Reference on EC 2.7.7.2 - FAD synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yamada, Y.; Merrill, A.; McCormick, D.N.
Probable reaction mechanisms of flavokinase and FAD synthetase from rat liver
Arch. Biochem. Biophys.
278
125-130
1990
Rattus norvegicus
Mack, M.; van Loon, A.P.; Hohmann, H.P.
Regulation of riboflavin biosynthesis in Bacillus subtilis is affected by the activity of the flavokinase/flavin adenine dinucleotide synthetase encoded by ribC
J. Bacteriol.
180
950-955
1998
Bacillus subtilis (P54575), Bacillus subtilis, Bacillus subtilis 168 (P54575)
Schrecker, A.W.; Kornberg, A.
Reversible enzymatic synthesis of flavin-adenine dinucleotide
J. Biol. Chem.
182
795-803
1950
Saccharomyces cerevisiae
Gomes, B.; McCormick, D.B.
Purification and general characterization of FAD synthetase from rat liver
Proc. Soc. Exp. Biol. Med.
172
250-254
1983
Rattus norvegicus
Oka, M.; McCormick, D.B.
Complete purification and general characterization of FAD synthetase from rat liver
J. Biol. Chem.
262
7418-7422
1987
Rattus norvegicus
Bowers-Komro, D.; Yamada, Y.; McCormick, D.B.
Substrate specificity and variables affecting efficiency of mammalian flavin adenine dinucleotide synthetase
Biochemistry
28
8439-8446
1989
Rattus norvegicus
Hartman, H.A.; Edmondson, D.E.; McCormick, D.B.
Riboflavin 5-pyrophosphate: a contaminant of commercial FAD, a coenzyme for FAD-dependent oxidases, and an inhibitor of FAD synthetase
Anal. Biochem.
202
348-355
1992
Bos taurus
Hagihara, T.; Fujio, T.; Aisaka, K.
Cloning of FAD synthetase gene from Corynebacterium ammoniagenes and its application to FAD and FMN production
Appl. Microbiol. Biotechnol.
42
724-729
1995
Corynebacterium ammoniagenes
Nakagawa, S.; Igarashi, A.; Ohta, T.; Hagihara, T.; Fujio, T.; Aisaka, K.
Nucleotide sequence of the FAD synthetase gene from Corynebacterium ammoniagenes and its expression in Escherichia coli
Biosci. Biotechnol. Biochem.
59
694-702
1995
Corynebacterium ammoniagenes, Corynebacterium ammoniagenes (Q59263), Corynebacterium ammoniagenes ATCC 6872
Wu, M.; Repetto, B.; Glerum, D.M.; Tzagoloff, A.
Cloning and characterization of FAD1, the structural gene for flavin adenine dinucleotide synthetase of Saccharomyces cerevisiae
Mol. Cell. Biol.
15
264-271
1995
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P38913)
McCormick, D.B.; Oka, M.; Bowers-Komro, D.M.; Yamada, Y.; Hartman, H.A.
Purification and properties of FAD synthetase from liver
Methods Enzymol.
280
407-413
1997
Bos taurus, Corynebacterium ammoniagenes, Rattus norvegicus
Efimov, I.; Kuusk, V.; Zhang, X.; McIntire, W.S.
Proposed steady-state kinetic mechanism for Corynebacterium ammoniagenes FAD synthetase produced by Escherichia coli
Biochemistry
37
9716-9723
1998
Corynebacterium ammoniagenes
Krupa, A.; Sandhya, K.; Srinivasan, N.; Jonnalagadda, S.
A conserved domain in prokaryotic bifunctional FAD synthetases can potentially catalyze nucleotide transfer
Trends Biochem. Sci.
28
9-12
2003
Corynebacterium ammoniagenes
Wang, W.; Kim, R.; Yokota, H.; Kim, S.H.
Crystal structure of flavin binding to FAD synthetase of Thermotoga maritima
Proteins Struct. Funct. Bioinform.
58
246-248
2004
Thermotoga maritima, Thermotoga maritima TM379
-
Brizio, C.; Galluccio, M.; Wait, R.; Torchetti, E.M.; Bafunno, V.; Accardi, R.; Gianazza, E.; Indiveri, C.; Barile, M.
Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase
Biochem. Biophys. Res. Commun.
344
1008-1016
2006
Homo sapiens (Q8NFF5), Homo sapiens
Galluccio, M.; Brizio, C.; Torchetti, E.M.; Ferranti, P.; Gianazza, E.; Indiveri, C.; Barile, M.
Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase
Protein Expr. Purif.
52
175-181
2007
Homo sapiens (Q8NFF5), Homo sapiens
Grill, S.; Busenbender, S.; Pfeiffer, M.; Koehler, U.; Mack, M.
The bifunctional flavokinase/flavin adenine dinucleotide synthetase from Streptomyces davawensis produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin
J. Bacteriol.
190
1546-1553
2008
Streptomyces davaonensis
Frago, S.; Martinez-Julvez, M.; Serrano, A.; Medina, M.
Structural analysis of FAD synthetase from Corynebacterium ammoniagenes
BMC Microbiol.
8
160
2008
Corynebacterium ammoniagenes (Q59263)
Sandoval, F.J.; Zhang, Y.; Roje, S.
Flavin nucleotide metabolism in plants: monofunctional enzymes synthesize FAD in plastids
J. Biol. Chem.
283
30890-30900
2008
Arabidopsis thaliana (Q0WS47), Arabidopsis thaliana (Q8VZR0), Arabidopsis thaliana (Q9FMW8), Arabidopsis thaliana
Herguedas, B.; Martinez-Julvez, M.; Frago, S.; Medina, M.; Hermoso, J.A.
Crystallization and preliminary X-ray diffraction studies of FAD synthetase from Corynebacterium ammoniagenes
Acta Crystallogr. Sect. F
65
1285-1288
2009
Corynebacterium ammoniagenes
Giancaspero, T.A.; Locato, V.; de Pinto, M.C.; De Gara, L.; Barile, M.
The occurrence of riboflavin kinase and FAD synthetase ensures FAD synthesis in tobacco mitochondria and maintenance of cellular redox status
FEBS J.
276
219-231
2009
Nicotiana tabacum
Frago, S.; Velazquez-Campoy, A.; Medina, M.
The puzzle of ligand binding to Corynebacterium ammoniagenes FAD synthetase
J. Biol. Chem.
284
6610-6619
2009
Corynebacterium ammoniagenes
Huerta, C.; Borek, D.; Machius, M.; Grishin, N.V.; Zhang, H.
Structure and mechanism of a eukaryotic FMN adenylyltransferase
J. Mol. Biol.
389
388-400
2009
[Candida] glabrata (Q6FNA9)
Torchetti, E.M.; Brizio, C.; Colella, M.; Galluccio, M.; Giancaspero, T.A.; Indiveri, C.; Roberti, M.; Barile, M.
Mitochondrial localization of human FAD synthetase isoform 1
Mitochondrion
10
263-273
2010
Homo sapiens (Q8NFF5), Homo sapiens
Pedrolli, D.B.; Nakanishi, S.; Barile, M.; Mansurova, M.; Carmona, E.C.; Lux, A.; Gaertner, W.; Mack, M.
The antibiotics roseoflavin and 8-demethyl-8-amino-riboflavin from Streptomyces davawensis are metabolized by human flavokinase and human FAD synthetase
Biochem. Pharmacol.
82
1853-1859
2011
Homo sapiens
Mashhadi, Z.; Xu, H.; Grochowski, L.L.; White, R.H.
Archaeal RibL: a new FAD synthetase that is air sensitive
Biochemistry
49
8748-8755
2010
Methanocaldococcus jannaschii (Q58579), Methanocaldococcus jannaschii
Marcuello, C.; Arilla-Luna, S.; Medina, M.; Lostao, A.
Detection of a quaternary organization into dimer of trimers of Corynebacterium ammoniagenes FAD synthetase at the single-molecule level and at the in cell level
Biochim. Biophys. Acta
1834
665-676
2013
Corynebacterium ammoniagenes (Q59263)
Serrano, A.; Frago, S.; Herguedas, B.; Martinez-Julvez, M.; Velazquez-Campoy, A.; Medina, M.
Key residues at the riboflavin kinase catalytic site of the bifunctional riboflavin kinase/FMN adenylyltransferase from Corynebacterium ammoniagenes
Cell Biochem. Biophys.
65
57-68
2013
Corynebacterium ammoniagenes
Torchetti, E.; Bonomi, F.; Galluccio, M.; Gianazza, E.; Giancaspero, T.; Iametti, S.; Indiveri, C.; Barile, M.
Human FAD synthase (isoform 2): A component of the machinery that delivers FAD to apo-flavoproteins
FEBS J.
278
4435-4449
2011
Homo sapiens (Q8NFF5)
-
Leulliot, N.; Blondeau, K.; Keller, J.; Ulryck, N.; Quevillon-Cheruel, S.; van Tilbeurgh, H.
Crystal structure of yeast FAD synthetase (Fad1) in complex with FAD
J. Mol. Biol.
398
641-646
2010
Saccharomyces cerevisiae (P38913)
Herguedas, B.; Martinez-Julvez, M.; Frago, S.; Medina, M.; Hermoso, J.A.
Oligomeric state in the crystal structure of modular FAD synthetase provides insights into its sequential catalysis in prokaryotes
J. Mol. Biol.
400
218-230
2010
Corynebacterium ammoniagenes
Herguedas, B.; Lans, I.; Sebastian, M.; Hermoso, J.A.; Martinez-Julvez, M.; Medina, M.
Structural insights into the synthesis of FMN in prokaryotic organisms
Acta Crystallogr. Sect. D
71
2526-2542
2015
Corynebacterium ammoniagenes (Q59263)
Huerta, C.; Grishin, N.V.; Zhang, H.
The super mutant of yeast FMN adenylyltransferase enhances the enzyme turnover rate by attenuating product inhibition
Biochemistry
52
3615-3617
2013
[Candida] glabrata (Q6FNA9)
Serrano, A.; Sebastian, M.; Arilla-Luna, S.; Baquedano, S.; Pallares, M.C.; Lostao, A.; Herguedas, B.; Velazquez-Campoy, A.; Martinez-Julvez, M.; Medina, M.
Quaternary organization in a bifunctional prokaryotic FAD synthetase: Involvement of an arginine at its adenylyltransferase module on the riboflavin kinase activity
Biochim. Biophys. Acta
1854
897-906
2015
Corynebacterium ammoniagenes (Q59263), Corynebacterium ammoniagenes
Giancaspero, T.A.; Busco, G.; Panebianco, C.; Carmone, C.; Miccolis, A.; Liuzzi, G.M.; Colella, M.; Barile, M.
FAD synthesis and degradation in the nucleus create a local flavin cofactor pool
J. Biol. Chem.
288
29069-29080
2013
Rattus norvegicus (D4A4P4), Rattus norvegicus Wistar (D4A4P4)
Iamurri, S.M.; Daugherty, A.B.; Edmondson, D.E.; Lutz, S.
Truncated FAD synthetase for direct biocatalytic conversion of riboflavin and analogs to their corresponding flavin mononucleotides
Protein Eng. Des. Sel.
26
791-795
2013
Corynebacterium ammoniagenes (Q59263)
Sebastian, M.; Serrano, A.; Velazquez-Campoy, A.; Medina, M.
Kinetics and thermodynamics of the protein-ligand interactions in the riboflavin kinase activity of the FAD synthetase from Corynebacterium ammoniagenes
Sci. Rep.
7
7281
2017
Corynebacterium ammoniagenes (Q59263), Corynebacterium ammoniagenes
Lans, I.; Seco, J.; Serrano, A.; Burbano, R.; Cossio, P.; Daza, M.C.; Medina, M.
The dimer-of-trimers assembly prevents catalysis at the transferase site of prokaryotic FAD synthase
Biophys. J.
115
988-995
2018
Corynebacterium ammoniagenes (Q59263), Corynebacterium ammoniagenes
Leone, P.; Galluccio, M.; Brizio, C.; Barbiroli, A.; Iametti, S.; Indiveri, C.; Barile, M.
The hidden side of the human FAD synthase 2
Int. J. Biol. Macromol.
138
986-995
2019
Homo sapiens
Arilla-Luna, S.; Serrano, A.; Medina, M.
Specific features for the competent binding of substrates at the FMN adenylyltransferase site of FAD synthase from Corynebacterium ammoniagenes
Int. J. Mol. Sci.
20
5083
2019
Corynebacterium ammoniagenes (Q59263), Corynebacterium ammoniagenes
Serrano, A.; Arilla-Luna, S.; Medina, M.
Insights into the fmnat active site of FAD synthase Aromaticity is essential for flavin binding and catalysis
Int. J. Mol. Sci.
21
3738
2020
Corynebacterium ammoniagenes (Q59263), Corynebacterium ammoniagenes
Liu, S.; Diao, N.; Wang, Z.; Lu, W.; Tang, Y.J.; Chen, T.
Modular engineering of the flavin pathway in Escherichia coli for improved flavin mononucleotide and flavin adenine dinucleotide production
J. Agric. Food Chem.
67
6532-6540
2019
Escherichia coli (P0AG40)
Leone, P.; Galluccio, M.; Barbiroli, A.; Eberini, I.; Tolomeo, M.; Vrenna, F.; Gianazza, E.; Iametti, S.; Bonomi, F.; Indiveri, C.; Barile, M.
Bacterial production, characterization and protein modeling of a novel monofuctional isoform of FAD synthase in humans An emergency protein?
Molecules
23
116
2018
Homo sapiens (Q8NFF5), Homo sapiens
Lans, I.; Anoz-Carbonell, E.; Palacio-Rodriguez, K.; Ainsa, J.A.; Medina, M.; Cossio, P.
In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target
PLoS Comput. Biol.
16
e1007898
2020
Corynebacterium ammoniagenes (Q59263), Corynebacterium ammoniagenes
Zhou, G.; Pan, Q.; Hu, Z.; Qiu, J.; Yu, Z.
Heterologous expression and characterization of flavinadenine dinucleotide synthetase from Candida famata for flavin adenine dinucleotide production
Protein Pept. Lett.
28
229-239
2020
Debaryomyces hansenii (A0A5J6E2Y6)
Serrano, A.; Sebastian, M.; Arilla-Luna, S.; Baquedano, S.; Herguedas, B.; Velazquez-Campoy, A.; Martinez-Julvez, M.; Medina, M.
The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from Corynebacterium ammoniagenes
Sci. Rep.
7
404
2017
Corynebacterium ammoniagenes (Q59263)
Sebastian, M.; Lira-Navarrete, E.; Serrano, A.; Marcuello, C.; Velazquez-Campoy, A.; Lostao, A.; Hurtado-Guerrero, R.; Medina, M.; Martinez-Julvez, M.
The FAD synthetase from the human pathogen Streptococcus pneumoniae a bifunctional enzyme exhibiting activity-dependent redox requirements
Sci. Rep.
7
7609
2017
Streptococcus pneumoniae
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