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Information on EC - taurine-pyruvate aminotransferase

for references in articles please use BRENDA:EC2.6.1.77
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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
       taurine-pyruvate aminotransferase
IUBMB Comments
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
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The enzyme appears in viruses and cellular organisms
aminotransferase, taurine-pyruvate, HPA, hypotaurine-inducible hypotaurine:pyruvate aminotransferase, Pden_4273, taurine transaminase, taurine:pyruvate aminotransferase, tPA, more
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde
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; first step; The enzyme from Bilophila wadsworthia requires pryidoxal 5'-phosphate as a cofactor, is reversible, and catalyses the first step of anaerobic taurine degradation. Hypotaurine (i.e. 2-aminoethanesulfinate) and beta-alanine are also significant donors of an amino group. Unlike, EC, taurine-2-oxoglutarate transaminase, 2-oxoglutarate is not an acceptor of amino groups
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