Reference on EC 2.7.11.30 - receptor protein serine/threonine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ge, R.; Rajeev, V.; Subramanian, G.; Reiss, K.A.; Liu, D.; Higgins, L.; Joly, A.; Dugar, S.; Chakravarty, J.; Henson, M.; McEnroe, G.; Schreiner, G.; Reiss, M.
Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling
Biochem. Pharmacol.
68
41-50
2004
Homo sapiens
Ottesen, J.J.; Huse, M.; Sekedat, M.D.; Muir, T.W.
Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated TbetaRI kinase
Biochemistry
43
5698-5706
2004
Homo sapiens (P36897), Homo sapiens
Peng, S.B.; Yan, L.; Xia, X.; Watkins, S.A.; Brooks, H.B.; Beight, D.; Herron, D.K.; Jones, M.L.; Lampe, J.W.; McMillen, W.T.; Mort, N.; Sawyer, J.S.; Yingling, J.M.
Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition
Biochemistry
44
2293-2304
2005
Homo sapiens
Roberts, H.J.; Hu, S.; Qiu, Q.; Leung, P.C.; Caniggia, I.; Gruslin, A.; Tsang, B.; Peng, C.
Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta
Biol. Reprod.
68
1719-1726
2003
Homo sapiens (Q8NER5), Homo sapiens
Sawyer, J.S.; Beight, D.W.; Britt, K.S.; Anderson, B.D.; Campbell, R.M.; Goodson, T.Jr.; Herron, D.K.; Li, H.Y.; McMillen, W.T.; Mort, N.; Parsons, S.; Smith, E.C.; Wagner, J.R.; Yan, L.; Zhang, F.; Yingling, J.M.
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain
Bioorg. Med. Chem. Lett.
14
3581-3584
2004
Homo sapiens, Mus musculus
Desgrosellier, J.S.; Mundell, N.A.; McDonnell, M.A.; Moses, H.L.; Barnett, J.V.
Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation
Dev. Biol.
280
201-210
2005
Gallus gallus
Zhang, N.; Kumar, M.; Xu, G.; Ju, W.; Yoon, T.; Xu, E.; Huang, X.; Gaisano, H.; Peng, C.; Wang, Q.
Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines
Diabetologia
49
506-518
2006
Rattus norvegicus
Liu, C.; Gaca, M.D.; Swenson, E.S.; Vellucci, V.F.; Reiss, M.; Wells, R.G.
Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
J. Biol. Chem.
278
11721-11728
2003
Rattus norvegicus
Harrison, C.A.; Gray, P.C.; Koerber, S.C.; Fischer, W.; Vale, W.
Identification of a functional binding site for activin on the type I receptor ALK4
J. Biol. Chem.
278
21129-21135
2003
Homo sapiens
Kim, B.C.; van Gelder, H.; Kim, T.A.; Lee, H.J.; Baik, K.G.; Chun, H.H.; Lee, D.A.; Choi, K.S.; Kim, S.J.
Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells
J. Biol. Chem.
279
28458-28465
2004
Homo sapiens
Yakymovych, I.; Heldin, C.H.; Souchelnytskyi, S.
Smad2 phosphorylation by type I receptor. Contribution of arginine 462 and cysteine 463 In the C terminus of Smad2 for specificity
J. Biol. Chem.
279
35781-35787
2004
Mus musculus
Ungefroren, H.; Groth, S.; Ruhnke, M.; Kalthoff, H.; Fandrich, F.
Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta
J. Biol. Chem.
280
2644-2652
2005
Homo sapiens
Lux, A.; Beil, C.; Majety, M.; Barron, S.; Gallione, C.J.; Kuhn, H.M.; Berg, J.N.; Kioschis, P.; Marchuk, D.A.; Hafner, M.
Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1
J. Biol. Chem.
280
8482-8493
2005
Homo sapiens
Forrester, S.G.; Warfel, P.W.; Pearce, E.J.
Tegumental expression of a novel type II receptor serine/threonine kinase (SmRK2) in Schistosoma mansoni
Mol. Biochem. Parasitol.
136
149-156
2004
Schistosoma mansoni (Q6GZL5), Schistosoma mansoni
Goumans, M.J.; Valdimarsdottir, G.; Itoh, S.; Lebrin, F.; Larsson, J.; Mummery, C.; Karlsson, S.; ten Dijke, P.
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
Mol. Cell
12
817-828
2003
Mus musculus
Mazerbourg, S.; Klein, C.; Roh, J.; Kaivo-Oja, N.; Mottershead, D.G.; Korchynskyi, O.; Ritvos, O.; Hsueh, A.J.
Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5
Mol. Endocrinol.
18
653-665
2004
Rattus norvegicus (P80204)
Halder, S.K.; Beauchamp, R.D.; Datta, P.K.
A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers
Neoplasia
7
509-521
2005
Homo sapiens
Fink, S.P.; Mikkola, D.; Willson, J.K.V.; Markowitz, S.
TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines
Oncogene
22
1317-1323
2003
Homo sapiens
Watanabe, R.; Shen, Z.P.; Tsuda, K.; Yamada, Y.
Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells
Biochem. Biophys. Res. Commun.
377
867-872
2008
Homo sapiens
Kim, D.K.; Choi, J.H.; An, Y.J.; Lee, H.S.
Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-beta type1 receptor kinase inhibitors
Bioorg. Med. Chem. Lett.
18
2122-2127
2008
Rattus norvegicus
Zhou, L.; Nguyen, A.N.; Sohal, D.; Ying Ma, J.; Pahanish, P.; Gundabolu, K.; Hayman, J.; Chubak, A.; Mo, Y.; Bhagat, T.D.; Das, B.; Kapoun, A.M.; Navas, T.A.; Parmar, S.; Kambhampati, S.; Pellagatti, A.; Braunchweig, I.; Zhang, Y.; Wickrema, A.; Medicherla, S.; Boultwood, J.; Platanias, L.C.; Higgins, L.S.
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS
Blood
112
3434-3443
2008
Homo sapiens (P36897)
Xu, Y.; Tabe, Y.; Jin, L.; Watt, J.; McQueen, T.; Ohsaka, A.; Andreeff, M.; Konopleva, M.
TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells
Br. J. Haematol.
142
192-201
2008
Homo sapiens
Fujiwara, M.; Yagi, H.; Matsuoka, R.; Akimoto, K.; Furutani, M.; Imamura, S.; Uehara, R.; Nakayama, T.; Takao, A.; Nakazawa, M.; Saji, T.
Implications of mutations of activin receptor-like kinase 1 gene (ALK1) in addition to bone morphogenetic protein receptor II gene (BMPR2) in children with pulmonary arterial hypertension
Circ. J.
72
127-133
2008
Homo sapiens (P37023), Homo sapiens
Bueno, L.; de Alwis, D.P.; Pitou, C.; Yingling, J.; Lahn, M.; Glatt, S.; Troconiz, I.F.
Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice
Eur. J. Cancer
44
142-150
2008
Homo sapiens
Zhao, S.; Ammanamanchi, S.; Brattain, M.; Cao, L.; Thangasamy, A.; Wang, J.; Freeman, J.W.
Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells
J. Biol. Chem.
283
11293-11301
2008
Homo sapiens
Young, J.M.; Juengel, J.L.; Dodds, K.G.; Laird, M.; Dearden, P.K.; McNeilly, A.S.; McNatty, K.P.; Wilson, T.
The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures
J. Endocrinol.
196
251-261
2008
Ovis aries
Xu, G.; Bernaudo, S.; Fu, G.; Lee, D.Y.; Yang, B.B.; Peng, C.
Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7
Mol. Biol. Cell
19
4968-4979
2008
Homo sapiens
Haneen, S.; Johanna, H.; Ulrich, G.; Jens, S.S.; Frank, R.; Karl, H.; Peter, B.
Mutation analysis of "Endoglin" and "Activin receptor-like kinase" genes in German patients with hereditary hemorrhagic telangiectasia and the value of rapid genotyping using an allele-specific PCR-technique
BMC Med. Genet.
10
53
2009
Homo sapiens (P37023), Homo sapiens
Long, L.; Crosby, A.; Yang, X.; Southwood, M.; Upton, P.D.; Kim, D.K.; Morrell, N.W.
Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease
Circulation
119
566-576
2009
Rattus norvegicus
Upton, P.D.; Davies, R.J.; Trembath, R.C.; Morrell, N.W.
Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
J. Biol. Chem.
284
15794-15804
2009
Homo sapiens
Mahmoud, M.; Borthwick, G.M.; Hislop, A.A.; Arthur, H.M.
Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH
Lab. Invest.
89
15-25
2009
Mus musculus
Li, L.; Zhao, X.Y.; Wang, B.E.
Down-regulation of transforming growth factor beta 1/activin receptor-like kinase 1 pathway gene expression by herbal compound 861 is related to deactivation of LX-2 cells
World J. Gastroenterol.
14
2894-2899
2008
Homo sapiens
Zhou, L.; McMahon, C.; Bhagat, T.; Alencar, C.; Yu, Y.; Fazzari, M.; Sohal, D.; Heuck, C.; Gundabolu, K.; Ng, C.; Mo, Y.; Shen, W.; Wickrema, A.; Kong, G.; Friedman, E.; Sokol, L.; Mantzaris, I.; Mantzaris, G.; Pellagatti, A.; Boultwood, J.; Platanias, L.C.; Steidl, U.; Yan, L.; Yingling, J.M.; Lahn, M.M.
Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase
Cancer Res.
71
955-963
2011
Homo sapiens (P36897)
Chen, C.L.; Kao, Y.C.; Yang, P.H.; Sung, P.J.; Wen, Z.H.; Chen, J.J.; Huang, Y.B.; Chen, P.Y.
A small dibromotyrosine derivative purified from Pseudoceratina sp. suppresses TGF-beta responsiveness by inhibiting TGF-beta type I receptor serine/threonine kinase activity
J. Cell. Biochem.
117
2800-2814
2016
Homo sapiens (P36897)
Sun, X.L.; Yu, Q.Y.; Tang, L.L.; Ji, W.; Bai, X.; Cai, H.; Liu, X.F.; Ding, X.D.; Zhu, Y.M.
GsSRK, a G-type lectin S-receptor-like serine/threonine protein kinase, is a positive regulator of plant tolerance to salt stress
J. Plant Physiol.
170
505-515
2013
Glycine soja
Liu, J.; Cao, D.; Liu, Y.; Li, Z.; Si, Y.; Wang, Z.; Zhang, Q.; Yu, H.; Wang, X.
Expression and functional analysis of receptor-interacting serine/threonine kinase 2 (RIP2) in Japanese flounder (Paralichthys olivaceus)
Fish Shellfish Immunol.
75
327-335
2018
Paralichthys olivaceus
Ota, M.; Tahara, T.; Otsuka, T.; Jing, W.; Nomura, T.; Hayashi, R.; Shimasaki, T.; Nakamura, M.; Shibata, T.; Arisawa, T.
Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility
Oncol. Lett.
15
3772-3778
2018
Homo sapiens (O43353)
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