Disease on EC 2.7.1.32 - choline kinase
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acylglycerol kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Adenocarcinoma
Choline Kinase Alpha (CHK?) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.
Adenocarcinoma
Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer.
Adenoma
Increased choline kinase activity and elevated phosphocholine levels in human colon cancer.
Alzheimer Disease
Alterations of selected enzymes of phospholipid metabolism in Alzheimer's disease brain tissue as compared to non-Alzheimer's demented controls.
Barth Syndrome
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Brain Neoplasms
Fully automated SPE-based synthesis and purification of 2-[18F]fluoroethyl-choline for human use.
Brain Neoplasms
Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors.
Breast Neoplasms
Activation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells.
Breast Neoplasms
Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway.
Breast Neoplasms
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.
Breast Neoplasms
Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer.
Breast Neoplasms
Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells.
Breast Neoplasms
Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells.
Breast Neoplasms
Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study.
Breast Neoplasms
Direct inhibition of choline kinase by a near-infrared fluorescent carbocyanine.
Breast Neoplasms
Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells.
Breast Neoplasms
Functional interactions between Choline kinase ?, epidermal growth factor receptor and c-Src in breast cancer cell proliferation.
Breast Neoplasms
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.
Breast Neoplasms
Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method.
Breast Neoplasms
Molecular causes of the aberrant choline phospholipid metabolism in breast cancer.
Breast Neoplasms
Near infrared fluorescent imaging of choline kinase alpha expression and inhibition in breast tumors.
Breast Neoplasms
Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft.
Breast Neoplasms
Novel 4-Amino Bis-pyridinium and Bis-quinolinium Derivatives as Choline Kinase Inhibitors with Antiproliferative Activity against the Human Breast Cancer SKBR-3 Cell Line.
Breast Neoplasms
Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells.
Breast Neoplasms
Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies.
Breast Neoplasms
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.
Breast Neoplasms
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation.
Breast Neoplasms
[Increased activity of choline kinase in human breast cancer and 7, 12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary carcinoma, and activated by 17 beta-estradiol: preliminary report]
Breast Neoplasms
[Methyl-3H]-choline incorporation into MCF-7 cells: correlation with proliferation, choline kinase and phospholipase D assay.
Carcinogenesis
CHKA mediates the poor prognosis of lung adenocarcinoma and acts as a prognostic indicator.
Carcinogenesis
Choline Kinase ? Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression.
Carcinogenesis
Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.
Carcinogenesis
Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis.
Carcinogenesis
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.
Carcinogenesis
EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
Carcinogenesis
Increased choline kinase activity and elevated phosphocholine levels in human colon cancer.
Carcinogenesis
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.
Carcinogenesis
Involvement of human choline kinase alpha and beta in carcinogenesis: A different role in lipid metabolism and biological functions.
Carcinogenesis
Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
Carcinoma
A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas.
Carcinoma
Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas.
Carcinoma
Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.
Carcinoma
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.
Carcinoma
[Increased activity of choline kinase in human breast cancer and 7, 12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary carcinoma, and activated by 17 beta-estradiol: preliminary report]
Carcinoma, Hepatocellular
Choline Kinase ? Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression.
Carcinoma, Hepatocellular
Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.
Carcinoma, Hepatocellular
The effect of polycyclic aromatic hydrocarbons on choline kinase activity in mouse hepatoma cells.
Carcinoma, Ovarian Epithelial
Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer.
Carcinoma, Ovarian Epithelial
Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.
Carcinoma, Squamous Cell
Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas.
Cardiomyopathies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Cardiomyopathy, Dilated
Clinical characteristics of megaconial congenital muscular dystrophy due to choline kinase beta gene defects in a series of 15 patients.
Cataract
Effects of cataractogenesis on the CDP-choline pathway: changes in ATP concentration and phosphocholine synthesis during and after exposure of rat lenses to sugars in vitro and in vivo.
Cholangiocarcinoma
Synergistic antiproliferative effects of an mTOR inhibitor (rad001) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity.
Choline Deficiency
Effect of choline deficiency on CTP: phosphocholine cytidylyltransferase and choline kinase activities in rat liver subcellular fractions.
choline kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Colonic Neoplasms
Increased choline kinase activity and elevated phosphocholine levels in human colon cancer.
Colonic Neoplasms
Increased choline kinase activity in 1,2-dimethylhydrazine-induced rat colon cancer.
Colonic Neoplasms
Synthesis and biological activity of new bispyridinium salts of 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazoles.
Colorectal Neoplasms
Combined 5-FU and ChoK? inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.
Colorectal Neoplasms
Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma.
Congenital Abnormalities
Molecular structure and differential function of choline kinases CHK? and CHK? in musculoskeletal system and cancer.
Endometrial Neoplasms
Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway.
Glioblastoma
Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.
Glioma
(1)H HR-MAS and genomic analysis of human tumor biopsies discriminate between high and low grade astrocytomas.
Glioma
Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase ?.
Glioma
[Knockdown of choline kinase ? (CHKA) inhibits the proliferation, invasion and migration of human U87MG glioma cells].
Hyperparathyroidism, Secondary
Altered acetylcholine metabolism of brain in uremia: role of secondary hyperparathyroidism.
Hyperparathyroidism, Secondary
Derangements in acetylcholine metabolism in brain synaptosomes in chronic renal failure.
Infections
Inhibition of giant cell formation by Compound 48-80 after infection with herpesvirus hominis. IV. Compound 48-80, an inhibitor of choline kinase activity.
Infections
The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment.
Intellectual Disability
A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis.
Intellectual Disability
Clinical characteristics of megaconial congenital muscular dystrophy due to choline kinase beta gene defects in a series of 15 patients.
Leukemia
A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma.
Leukemia
EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
Liver Neoplasms
The emerging role of positron emission tomography in hepatocellular carcinoma.
Lung Neoplasms
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase ? inhibition.
Lung Neoplasms
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.
Lung Neoplasms
Disease-specific target gene expression profiling of molecular imaging probes: database development and clinical validation.
Lung Neoplasms
Disease-Specific Target Gene Expression Profiling of Molecular Imaging Probes: Database Development and Clinical Validation.
Lung Neoplasms
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.
Lung Neoplasms
Value of 11C-choline PET/CT for lung cancer diagnosis and the relation between choline metabolism and proliferation of cancer cells.
Malaria
Effect of choline kinase inhibitor hexadecyltrimethylammonium bromide on Plasmodium falciparum gene expression.
Malaria
Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: a possible antimalarial mechanism.
Malaria
Molecular characterization and localization of Plasmodium falciparum choline kinase.
Mitochondrial Myopathies
Congenital megaconial myopathy due to a novel defect in the choline kinase Beta gene.
Muscular Dystrophies
A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis.
Muscular Dystrophies
A rostrocaudal muscular dystrophy caused by a defect in choline kinase Beta, the first enzyme in phosphatidylcholine biosynthesis.
Muscular Dystrophies
Choline Kinase Beta-Related Muscular Dystrophy, Appearance of Muscle Involvement on Magnetic Resonance Imaging.
Muscular Dystrophies
Clinical characteristics of megaconial congenital muscular dystrophy due to choline kinase beta gene defects in a series of 15 patients.
Muscular Dystrophies
Congenital neurogenic muscular atrophy in megaconial myopathy due to a mutation in CHKB gene.
Muscular Dystrophies
Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse.
Muscular Dystrophies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Muscular Dystrophies
Exome sequencing identifies a CHKB mutation in Spanish patient with Megaconial Congenital Muscular Dystrophy and mtDNA depletion.
Muscular Dystrophies
Megaconial congenital muscular dystrophy due to loss-of-function mutations in choline kinase ?.
Muscular Dystrophies
Megaconial muscular dystrophy caused by mitochondrial membrane homeostasis defect, new insights from skeletal and heart muscle analyses.
Muscular Dystrophies
Molecular structure and differential function of choline kinases CHK? and CHK? in musculoskeletal system and cancer.
Muscular Dystrophies
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy.
Muscular Dystrophies
New splicing mutation in the choline kinase beta (CHKB) gene causing a muscular dystrophy detected by whole-exome sequencing.
Muscular Dystrophies
Novel CHKB mutation expands the megaconial muscular dystrophy phenotype.
Muscular Dystrophies
Reduced mitochondrial fission and impaired energy metabolism in human primary skeletal muscle cells of Megaconial Congenital Muscular Dystrophy.
Muscular Dystrophies
Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice.
Myoglobinuria
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Neoplasm Metastasis
Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells.
Neoplasm Metastasis
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.
Neoplasms
A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration.
Neoplasms
A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas.
Neoplasms
A moonlighting function of choline kinase alpha 2 in the initiation of lipid droplet lipolysis in cancer cells.
Neoplasms
A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival.
Neoplasms
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase ? inhibition.
Neoplasms
Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy.
Neoplasms
An evaluation of motion compensation strategies and repeatability for abdominal (1) H MR spectroscopy measurements in volunteer studies and clinical trials.
Neoplasms
An illustration of the potential for mapping MRI/MRS parameters with genetic over-expression profiles in human prostate cancer.
Neoplasms
Association of CHKA polymorphism (rs3794186) with ?-fetoprotein levels in hepatocellular carcinoma.
Neoplasms
Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase-targeted cancer therapy.
Neoplasms
Biochemical and Pathophysiological Premises to Positron Emission Tomography With Choline Radiotracers.
Neoplasms
Biomimetic Magnetic Nanocarriers Drive Choline Kinase Alpha Inhibitor inside Cancer Cells for Combined Chemo-Hyperthermia Therapy.
Neoplasms
Choline Kinase ? Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression.
Neoplasms
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.
Neoplasms
Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.
Neoplasms
Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.
Neoplasms
Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer.
Neoplasms
Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.
Neoplasms
Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells.
Neoplasms
Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells.
Neoplasms
Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.
Neoplasms
Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells.
Neoplasms
Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells.
Neoplasms
Choline transporter-like proteins CTLs/SLC44 family as a novel molecular target for cancer therapy.
Neoplasms
Combined 5-FU and ChoK? inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.
Neoplasms
Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy.
Neoplasms
Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.
Neoplasms
Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors.
Neoplasms
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.
Neoplasms
Discovery of a new binding site on human choline kinase ?1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives.
Neoplasms
EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
Neoplasms
Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications.
Neoplasms
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.
Neoplasms
Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: A target molecule for lung cancer therapy.
Neoplasms
Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer.
Neoplasms
Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.
Neoplasms
Histone Deacetylase Inhibition Increases Levels of Choline Kinase ? and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers.
Neoplasms
Increased choline kinase activity in 1,2-dimethylhydrazine-induced rat colon cancer.
Neoplasms
Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism.
Neoplasms
Kinetics from Indirectly Detected Hyperpolarized NMR Spectroscopy by Using Spatially Selective Coherence Transfers.
Neoplasms
Kinetics from indirectly detected hyperpolarized NMR spectroscopy by using spatially selective coherence transfers.
Neoplasms
Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase ?1 inhibitors.
Neoplasms
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
Neoplasms
Metabolomics analysis uncovers that dietary restriction buffers metabolic changes associated with aging in Caenorhabditis elegans.
Neoplasms
Modulation of choline kinase activity in human cancer cells observed by dynamic 31P NMR.
Neoplasms
Molecular structure and differential function of choline kinases CHK? and CHK? in musculoskeletal system and cancer.
Neoplasms
Multimodal Mass Spectrometric Imaging of Small Molecules Reveals Distinct Spatio-Molecular Signatures in Differentially Metastatic Breast Tumor Models.
Neoplasms
Near infrared fluorescent imaging of choline kinase alpha expression and inhibition in breast tumors.
Neoplasms
Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft.
Neoplasms
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.
Neoplasms
Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019.
Neoplasms
Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma.
Neoplasms
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.
Neoplasms
Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies.
Neoplasms
Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets.
Neoplasms
Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells.
Neoplasms
Preclinical development of a non-toxic oral formulation of monoethanolamine, a lipid precursor, for prostate cancer treatment.
Neoplasms
Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate.
Neoplasms
Recent advances in the design of choline kinase ? inhibitors and the molecular basis of their inhibition.
Neoplasms
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.
Neoplasms
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation.
Neoplasms
Sensitization of (colon) cancer cells to death receptor related therapies: A report from the FP6-ONCODEATH research consortium.
Neoplasms
Significantly increased monounsaturated lipids relative to polyunsaturated lipids in six types of cancer microenvironment are observed by mass spectrometry imaging.
Neoplasms
Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.
Neoplasms
Synthesis and preclinical evaluation of the choline transport tracer deshydroxy-[18F]fluorocholine ([18F]dOC).
Neoplasms
The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth.
Neoplasms
[18F]fluoromethyl-[1,2-2H4]-choline: a novel radiotracer for imaging choline metabolism in tumors by positron emission tomography.
Neuroblastoma
KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells.
Ovarian Neoplasms
Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells.
Ovarian Neoplasms
Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer.
Paraplegia
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Peripheral Nervous System Diseases
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Prostatic Intraepithelial Neoplasia
Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.
Prostatic Neoplasms
An illustration of the potential for mapping MRI/MRS parameters with genetic over-expression profiles in human prostate cancer.
Prostatic Neoplasms
Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.
Prostatic Neoplasms
Choline phosphorylation and regulation of transcription of choline kinase ? in hypoxia.
Prostatic Neoplasms
Circulating androgen receptor combined with 18F-fluorocholine PET/CT metabolic activity and outcome to androgen receptor signalling-directed therapies in castration-resistant prostate cancer.
Prostatic Neoplasms
Exploiting altered patterns of choline kinase-alpha expression on human prostate tissue to prognosticate prostate cancer.
Prostatic Neoplasms
Fully automated SPE-based synthesis and purification of 2-[18F]fluoroethyl-choline for human use.
Prostatic Neoplasms
Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model.
Prostatic Neoplasms
Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.
Prostatic Neoplasms
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
Prostatic Neoplasms
Quantification of 18F-Fluorocholine Kinetics in Patients with Prostate Cancer.
Prostatic Neoplasms
Role of p115RhoGEF in the regulation of extracellular Ca(2+)-induced choline kinase activation and prostate cancer cell proliferation.
Prostatic Neoplasms
Sci-Fri AM: Imaging - 01: Feasibility of estimating choline kinase activity with kinetic modeling of 18F-fluorocholine pet imaging of prostate cancer.
Prostatic Neoplasms
Use of [11C]choline PET-CT as a noninvasive method for detecting pelvic lymph node status from prostate cancer and relationship with choline kinase expression.
Renal Insufficiency
Derangements in acetylcholine metabolism in brain synaptosomes in chronic renal failure.
Sepsis
Influence of a beta-adrenergic agonist on septic shock-induced alterations of phosphatidylcholine metabolism in rat lung.
Sepsis
Influence of a?-adrenergic agonist on septic shock-induced alterations of phosphatidylcholine metabolism in rat lung.
Small Cell Lung Carcinoma
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase ? inhibition.
Spinal Dysraphism
CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.
Starvation
Appropriate leucine supplementation promotes glucose metabolism and enhances energy homeostasis in juvenile crucian carp (Carassius auratus gibelio var. CAS III).
Urinary Bladder Neoplasms
A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas.
Uterine Cervical Neoplasms
Modulation of choline kinase activity in human cancer cells observed by dynamic 31P NMR.
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