Reference on EC 2.7.11.23 - [RNA-polymerase]-subunit kinase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cisek, L.J.; Corden, J.L.
Purification of protein kinases that phosphorylate the repetitive carboxyl-terminal domain of eukaryotic RNA polymerase II
Methods Enzymol.
200
301-325
1991
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Triticum aestivum
Lee, J.M.; Greenleaf, A.L.
A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II
Proc. Natl. Acad. Sci. USA
86
3624-3628
1989
Saccharomyces cerevisiae, Drosophila sp. (in: flies), Homo sapiens, Drosophila sp. (in: flies) Kc
Stevens, A.; Maupin, M.K.
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptide
Biochem. Biophys. Res. Commun.
159
508-515
1989
Homo sapiens
Feuerstein, N.
Phosphorylation of numatrin and other nuclear proteins by cdc2 containing CTD kinase cdc2/p58
J. Biol. Chem.
266
16200-16206
1991
Mus musculus
Payne, J.M.; Dahmus, M.E.
Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit IIa
J. Biol. Chem.
268
80-87
1993
Homo sapiens
Dvir, A.; Stein, L.Y.; Calore, B.L.; Dynan, W.S.
Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II
J. Biol. Chem.
268
10440-10447
1993
Homo sapiens
Guilfoyle, T.J.
A protein kinase from wheat germ that phosphorylates the largest subunit of RNA polymerase II
Plant Cell
1
827-836
1989
Triticum aestivum
Stone, N.; Reinberg, D.
Protein kinases from Aspergillus nidulans that phosphorylate the carboxyl-terminal domain of the largest subunit of RNA polymerase II
J. Biol. Chem.
267
6353-6360
1992
Aspergillus sp.
Morris, D.P.; Lee, J.M.; Sterner, D.E.; Brickey, W.J.; Greenleaf, A.L.
Assaying CTD kinases in vitro and phosphorylation-modulated properties of RNA polymerase II in vivo
Methods
12
264-275
1997
Saccharomyces cerevisiae
Baskaran, R.; Escobar, S.R.; Wang, J.Y.
Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: possible role in transcription elongation
Cell Growth Differ.
10
387-396
1999
Mus musculus
Skaar, D.A.; Greenleaf, A.L.
The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p
Mol. Cell
10
1429-1439
2002
Saccharomyces cerevisiae
Jona, G.; Wittschieben, B.O.; Svejstrup, J.Q.; Gileadi, O.
Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo
Gene
267
31-36
2001
Saccharomyces cerevisiae
Prelich, G.
RNA polymerase II carboxy-terminal domain kinases: emerging clues to their function
Eukaryot. Cell
1
153-162
2002
Saccharomyces cerevisiae, Drosophila sp. (in: flies), Mus musculus
Hautbergue, G.; Goguel, V.
Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits
J. Biol. Chem.
276
8005-8013
2001
Saccharomyces cerevisiae
Patturajan, M.; Conrad, N.K.; Bregman, D.B.; Corden, J.L.
Yeast carboxyl-terminal domain kinase I positively and negatively regulates RNA polymerase II carboxyl-terminal domain phosphorylation
J. Biol. Chem.
274
27823-27828
1999
Saccharomyces cerevisiae
Phatnani, H.P.; Jones, J.C.; Greenleaf, A.L.
Expanding the functional repertoire of CTD kinase I and RNA polymerase II: novel phosphoCTD-associating proteins in the yeast proteome
Biochemistry
43
15702-15719
2004
Saccharomyces cerevisiae
Medlin, J.E.; Uguen, P.; Taylor, A.; Bentley, D.L.; Murphy, S.
The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA
EMBO J.
22
925-934
2003
Homo sapiens
Kim, M.; Ahn, S.H.; Krogan, N.J.; Greenblatt, J.F.; Buratowski, S.
Transitions in RNA polymerase II elongation complexes at the 3' ends of genes
EMBO J.
23
354-364
2004
Saccharomyces cerevisiae
Palancade, B.; Bensaude, O.
Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation
Eur. J. Biochem.
270
3859-3870
2003
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Schizosaccharomyces pombe
Xiao, T.; Hall, H.; Kizer, K.O.; Shibata, Y.; Hall, M.C.; Borchers, C.H.; Strahl, B.D.
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast
Genes Dev.
17
654-663
2003
Saccharomyces cerevisiae, Saccharomyces cerevisiae AS4
Wilcox, C.B.; Rossettini, A.; Hanes, S.D.
Genetic interactions with C-terminal domain (CTD) kinases and the CTD of RNA Pol II suggest a role for ESS1 in transcription initiation and elongation in Saccharomyces cerevisiae
Genetics
167
93-105
2004
Saccharomyces cerevisiae
Jones, J.C.; Phatnani, H.P.; Haystead, T.A.; MacDonald, J.A.; Alam, S.M.; Greenleaf, A.L.
C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats
J. Biol. Chem.
279
24957-24964
2004
Saccharomyces cerevisiae
Kong, S.E.; Kobor, M.S.; Krogan, N.J.; Somesh, B.P.; Sogaard, T.M.; Greenblatt, J.F.; Svejstrup, J.Q.
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator
J. Biol. Chem.
280
4299-4306
2005
Saccharomyces cerevisiae
Tamrakar, S.; Kapasi, A.J.; Spector, D.H.
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7
J. Virol.
79
15477-15493
2005
Homo sapiens
Jacobs, E.Y.; Ogiwara, I.; Weiner, A.M.
Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing
Mol. Cell. Biol.
24
846-855
2004
Homo sapiens
Ahn, S.H.; Kim, M.; Buratowski, S.
Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing
Mol. Cells
13
67-76
2004
Saccharomyces cerevisiae
Bouchoux, C.; Hautbergue, G.; Grenetier, S.; Carles, C.; Riva, M.; Goguel, V.
CTD kinase I is involved in RNA polymerase I transcription
Nucleic Acids Res.
32
5851-5860
2004
Schizosaccharomyces pombe
Fulop, K.; Pettko-Szandtner, A.; Magyar, Z.; Miskolczi, P.; Kondorosi, E.; Dudits, D.; Bako, L.
The Medicago CDKC;1-CYCLINT;1 kinase complex phosphorylates the carboxy-terminal domain of RNA polymerase II and promotes transcription
Plant J.
42
810-820
2005
Medicago sativa
Roether, S.; Straesser, K.
The RNA polymerase II CTD kinase Ctk1 functions in translation elongation
Genes Dev.
21
1409-1421
2007
Saccharomyces cerevisiae
Hirose, Y.; Ohkuma, Y.
Phosphorylation of the C-terminal domain of RNA polymerase II plays central roles in the integrated events of eucaryotic gene expression
J. Biochem.
141
601-608
2007
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Xenopus laevis
Sogaard, T.M.; Svejstrup, J.Q.
Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator
J. Biol. Chem.
282
14113-14120
2007
Saccharomyces cerevisiae
Kapasi, A.J.; Spector, D.H.
Inhibition of the cyclin-dependent kinases at the beginning of the human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome
J. Virol.
82
394-407
2007
Homo sapiens, Homo sapiens (P50613), Homo sapiens (P50750)
Xiao, T.; Shibata, Y.; Rao, B.; Laribee, R.N.; ORourke, R.; Buck, M.J.; Greenblatt, J.F.; Krogan, N.J.; Lieb, J.D.; Strahl, B.D.
The RNA polymerase II kinase Ctk1 regulates positioning of a 5 histone methylation boundary along genes
Mol. Cell. Biol.
27
721-731
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Bark-Jones, S.J.; Webb, H.M.; West, M.J.
EBV EBNA 2 stimulates CDK9-dependent transcription and RNA polymerase II phosphorylation on serine 5
Oncogene
25
1775-1785
2006
Homo sapiens
Bres, V.; Yoh, S.M.; Jones, K.A.
The multi-tasking P-TEFb complex
Curr. Opin. Cell Biol.
20
334-340
2008
Saccharomyces cerevisiae
Ni, Z.; Saunders, A.; Fuda, N.J.; Yao, J.; Suarez, J.R.; Webb, W.W.; Lis, J.T.
P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo
Mol. Cell. Biol.
28
1161-1170
2008
Drosophila melanogaster
Youdell, M.L.; Kizer, K.O.; Kisseleva-Romanova, E.; Fuchs, S.M.; Duro, E.; Strahl, B.D.; Mellor, J.
Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36
Mol. Cell. Biol.
28
4915-4926
2008
Saccharomyces cerevisiae (Q03957)
Bennett, C.B.; Westmoreland, T.J.; Verrier, C.S.; Blanchette, C.A.; Sabin, T.L.; Phatnani, H.P.; Mishina, Y.V.; Huper, G.; Selim, A.L.; Madison, E.R.; Bailey, D.D.; Falae, A.I.; Galli, A.; Olson, J.A.; Greenleaf, A.L.; Marks, J.R.
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction
PLoS ONE
3
e1448
2008
Saccharomyces cerevisiae
Kanin, E.I.; Kipp, R.T.; Kung, C.; Slattery, M.; Viale, A.; Hahn, S.; Shokat, K.M.; Ansari, A.Z.
Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis
Proc. Natl. Acad. Sci. USA
104
5812-5817
2007
Saccharomyces cerevisiae
Heidemann, M.; Hintermair, C.; Vo, K.; Eick, D.
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
Biochim. Biophys. Acta
1829
55-62
2013
Schizosaccharomyces pombe (O14098), Schizosaccharomyces pombe (Q12126), Schizosaccharomyces pombe (Q96WV9), Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae (P39073), Saccharomyces cerevisiae (Q03957), Homo sapiens (P49336), Homo sapiens (P50613), Homo sapiens (P50750), Homo sapiens (Q9H4B4), Drosophila melanogaster (Q24216), Drosophila melanogaster (Q9VT57), Schizosaccharomyces pombe ATCC 24843 (O14098), Schizosaccharomyces pombe ATCC 24843 (Q12126), Schizosaccharomyces pombe ATCC 24843 (Q96WV9)
Bartkowiak, B.; Liu, P.; Phatnani, H.P.; Fuda, N.J.; Cooper, J.J.; Price, D.H.; Adelman, K.; Lis, J.T.; Greenleaf, A.L.
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1
Genes Dev.
24
2303-2316
2010
Homo sapiens (Q14004), Homo sapiens (Q9NYV4), Homo sapiens, Drosophila melanogaster (Q9VP22)
Tyagi, S.; Ochem, A.; Tyagi, M.
DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression
J. Gen. Virol.
92
1710-1720
2011
Homo sapiens
Badjatia, N.; Ambrosio, D.L.; Lee, J.H.; Guenzl, A.
Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of the RNA polymerase II subunit RPB1
Mol. Cell. Biol.
33
1965-1975
2013
Trypanosoma brucei
Bataille, A.R.; Jeronimo, C.; Jacques, P.E.; Laramee, L.; Fortin, M.E.; Forest, A.; Bergeron, M.; Hanes, S.D.; Robert, F.
A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes
Mol. Cell
45
158-170
2012
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae (Q03957)
Di Vona, C.; Bezdan, D.; Islam, A.B.; Salichs, E.; Lopez-Bigas, N.; Ossowski, S.; de la Luna, S.
Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase
Mol. Cell
57
506-520
2015
Homo sapiens
Allepuz-Fuster, P.; Martinez-Fernandez, V.; Garrido-Godino, A.I.; Alonso-Aguado, S.; Hanes, S.D.; Navarro, F.; Calvo, O.
Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation
Nucleic Acids Res.
42
13674-13688
2014
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae (P39073), Saccharomyces cerevisiae (Q03957)
Devaiah, B.N.; Lewis, B.A.; Cherman, N.; Hewitt, M.C.; Albrecht, B.K.; Robey, P.G.; Ozato, K.; Sims, R.J.; Singer, D.S.
BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain
Proc. Natl. Acad. Sci. USA
109
6927-6932
2012
Mus musculus (Q9ESU6)
Muehlbacher, W.; Mayer, A.; Sun, M.; Remmert, M.; Cheung, A.C.; Niesser, J.; Soeding, J.; Cramer, P.
Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold
Proteins
83
1849-1858
2015
Schizosaccharomyces pombe (Q9USJ8), Schizosaccharomyces pombe
Li, X.; Chatterjee, N.; Spirohn, K.; Boutros, M.; Bohmann, D.
Cdk12 is a gene-selective RNA polymerase II kinase that regulates a subset of the transcriptome, including Nrf2 target genes
Sci. Rep.
6
21455
2016
Drosophila melanogaster
Narita, T.; Ishida, T.; Ito, A.; Masaki, A.; Kinoshita, S.; Suzuki, S.; Takino, H.; Yoshida, T.; Ri, M.; Kusumoto, S.; Komatsu, H.; Imada, K.; Tanaka, Y.; Takaori-Kondo, A.; Inagaki, H.; Scholz, A.; Lienau, P.; Kuroda, T.; Ueda, R.; Iida, S.
Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma
Blood
130
1114-1124
2017
Mus musculus (Q99J95)
Duan, J.; Liu, Q.; Su, S.; Cha, J.; Zhou, Y.; Tang, R.; Liu, X.; Wang, Y.; Liu, Y.; He, Q.
The Neurospora RNA polymerase II kinase CTK negatively regulates catalase expression in a chromatin context-dependent manner
Environ. Microbiol.
22
76-90
2020
Neurospora crassa, Neurospora crassa 87-3
Donnio, L.M.; Lagarou, A.; Sueur, G.; Mari, P.O.; Giglia-Mari, G.
CSB-dependent cyclin-dependent kinase 9 degradation and RNA polymerase II phosphorylation during transcription-coupled repair
Mol. Cell. Biol.
39
e00225-18
2019
Homo sapiens (P50750)
html completed
