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Information on EC 2.7.7.10 - UTP-hexose-1-phosphate uridylyltransferase
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2.7.7.10 UTP-hexose-1-phosphate uridylyltransferaseIUBMB Comments
alpha-D-Glucose 1-phosphate can also act as acceptor, but more slowly.
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Word Map
- 2.7.7.10
- galactosemia
- newborn
- galactokinase
- erythrocyte
-
duarte
- ovarian
- infant
- error
- cataract
- children
-
inborn
-
leloir
- galactitol
-
speech
-
gal-1-p
- jaundice
-
galactose-restricted
-
2.7.7.12
- glucose-1-phosphate
-
angeles
-
epimerase
-
hypergonadotropic
-
hypogonadism
-
4'-epimerase
- galactonate
-
galactose-free
-
transferase-deficient
- udpglucose
- dyspraxia
- hepatomegaly
-
uridylylation
-
gale
The enzyme appears in viruses and cellular organisms
Synonyms
galactose-1-phosphate uridyltransferase, galactose-1-phosphate uridyl transferase, galactose-1-phosphate uridylyltransferase, galactose 1-phosphate uridylyltransferase, galactose 1-phosphate uridyltransferase, utp-hexose-1-phosphate uridylyltransferase, udpgalactose pyrophosphorylase, uridine diphosphogalactose pyrophosphorylase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alpha-D-galactose 1-phosphate uridylyltransferase
-
-
-
-
galactose 1-phosphate uridyltransferase
-
-
-
-
galactose 1-phosphate uridylyltransferase
-
-
-
-
galactose-1-phosphate uridyltransferase
galactose-1-phosphate uridylyltransferase
-
-
-
-
GALT
UDPgalactose pyrophosphorylase
-
-
-
-
uridine diphosphate galactose pyrophosphorylase
-
-
-
-
uridine diphosphogalactose pyrophosphorylase
-
-
-
-
uridylyltransferase, galactose 1-phosphate
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
UTP:alpha-D-hexose-1-phosphate uridylyltransferase
alpha-D-Glucose 1-phosphate can also act as acceptor, but more slowly.
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CAS REGISTRY NUMBER
COMMENTARY
9016-11-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
diphosphate + UDP-alpha-D-galactose
UTP + alpha-D-galactose 1-phosphate
-
-
-
-
?
diphosphate + UDP-xylose
?
-
at 10% the rate of UDP-glucose or UDP-galactose
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reverse reaction at the same rate as UDP-glucose
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reverse reaction at the same rate as UDP-glucose
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
same active site for the 2 substrates alpha-D-galactose 1-phosphate and alpha-D-glucose 1-phosphate
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
preferred substrate
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
?, r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
constitutive enzyme
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
Entamoeba histolytica K-9 / ATCC 30015
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
Entamoeba histolytica K-9 / ATCC 30015
-
constitutive enzyme
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
alternate pathway of galactose metabolism
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
involved in galactose and glucose metabolism
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
?, ir
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
Saccharomyces fragilis
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction at the same rate as UDP-galactose
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction at the same rate as UDP-galactose
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
same active site for the 2 substrates alpha-D-galactose 1-phosphate and alpha-D-glucose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction at 75% the rate of alpha-D-galactose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction at 75% the rate of alpha-D-galactose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Entamoeba histolytica K-9 / ATCC 30015
-
reaction at 75% the rate of alpha-D-galactose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in galactose and glucose metabolism
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
additional information
?
-
-
no activity in the reverse reaction with UDP-N-acetylglucosamine, ADP-glucose, CDP-glucose, GDP-mannose or TDP-glucose
-
-
?
additional information
?
-
-
no activity with ATP, ITP, CTP or GTP
-
-
?
additional information
?
-
Entamoeba histolytica K-9 / ATCC 30015
-
no activity with ATP, ITP, CTP or GTP
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
constitutive enzyme
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
Entamoeba histolytica K-9 / ATCC 30015
-
constitutive enzyme
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
alternate pathway of galactose metabolism
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
involved in galactose and glucose metabolism
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in galactose and glucose metabolism
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
no inhibitors of UDP-galactose pyrophosphorolysis are alpha-D-glucose 1-phosphate, alpha-D-galactose 1-phosphate or galactose 6-phosphate
-
UDP-galactose
-
UDP-glucose pyrophosphorolysis or UDP-galactose synthesis
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
no effectors of UDP-galactose-forming reaction are MgUDP, magnesium citrate, magnesium oxaloacetate or sucrose
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
complete, or near complete, deficiency of GALT causes classic galactosaemia
Show AA Sequence and Transmembrane Helices (161 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K285N
additional information
additional information
-
construction of deletion mutant mice, in the urine of GALT-deleted mice, despite the absence of GALT enzyme, the acetaminophen glucuronide anomeric carbon clearly shows enrichment, though of lesser intensity than in the normal controls
additional information
-
construction of deletion mutant mice, in the urine of GALT-deleted mice, despite the absence of GALT enzyme, the acetaminophen glucuronide anomeric carbon clearly shows enrichment, though of lesser intensity than in the normal controls
-
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
-
15 min, 70% loss of activity, t1/2: 7.5 min, enzyme from healthy individual, and 10 min, enzyme from galactosemic individual
56
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, in 20 mM imidazole-HCl buffer, pH 7, 20% v/v glycerol, 30% loss of activity within 6 weeks
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kalckar, H.M.
The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides
Biochim. Biophys. Acta
12
250-264
1953
Saccharomyces fragilis
brenda
Lobelle-Rich, P.A.; Reeves, R.E.
Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica
Mol. Biochem. Parasitol.
7
173-182
1983
Entamoeba histolytica
brenda
Chacko, C.M.; McCrone, L.; Nadler, H.L.
Uridine diphosphoglucose pyrophosphorylase and uridine diphosphogalactose pyrophosphorylase in human skin fibroblasts derived from normal and galactosemic individuals
Biochim. Biophys. Acta
268
113-120
1972
Homo sapiens
brenda
Frydman, R.B.; Neufeld, E.F.; Hassid, W.Z.
Thymidine diphosphate D-galactose pyrophosphorylase of Phaseolus aureus
Biochim. Biophys. Acta
77
332-334
1963
Vigna radiata var. radiata
brenda
Lobelle-Rich, P.A.; Reeves, R.E.
Galactose-1-phosphate uridylyltransferase from Entamoeba histolytica
Methods Enzymol.
90
552-555
1982
Entamoeba histolytica, Entamoeba histolytica K-9 / ATCC 30015
-
brenda
Lee, L.J.; Kimura, A.; Tochikura, T.
Presence of a single enzyme catalyzing the pyrophosphorolysis of UDP-glucose and UDP-galactose in Bifidobacterium bifidum
Biochim. Biophys. Acta
527
301-304
1978
Bifidobacterium bifidum
brenda
Lee, L.J.; Kimura, A.; Tochikura, T.
Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum
J. Biochem.
86
923-928
1979
Bifidobacterium bifidum
brenda
Smart, E.L.; Pharr, D.M.
Separation and characteristics of galactose-1-phosphate and glucose-1-phosphate uridyltranferase from fruit peduncles of cucumber
Planta
153
370-375
1981
Cucumis sativus
brenda
Pazur, J.H.; Anderson, J.S.
Thymidine triphosphate: alpha-D-galactose 1-phosphate thymidylyltransferase from Streptococcus faecalis grown on D-galactose
J. Biol. Chem.
238
3155-3160
1963
Enterococcus faecalis
brenda
Feusi, M.E.S.; Burton, J.D.; Williamson, J.D.; Pharr, D.M.
Galactosyl-sucrose metabolism and UDP-galactose pyrophosphorylase from Cucumis melo L. fruit
Physiol. Plant.
106
9-16
1999
Cucumis melo, Glycine max
-
brenda
Leslie, N.; Yager, C.; Reynolds, R.; Segal, S.
UDP-galactose pyrophosphorylase in mice with galactose-1-phosphate uridyltransferase deficiency
Mol. Genet. Metab.
85
21-27
2005
Mus musculus
brenda
Mirzajani, F.; Mirfakhraie, R.; Nabati, F.; Tabatabaei, N.N.; Talachian, E.; Houshmand, M.
The first study of galactose-1-phosphate uridyl transferase mutations in Iranian galactosemia patients
Clin. Biochem.
39
697-699
2006
Homo sapiens
brenda
Wehrli, S.; Reynolds, R.; Segal, S.
Evidence for function of UDP galactose pyrophosphorylase in mice with absent galactose-1-phosphate uridyltransferase
Mol. Genet. Metab.
91
191-194
2007
Mus musculus, Mus musculus BALB/c
brenda
Karas-Kuzelicki, N.; Pfeifer, V.; Lukac-Bajalo, J.
Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation
Clin. Biochem.
41
869-874
2008
Homo sapiens
brenda
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