Reference on EC 2.7.11.16 - G-protein-coupled receptor kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sallese, M.; Mariggio, S.; Collodel, G.; Moretti, E.; Piomboni, P.; Baccetti, B.; De Blasi, A.
G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells
J. Biol. Chem.
272
10188-10195
1997
Homo sapiens (P32298), Homo sapiens
Sallese, M.; Lombardi, M.S.; De Blasi, A.
Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning
Biochem. Biophys. Res. Commun.
199
848-854
1994
Homo sapiens (P32298)
Ambrose, C.; James, M.; Barnes, G.; Lin, C.; Bates, G.; Altherr, M.; Duyao, M.; Groot, N.; Church, D.; Wasmuth, J.J.; et al.
A novel G protein-coupled receptor kinase gene cloned from 4p16.3
Hum. Mol. Genet.
1
697-703
1992
Homo sapiens (P32298)
Kunapuli, P.; Benovic, J.L.
Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family
Proc. Natl. Acad. Sci. USA
90
5588-5592
1993
Homo sapiens (P34947)
Premont, R.T.; Koch, W.J.; Inglese, J.; Lefkowitz, R.J.
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases
J. Biol. Chem.
269
6832-6841
1994
Bos taurus (P43249)
Stoffel, R.H.; Randall, R.R.; Premont, R.T.; Lefkowitz, R.J.; Inglese, J.
Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family
J. Biol. Chem.
269
27791-27794
1994
Homo sapiens (P43250)
Benovic, J.L.; Gomez, J.
Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family
J. Biol. Chem.
268
19521-19527
1993
Homo sapiens (P43250)
Fehr, C.; Fickova, M.; Hiemke, C.; Reuss, S.; Dahmen, N.
Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues
Brain Res. Mol. Brain Res.
49
278-282
1997
Rattus norvegicus (P97711)
Nagayama, Y.; Tanaka, K.; Hara, T.; Namba, H.; Yamashita, S.; Taniyama, K.; Niwa, M.
Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor
J. Biol. Chem.
271
10143-10148
1996
Rattus norvegicus (Q62833)
Walker, J.K.; Gainetdinov, R.R.; Feldman, D.S.; McFawn, P.K.; Caron, M.G.; Lefkowitz, R.J.; Premont, R.T.; Fisher, J.T.
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation
Am. J. Physiol.
286
L312-319
2004
Mus musculus
Fraga, S.; Jose, P.A.; Soares-da-Silva, P.
Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells
Am. J. Physiol.
287
R772-779
2004
Rattus norvegicus
Ghadessy, R.S.; Willets, J.M.; Kelly, E.
G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells
Br. J. Pharmacol.
138
660-670
2003
Homo sapiens
Penela, P.; Ribas, C.; Mayor, F.
Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
Cell. Signal.
15
973-981
2003
Homo sapiens, Mus musculus
Oyama, N.; Urasawa, K.; Kaneta, S.; Sakai, H.; Saito, T.; Takagi, C.; Yoshida, I.; Kitabatake, A.; Tsutsui, H.
Chronic beta-adrenergic receptor stimulation enhances the expression of G-protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes
Circ. J.
69
987-990
2005
Homo sapiens, Rattus norvegicus
Keys, J.R.; Zhou, R.H.; Harris, D.M.; Druckman, C.A.; Eckhart, A.D.
Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling
Circulation
112
1145-1153
2005
Bos taurus
Simon, V.; Robin, M.T.; Legrand, C.; Cohen-Tannoudji, J.
Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells
Endocrinology
144
3058-3066
2003
Rattus norvegicus
Voigt, C.; Holzapfel, H.P.; Paschke, R.
Decreased expression of G-protein coupled receptor kinase 2 in cold thyroid nodules
Exp. Clin. Endocrinol. Diabetes
113
102-106
2005
Homo sapiens
Vatter, P.; Stoesser, C.; Samel, I.; Gierschik, P.; Moepps, B.
The variable C-terminal extension of G-protein-coupled receptor kinase 6 constitutes an accessorial autoregulatory domain
FEBS J.
272
6039-6051
2005
Mus musculus
Picascia, A.; Capobianco, L.; Iacovelli, L.; De Blasi, A.
Analysis of differential modulatory activities of GRK2 and GRK4 on Galphaq-coupled receptor signaling
Methods Enzymol.
390
337-353
2004
Homo sapiens
Kohout, T.A.; Lefkowitz, R.J.
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization
Mol. Pharmacol.
63
9-18
2003
Mus musculus
Willets, J.M.; Mistry, R.; Nahorski, S.R.; Challiss, R.A.
Specificity of G protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell M3 muscarinic acetylcholine receptor signaling
Mol. Pharmacol.
64
1059-1068
2003
Homo sapiens
Neve, K.A.
Novel features of G protein-coupled receptor kinase 4
Mol. Pharmacol.
69
673-676
2006
Homo sapiens
Zhu, H.; Lu, Y.; Wang, X.; Treiber, F.A.; Harshfield, G.A.; Snieder, H.; Dong, Y.
The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins
Am. J. Hypertens.
19
61-66
2006
Homo sapiens
Wang, Y.; Li, B.; Zhao, W.; Liu, P.; Zhao, Q.; Chen, S.; Li, H.; Gu, D.
Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese
Ann. Hum. Genet.
70
778-783
2006
Homo sapiens
Premont, R.T.; Gainetdinov, R.R.
Physiological roles of G protein-coupled receptor kinases and arrestins
Annu. Rev. Physiol.
69
511-534
2007
Homo sapiens, Mus musculus
Ribas, C.; Penela, P.; Murga, C.; Salcedo, A.; Garcia-Hoz, C.; Jurado-Pueyo, M.; Aymerich, I.; Mayor, F.
The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling
Biochim. Biophys. Acta
1768
913-922
2007
Homo sapiens, Mammalia
Fraga, S.; Luo, Y.; Jose, P.; Zandi-Nejad, K.; Mount, D.B.; Soares-da-Silva, P.
Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6)
Cell. Physiol. Biochem.
18
347-360
2006
Rattus norvegicus
Lodowski, D.T.; Tesmer, V.M.; Benovic, J.L.; Tesmer, J.J.
The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs
J. Biol. Chem.
281
16785-16793
2006
Homo sapiens
Parameswaran, N.; Pao, C.S.; Leonhard, K.S.; Kang, D.S.; Kratz, M.; Ley, S.C.; Benovic, J.L.
Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages
J. Biol. Chem.
281
34159-34170
2006
Mus musculus
rawaka, S.; Wada, M.; Goto, S.; Karube, H.; Sakamoto, M.; Ren, C.H.; Koyama, S.; Nagasawa, H.; Kimura, H.; Kawanami, T.; Kurita, K.; Tajima, K.; Daimon, M.; Baba, M.; Kido, T.; Saino, S.; Goto, K.; Asao, H.; Kitanaka, C.; Takashita, E.; Hongo, S.; Nakamura, T.; Kayama, T.; Suzuki, Y.; Kobayashi, K.; Kat, K.a.t.a.
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinsons disease
J. Neurosci.
26
9227-9238
2006
Homo sapiens
Yang, W.; Xia, S.
Mechanisms of regulation and function of G-protein-coupled receptor kinases
World J. Gastroenterol.
12
7753-7757
2006
Homo sapiens
Cohn, H.I.; Harris, D.M.; Pesant, S.; Pfeiffer, M.; Zhou, R.H.; Koch, W.J.; Dorn, G.W.; Eckhart, A.D.
Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction
Am. J. Physiol. Heart Circ. Physiol.
295
H1695-H1704
2008
Mus musculus, Mus musculus (Q99MK8)
Keever, L.B.; Jones, J.E.; Andresen, B.T.
G protein-coupled receptor kinase 4gamma interacts with inactive GalphaS and Galpha13
Biochem. Biophys. Res. Commun.
367
649-655
2008
Homo sapiens (P32298)
Tran, T.M.; Jorgensen, R.; Clark, R.B.
Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5
Biochemistry
46
14438-14449
2007
Homo sapiens (P34947)
Eijkelkamp, N.; Heijnen, C.J.; Elsenbruch, S.; Holtmann, G.; Schedlowski, M.; Kavelaars, A.
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia
Brain Behav. Immun.
23
18-26
2008
Mus musculus (O70293)
Eijkelkamp, N.; Heijnen, C.J.; Lucas, A.; Premont, R.T.; Elsenbruch, S.; Schedlowski, M.; Kavelaars, A.
G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice
Gut
56
847-854
2007
Mus musculus
Loniewski, K.; Shi, Y.; Pestka, J.; Parameswaran, N.
Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages
Mol. Immunol.
45
2312-2322
2008
Mus musculus (O70293), Mus musculus (Q8VEB1), Mus musculus C57BL/6 (O70293), Mus musculus C57BL/6 (Q8VEB1)
Martini, J.S.; Raake, P.; Vinge, L.E.; DeGeorge, B.; Chuprun, J.K.; Harris, D.M.; Gao, E.; Eckhart, A.D.; Pitcher, J.A.; Koch, W.J.
Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes
Proc. Natl. Acad. Sci. USA
105
12457-12462
2008
Mus musculus (Q8VEB1)
Mayer, G.; Wulffen, B.; Huber, C.; Brockmann, J.; Flicke, B.; Neumann, L.; Hafenbradl, D.; Klebl, B.M.; Lohse, M.J.; Krasel, C.; Blind, M.
An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro
RNA
14
524-534
2008
Homo sapiens (P34947)
Wang, L.; Gesty-Palmer, D.; Fields, T.A.; Spurney, R.F.
Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2)
Mol. Endocrinol.
23
1455-1465
2009
Homo sapiens
Sorriento, D.; Ciccarelli, M.; Santulli, G.; Campanile, A.; Altobelli, G.G.; Cimini, V.; Galasso, G.; Astone, D.; Piscione, F.; Pastore, L.; Trimarco, B.; Iaccarino, G.
The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha
Proc. Natl. Acad. Sci. USA
105
17818-17823
2008
Homo sapiens
Chen, X.; Zhu, H.; Yuan, M.; Fu, J.; Zhou, Y.; Ma, L.
G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis
J. Biol. Chem.
285
12823-12830
2010
Homo sapiens
So, C.H.; Michal, A.M.; Mashayekhi, R.; Benovic, J.L.
G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition
J. Biol. Chem.
287
17088-17099
2012
Homo sapiens
Michal, A.M.; So, C.H.; Beeharry, N.; Shankar, H.; Mashayekhi, R.; Yen, T.J.; Benovic, J.L.
G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression
J. Biol. Chem.
287
6928-6940
2012
Homo sapiens
Kim, J.I.; Chakraborty, P.; Wang, Z.; Daaka, Y.
G-protein coupled receptor kinase 5 regulates prostate tumor growth
J. Urol.
187
322-329
2012
Homo sapiens
Guo, Q.; Subramanian, H.; Gupta, K.; Ali, H.
Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases
PLoS ONE
6
e22559
2011
Homo sapiens
Bychkov, E.; Zurkovsky, L.; Garret, M.B.; Ahmed, M.R.; Gurevich, E.V.
Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum
PLoS ONE
7
e48912
2012
Rattus norvegicus
Chakraborty, P.K.; Zhang, Y.; Coomes, A.S.; Kim, W.J.; Stupay, R.; Lynch, L.D.; Atkinson, T.; Kim, J.I.; Nie, Z.; Daaka, Y.
G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer
Cancer Res.
74
3489-3500
2014
Homo sapiens (P34947), Homo sapiens
Packiriswamy, N.; Steury, M.; McCabe, I.C.; Fitzgerald, S.D.; Parameswaran, N.
Bacterial dose-dependent role of G protein-coupled receptor kinase 5 in Escherichia coli-induced pneumonia
Infect. Immun.
84
1633-1641
2016
Mus musculus (Q8VEB1)
Franklin, J.M.; Carrasco, G.A.
G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors
J. Biol. Chem.
288
15712-15724
2013
Rattus norvegicus (Q62833)
Li, L.; Homan, K.T.; Vishnivetskiy, S.A.; Manglik, A.; Tesmer, J.J.; Gurevich, V.V.; Gurevich, E.V.
G protein-coupled receptor kinases of the GRK4 protein subfamily phosphorylate inactive G protein-coupled receptors (GPCRs)
J. Biol. Chem.
290
10775-10790
2015
Homo sapiens (P34947)
Allen, S.J.; Parthasarathy, G.; Darke, P.L.; Diehl, R.E.; Ford, R.E.; Hall, D.L.; Johnson, S.A.; Reid, J.C.; Rickert, K.W.; Shipman, J.M.; Soisson, S.M.; Zuck, P.; Munshi, S.K.; Lumb, K.J.
Structure and function of the hypertension variant A486V of G protein-coupled receptor kinase 4
J. Biol. Chem.
290
20360-20373
2015
Homo sapiens (P32298), Homo sapiens
Homan, K.T.; Waldschmidt, H.V.; Glukhova, A.; Cannavo, A.; Song, J.; Cheung, J.Y.; Koch, W.J.; Larsen, S.D.; Tesmer, J.J.
Crystal structure of G protein-coupled receptor kinase 5 in complex with a rationally designed inhibitor
J. Biol. Chem.
290
20649-20659
2015
Bos taurus (P43249)
Park, C.H.; Lee, J.H.; Lee, M.Y.; Lee, J.H.; Lee, B.H.; Oh, K.S.
A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2UT cells
Mol. Cell. Biochem.
422
151-160
2016
Rattus norvegicus (Q62833)
Johnson, L.R.; Robinson, J.D.; Lester, K.N.; Pitcher, J.A.
Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability
PLoS ONE
8
e62508
2013
Homo sapiens (P34947)
Rowlands, R.A.; Cato, M.C.; Waldschmidt, H.V.; Bouley, R.A.; Chen, Q.; Avramova, L.; Larsen, S.D.; Tesmer, J.J.G.; White, A.D.
Structure-based design of selective, covalent G protein-coupled receptor kinase 5 inhibitors
ACS Med. Chem. Lett.
10
1628-1634
2019
Homo sapiens (P34947)
Zeng, X.; Chen, S.; Gao, Q.; Zong, W.; Jiang, D.; Zeng, G.; Zhou, L.; Chen, L.; Luo, W.; Xiao, J.; Xiao, B.; Ouyang, D.; Hu, K.
The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus
Epilepsy Res.
138
62-70
2017
Rattus norvegicus (Q62833)
Yao, S.; Wu, D.; Chen, J.; Wang, P.; Lv, X.; Huang, J.
Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPalpha, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells
FEBS Open Bio
9
605-617
2019
Homo sapiens (P43250)
Zhao, J.; Li, X.; Chen, X.; Cai, Y.; Wang, Y.; Sun, W.; Mai, H.; Yang, J.; Fan, W.; Tang, P.; Ou, M.; Zhang, Y.; Huang, X.; Zhao, B.; Cui, L.
GRK5 influences the phosphorylation of tau via GSK3beta and contributes to Alzheimer's disease
J. Cell. Physiol.
234
10411-10420
2019
Mus musculus (Q8VEB1), Mus musculus
Lagman, J.; Sayegh, P.; Lee, C.S.; Sulon, S.M.; Jacinto, A.Z.; Sok, V.; Peng, N.; Alp, D.; Benovic, J.L.; So, C.H.
G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel
Mol. Cell. Biochem.
461
103-118
2019
Homo sapiens (P34947)
Wu, W.; Sung, C.C.; Yu, P.; Li, J.; Chung, K.K.K.
S-nitrosylation of G protein-coupled receptor kinase 6 and casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinsons disease
PLoS ONE
15
e0232019
2020
Homo sapiens (P43250)
Beyett, T.; Chen, Q.; Labudde, E.; Krampen, J.; Sharma, P.; Tesmer, J.
Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli
Protein Expr. Purif.
168
105547
2020
Homo sapiens (P34947), Homo sapiens
Lessel, D.; Muhammad, T.; Casar Tena, T.; Moepps, B.; Burkhalter, M.D.; Hitz, M.P.; Toka, O.; Rentzsch, A.; Schubert, S.; Schalinski, A.; Bauer, U.M.; Kubisch, C.; Ware, S.M.; Philipp, M.
The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5
Sci. Rep.
6
33231
2016
Homo sapiens (P34947), Homo sapiens
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