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IUBMB CommentsA pyridoxal-phosphate protein. Also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine.
The expected taxonomic range for this enzyme is: Rattus norvegicus
Synonyms
aminotransferase, diiodotyrosine, diiodotyrosine aminotransferase, EC 2.6.1.25, halogenated tyrosine aminotransferase, halogenated tyrosine transaminase,
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aminotransferase, diiodotyrosine
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diiodotyrosine aminotransferase
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EC 2.6.1.25
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formerly
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halogenated tyrosine aminotransferase
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halogenated tyrosine transaminase
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3,5-diiodo-L-tyrosine + 2-oxoglutarate = 4-hydroxy-3,5-diiodophenylpyruvate + L-glutamate
also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine
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amino group transfer
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3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. Also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine.
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3,5-dibromo-L-tyrosine + 2-oxoglutarate
3,5-dibromo-4-hydroxyphenylpyruvate + L-glutamate
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at 127% the rate of 3,5-diiodo-L-tyrosine
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3,5-dichloro-L-tyrosine + 2-oxoglutarate
3,5-dichloro-4-hydroxyphenylpyruvate + L-glutamate
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at 110% the rate of 3,5-diiodo-L-tyrosine
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3,5-diiodo-L-tyrosine + 2-oxoglutarate
3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
3,5-diiodo-L-tyrosine + oxaloacetate
3,5-diiodo-4-hydroxyphenylpyruvate + L-aspartate
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30% substitution of 2-oxoglutarate by oxaloacetate as amino acceptor
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3-(4-fluorophenyl)alanine + 2-oxoglutarate
(4-fluorophenyl)pyruvate + L-glutamate
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i.e. p-fluoro-DL-phenylalanine, at 3.1% the rate of 3,5-diiodo-L-tyrosine
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3-iodo-L-tyrosine + 2-oxoglutarate
3-iodo-4-hydroxyphenylpyruvate + L-glutamate
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at 76% the rate of 3,5-diiodo-L-tyrosine
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L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
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at 3.9% the rate of 3,5-diiodo-L-tyrosine
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L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
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at 3.6% the rate of 3,5-diiodo-L-tyrosine
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L-tyrosine + 2-oxoglutarate
(4-hydroxyphenyl)pyruvate + L-glutamate
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at 3.9% the rate of 3,5-diiodo-L-tyrosine
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additional information
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3,5-diiodo-L-tyrosine + 2-oxoglutarate
3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
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3,5-diiodo-L-tyrosine + 2-oxoglutarate
3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
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specific for 2-oxoglutarate as amino acceptor
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additional information
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substrate specificity
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additional information
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no activity with: D-diiodotyrosine, tyrosine analogues with nitro, amino or hydroxy substituents in position 3 or 3 and 5
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additional information
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no activity with pyruvate as amino acceptor
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3,5-diiodo-L-tyrosine + 2-oxoglutarate
3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
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pyridoxal 5'-phosphate
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required
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3,5-Diiodo-4-hydroxyphenyl-DL-lactic acid
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3,5-Diiodo-4-hydroxyphenylacetate
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strong inhibition, mixed type
4-chloromercuribenzoate
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4-hydroxyphenyl-DL-lactic acid
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weak
4-hydroxyphenylacetic acid
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3.4 - 3.7
3,5-Dibromo-L-tyrosine
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pH 6.5, 37°C
6.1
3,5-dichloro-L-tyrosine
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pH 6.-L-7, 37°C
1.1 - 1.3
3,5-diiodo-L-tyrosine
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pH 6.2, 37°C
6.5
3-iodo-L-tyrosine
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pH 7.4, 37°C
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0.53
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partially purified enzyme
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with substrate diiodo-L-tyrosine
6.5
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with substrate dibromo-L-tyrosine, dichloro-L-tyrosine
7 - 7.5
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with substrate monoiodo-L-tyrosine
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brenda
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brenda
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brenda
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0°C, 50 mM sodium phosphate buffer, 1 mM EDTA, 1 mM 2-mercaptoethanol, 0.15 M NaCl, approximately 4 mg protein/ml, 40% loss of activity after 1 week
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Nakano, M.
Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria
J. Biol. Chem.
242
73-81
1967
Rattus norvegicus
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2.6.1.24 diiodotyrosine transaminase
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