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EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
aminotransferase, thymidine diphosphoaminodideoxygalactose, thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase, thymidine diphospho-4-keto-6-deoxy-D-glucose glucamic transaminase, thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase,
WecE ,
more
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aminotransferase, thymidine diphosphoaminodideoxygalactose
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thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase
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thymidine diphospho-4-keto-6-deoxy-D-glucose glucamic transaminase
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thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase
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dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-galactose + L-glutamate
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amino group transfer
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dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein.
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dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
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?
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamine
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutaramate
65% of the activity with L-glutamate
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?
dTDP-4-dehydro-6-deoxy-D-mannose + L-glutamate
? + 2-oxoglutarate
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?
TDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
TDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
additional information
?
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dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
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?
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
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?
TDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
TDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
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r
TDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
TDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
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r
additional information
?
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little activity with L-glutamine or L-alanine
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?
additional information
?
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little activity with L-glutamine or L-alanine
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?
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dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
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?
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate
dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
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?
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pyridoxal 5'-phosphate
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pyridoxal 5'-phosphate
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absolute requirement, a pyridoxal phosphate protein
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Maleate
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stabilizing effect
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Yersinia pseudotuberculosis Infections
Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. IV. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Pasteurella pseudotuberculosis.
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0.22
2-oxoglutarate
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pH 7.0, 38°C
0.11
dTDP-4-dehydro-6-deoxy-D-glucose
pH 7.5, 25°C
7.9
L-glutamate
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pH 7.0, 38°C
0.16
TDP-4-amino-4,6-dideoxy-D-galactose
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pH 7.0, 38°C
1
TDP-4-keto-6-deoxy-D-glucose
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pH 7.0, 38°C
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0.38
dTDP-4-dehydro-6-deoxy-D-glucose
pH 7.5, 25°C
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3.62
dTDP-4-dehydro-6-deoxy-D-glucose
pH 7.5, 25°C
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UniProt
brenda
type VO
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brenda
type VO
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brenda
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44000
4 * 44000, SDS-PAGE
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tetramer
4 * 44000, SDS-PAGE
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65
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10 min: 7% remaining activity, 72% remaining activity with addition of pyridoxal 5'-phosphate, 86% remaining activity with addition of pyridoxal 5'-phosphate and potassium maleate
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crude extract and partially purified enzyme are unstable, necessity of addition of pyridoxal phosphate during purification
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maleate enhances stabilizing effect of pyridoxal phosphate
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0°C or -15°C, purified enzyme, stable for several weeks
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expression in Escherichia coli BL21
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Ohashi, H.; Matsuhashi, M.; Matsuhashi, S.
Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. IV. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Pasteurella pseudotuberculosis
J. Biol. Chem.
246
2325-2330
1971
Yersinia pseudotuberculosis, Yersinia pseudotuberculosis VO
brenda
Hwang, B.Y.; Lee, H.J.; Yang, Y.H.; Joo, H.S.; Kim, B.G.
Characterization and investigation of substrate specificity of the sugar aminotransferase WecE from E. coli K12
Chem. Biol.
11
915-925
2004
Escherichia coli (P27833)
brenda
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