide affinity chromatography
J. Biol. Chem.
253
3765-3767
1978
Bos taurus, Homo sapiens
Deibel, M.R.; Coleman, M.S.
Biochemical properties of purified human terminal deoxynucleotidyltransferase
J. Biol. Chem.
255
4206-4212
1980
Homo sapiens
Deibel, M.R.; Coleman, M.S.
Purification of a high molecular weight human terminal deoxynucleotidyl transferase
J. Biol. Chem.
254
8634-8649
1979
Homo sapiens
Benedict, C.L.; Gilfillan, S.; Kearney, J.F.
The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoform
J. Exp. Med.
193
89-99
2001
Mus musculus (P09838)
Yamadori, I.; Yoshino, T.; Kondo, E.; Cao, L.; Akagi, T.; Matsuo, Y.; Minowada, J.
Comparison of two methods of staining apoptotic cells of leukemia cell lines: terminal deoxynucleotidyl transferase and DNA polymerase I reactions
J. Histochem. Cytochem.
46
85-90
1998
Bos taurus
Fujita, K.; Shimazaki, N.; Ohta, Y.; Kubota, T.; Ibe, S.; Toji, S.; Tamai, K.; Fujisaki, S.; Hayano, T.; Koiwai, O.
Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone
Genes Cells
8
559-571
2003
Homo sapiens
Focher, F.; Maga, G.; Bendiscioli, A.; Capobianco, M.; Colonna, F.; Garbesi, A.; Spadari, S.
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate
Nucleic Acids Res.
23
2840-2847
1995
Bos taurus
Arzumanov, A.A.; Victorova, L.S.; Jasko, M.V.
Synthesis of non-nucleoside triphosphate analogues, a new type of substrates for terminal deoxynucleotidyl transferase
Nucleosides Nucleotides Nucleic Acids
19
1787-1793
2000
Homo sapiens
Ramadan, K.; Maga, G.; Shevelev, I.V.; Villani, G.; Blanco, L.; Hubscher, U.
Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions
J. Mol. Biol.
328
63-72
2003
Homo sapiens
Boule, J.B.; Rougeon, F.; Papanicolaou, C.
Comparison of the two murine terminal deoxynucleotidyltransferase isoforms. A 20-amino acid insertion in the highly conserved carboxyl-terminal region modifies the thermosensitivity but not the catalytic activity.
J. Biol. Chem.
275
33184
2000
Mus musculus
Koziolkiewicz, M.; Maciaszek, A.; Stec, W.J.; Semizarov, D.; Victorova, L.; Krayevsky, A.
Effect of P-chirality of oligo(deoxyribonucleoside phosphorothioate)s on the activity of terminal deoxyribonucleotidyl transferase
FEBS Lett.
434
77-82
1998
Bos taurus
Arzumanov, A.A.; Victorova, L.S.; Jasko, M.V.; Yesipov, D.S.; Krayevsky, A.A.
Terminal deoxynucleotidyl transferase catalyzes the reaction of DNA phosphorylation
Nucleic Acids Res.
28
1276-1281
2000
Bos taurus
Delarue, M.; Boule, J.B.; Lescar, J.; Expert-Bezancon, N.; Jourdan, N.; Sukumar, N.; Rougeon, F.; Papanicolaou, C.
Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase
EMBO J.
21
427-439
2002
Mus musculus
Sukumar, N.; Boule, J.B.; Expert-Bezancon, N.; Jourdan, N.; Lescar, J.; Rougeon, F.; Papanicolaou, C.; Delarue, M.
Crystallization of the catalytic domain of murine terminal deoxynucleotidyl transferase
Acta Crystallogr. Sect. D
56
1662-1664
2000
Mus musculus
Boule, J.B.; Johnson, E.; Rougeon, F.; Papanicolaou, C.
High-level expression of murine terminal deoxynucleotidyl transferase in Escherichia coli grown at low temperature and overexpressing argU tRNA
Mol. Biotechnol.
10
199-208
1998
Mus musculus
Mathewson, R.C.; Kjeldsberg, C.R.; Perkins, S.L.
Detection of terminal deoxynucleotidyl transferase (TdT) in nonhematopoietic small round cell tumors of children
Pediatr. Pathol. Lab. Med.
17
835-844
1997
Homo sapiens
Hansen, J.D.
Characterization of rainbow trout terminal deoxynucleotidyl transferase structure and expression. TdT and RAG1 co-expression define the trout primary lymphoid tissues
Immunogenetics
46
367-375
1997
Oncorhynchus mykiss
Thai, T.H.; Kearney, J.F.
Isoforms of terminal deoxynucleotidyltransferase: Developmental aspects and function
Adv. Immunol.
86
113-136
2005
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Uchiyama, Y.; Tagami, J.; Kamisuki, S.; Kasai, N.; Oshige, M.; Chiku, H.; Ibe, S.; Koiwai, O.; Sugawara, F.; Sakaguchi, K.
Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin
Biochim. Biophys. Acta
1725
298-304
2005
Homo sapiens
Repasky, J.A.; Corbett, E.; Boboila, C.; Schatz, D.G.
Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination
J. Immunol.
172
5478-5488
2004
Mus musculus
Doyen, N.; Boule, J.B.; Rougeon, F.; Papanicolaou, C.
Evidence that the long murine terminal deoxynucleotidyltransferase isoform plays no role in the control of V(D)J junctional diversity
J. Immunol.
172
6764-6767
2004
Mus musculus
Thai, T.H.; Kearney, J.F.
Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants
J. Immunol.
173
4009-4019
2004
Homo sapiens
Ramadan, K.; Shevelev, I.V.; Maga, G.; Huebscher, U.
De novo DNA synthesis by human DNA polymerase l, DNA polymerase m and terminal deoxyribonucleotidyl transferase
J. Mol. Biol.
339
395-404
2004
Homo sapiens
Locatelli, G.A.; Di Santo, R.; Crespan, E.; Costi, R.; Roux, A.; Hubscher, U.; Shevelev, I.; Blanca, G.; Villani, G.; Spadari, S.; Maga, G.
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells
Mol. Pharmacol.
68
538-550
2005
Bos taurus
Lue, N.F.; Bosoy, D.; Moriarty, T.J.; Autexier, C.; Altman, B.; Leng, S.
Telomerase can act as a template- and RNA-independent terminal transferase
Proc. Natl. Acad. Sci. USA
102
9778-9783
2005
Saccharomyces cerevisiae
Mizushina, Y.; Yagita, E.; Kuramochi, K.; Kuriyama, I.; Shimazaki, N.; Koiwai, O.; Uchiyama, Y.; Yomezawa, Y.; Sugawara, F.; Kobayashi, S.; Sakaguchi, K.; Yoshida, H.
5-(Hydroxymethyl)-2-furfural: a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase
Arch. Biochem. Biophys.
446
69-76
2006
Bos taurus
Weaver, C.V.; Liu, S.P.; Lu, J.F.; Lin, B.S.
The effects of benzene exposure on apoptosis in epithelial lung cells: localization by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) and the immunocytochemical localization of apoptosis-related gene products
Cell Biol. Toxicol.
23
201-220
2007
Rattus norvegicus
Fowler, J.D.; Suo, Z.
Biochemical, structural, and physiological characterization of terminal deoxynucleotidyl transferase
Chem. Rev.
106
2092-2110
2006
Bos taurus, Mus musculus
Cho, Y.; Kool, E.T.
Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone
ChemBioChem
7
669-672
2006
Bos taurus
Di Santo, R.; Maga, G.
Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy
Curr. Med. Chem.
13
2353-2368
2006
Homo sapiens, Mus musculus
Bertocci, B.; De Smet, A.; Weill, J.C.; Reynaud, C.A.
Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo
Immunity
25
31-41
2006
Mus musculus
Beetz, S.; Diekhoff, D.; Steiner, L.A.
Characterization of terminal deoxynucleotidyl transferase and polymerase micro in zebrafish
Immunogenetics
59
735-744
2007
Danio rerio, Danio rerio (Q5J2Q9)
Anne, A.; Bonnaudat, C.; Demaille, C.; Wang, K.
Enzymatic redox 3-end-labeling of DNA oligonucleotide monolayers on gold surfaces using terminal deoxynucleotidyl transferase (TdT)-mediated single base extension
J. Am. Chem. Soc.
129
2734-2735
2007
Bos taurus
Tian, C.; Luskin, G.K.; Dischert, K.M.; Higginbotham, J.N.; Shepherd, B.E.; Crowe, J.E.
Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naive and memory B cells
Mol. Immunol.
44
2173-2183
2007
Homo sapiens
Nishida, M.; Hada, T.; Kuramochi, K.; Yoshida, H.; Yonezawa, Y.; Kuriyama, I.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
Diallyl sulfides: Selective inhibitors of family X DNA polymerases from garlic (Allium sativum L.)
Food Chem.
108
551-560
2008
Bos taurus
Kubota, T.; Maezawa, S.; Koiwai, K.; Hayano, T.; Koiwai, O.
Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity
Genes Cells
12
941-959
2007
Homo sapiens
Zhao, B.; Gong, Z.; Ma, Z.; Wang, D.; Jin, Y.
Simple and sensitive microRNA labeling by terminal deoxynucleotidyl transferase
Acta Biochim. Biophys. Sin. (Shanghai)
44
129-135
2012
Bos taurus
Marsin, S.; Forterre, P.
A rolling circle replication initiator protein with a nucleotidyl-transferase activity encoded by the plasmid pGT5 from the hyperthermophilic archaeon Pyrococcus abyssi
Mol. Microbiol.
27
1183-1192
1998
Pyrococcus abyssi (O54003), Pyrococcus abyssi, Pyrococcus abyssi GE5 / CNCM I-1302 / DSM 25543 (O54003)
Boubakour-Azzouz, I.; Bertrand, P.; Claes, A.; Lopez, B.S.; Rougeon, F.
Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells
Nucleic Acids Res.
40
8381-8391
2012
Mus musculus (P09838)
Horakova, P.; Macickova-Cahova, H.; Pivonkova, H.; Spacek, J.; Havran, L.; Hocek, M.; Fojta, M.
Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl transferase. Application in electrochemical DNA hybridization and protein-DNA binding assays
Org. Biomol. Chem.
9
1366-1371
2011
Bos taurus (P06526)
Maezawa, S.; Fukushima, R.; Matsushita, T.; Kato, T.; Takagaki, Y.; Nishiyama, Y.; Ando, S.; Matsumoto, T.; Kouda, K.; Hayano, T.; Suzuki, M.; Koiwai, K.; Koiwai, O.
Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity
PLoS ONE
7
e39511
2012
Bos taurus
Maezawa, S.; Nakano, S.; Kuniya, T.; Koiwai, O.; Koiwai, K.
Double-strand break repair based on short-homology regions is suppressed under terminal deoxynucleotidyltransferase expression, as revealed by a novel vector system for analysing DNA repair by nonhomologous end joining
FEBS open bio
6
16-23
2016
Homo sapiens
Troshchynsky, A.; Dzneladze, I.; Chen, L.; Sheng, Y.; Saridakis, V.; Wu, G.E.
Functional analyses of polymorphic variants of human terminal deoxynucleotidyl transferase
Genes Immun.
16
388-398
2015
Homo sapiens (P04053), Homo sapiens
Gouge, J.; Rosario, S.; Romain, F.; Beguin, P.; Delarue, M.
Structures of intermediates along the catalytic cycle of terminal deoxynucleotidyltransferase: dynamical aspects of the two-metal ion mechanism
J. Mol. Biol.
425
4334-4352
2013
Mus musculus (P09838)
Ma, C.; Liu, H.; Li, W.; Chen, H.; Jin, S.; Wang, J.; Wang, J.
Label-free monitoring of DNA methyltransferase activity based on terminal deoxynucleotidyl transferase using a thioflavin T probe
Mol. Cell. Probes
30
118-121
2016
unidentified
Loch, J.; Rosario, S.; Delarue, M.
Structural basis for a new templated activity by terminal deoxynucleotidyl transferase: implications for V(D)J recombination
Structure
24
1452-1463
2016
Mus musculus (P09838)
Chua, J.P.S.; Go, M.K.; Osothprarop, T.; Mcdonald, S.; Karabadzhak, A.G.; Yew, W.S.; Peisajovich, S.; Nirantar, S.
Evolving a thermostable terminal deoxynucleotidyl transferase
ACS Synth. Biol.
9
1725-1735
2020
Bos taurus (P06526)
Barthel, S.; Palluk, S.; Hillson, N.J.; Keasling, J.D.; Arlow, D.H.
Enhancing terminal deoxynucleotidyl transferase activity on substrates with 3 terminal structures for enzymatic de novo DNA Synthesis
Genes (Basel)
11
102
2020
Mus musculus (P09838)
Deshpande, S.; Yang, Y.; Chilkoti, A.; Zauscher, S.
Enzymatic synthesis and modification of high molecular weight DNA using terminal deoxynucleotidyl transferase
Methods Enzymol.
627
163-188
2019
Mus musculus (P09838)
Zhou, F.; Cui, X.; Shang, A.; Lian, J.; Yang, L.; Jin, Y.; Li, B.
Fluorometric determination of the activity and inhibition of terminal deoxynucleotidyl transferase via in-situ formation of copper nanoclusters using enzymatically generated DNA as template
Microchim. Acta
184
773-779
2017
Homo sapiens
Tauraite, D.; Jakubovska, J.; Dabuzinskaite, J.; Bratchikov, M.; Meskys, R.
Modified nucleotides as substrates of terminal deoxynucleotidyl transferase
Molecules
22
672
2017
Bos taurus (P06526)
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