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Information on EC 2.7.11.11 - cAMP-dependent protein kinase

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IUBMB Comments
cAMP is required to activate this enzyme. The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits [i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C].
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
camp-pka, camp/protein kinase a, capk, camp dependent protein kinase, prkaca, cyclic amp dependent protein kinase, type ii pka, pka type i, pka-i, pkaii, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
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