Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Rattus norvegicus

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The taxonomic range for the selected organisms is: Rattus norvegicus

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.10.1
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RECOMMENDED NAME
GeneOntology No.
receptor protein-tyrosine kinase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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brain-derived neurotrophic factor and TrkB signaling activates Narp expression alone
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + insulin receptor substrate 2-L-tyrosine
ADP + insulin receptor substrate 2-L-tyrosine phosphate
show the reaction diagram
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tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
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?
ATP + poly-(Glu-Tyr)
ADP + poly-(Glu-Tyr) phosphate
show the reaction diagram
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Tyr-phosphate
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?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
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phospholipase C-gamma 1 is directly phosphorylated by TrkB
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?
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6,7-dimethyl-2-phenylquinoxaline
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AEE788
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50 mg/kg AEE788 inhibits the autophosphorylation of both epidermal growth factor receptor andvascular endothelial growth factor receptor
AG1296
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selective inhibitor
AG1478
FPT III
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inhibition of epidermal growth factor receptor tyrosine kinase
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genistein
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inhibition of epidermal growth factor receptor tyrosine kinase
herceptin
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hexachlorobenzene
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increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses of 1 mg per kg body weight, reduced enzyme activity at higher doses of 100 mg hexachlorobenzene per kg body weight and above, chronic treatment induces a down-regulation of epidermal growth factor receptor and increases the EGFR-tyrosine kinase activity in the microsomal fraction
imatinib
K-252a
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complete inhibition at 200 nM
KN93
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inhibition of epidermal growth factor receptor tyrosine kinase
N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide
shows in vivo inhibition of corneal angiogenesis
PKI-166
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0.5 mM/kg body weight
ZD1839
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selective inhibitor
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dibutyryl cAMP
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tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
hexachlorobenzene
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increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses, reduced enzyme activity at higher doses of hexachlorobenzene
hydrogen peroxide
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protein S
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reactive oxygen species
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additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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expressed during central nervous system neurogenesis
Manually annotated by BRENDA team
hippocampal neurons obtained from 17.5-day-old embryos
Manually annotated by BRENDA team
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primary cells
Manually annotated by BRENDA team
isoforms are products of abnormal alternative splicing in tumor cell lines
Manually annotated by BRENDA team
isoforms are products of abnormal alternative splicing in tumor cell lines
Manually annotated by BRENDA team
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normal peripheral blood mononuclear cell
Manually annotated by BRENDA team
proliferating L6 alpha 1 myoblasts, mrfms gene is transcriptionally active only in undifferentiated myoblasts
Manually annotated by BRENDA team
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adult ventricular myocyte
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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nerve growth factor-mediated survival in PC12 cells is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
120000
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SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
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phosphoprotein
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cloning of the complete coding region of the rat HGF receptor
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expressed in cultured NIH-3T3 mouse fibroblasts
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expression in HEK 293 and B104-1-1 cells
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isolation and sequencing of cDNA clones
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isolation of cDNA
the gene for c-fgr is located on chromosome 1
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
V664E
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oncogenic mutation in TM domain, mutation increases the dimerizing propensities of the transmembrane domains
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
medicine