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Information on EC 2.7.2.1 - acetate kinase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC2.7.2.1

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IUBMB Comments

Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate , others have found that the enzyme can also use propanoate as a substrate, but more slowly . Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate .

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
acetate kinase, ack, acetokinase, acka2, acka1, ackase, atp-ecoak, urkinase, acetic kinase, atp-specific ak, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetate kinase (phosphorylating)
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acetic kinase
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acetokinase
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AK
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(S)-lactate fermentation to propanoate, acetate and hydrogen, (S)-propane-1,2-diol degradation, acetate and ATP formation from acetyl-CoA I, acetylene degradation (anaerobic), Bifidobacterium shunt, ethanolamine utilization, gallate degradation III (anaerobic), glycine degradation (reductive Stickland reaction), L-lysine fermentation to acetate and butanoate, L-threonine degradation I, lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales), methanogenesis from acetate, mixed acid fermentation, purine nucleobases degradation I (anaerobic), purine nucleobases degradation II (anaerobic), pyruvate fermentation to acetate II, pyruvate fermentation to acetate IV, reductive glycine pathway of autotrophic CO2 fixation, superpathway of fermentation (Chlamydomonas reinhardtii)
SYSTEMATIC NAME
IUBMB Comments
ATP:acetate phosphotransferase
Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate [4], others have found that the enzyme can also use propanoate as a substrate, but more slowly [7]. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate [9].
CAS REGISTRY NUMBER
COMMENTARY hide
9027-42-3
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A072ZNE2_PSEAI
394
0
42421
TrEMBL
-
A0A3M5EQW8_PSEAI
379
0
40991
TrEMBL
-
A0A643J0F9_PSEAI
394
0
42394
TrEMBL
-
A0A6B1YRA5_PSEAI
402
0
43401
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7M2ZQ06_PSEAI
377
0
39976
TrEMBL
-
A0A9P1R4K2_PSEAI
377
0
39910
TrEMBL
-
A0AAQ3LP00_PSEAI
402
0
43697
TrEMBL
-
A0ABD7K045_PSEAI
394
0
42363
TrEMBL
-