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Information on EC 2.6.1.26 - thyroid-hormone transaminase for references in articles please use BRENDA:EC2.6.1.26
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EC Tree
IUBMB Comments A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.
The expected taxonomic range for this enzyme is: Oryctolagus cuniculus
Synonyms
3,5-dinitrotyrosine transaminase, aminotransferase, thyroid hormone,
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3,5-dinitrotyrosine transaminase
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aminotransferase, thyroid hormone
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L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
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amino group transfer
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L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.
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3,5-dibromo-L-tyrosine + 2-oxoglutarate
3-(3,5-dibromo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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r
3,5-diiodo-D-tyrosine + 2-oxoglutarate
3-(3,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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very low activity
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r
3,5-diiodo-L-tyrosine + 2-oxoglutarate
3-(3,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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r
3,5-dinitro-L-tyrosine + 2-oxoglutarate
3-(3,5-dinitro-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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i.e. 3,5-dinitro-p-hydroxyphenylpyruvic acid + Glu
r
3-amino-L-tyrosine + 2-oxoglutarate
3-(3-amino-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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very low activity
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r
3-iodo-L-tyrosine + 2-oxoglutarate
3-(3-iodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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r
3-nitro-L-tyrosine + 2-oxoglutarate
3-(3-nitro-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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r
L-3,5,3'-triiodothyronine + 2-oxoglutarate
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
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i.e. 3,5,3'-triiodothyropyruvate + L-Glu
r
L-3,5,3'-triiodothyronine + oxaloacetate
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + glycine
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i.e. 3,5,3'-triiodothyrophenylpyruvate + Gly
r
L-3,5,3'-triiodothyronine + pyruvate
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-alanine
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i.e. 3,5,3'-triiodothyrophenylpyruvate + L-Ala
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L-phenylalanine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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low activtiy
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r
L-thyroxine + 2-oxoglutarate
3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
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r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
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low activtiy
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r
L-tyrosine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
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low activtiy
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r
additional information
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additional information
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specific for 2-oxoglutarate
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additional information
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pyruvate and oxalacetate are ineffective with 3,5-dinitro-L-tyrosine and only partially effective with iodinated tyrosines
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L-3,5,3'-triiodothyronine + 2-oxoglutarate
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
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i.e. 3,5,3'-triiodothyropyruvate + L-Glu
r
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pyridoxal 5'-phosphate
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partial requirement
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p-hydroxymercuribenzoate
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complete inhibition at 0.1 mM
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2-mercaptoethanol
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absolutely required
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0.9
3,5-diiodo-L-tyrosine
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pH 7.8, 37°C
4.4
3,5-Dinitro-L-tyrosine
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pH 7.8, 37°C
3.8
3-iodo-L-tyrosine
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pH 7.8, 37°C
2.12
L-thyronine
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pH 7.8, 37°C
0.034
L-triiodothyronine
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pH 7.8, 37°C
2
pyruvate
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cosubstrate L-triiodothyronine, pH 7.8, 37°C
0.2
2-oxoglutarate
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cosubstrate L-thyroxine, pH 7.8, 37°C; cosubstrate triiodothyronine, pH 7.8, 37°C
2
2-oxoglutarate
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cosubstrate 3,5-dinitro-L-tyrosine, pH 7.8, 37°C
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1.1 - 6.6
3,5-diiodo-L-tyrosine
39.9
3,5-Dinitro-L-tyrosine
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pH 7.8, 37°C
3.68
3-iodo-L-tyrosine
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pH 7.8, 37°C
0.0233
L-thyroxine
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pH 7.8, 37°C
0.0317
L-triiodothyronine
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pH 7.8, 37°C
1.1
3,5-diiodo-L-tyrosine
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pH 7.8, 37°C
6.6
3,5-diiodo-L-tyrosine
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pH 7.8, 37°C
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0.013
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purified enzyme, substrates L-3,5,3'-triiodothyronine + 2-oxoglutarate
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purified enzyme, substrates 3,5-dinitro-L-tyrosine + 2-oxoglutarate
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7.4 - 8.6
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broad optimum
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7 - 8.6
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pH 7.0: 30% of maximal activity with L-triiodothyronine, 15% of maximal activity with 3,5-dinitro-L-tyrosine, pH 7.4-8.6: maximal activity with triiodothyronine and 3,5-dinitro-L-tyrosine
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brenda
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low activity
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low activity
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low activity
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low activity
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additional information
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not in serum
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brenda
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48000
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2 * 48000, SDS-PAGE
95000
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glycerol density gradient centrifugation
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dimer
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2 * 48000, SDS-PAGE
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-20°C, 30% loss of activity per month
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Soffer, R.L.; Hechtman, P.; Savage, M.
L-Triiodothyronine aminotransferase
J. Biol. Chem.
248
1224-1230
1973
Oryctolagus cuniculus
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2.6.1.26 thyroid-hormone transaminase
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