Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Bos taurus

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This record set is specific for:
Bos taurus


The taxonomic range for the selected organisms is: Bos taurus

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.10.2
-
RECOMMENDED NAME
GeneOntology No.
non-specific protein-tyrosine kinase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
additional information
?
-
enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
show the reaction diagram
Q38KH2
-
-
-
?
additional information
?
-
Q95126
enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins
-
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
PDB
SCOP
CATH
UNIPROT
ORGANISM
Bos taurus;
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
31000
determined by SDS-PAGE and Western Blot analysis
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
alternative splicing is responsible for the generation of these bActRIIB isoforms
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE