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Information on EC 2.6.1.77 - taurine-pyruvate aminotransferase
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EC Tree
2.6.1.77 taurine-pyruvate aminotransferaseIUBMB Comments
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
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Word Map
- 2.6.1.77
- sulfoacetaldehyde
-
2-aminoethanesulfonate
- sulfur
- sulfonate
-
bilophila
- wadsworthia
-
transamination
- sulfite
- cysteate
- sulfoacetate
-
paracoccus
-
desulfonation
-
deamination
-
rhodobacter
- isethionate
- acetaldehyde
-
organosulfonate
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
taurine:pyruvate aminotransferase, taurine-pyruvate aminotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
aminotransferase, taurine-pyruvate
-
-
-
-
HPA
hypotaurine-inducible hypotaurine:pyruvate aminotransferase
Pden_4273
taurine transaminase
taurine:pyruvate aminotransferase
tPA
hypotaurine-inducible hypotaurine:pyruvate aminotransferase
-
hypotaurine-inducible hypotaurine:pyruvate aminotransferase
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde
-
-
-
-
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde
first step
-
-
-
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde
The enzyme from Bilophila wadsworthia requires pryidoxal 5'-phosphate as a cofactor, is reversible, and catalyses the first step of anaerobic taurine degradation. Hypotaurine (i.e. 2-aminoethanesulfinate) and beta-alanine are also significant donors of an amino group. Unlike, EC 2.6.1.55, taurine-2-oxoglutarate transaminase, 2-oxoglutarate is not an acceptor of amino groups
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
transamination
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
taurine:pyruvate aminotransferase
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
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CAS REGISTRY NUMBER
COMMENTARY
51901-18-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
taurine + 2-oxobutyrate
2-sulfoacetaldehyde + 2-aminobutyrate
-
-
?
taurine + glycolaldehyde
2-sulfoacetaldehyde + ?
-
-
-
?
taurine + glyoxylate
2-sulfoacetaldehyde + glycine
-
-
-
?
taurine + hexanal
2-sulfoacetaldehyde + hexyl-1-amine
-
-
-
?
taurine + methanal
2-sulfoacetaldehyde + methylamine
-
-
-
?
taurine + pentanal
2-sulfoacetaldehyde + pentylamine
-
-
-
?
taurine + propanal
2-sulfoacetaldehyde + propyl-1-amine
-
-
-
?
(S)-1-methylbenzylamine + pyruvate
acetophenone + L-alanine
no substrate: (R)-enantiomer
-
-
?
(S)-1-methylbenzylamine + pyruvate
acetophenone + L-alanine
no substrate: (R)-enantiomer
-
-
?
1,4-diaminobutane + pyruvate
? + L-alanine
-
3.1% of activity with taurine
-
-
?
1,4-diaminobutane + pyruvate
? + L-alanine
-
3.1% of activity with taurine
-
-
?
1,6-diaminohexane + pyruvate
? + L-alanine
-
2.6% of activity with taurine
-
-
?
1,6-diaminohexane + pyruvate
? + L-alanine
-
2.6% of activity with taurine
-
-
?
1,7-diaminoheptane + pyruvate
? + L-alanine
-
2.1% of activity with taurine
-
-
?
1-amylamine + pyruvate
pentanaldehyde + L-alanine
-
low activity
-
-
?
1-amylamine + pyruvate
pentanaldehyde + L-alanine
-
8.1% of activity with taurine
-
-
?
1-butylamine + pyruvate
4-aminobutyraldehyde + L-alanine
-
low activity
-
-
?
1-butylamine + pyruvate
4-aminobutyraldehyde + L-alanine
-
12% of activity with taurine
-
-
?
beta-alanine + pyruvate
3-oxopropanoate + L-alanine
-
best substrate
-
-
?
beta-alanine + pyruvate
3-oxopropanoate + L-alanine
-
best substrate
-
-
?
hypotaurine + pyruvate
2-aminoethanesulfinic acid + L-alanine
-
product 2-aminoethanesulfinic acid desulfinates spontaneously to acetaldehyde and sulfite
-
?
hypotaurine + pyruvate
2-aminoethanesulfinic acid + L-alanine
-
product 2-aminoethanesulfinic acid desulfinates spontaneously to acetaldehyde and sulfite
-
?
hypotaurine + pyruvate
?
i.e. 2-aminoethanesulfinate
-
-
?
spermidine + pyruvate
? + L-alanine
-
4.7% of activity with taurine
-
-
?
spermine + pyruvate
? + L-alanine
-
4.2% of activity with taurine
-
-
?
taurine + 2-oxobutanoate
2-sulfoacetaldehyde + 2-aminobutanoate
about 50% of the activity with taurine
product 2-sulfoacetaldehyde desulfinates spontaneously to acetaldehyde and sulfite
-
?
taurine + 2-oxobutanoate
2-sulfoacetaldehyde + 2-aminobutanoate
about 50% of the activity with taurine
product 2-sulfoacetaldehyde desulfinates spontaneously to acetaldehyde and sulfite
-
?
taurine + 2-oxoglutarate
2-sulfoacetaldehyde + L-glutamate
-
less active compared to pyruvate
-
-
?
taurine + 2-oxoglutarate
2-sulfoacetaldehyde + L-glutamate
-
56% of activity with pyruvate
-
-
?
taurine + butanal
2-sulfoacetaldehyde + butyl-1-amine
-
-
-
?
taurine + butanal
2-sulfoacetaldehyde + butyl-1-amine
-
-
-
?
taurine + ethanal
2-sulfoacetaldehyde + ethylamine
-
-
-
?
taurine + ethanal
2-sulfoacetaldehyde + ethylamine
-
-
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
best substrates
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
i.e. 2-aminoethanesulfonate
-
r
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
i.e. 2-aminoethanesulfonate
-
r
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
-
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
specific for taurine
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
i.e. 2-aminoethanesulfonate
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
specific for taurine
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
i.e. 2-aminoethanesulfonate
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
-
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
-
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
-
-
-
?
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
involved in taurine catabolism
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
essential for growth on taurine
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
essential for growth on taurine
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
best substrate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
best substrate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
i.e. 2-aminoethanesulfonate
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in the desulfonation pathway dissimilating taurine
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
i.e. 2-aminoethanesulfonate
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
enzyme is involved in the desulfonation pathway dissimilating taurine, overview, homeostatic mechanism
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
i.e. 2-aminoethanesulfonate
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
enzyme is involved in the desulfonation pathway dissimilating taurine, overview, homeostatic mechanism
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
best substrate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
best substrate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
sulfoacetaldehyde + L-alanine
-
inducible enzyme
-
-
?
additional information
?
-
no activity with 2-oxoglutarate and phenylpyruvate as amino group acceptor
-
-
?
additional information
?
-
-
no activity with 2-oxoglutarate and phenylpyruvate as amino group acceptor
-
-
?
additional information
?
-
cysteate, glutamate and 2-aminoethanephosphonate are poor amino group donor substrates
-
-
?
additional information
?
-
-
cysteate, glutamate and 2-aminoethanephosphonate are poor amino group donor substrates
-
-
?
additional information
?
-
no activity with 2-oxoglutarate and phenylpyruvate as amino group acceptor
-
-
?
additional information
?
-
-
no activity with 2-oxoglutarate and phenylpyruvate as amino group acceptor
-
-
?
additional information
?
-
cysteate, glutamate and 2-aminoethanephosphonate are poor amino group donor substrates
-
-
?
additional information
?
-
-
cysteate, glutamate and 2-aminoethanephosphonate are poor amino group donor substrates
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source, and partial carbon source, in presence of CO2 during photoheterotrophic growth
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source, and partial carbon source, in presence of CO2 during photoheterotrophic growth
-
-
?
additional information
?
-
the enzyme displays broad donor and acceptor ranges for unnatural substrates, with relatively good activity toward ketoses. Enzyme shows a unique mechanism of sulfonate/alpha-carboxylate recognition contributed by Arg163 and Gln160
-
-
?
additional information
?
-
the enzyme displays broad donor and acceptor ranges for unnatural substrates, with relatively good activity toward ketoses. Enzyme shows a unique mechanism of sulfonate/alpha-carboxylate recognition contributed by Arg163 and Gln160
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source during photoautotrophic growth
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source during photoautotrophic growth
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
taurine + pyruvate
2-sulfoacetaldehyde + L-alanine
involved in taurine catabolism
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
essential for growth on taurine
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
essential for growth on taurine
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
one of several mechanisms for desulfonation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
initial step in anaerobic taurine degradation
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in the desulfonation pathway dissimilating taurine
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
enzyme is involved in the desulfonation pathway dissimilating taurine, overview, homeostatic mechanism
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
enzyme is involved in the desulfonation pathway dissimilating taurine, overview, homeostatic mechanism
-
-
r
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
L-alanine + 2-sulfoacetaldehyde
-
enzyme is involved in desulfonation in the cells, the pathway produces bisulfite and acetyl phosphate, in vivo independently of pyruvate
-
-
?
taurine + pyruvate
sulfoacetaldehyde + L-alanine
-
inducible enzyme
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source, and partial carbon source, in presence of CO2 during photoheterotrophic growth
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source, and partial carbon source, in presence of CO2 during photoheterotrophic growth
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source during photoautotrophic growth
-
-
?
additional information
?
-
-
cells grow on taurine as sole electron donor, sulfur and nitrogen source during photoautotrophic growth
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
pyridoxyl 5'-phosphate is not essentially required
pyridoxal 5'-phosphate
pyridoxyl 5'-phosphate is not essentially required
additional information
-
pyridoxal 5'-phosphate is not necessary for activity
-
additional information
-
pyridoxal 5'-phosphate is not necessary for activity
-
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
L-alanine
-
feed-back inhibition, no growth of the organism in presence of L-alanine
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
enzyme is inducible by taurine, and beta-alanine + sulfate
-
additional information
incubation th at 50°C for 8 h or at 60°C for 30 min increases activity by up to 2.5fold
-
additional information
-
enzyme is induced under nitrogen- and carbon-limited conditions
-
additional information
enzyme is induced under nitrogen- and carbon-limited conditions
-
additional information
-
enzyme is induced under nitrogen- and carbon-limited conditions
-
additional information
-
enzyme is inducible by taurine, and beta-alanine + sulfate
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
5.3
taurine