Information on EC 2.7.7.18 - nicotinate-nucleotide adenylyltransferase and Organism(s) Homo sapiens

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Homo sapiens


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
2.7.7.18
-
RECOMMENDED NAME
GeneOntology No.
nicotinate-nucleotide adenylyltransferase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
-
-
NAD de novo biosynthesis I (from aspartate)
-
-
NAD salvage pathway I (PNC VI cycle)
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-
NAD salvage pathway II (PNC IV cycle)
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-
NAD salvage pathway V (PNC V cycle)
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pyridine nucleotide cycling (plants)
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NAD metabolism
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Nicotinate and nicotinamide metabolism
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-
Metabolic pathways
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:nicotinate-ribonucleotide adenylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-98-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
show the reaction diagram
ATP + nicotinic acid mononucleotide
nicotinic acid adenine dinucleotide + diphosphate
show the reaction diagram
-
-
-
-
r
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
show the reaction diagram
activity observed with GTP, ITP
-
-
r
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
product inhibition
nicotinic acid adenine dinucleotide
product inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.119
diphosphate
-
0.07
NAD+
-
0.021
nicotinamide mononucleotide
range 0.021-0.032 mM
0.015
nicotinic acid mononucleotide
-
0.0304
reduced nicotinamide mononucleotide
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
isoform NMNAT2 localizes to the cis-Golgi and endoplasmic reticulum-Golgi intermediate compartment. It is palmitoylated at two adjacent cysteine residues of its isoform-specific domain and thereby anchored at the cytoplasmic surface
Manually annotated by BRENDA team
sequence of isoform NMNAT1 contains a predicted nuclear localization signal
Manually annotated by BRENDA team
additional information
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
34439
4 * 34439, calculated
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homohexamer
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-
homotetramer
4 * 34439, calculated
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in HeLa S3 cells; expression in HeLa S3 cells; expression in HeLa S3 cells
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information