We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments The enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), participates in the biosynthesis of coelimycin P1, where it catalyses the amination of (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal. L-glutamate can also serve as the amino group donor with lower efficiency.
The expected taxonomic range for this enzyme is: Streptomyces coelicolor
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cpkG
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol:pyruvate aminotransferase
The enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), participates in the biosynthesis of coelimycin P1, where it catalyses the amination of (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal. L-glutamate can also serve as the amino group donor with lower efficiency.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
1,1-dicyclopentylmethanamine + 2-oxoglutarate
1-dicyclopentylmethanal + L-glutamate
2-methylpropan-1-amine + 2-oxoglutarate
2-methylpropanal + L-glutamate
-
-
-
?
butan-1-amine + 2-oxoglutarate
butanal + L-glutamate
-
-
-
?
octanal + L-alanine
octyl-1-amine + pyruvate
-
-
-
r
octyl-1-amine + pyruvate
octanal + L-alanine
-
-
-
r
phenylamine + 2-oxoglutarate
benzaldehyde + L-glutamate
-
-
-
?
additional information
?
-
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
-
-
-
?
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
-
-
-
?
1,1-dicyclopentylmethanamine + 2-oxoglutarate
1-dicyclopentylmethanal + L-glutamate
-
-
-
?
1,1-dicyclopentylmethanamine + 2-oxoglutarate
1-dicyclopentylmethanal + L-glutamate
-
-
-
?
additional information
?
-
-
enzyme displays broad substrate tolerance. Highest level of activity is observed for octylamine using pyruvate as the cosubstrate. Only L-alanine is formed from pyruvate
-
?
additional information
?
-
-
enzyme displays broad substrate tolerance. Highest level of activity is observed for octylamine using pyruvate as the cosubstrate. Only L-alanine is formed from pyruvate
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
-
CpkG is encoded within the cpk gene cluster encoding a tyxpe I polyketide synthase
physiological function
-
CpkG is encoded within the cpk gene cluster encoding a tyxpe I polyketide synthase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Pawlik, K.; Kotowska, M.; Chater, K.; Kuczek, K.; Takano, E.
A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2)
Arch. Microbiol.
187
87-99
2007
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
brenda
Awodi, U.; Ronan, J.; Masschelein, J.; De Los Santos, E.; Challis, G.
Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis
Chem. Sci.
8
411-415
2016
Streptomyces coelicolor, Streptomyces coelicolor M145
brenda
Select items on the left to see more content.
html completed