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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
phosphoglucokinase,
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glucose-phosphate kinase
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kinase, phosphogluco- (phosphorylating)
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additional information
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enzyme is probably identical with phosphofructokinase, EC 2.7.1.11
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ATP + alpha-D-glucose 1-phosphate = ADP + alpha-D-glucose 1,6-bisphosphate
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phospho group transfer
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ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase
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ATP + D-glucose 1-phosphate
ADP + D-glucose 1,6-bisphosphate
ATP + D-glucose 1-phosphate

ADP + D-glucose 1,6-bisphosphate
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phosphofructokinase contributes to the major glucose 1-phosphate kinase activity in human muscle
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ATP + D-glucose 1-phosphate
ADP + D-glucose 1,6-bisphosphate
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ATP + D-glucose 1-phosphate
ADP + D-glucose 1,6-bisphosphate
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reaction is catalyzed by crystalline rabbit muscle phosphofructokinase
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ATP + D-glucose 1-phosphate
ADP + D-glucose 1,6-bisphosphate
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main route for glucose 1,6-bisphosphate synthesis in rabbit skeletal muscle
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ATP + D-glucose 1-phosphate
ADP + D-glucose 1,6-bisphosphate
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ATP + D-glucose 1-phosphate
ADP + D-glucose 1,6-bisphosphate
ATP + D-glucose 1-phosphate

ADP + D-glucose 1,6-bisphosphate
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phosphofructokinase contributes to the major glucose 1-phosphate kinase activity in human muscle
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?
ATP + D-glucose 1-phosphate
ADP + D-glucose 1,6-bisphosphate
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main route for glucose 1,6-bisphosphate synthesis in rabbit skeletal muscle
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Mg2+

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Mg2+
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activates, maximal activity at 1.5 mM
Mg2+
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activates, maximal activity at 1.5 mM
Mn2+

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can partially replace Mg2+ in activation
Mn2+
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can partially replace Mg2+ in activation
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ATP

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at high concentrations
ATP
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at high concentrations
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Neoplasms
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
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6.8

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patients with glycogenosis
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brenda
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brewer's yeast
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Paladini, A.C.; Caputto, R.; Leloir, L.F.; Trucco, R.E.; Cardini, C.E.
The enzymatic synthesis of glucose-1,6-dephosphate
Arch. Biochem. Biophys.
23
55-66
1949
Saccharomyces cerevisiae, Oryctolagus cuniculus
brenda
Eyer, P.; Hofer, H.W.; Krystek, E.; Pette, D.
Synthesis of glucose 1,6-biphosphate by the action of crystalline rabbit muscle phosphofructokinase
Eur. J. Biochem.
20
153-159
1971
Oryctolagus cuniculus
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Yamada, Y.; Kono, N.; Nakajima, H.; Shimizu, T.; Kiyokawa, H.; Kawachi, M.; Ono, A.; Nishimura, T.; Kuwajima, M.; Tarui, S.
Low glucose-1,6-bisphosphate and high fructose-2,6-bisphosphate concentrations in muscles of patients with glycogenosis types VII and V
Biochem. Biophys. Res. Commun.
176
7-10
1991
Homo sapiens
brenda
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