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Disease on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
4-aminobutyrate-2-oxoglutarate transaminase deficiency
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency.
4-aminobutyrate-2-ketoglutarate aminotransferase (GABA-T) in human hair follicle.
?-Aminobutyric acid transaminase deficiency impairs central carbon metabolism and leads to cell wall defects during salt stress in Arabidopsis roots.
A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy.
Cerebrospinal fluid as a tool in the diagnosis of neurometabolic diseases: amino acid analysis before and after acid hydrolysis.
Clinical aspects of the disorders of GABA metabolism in children.
Corrigendum: 2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
Demonstration of 4-aminobutyric acid aminotransferase deficiency in lymphocytes and lymphoblasts.
Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies.
GABA Transaminase Deficiency With Survival Into Adulthood.
GABA transaminase deficiency. Case report and literature review.
Identification of a familial mutation associated with GABA-transaminase deficiency disease.
Inherited disorders of GABA metabolism.
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Paroxysmal dyskinesias with drowsiness and thalamic lesions in GABA transaminase deficiency.
Pediatric neurotransmitter diseases.
Phenotype of GABA-transaminase deficiency.
Phenotyping GABA transaminase deficiency: a case description and literature review.
Review: Normal and abnormal central nervous system GABA metabolism in childhood.
Serial Magnetic Resonance Imaging and
The pediatric neurotransmitter disorders.
[gamma-Aminobutyric acid transaminase deficiency]
Acidosis
[The effect of chronic acidosis on the activity of renal glutamate decarboxylase and GABA-transaminase]
adenylosuccinate lyase deficiency
Cerebrospinal fluid as a tool in the diagnosis of neurometabolic diseases: amino acid analysis before and after acid hydrolysis.
alcohol dehydrogenase deficiency
Clinical aspects of the disorders of GABA metabolism in children.
Alzheimer Disease
Basic aspects of GABA-transaminase in neuropsychiatric disorders.
Brain aminobutyrate aminotransferase activity in Alzheimer's disease.
Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease.
GABA-transaminase in brain and blood platelets: basic and clinical aspects.
GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease.
Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients.
Increased gamma-aminobutyrate aminotransferase activity in brain of patients with Alzheimer's disease.
Amnesia
GABAergic modulation of memory with regard to passive avoidance and conditioned suppression task in mice.
Asphyxia Neonatorum
[Experimental pathology of the asphyxia neonatorum. GABA and activities of GAD and GABA-T in the brain of newborn rats]
beta-ala-his dipeptidase deficiency
Inherited disorders of GABA metabolism.
Bradycardia
Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.
Brain Diseases
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.
Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies.
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
GABA transaminase deficiency. Case report and literature review.
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Phenotype of GABA-transaminase deficiency.
Serial Magnetic Resonance Imaging and
Breast Neoplasms
Human breast cancer metastases to the brain display GABAergic properties in the neural niche.
Carcinoma, Hepatocellular
Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
Catalepsy
Graded increases in brain GABA: differential effects on feeding and other behaviours in rats.
Cerebellar Ataxia
A controlled study of oral vigabatrin (gamma-vinyl GABA) in patients with cerebellar ataxia.
Effect of gamma-vinyl GABA in Friedreich's ataxia.
Cerebral Infarction
Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating ?-aminobutyric acid transaminase and enhancing ?-aminobutyric acid.
Chorea
Paroxysmal dyskinesias with drowsiness and thalamic lesions in GABA transaminase deficiency.
Coma
Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats.
Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride.
Deficiency Diseases
4-aminobutyrate-2-ketoglutarate aminotransferase (GABA-T) in human hair follicle.
Identification of a familial mutation associated with GABA-transaminase deficiency disease.
Dehydration
Arbuscular mycorrhiza induced putrescine degradation into ?-aminobutyric acid, malic acid accumulation, and improvement of nitrogen assimilation in roots of water-stressed maize plants.
Proteomic analyses unraveling water stress response in two Eucalyptus species originating from contrasting environments for aridity.
Disorders of Excessive Somnolence
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Phenotype of GABA-transaminase deficiency.
Drug Resistant Epilepsy
Gamma-vinyl GABA (vigabatrin): relationship between dosage, plasma concentrations, platelet GABA-transaminase inhibition, and seizure reduction in epileptic children.
Neuropathology of a human hippocampus following long-term treatment with vigabatrin: lack of microvacuoles.
Dyskinesias
An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin.
Does homocarnosine mediate the dyskinetic movements induced by gaba-transaminase inhibitors.
Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin.
Dystonia
Double-blind study of oral gamma-vinyl GABA in the treatment of dystonia.
Epilepsies, Partial
Platelet GABA-transaminase in epileptic children: influence of epilepsy and anticonvulsants.
Epilepsy
(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.
A comparative study of the pharmacology of inhibitors of GABA-metabolism.
An enhanced serum prolactin response to TRH in the presence of GABA transaminase inhibition.
Antiepileptic action induced by a combination of vigabatrin and tiagabine.
Basic aspects of GABA-transaminase in neuropsychiatric disorders.
Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity.
Clinical aspects of the disorders of GABA metabolism in children.
Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions.
Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor.
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.
Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy.
Ethnopharmacology of Q'eqchi' Maya antiepileptic and anxiolytic plants: effects on the GABAergic system.
GABA transamination regulates neuronal glutamate content in the retina.
GABA-transaminase in brain and blood platelets: basic and clinical aspects.
Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?
Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues.
Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase.
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis.
Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors.
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
Neurotoxic effects of GABA-transaminase inhibitors in the treatment of epilepsy: ocular perfusion and visual performance.
Pediatric neurotransmitter diseases.
Pharmacokinetics of the S(+) and R(-) enantiomers of vigabatrin during chronic dosing in a patient with renal failure.
Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats.
Platelet GABA-transaminase in epileptic children: influence of epilepsy and anticonvulsants.
Pregabalin peptides: conformational comparison of ?3- and ?4-substituted ?-amino acids in ????? pentapeptides.
Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies.
Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells.
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase.
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase.
Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase.
Synthesis of Functionalized Pyrrolidin-2-ones and (S)-Vigabatrin from Pyrrole.
Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina.
Vigabatrin-associated visual field defects in children.
Epilepsy, Absence
Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?
Starting and stopping mechanisms of absence epileptic seizures are revealed by hazard functions.
Uptake of GABA and activity of GABA transaminase in blood platelets from children with absence epilepsy.
Epilepsy, Generalized
GABA and epilepsy: their complex relationship and the evolution of our understanding.
Epilepsy, Reflex
Catalytic inhibitors of GABA-transaminase as anticonvulsants in baboons with photosensitive epilepsy [proceedings]
Epileptic Syndromes
Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients.
Friedreich Ataxia
A controlled study of oral vigabatrin (gamma-vinyl GABA) in patients with cerebellar ataxia.
Effect of gamma-vinyl GABA in Friedreich's ataxia.
Gastroesophageal Reflux
4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease.
Genetic Diseases, Inborn
Inherited disorders of GABA metabolism.
Glioma
[Changes in GAT-3 and GABA-T mRNA expression of C6 glioma cells in response to a 2-week treatment with sodium valproate and withdrawal]
Glucose Intolerance
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
glutamate decarboxylase deficiency
The pediatric neurotransmitter disorders.
Hepatic Encephalopathy
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats.
Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride.
Herpes Zoster
Distribution of GABA-T-intensive neurons in the rat forebrain and midbrain.
Presumptive gamma-aminobutyric acid pathways from the midbrain to the superior colliculus studied by a combined horseradish peroxidase-gamma-aminobutyric acid transaminase pharmacohistochemical method.
Huntington Disease
Abnormalities of neurotransmitter enzymes in Huntington's chorea.
Failure of aminooxyacetic acid therapy in Huntington disease.
Isoniazid therapy of Huntington disease.
Reduced GABA transaminase activity in the Huntington's disease putamen.
The biochemical genetics of human gamma-aminobutyric acid transaminase.
Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration.
Hyperglycemia
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
Hyperglycinemia, Nonketotic
The pediatric neurotransmitter disorders.
Hyperinsulinism
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
Hyperprolactinemia
Estriol affects prolactin and LH secretion in rats.
GABAergic biochemical parameters of the tuberoinfundibular neurons following chronic hyperprolactinemia.
Hypersensitivity
?-Aminobutyric acid transaminase deficiency impairs central carbon metabolism and leads to cell wall defects during salt stress in Arabidopsis roots.
Hypertension
Cardiovascular effects of GABA system activating drugs injected into the caudal ventrolateral medulla of the rat.
Hypertension, Pulmonary
A study on the involvement of GABA-transaminase in MCT induced pulmonary hypertension.
Hypoglycemia
Aminobutyrate aminotransferase and succinate semialdehyde dehydrogenase in regions of rat brain after insulin-induced hypoglycemia.
Comparison of results obtained with different methods for estimating GABA turnover in rat neostriatum.
Hypotension
Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.
Infections
Effect of Plasmodium yoelii infection on GABA metabolism of mouse brain.
Insulin Resistance
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
Intellectual Disability
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
Iron Deficiencies
Effect of iron deficiency on developing rat brain.
Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues.
Language Development Disorders
GABA-transaminase, the liver and infantile autism.
Lethargy
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia.
Liver Failure
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
Liver Failure, Acute
Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity.
Medulloblastoma
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Migraine Disorders
Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation.
Movement Disorders
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
Hypersomnolence-hyperkinetic movement disorder in a child with compound heterozygous mutation in 4-aminobutyrate aminotransferase (ABAT) gene.
Muscle Hypotonia
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Serial Magnetic Resonance Imaging and
Muscle Spasticity
Influence of aminooxyacetic acid, a gamma-aminobutyrate transaminase inhibitor, on hereditary spastic defect in the mouse.
Myelodysplastic Syndromes
High methylation of the 4-aminobutyrate aminotransferase gene predicts a poor prognosis in patients with myelodysplastic syndrome.
Myoclonus
A functional interaction between GABA and 5-HT in inhibiting picrotoxin-induced myoclonus in rats.
Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid).
The antimyoclonic action of clonazepam through a GABA--independent mechanism.
Neoplasm Metastasis
Human breast cancer metastases to the brain display GABAergic properties in the neural niche.
Neoplasms
Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism.
Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
In search of druggable targets for GBM amino acid metabolism.
Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca2+-NFAT1 Axis.
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
[Effects of 3-methylcholanthrene and 3-methylcholanthrene plus piracetam on the gamma-amino-butyric acid (GABA) content of several cerebral regions (author's transl)]
Nervous System Diseases
Bicyclic ?-amino acids as inhibitors of ?-aminobutyrate aminotransferase.
Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity.
Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease.
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site.
Neuroblastoma
Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism.
Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase.
Neurodegenerative Diseases
Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector.
Neuroinflammatory Diseases
Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice.
Obesity
Anorectic potency of inhibiting GABA transaminase in brain: studies of hypothalamic, dietary and genetic obesities.
Osteoarthritis
Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.
Pituitary ACTH Hypersecretion
Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease.
Propionic Acidemia
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia.
Reflex, Abnormal
Serial Magnetic Resonance Imaging and
Respiratory Insufficiency
Neuropharmacological aspects of central respiratory regulation. An experimental study in the rat.
Seizures
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent ?-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
(4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor.
2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.
4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency.
Amygdaloid kindling and the GABA system.
An overview of third-generation antiseizure drugs: Clobazam, lacosamide, rufinamide, and vigabatrin.
Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures.
Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice.
Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors.
Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid).
Coadministration of vigabatrin and valproate in children with refractory epilepsy.
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models.
Correlation between alterations in brain GABA metabolism and seizure excitability following administration of GABA aminotransferase inhibitors and valproic acid-a re-evaluation.
Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures.
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy.
Effect of depth electrode implantation with or without subsequent kindling on GABA turnover in various rat brain regions.
Effect of elevated brain GABA concentrations on the actions of bicuculline and picrotoxin in mice.
Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography.
Evidence implicating substantia nigra in regulation of kindled seizure threshold.
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo.
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brainstem.
Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats.
GABA and epilepsy: their complex relationship and the evolution of our understanding.
GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice.
GABAergic modulation of lindane (gamma-hexachlorocyclohexane)-induced seizures.
Gamma-vinyl GABA (vigabatrin): relationship between dosage, plasma concentrations, platelet GABA-transaminase inhibition, and seizure reduction in epileptic children.
gamma-Vinyl GABA in endopiriform area suppresses kindled amygdala seizures.
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions.
Hippocampal electrical activity and gamma-aminobutyrate metabolism in brain tissue following administration of homocysteine.
Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduaia, somnolence and seizures.
Identification of a familial mutation associated with GABA-transaminase deficiency disease.
Identification of a median thalamic system regulating seizures and arousal.
Influence of a GABA transaminase inhibitor on central nervous system oxygen toxicity.
Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil.
Inherited disorders of GABA metabolism.
Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation.
Inhibitory effects of the fragrance inhalation of essential oil from Acorus gramineus on central nervous system.
Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction.
Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats.
L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats.
Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors.
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment.
Picrotoxin convulsions and GABA metabolism after injection of anticonvulsants in chicks.
Platelet and brain GABA-transaminase and monoamine oxidase activities in patients with complex partial seizures.
Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions.
Reversible suppression of amygdaloid kindled convulsion following unilateral gabaculine injection into the substantia innominata.
Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex.
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.
Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition.
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Serial Magnetic Resonance Imaging and
Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.
Starting and stopping mechanisms of absence epileptic seizures are revealed by hazard functions.
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase.
Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4-(hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole.
The alteration of gamma-aminobutyric acid-transaminase expression in the gerbil hippocampus induced by seizure.
The central piriform cortex: anatomical connections and anticonvulsant effect of GABA elevation in the kindling model.
The influence in rabbits and rats of gamma-acetylenic GABA on seizures generated by pentylenetetrazol.
The mode of action of homocysteine on mouse brain glutamic decarboxylase and gamma-aminobutyrate aminotransferase.
The pediatric neurotransmitter disorders.
The role of gamma-aminobutyric acid in the mechanism of seizures.
Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study. The Canadian Vigabatrin Study Group.
Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up.
Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors.
Seizures, Febrile
Experimental febrile convulsions in epileptic chickens: the anticonvulsant effect of elevated gamma-aminobutyric acid concentrations.
Spasm
The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.
Spasms, Infantile
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent ?-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
An overview of third-generation antiseizure drugs: Clobazam, lacosamide, rufinamide, and vigabatrin.
Current role of vigabatrin in infantile spasms.
Mechanism of Inactivation of ?-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115).
The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.
Starvation
[The effect of starvation on GABA-transaminase and glutamate decarboxylase activity on mitochondria of dog limbic structures during postnatal ontogenesis]
Stupor
[Characteristics of dopamine and GABA system functions in the brain of animals with different durations of ethanol sleep]
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Inherited disorders of GABA metabolism.
Pediatric neurotransmitter diseases.
Review: Normal and abnormal central nervous system GABA metabolism in childhood.
The pediatric neurotransmitter disorders.
Tachycardia
Cardiovascular effects of GABA system activating drugs injected into the caudal ventrolateral medulla of the rat.
Tardive Dyskinesia
Effect of gamma-vinyl GABA in tardive dyskinesia.
Gamma-Acetylenic GABA in tardive dyskinesia.
gamma-Acetylenic GABA in tardive dyskinesia.
[Therapeutic trial of gamma-vinyl GABA, an inhibitor of GABA transaminase, in tardive dyskinesias induced by neuroleptics]
Tinnitus
Forward acoustic masking enhances the auditory brainstem response in a diotic, but not dichotic, paradigm in salicylate-induced tinnitus.
PHARMACOLOGICAL TREATMENTS FOR TINNITUS: NEW AND OLD.
Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model.
Toxic Optic Neuropathy
Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects.
Tremor
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Vitamin B 6 Deficiency
Effect of pyridoxine deficiency and prednisolone on beta-alanine-oxoglutarate aminotransferase and D-3-aminoisobutyrate aminotransferase in rat liver and kidney.