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IUBMB Comments This bacterial enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids, much like EC 2.7.7.15 , choline-phosphate cytidylyltransferase, activates phosphocholine for the same purpose.
Synonyms pntC ,
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pntC
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CTP + (2-aminoethyl)phosphonate = diphosphate + CMP-(2-aminoethyl)phosphonate
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MetaCyc
cell-surface glycoconjugate-linked phosphonate biosynthesis
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CTP:(2-aminoethyl)phosphonate cytidylyltransferase
This bacterial enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids, much like EC 2.7.7.15, choline-phosphate cytidylyltransferase, activates phosphocholine for the same purpose.
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CTP + (2-aminoethyl)phosphonate
diphosphate + CMP-(2-aminoethyl)phosphonate
additional information
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CTP + (2-aminoethyl)phosphonate
diphosphate + CMP-(2-aminoethyl)phosphonate
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Substrates: -
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CTP + (2-aminoethyl)phosphonate
diphosphate + CMP-(2-aminoethyl)phosphonate
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Substrates: -
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CTP + (2-aminoethyl)phosphonate
diphosphate + CMP-(2-aminoethyl)phosphonate
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Substrates: -
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CTP + (2-aminoethyl)phosphonate
diphosphate + CMP-(2-aminoethyl)phosphonate
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Substrates: -
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additional information
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Substrates: enzyme displays more than 400fold specificity for (2-aminoethyl)phosphonate over choline phosphate, substrate of EC 2.7.7.15
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additional information
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Substrates: enzyme displays more than 400fold specificity for (2-aminoethyl)phosphonate over choline phosphate, substrate of EC 2.7.7.15
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Mg2+
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presence of two adjacent magnesium ions in the PntC active site
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0.012 - 0.016
(2-aminoethyl)phosphonate
0.012
(2-aminoethyl)phosphonate
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pH 7.8, temperature not specified in the publication
0.016
(2-aminoethyl)phosphonate
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pH 7.8, temperature not specified in the publication
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1.05 - 3.7
(2-aminoethyl)phosphonate
1.05
(2-aminoethyl)phosphonate
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pH 7.8, temperature not specified in the publication
3.7
(2-aminoethyl)phosphonate
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pH 7.8, temperature not specified in the publication
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68 - 320
(2-aminoethyl)phosphonate
68
(2-aminoethyl)phosphonate
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pH 7.8, temperature not specified in the publication
320
(2-aminoethyl)phosphonate
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pH 7.8, temperature not specified in the publication
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Highest Expressing Human Cell Lines
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physiological function
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enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids
physiological function
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enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids
physiological function
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enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids
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physiological function
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enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids
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PntC structural analyses reveal steric discrimination against phosphocholine, substrate of EC 2.7.7.15
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structures determined in apo form and in the presence of CTP and (2-aminoethyl)phosphonate reveal steric discrimination against phosphocholine, substrate of EC 2.7.7.15. Water, residues Glu196 and Glu104 are positioned to interact with the primary amine of (2-aminoethyl)phosphonate via hydrogen bonds
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K153A
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less than 10% of wild-type activity
K25A
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less than 10% of wild-type activity
R15A
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less than 10% of wild-type activity
K153A
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less than 10% of wild-type activity
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K25A
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less than 10% of wild-type activity
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R15A
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less than 10% of wild-type activity
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Rice, K.; Batul, K.; Whiteside, J.; Kelso, J.; Papinski, M.; Schmidt, E.; Pratasouskaya, A.; Wang, D.; Sullivan, R.; Bartlett, C.; Weadge, J.; Van der Kamp, M.; Moreno-Hagelsieb, G.; Suits, M.; Horsman, G.
The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis
Nat. Commun.
10
3698
2019
Lancefieldella rimae, Lancefieldella rimae ATCC 49626, Treponema denticola, Treponema denticola ATCC 35405
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