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Disease on EC 2.7.1.151 - inositol-polyphosphate multikinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Bone Marrow Failure Disorders
IP3 3-kinase B prevents bone marrow failure.
Brain Injuries
MicroRNA-23b alleviates neuroinflammation and brain injury in intracerebral hemorrhage by targeting inositol polyphosphate multikinase.
Brain Ischemia
Effects of focal cerebral ischemia on expression and activity of inositol 1,4,5-trisphosphate 3-kinase in rat cortex.
Effects of focal cerebral ischemia on inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities in rat cortex.
In situ hybridization of mRNA expression for IP3 receptor and IP3-3-kinase in rat brain after transient focal cerebral ischemia.
Breast Neoplasms
The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation.
Type I? phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-?B.
Carcinogenesis
Familial small-intestine carcinoids: Chromosomal alterations and germline inositol polyphosphate multikinase sequencing.
Carcinoid Tumor
A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase.
Familial small-intestine carcinoids: Chromosomal alterations and germline inositol polyphosphate multikinase sequencing.
Carcinoma
Ribavirin and quercetin synergistically downregulate signal transduction and are cytotoxic in human ovarian carcinoma cells.
Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells.
Carcinoma, Hepatocellular
1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme.
Cerebral Hemorrhage
MicroRNA-23b alleviates neuroinflammation and brain injury in intracerebral hemorrhage by targeting inositol polyphosphate multikinase.
Cystic Fibrosis
Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis.
Friedreich Ataxia
The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase.
Gastrointestinal Stromal Tumors
Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b, multicentre study.
Graves Disease
Identification Of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases By Deep Sequencing Of Linked Loci.
Heart Failure
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
Hepatitis B
Immune recognition of linear antigenic regions within the hepatitis B pre-C and C-gene translation products using synthetic peptides.
Huntington Disease
Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase.
Infections
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.
Influenza, Human
Phosphatidylinositol 5-kinase stimulates apical biosynthetic delivery via an Arp2/3-dependent mechanism.
inositol-polyphosphate multikinase deficiency
Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
Lung Neoplasms
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
Lupus Erythematosus, Systemic
Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells.
Melanoma
Whole-genome landscapes of major melanoma subtypes.
Neoplasms
Amplified increase in signal transduction activity in cancer cells.
Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b, multicentre study.
MicroRNA-18a inhibits ovarian cancer growth via directly targeting TRIAP1 and IPMK.
RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors.
Neural Tube Defects
The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population.
Neuroinflammatory Diseases
MicroRNA-23b alleviates neuroinflammation and brain injury in intracerebral hemorrhage by targeting inositol polyphosphate multikinase.
Obesity
Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole body metabolic homeostasis.
Sepsis
Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.
Starvation
ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.
Stroke
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
Thyroiditis
Identification Of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases By Deep Sequencing Of Linked Loci.
Triple Negative Breast Neoplasms
Type I? phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-?B.