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Information on EC 2.7.1.106 - glucose-1,6-bisphosphate synthase
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2.7.1.106 glucose-1,6-bisphosphate synthaseIUBMB Comments
D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.
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Word Map
- 2.7.1.106
- phosphogluconate
-
phosphomutases
- araneus
-
glucuronidase
-
glutamate-oxaloacetate
- glycerate
-
tribe
-
hexose-1-phosphate
-
sorex
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
pgm2l1, phosphoglucomutase 2, glucose-1,6-bisphosphate synthase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
glucose 1,6-diphosphate synthase
-
-
-
-
glucose-1,6-bisphosphate synthetase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase
D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.
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CAS REGISTRY NUMBER
COMMENTARY
56214-39-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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i.e. 1,3-diphosphoglycerate
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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specific for 3-phospho-D-glyceroyl phosphate
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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no acceptor activity mannose 6-phosphate
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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i.e. 1,3-diphosphoglycerate
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-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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no phosphoryl donors are acetyl phosphate, ATP, phosphoenolpyruvate, creatine phosphate, fructose 1,6-diphosphate
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-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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little or no acceptor activity: glucose, glucose 6-sulfate, glucosamine 6-phosphate, 2-deoxy-glucose 6-phosphate, 3-phosphoglycerate, galactose or fructose monophosphates
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
no acceptor activity mannose 6-phosphate
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-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
responsible for glucose 1,6-diphosphate biosynthesis in brain
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-
r
3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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-
-
-
?
3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
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phosphorylation at 56% the rate of glucose 1-phosphate
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-
?
3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
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-
-
-
?
3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
-
phosphorylation at 81% the rate of glucose 1-phosphate
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
responsible for glucose 1,6-diphosphate biosynthesis in brain
-
-
r
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Zn2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
glucose-1,6-bisphosphate synthase deficiency
Impaired glucose-1,6-biphosphate production due to bi-allelic PGM2L1 mutations is associated with a neurodevelopmental disorder.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
25
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PGM2L_HUMAN
622
0
70442
Swiss-Prot
other Location (Reliability: 1)
PGM2L_MOUSE
621
0
70279
Swiss-Prot
other Location (Reliability: 1)
PGM2L_PONAB
622
0
70456
Swiss-Prot
other Location (Reliability: 1)
A0A086PUM0_TOXGO
597
0
65880
TrEMBL
Mitochondrion (Reliability: 4)
D1A257_THECD
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)
558
0
58581
TrEMBL
-
D5WY15_KYRT2
Kyrpidia tusciae (strain DSM 2912 / NBRC 15312 / T2)
584
0
63502
TrEMBL
-
A0A086LKE9_TOXGO
597
0
65850
TrEMBL
Mitochondrion (Reliability: 4)
D2SG68_GEOOG
Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20)
539
0
56117
TrEMBL
-
D5U3R4_BRAM5
Brachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150)
563
0
63005
TrEMBL
-
D2C6S7_THENR
Thermotoga naphthophila (strain ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10)
471
0
53017
TrEMBL
-
A0A061IBN9_CRIGR
179
0
20043
TrEMBL
other Location (Reliability: 1)
D6ZCD2_SEGRD
Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)
558
0
58685
TrEMBL
-
A0A2G8XS23_TOXGO
597
0
65947
TrEMBL
Mitochondrion (Reliability: 4)
A0A8M1NEU2_DANRE
619
0
69308
TrEMBL
other Location (Reliability: 2)
D2PKI1_KRIFD
Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
545
0
56888
TrEMBL
-
A0A425HP89_TOXGO
597
0
65880
TrEMBL
Mitochondrion (Reliability: 4)
D5UUP4_TSUPD
Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / CCUG 35730 / CIP 100753 / JCM 10117 / KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040)
541
0
55782
TrEMBL
-
D5UKW8_CELFN
Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / BCRC 11376 / JCM 18109 / NBRC 3775 / NCIMB 8073 / NRS 134)
614
0
63553
TrEMBL
-
C5CGT0_KOSOT
Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)
549
0
61925
TrEMBL
-
A0A125YJC3_TOXGG
Toxoplasma gondii (strain ATCC 50853 / GT1)
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4)
D6Y5R5_THEBD
Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / KCTC 9307 / NBRC 14880 / R51)
545
0
56985
TrEMBL
-
D2BD39_STRRD
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
547
0
56438
TrEMBL
-
A0A086JFY0_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4)
C8XE97_NAKMY
Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 / Y-104)
561
0
58402
TrEMBL
-
A0A086JVP4_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4)
B9PVD0_TOXGV
Toxoplasma gondii (strain ATCC 50861 / VEG)
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4)
D3Q7Y0_STANL
Stackebrandtia nassauensis (strain DSM 44728 / CIP 108903 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
553
0
58378
TrEMBL
-
A0A086PRB5_TOXGO
597
0
65880
TrEMBL
Mitochondrion (Reliability: 4)
A0A086KGP6_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4)
D0LDW6_GORB4
Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667)
562
0
58919
TrEMBL
-
S8GS96_TOXGM
Toxoplasma gondii (strain ATCC 50611 / Me49)
597
0
65882
TrEMBL
Mitochondrion (Reliability: 4)
A0A139XK63_TOXGO
597
0
65896
TrEMBL
Mitochondrion (Reliability: 4)
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli as fusion protein with a polyHis tag at their N-terminus
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rose, I.A.; Warms, J.V.B.; Kaklij, G.
A specific enzyme for glucose 1,6-bisphosphate synthesis
J. Biol. Chem.
250
3466-3470
1975
Mus musculus
brenda
Ueda, M.; Hirose, M.; Sasaki, R.; Chiba, H.
Regulation of glucose 1,6-bisphosphate level in liver. III. Purification and properties of bovine glucose 1,6-bisphosphate synthase
J. Biochem.
83
1721-1730
1978
Bos taurus
brenda
Rose, I.A.; Warms, J.V.B.; Wong, L.J.
Inhibitors of glucose-1,6-bisphosphate synthase
J. Biol. Chem.
252
4262-4268
1977
Bos taurus
brenda
Maliekal, P.; Sokolova, T.; Vertommen, D.; Veiga-da-Cunha, M.; Van Schaftingen, E.
Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family
J. Biol. Chem.
282
31844-31851
2007
Homo sapiens
brenda
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