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Information on EC - phosphorylase kinase

for references in articles please use BRENDA:EC2.7.11.19
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IUBMB Comments
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b . The gamma subunit of the tetrameric enzyme is the catalytic subunit.
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The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Reaction Schemes
dephosphophosphorylase kinase, DphK-gamma, EC, glycogen phosphorylase b kinase, Glycogen phosphorylase kinase, GPK, kinase kinase/phosphatase/inhibitor-2, kinase, phosphorylase (phosphorylating), KPI-2 kinase, More, more
2 ATP + phosphorylase b = 2 ADP + phosphorylase a
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