Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Caenorhabditis elegans

for references in articles please use BRENDA:EC2.7.10.1
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Caenorhabditis elegans


The taxonomic range for the selected organisms is: Caenorhabditis elegans

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.10.1
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RECOMMENDED NAME
GeneOntology No.
receptor protein-tyrosine kinase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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basolateral membrane domain of the epithelial vulval precursor cells
Manually annotated by BRENDA team
expressed during postembryonic development in the large hypodermal syncytium; expressed during postembryonic development in the large hypodermal syncytium
Manually annotated by BRENDA team
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basolateral membrane domain of the epithelial vulval precursor cells
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
transmembrane protein; transmembrane protein
Manually annotated by BRENDA team
PDB
SCOP
CATH
UNIPROT
ORGANISM
P24348
Caenorhabditis elegans;
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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mutations in the Caenorhabditis elegans let-23 EGFR-like gene
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
may serve as a new target for the development of new antibiotics