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ATP + 20kDa myosin light chain
ADP + 20kDa myosin light chain phosphate
-
phosphorylation occurs at Ser-19 and Thr-18
-
-
?
ATP + BpaKKRAARATSNVFA
ADP + ?
-
Bpa is the photoreactive amino acid p-benzoylphenylalanine
-
-
?
ATP + Dictyostelium myosin
ADP + Dictyostelium myosin phosphate
-
-
-
?
ATP + H-KKRAARATSNVFA-NH2
ADP + ?
-
peptide substrate
-
-
?
ATP + kemptamide
ADP + ?
-
-
-
-
?
ATP + kemptamide
ADP + kemptamide phosphate
i.e. peptide KKRPQRATSNVFS-NH2, activated enzyme
-
-
?
ATP + KKRAARATSNVFA
ADP + ?
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
ATP + Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala
ADP + ?
-
-
-
-
?
ATP + Lys-Lys-Arg-Pro-Gln-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ser
ADP + ?
-
-
-
-
?
ATP + myosin
ADP + myosin phosphate
-
-
-
?
ATP + myosin II
ADP + myosin II phosphate
from Dictyostelium discoideum, activated enzyme
-
-
?
ATP + myosin IIB
ADP + phosphorylated myosin IIB
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
ATP + myosin light chain
ADP + phosphorylated myosin light chain
ATP + myosin light chain 2
ADP + myosin light chain 2 phosphate
ATP + myosin regulatory light chain
?
-
-
-
-
?
ATP + myosin regulatory light chain
ADP + myosin regulatory light chain phosphate
ATP + myosin regulatory light chain
ADP + phosphorylated myosin regulatory light chain
-
-
-
-
?
ATP + myosin-II regulatory light chain
ADP + myosin-II regulatory light chain phosphate
-
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
ATP + protein
ADP + phosphoprotein
ATP + telokin
ADP + ?
-
telokin may modulate enzyme activity in vivo
-
-
?
ATP + TRPC5 channel
ADP + phosphorylated TRPC5 channel
Ca2+/calmodulin-dependent myosin light chain kinase is essential for activation of plasma membrane TRPC5 channels, responsible for Ca2+ influx, from Drosophila melanogaster expressed in HEK-293 cells, phosphorylation sites are Ser698, Ser775, and Thr700, mutational analysis
-
-
?
ATP + [myosin II light chain]
ADP + [myosin II lihght chain] phosphate
from Dictyostelium discoideum, activated enzyme
-
-
?
ATP + [myosin II regulatory light chain]
ADP + [myosin II regulatory light chain] phosphate
ATP + [myosin light chain 2a]
ADP + [myosin light chain 2a] phosphate
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
ATP + [non-muscle heavy meromyosin IIB]
ADP + [non-muscle heavy meromyosin IIB] phosphate
-
-
-
?
ATP + [non-muscle regulatory light chain]
ADP + [non-muscle regulatory light chain] phosphate
-
-
-
?
ATP + [rabbit white skeletal muscle myosin P-light chain]
ADP + [rabbit white skeletal muscle myosin P-light chain] phosphate
-
-
-
-
?
ATP + [smooth muscle heavy meromyosin]
ADP + [smooth muscle heavy meromyosin] phosphate
-
-
-
?
ATP + [smooth muscle regulatory light chain]
ADP + [smooth muscle regulatory light chain] phosphate
-
-
-
?
ATP + [ventricular isoform of myosin regulatory light chain MLC2v]
ADP + [ventricular isoform of myosin regulatory light chain MLC2v] phosphate
-
-
-
-
?
additional information
?
-
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
causes endothelial contraction
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
the cardiac-specific substrate cardiac-MLCKis phosphorylated by the cardiac-specific isozyme MLC2v
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
the enzyme is important in regulation of shape, adhesion and migration of fibrosarcoma cells, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin light chain
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
the cardiac-specific substrate MLC2v is phosphorylated by the cardiac-specific isozyme cardiac-MLCK
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
roles of MLCK and ROCK on myosin II activation, overview, a global, MLCK-dependent increase in myosin II cortical contractility accompanies the metaphase-anaphase transition in sea urchin eggs, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
phosphorylation at Ser19
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
MLCK plays a key role in the control of MLC-phosphorylation status, and it modulates barrier function through its regulation of intracellular contractile machinery, overview, endothelial mechanism of MLC-dependent barrier injury in burns, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, in thick filaments, isozyme L-MLCK plays a role in cytoskeleton organization
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of adrenal medullary myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2 b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is synapsin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
1 mol phosphate per mol light chain in skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myelin basic protein, glycogen synthase, tubulin, microtubule-associated protein 2, kemptide and peptide pp60src
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not 16 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone V-S
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
obligatory step in development of active tension in smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in regulation of actin-myosin contractile activity in adrenal medulla
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the enzyme has effects on the actin-myosin interaction in vitro, binding of full-length and fragmented enzyme, overview. The Asp-Phe-Arg-X-X-Leu motif plays a major role in the binding of MLCK to myofibrils. Regulation of actinmyosin interaction by MLCK through its non-kinase activity, overview
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
20 kDa regulatory light chain of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
no substrates are myosin heavy chain and phosvitin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
not 16 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
no substrates are myosin heavy chain and phosvitin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
1 mol phosphate per mol light chain in skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone V-S
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
inhibition of actin-myosin ineraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the enzyme has effects on the actin-myosin interaction in vitro, regulation of actin-myosin interaction by MLCK through its non-kinase activity, overview
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
20 kDa regulatory light chain of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
640618, 640626, 640631, 640632, 687922, 688218, 688628, 689353, 707084, 709236, 709287, 709713, 709858, 710379 -
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is protamine
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone V-S
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation at Ser19
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
MLCK plays a crucial role in the cell migration and tumor metastasis
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are actin and tropomyosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2 b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone H1
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
1 mol phosphate per mol light chain in skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
transfers the gamma-phosphate of ATP to a Ser-residue of myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not 16 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone V-S
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
ITP, GTP, CTP or UTP cannot replace ATP
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are 15 kDa and 22 kDa light-chain or heavy-chain fractions of myosin from white skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 18.5 kDa Dictyostelium or 19 kDa skeletal muscle light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
1 mol phosphate per mol light chain in skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is molluscan adductor myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of Ml3-myosin rabbit muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone III-S from thymus
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
MLCK plays a critically important role in regulation of contraction in both smooth muscle and non-muscle cells, MLCK is both necessary and sufficient to initiate smooth muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is synapsin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in myosin phosphorylation and enzyme secretion
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
myosin light chain is phosphorylated at Thr 18 and Ser 19 by myosin light chain kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is protamine
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
the enzyme phosphorylates the 18000 Da Dictyostelium myosin regulatory light chain
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
the enzyme phosphorylates the 18000 Da Dictyostelium myosin regulatory light chain
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
phosphorylation of myosin light chains by myosin light chain kinase is a key event in agonist-mediated endothelial cell gap formation and vascular permeability
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, in aortic rings from mice in which alpha1, the major catalytic subunit isoform in arterial smooth muscle, is deleted, KCl- or phenylephrine-induced contraction is increased, overview
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain 2
ADP + myosin light chain 2 phosphate
-
-
-
?
ATP + myosin light chain 2
ADP + myosin light chain 2 phosphate
MLCK is involved in sarcomere organization, cardiac MLCK promotes sarcomere organization and increases cardiomyocyte contractility, overview
-
-
?
ATP + myosin regulatory light chain
ADP + myosin regulatory light chain phosphate
-
-
-
-
?
ATP + myosin regulatory light chain
ADP + myosin regulatory light chain phosphate
-
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
-
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
-
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
-
-
-
-
?
ATP + protein
ADP + phosphoprotein
intramolecular autophosphorylation activates the enzyme
-
-
?
ATP + protein
ADP + phosphoprotein
intramolecular autophosphorylation activates the enzyme
-
-
?
ATP + [myosin II regulatory light chain]
ADP + [myosin II regulatory light chain] phosphate
-
-
-
-
?
ATP + [myosin II regulatory light chain]
ADP + [myosin II regulatory light chain] phosphate
-
involved in many cellular cytoskeletal functions
-
-
?
ATP + [myosin light chain 2a]
ADP + [myosin light chain 2a] phosphate
-
-
-
-
?
ATP + [myosin light chain 2a]
ADP + [myosin light chain 2a] phosphate
-
MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the multifunctional regulatory enzyme stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain, kinetics, overview
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
non-muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
non-muscle myosin II and preferred substrate smooth muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
phosphorylation of myosin on Ser19 of the regulatory light chain. Non-muscle myosin II regulatory light chain and preferred substrate smooth muscle myosin II regulatory light chain
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin regulatory light chain phosphorylation at Ser19
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
activation of the enzyme is a key regulatory step in the modulation of endothelial permeability, central to parthogenesis of inflammatory lung disease is disruption of the endothelial barrier function
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
enzyme is regulating cytoskeletal rearrangement and cell motility
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the endothelial isozyme is a mutifunctional contractile effector involved in vascular barrier regulation, leukocyte diapedesis, apoptosis, and angiogenesis
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
activated phosphorylated enzyme
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
non-muscle myosin II and preferred substrate smooth muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
phosphorylation levels of MLC2v in the apex of the hearts. The MLC2v phosphorylation in strain C57BL/6N is significantly lower than that in C57BL/6J mice
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
MLC2
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
phosphorylation of Thr-18/Ser-19 on the regulatory light chain of myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
phosphorylation levels of MLC2v in the apex of the hearts. The MLC2v phosphorylation in strain C57BL/6N is significantly lower than that in C57BL/6J mice
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
MLC2
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the non-muscle myosin light chain kinase is involved in regulation of hepatic functions in response to intra- and extracellular signals
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myyosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin
-
-
?
additional information
?
-
-
the enzyme possesses ATPase activity
-
-
?
additional information
?
-
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
-
infection of brain endothelial cells with Haemophilus somnus causes alterations in brain endothelial cell and blood-brain barrier integrity and causes inflammation involving the enzyme, which acts in rapid cytoskeletal rearrangement, overview
-
-
?
additional information
?
-
-
actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview
-
-
?
additional information
?
-
the enzyme also exerts non-kinase activity on myosin motor and myosin ATPase activities
-
-
?
additional information
?
-
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
-
the enzyme is a potential cytoskeleton integrator through its unique N-terminal domain, the enzyme binds tubulin and actin, and is involved in microtubule/microfilament association
-
-
?
additional information
?
-
-
the enzyme is a key regulator of various forms of cell motility involving actin and myosin II
-
-
?
additional information
?
-
-
actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview. MLCK phosphorylated at Ser828 stimulates the ATPase activity of unphosphorylated myosin more effectively than the control MLCK
-
-
?
additional information
?
-
MLCK is a substrate of AMP-activated protein kinase, AMPK
-
-
?
additional information
?
-
-
MLCK is a substrate of AMP-activated protein kinase, AMPK
-
-
?
additional information
?
-
-
the enzyme also exerts non-kinase activity on myosin motor and myosin ATPase activities
-
-
?
additional information
?
-
non-muscle myosin and smooth muscle myosin are the only known substrates of MLCK in vivo
-
-
?
additional information
?
-
MLCK has a 2fold higher kcat for both smooth muscle myosin II substrates compared with non-muscle myosin IIB substrates, whereas Km values are very similar. Myosin light chain kinase has a 1.6fold and 1.5fold higher specificity (kcat/Km) for smooth versus non-muscle-free regulatory light chain and heavy meromyosin, respectively, suggesting that differences in specificity are dictated by regulatory light chain sequences. Three residues, Glu70, Gly71, and Ser74, are found to be surface exposed in the N-terminal half of the regulatory light chain, consistent with their importance in substrate recognition. Substrate recognition and specificity, overview
-
-
?
additional information
?
-
static substrate binding structure of streptavidin-tagged enzyme, overview
-
-
?
additional information
?
-
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
the differentiation-dependent enzyme splice variant MLCK1 regulates epithelial tight junction permeability, the endothelial isozyme is responsible for Na+-glucose cotransport-induced tight junction regulation
-
-
?
additional information
?
-
-
the enzyme activity is cell cycle regulated with a decrease in activity during mitosis due to phosphorylation, inhibition of enzyme phosphorylation during mitosis leads to microtubule defects, overview
-
-
?
additional information
?
-
-
the enzyme interacts with macrophage migration inhibition factor MIF in endothelium which may be important for the regulation of both non-muscle cytoskeletal dynamics as well as pathobiological vascular events involving the enzyme
-
-
?
additional information
?
-
-
the enzyme mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner
-
-
?
additional information
?
-
-
the enzyme plays an important role in TNFalpha-dependent induction of NFkappaB activity, mechanism
-
-
?
additional information
?
-
-
Human T cell leukemia virus 1-infected lymphocytes can cause a breakdown of the blood-brain barrier inducing an increase in paracellular endothelial permeability and transcellular migration, this disruption is associated with tight junction disorganization between endothelial cells and altered tight junction proteinexpression involving the enzyme MLCK, enzyme inhibition prevents the changes in endothelial cells, overview
-
-
?
additional information
?
-
-
increased MLCK activity accompanies increases in MLC expression, overview
-
-
?
additional information
?
-
-
inhibition of MLCK results in spherical cells and marked impairment of adhesion and migration of fibrosarcoma cells, overview
-
-
?
additional information
?
-
-
ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview
-
-
?
additional information
?
-
MLCK in the plasma membrane distribution of TRPC5 channels, overview
-
-
?
additional information
?
-
MLCK in the plasma membrane distribution of TRPC5 channels, overview
-
-
?
additional information
?
-
-
MLCK in the plasma membrane distribution of TRPC5 channels, overview
-
-
?
additional information
?
-
-
cytochalasin-induced increases in paracellular permeability are also mediated by MLC in Caco-2 monolayers
-
-
?
additional information
?
-
myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2, overview
-
-
?
additional information
?
-
-
PKA regulates beta2-integrin avidity activation via a MLCK-dependent pathway, overview
-
-
?
additional information
?
-
-
the enzyme is involved in inflammation response, including apoptosis, vascular permeability, and leukocyte diapedesis. Single nucleotide polymorphisms are involved in the risk of sepsis-related acute lung injury and asthma
-
-
?
additional information
?
-
-
14-3-3 binding of nmMLCK
-
-
?
additional information
?
-
MLCK and truncated 1-75 MLCK interaction analysis with actin, overview
-
-
?
additional information
?
-
-
no intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
-
substrate specificity and binding structure, the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview
-
-
?
additional information
?
-
-
the enzyme is involved, probably via microfilament assembly, in sperm chromatin-induced cortical reorganization during oocyte maturation to a polarized egg
-
-
?
additional information
?
-
-
inhibition of the enzyme retards the growth of mammary cancer cells
-
-
?
additional information
?
-
-
regulation of the MLCK promoters and gene expression involving myocardin, model, overview
-
-
?
additional information
?
-
-
the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview
-
-
?
additional information
?
-
-
MLCK is a substrate of AMP-activated protein kinase, AMPK
-
-
?
additional information
?
-
-
myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice, overview
-
-
?
additional information
?
-
the cardiac-specific isozyme probably performs also autophosphorylation
-
-
?
additional information
?
-
-
the enzyme binds to thin filaments with high affinity, myofilament binding by Ig-like modules is blocked by disassembling of the filaments, overview
-
-
?
additional information
?
-
postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain phosphorylation, relations between myosin light chain phosphorylation and contractile force, overview
-
-
?
additional information
?
-
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
-
inhibition of the enzyme retards the growth of prostate cancer cells
-
-
?
additional information
?
-
-
MLCK is probably involved in development of diabetic nephropathy, overview
-
-
?
additional information
?
-
-
the enzyme is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons, overview
-
-
?
additional information
?
-
-
the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview
-
-
?
additional information
?
-
MLCK is a substrate of AMP-activated protein kinase, AMPK
-
-
?
additional information
?
-
-
no intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
ATP + myosin IIB
ADP + phosphorylated myosin IIB
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
ATP + myosin light chain
ADP + phosphorylated myosin light chain
ATP + myosin light chain 2
ADP + myosin light chain 2 phosphate
MLCK is involved in sarcomere organization, cardiac MLCK promotes sarcomere organization and increases cardiomyocyte contractility, overview
-
-
?
ATP + myosin regulatory light chain
ADP + phosphorylated myosin regulatory light chain
-
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
ATP + [myosin II regulatory light chain]
ADP + [myosin II regulatory light chain] phosphate
-
involved in many cellular cytoskeletal functions
-
-
?
ATP + [myosin light chain 2a]
ADP + [myosin light chain 2a] phosphate
-
MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
ATP + [ventricular isoform of myosin regulatory light chain MLC2v]
ADP + [ventricular isoform of myosin regulatory light chain MLC2v] phosphate
-
-
-
-
?
additional information
?
-
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
causes endothelial contraction
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
the enzyme is important in regulation of shape, adhesion and migration of fibrosarcoma cells, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
roles of MLCK and ROCK on myosin II activation, overview, a global, MLCK-dependent increase in myosin II cortical contractility accompanies the metaphase-anaphase transition in sea urchin eggs, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
MLCK plays a key role in the control of MLC-phosphorylation status, and it modulates barrier function through its regulation of intracellular contractile machinery, overview, endothelial mechanism of MLC-dependent barrier injury in burns, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, in thick filaments, isozyme L-MLCK plays a role in cytoskeleton organization
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
obligatory step in development of active tension in smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in regulation of actin-myosin contractile activity in adrenal medulla
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
640620, 640624, 640629, 640633, 640634, 640635, 640639, 640640, 640643, 640644, 684910 -
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
inhibition of actin-myosin ineraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
MLCK plays a crucial role in the cell migration and tumor metastasis
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
MLCK plays a critically important role in regulation of contraction in both smooth muscle and non-muscle cells, MLCK is both necessary and sufficient to initiate smooth muscle contraction
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in myosin phosphorylation and enzyme secretion
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
the enzyme phosphorylates the 18000 Da Dictyostelium myosin regulatory light chain
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
the enzyme phosphorylates the 18000 Da Dictyostelium myosin regulatory light chain
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
phosphorylation of myosin light chains by myosin light chain kinase is a key event in agonist-mediated endothelial cell gap formation and vascular permeability
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, in aortic rings from mice in which alpha1, the major catalytic subunit isoform in arterial smooth muscle, is deleted, KCl- or phenylephrine-induced contraction is increased, overview
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
-
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
-
-
-
-
?
ATP + obscurin
ADP + obscurin phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the multifunctional regulatory enzyme stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain, kinetics, overview
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
non-muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
non-muscle myosin II and preferred substrate smooth muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
activation of the enzyme is a key regulatory step in the modulation of endothelial permeability, central to parthogenesis of inflammatory lung disease is disruption of the endothelial barrier function
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
enzyme is regulating cytoskeletal rearrangement and cell motility
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the endothelial isozyme is a mutifunctional contractile effector involved in vascular barrier regulation, leukocyte diapedesis, apoptosis, and angiogenesis
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
non-muscle myosin II and preferred substrate smooth muscle myosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
phosphorylation levels of MLC2v in the apex of the hearts. The MLC2v phosphorylation in strain C57BL/6N is significantly lower than that in C57BL/6J mice
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
phosphorylation levels of MLC2v in the apex of the hearts. The MLC2v phosphorylation in strain C57BL/6N is significantly lower than that in C57BL/6J mice
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the non-muscle myosin light chain kinase is involved in regulation of hepatic functions in response to intra- and extracellular signals
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ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myyosin II
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ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin
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ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin
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additional information
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infection of brain endothelial cells with Haemophilus somnus causes alterations in brain endothelial cell and blood-brain barrier integrity and causes inflammation involving the enzyme, which acts in rapid cytoskeletal rearrangement, overview
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actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview
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the enzyme is a potential cytoskeleton integrator through its unique N-terminal domain, the enzyme binds tubulin and actin, and is involved in microtubule/microfilament association
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the enzyme is a key regulator of various forms of cell motility involving actin and myosin II
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actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview. MLCK phosphorylated at Ser828 stimulates the ATPase activity of unphosphorylated myosin more effectively than the control MLCK
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MLCK is a substrate of AMP-activated protein kinase, AMPK
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MLCK is a substrate of AMP-activated protein kinase, AMPK
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non-muscle myosin and smooth muscle myosin are the only known substrates of MLCK in vivo
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the differentiation-dependent enzyme splice variant MLCK1 regulates epithelial tight junction permeability, the endothelial isozyme is responsible for Na+-glucose cotransport-induced tight junction regulation
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the enzyme activity is cell cycle regulated with a decrease in activity during mitosis due to phosphorylation, inhibition of enzyme phosphorylation during mitosis leads to microtubule defects, overview
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the enzyme interacts with macrophage migration inhibition factor MIF in endothelium which may be important for the regulation of both non-muscle cytoskeletal dynamics as well as pathobiological vascular events involving the enzyme
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the enzyme mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner
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the enzyme plays an important role in TNFalpha-dependent induction of NFkappaB activity, mechanism
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Human T cell leukemia virus 1-infected lymphocytes can cause a breakdown of the blood-brain barrier inducing an increase in paracellular endothelial permeability and transcellular migration, this disruption is associated with tight junction disorganization between endothelial cells and altered tight junction proteinexpression involving the enzyme MLCK, enzyme inhibition prevents the changes in endothelial cells, overview
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increased MLCK activity accompanies increases in MLC expression, overview
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inhibition of MLCK results in spherical cells and marked impairment of adhesion and migration of fibrosarcoma cells, overview
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ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview
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cytochalasin-induced increases in paracellular permeability are also mediated by MLC in Caco-2 monolayers
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myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2, overview
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PKA regulates beta2-integrin avidity activation via a MLCK-dependent pathway, overview
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the enzyme is involved in inflammation response, including apoptosis, vascular permeability, and leukocyte diapedesis. Single nucleotide polymorphisms are involved in the risk of sepsis-related acute lung injury and asthma
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14-3-3 binding of nmMLCK
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the enzyme is involved, probably via microfilament assembly, in sperm chromatin-induced cortical reorganization during oocyte maturation to a polarized egg
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inhibition of the enzyme retards the growth of mammary cancer cells
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regulation of the MLCK promoters and gene expression involving myocardin, model, overview
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the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview
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MLCK is a substrate of AMP-activated protein kinase, AMPK
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myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice, overview
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the enzyme binds to thin filaments with high affinity, myofilament binding by Ig-like modules is blocked by disassembling of the filaments, overview
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postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain phosphorylation, relations between myosin light chain phosphorylation and contractile force, overview
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inhibition of the enzyme retards the growth of prostate cancer cells
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MLCK is probably involved in development of diabetic nephropathy, overview
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the enzyme is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons, overview
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the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview
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MLCK is a substrate of AMP-activated protein kinase, AMPK
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