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Information on EC 2.7.11.14 - rhodopsin kinase

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IUBMB Comments
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
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Word Map
  • 2.7.11.14
  • radial
  • keratotomy
  • eyes
  • desensitization
  • corneal
  • refract
  • photoreceptors
  • retinal
  • arrestins
  • acuity
  • postoperative
  • myopia
  • recoverin
  • incisions
  • diopter
  • phototransduction
  • transducin
  • preoperative
  • uncorrected
  • beta-adrenergic
  • astigmatism
  • photorefractive
  • beta-arrestins
  • light-dependent
  • intraocular
  • hyperopic
  • gpcrs
  • excimer
  • keratomileusis
  • keratoplasty
  • lasik
  • light-activated
  • agonist-dependent
  • photoresponse
  • keratometry
  • photolyzed
  • raspberry
  • pachymetry
  • overcorrection
  • metarhodopsin
  • spectacle-corrected
  • 11-cis-retinal
  • haze
  • snellen
  • cycloplegic
  • medicine
  • spectacle
  • bactrocera
  • agonist-occupied
  • photoreceptor-specific
  • glare
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
rk, g protein-coupled receptor kinase, g-protein receptor kinase, g-protein coupled receptor kinase, g protein-coupled receptor kinase 1, opsin kinase, gprk1, g-protein coupled receptor kinase 1, g-protein-coupled receptor kinase 1, gpcr kinase 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + rhodopsin = ADP + phosphorhodopsin
show the reaction diagram