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(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
dimethylallyl diphosphate + 4 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
additional information
?
-
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids
-
-
?
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
farnesyl diphosphate is the allylic substrate with the highest activity
-
-
?
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
-
farnesyl diphosphate shows 93% of the activity with geranylgeranyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
-
-
?
dimethylallyl diphosphate + 4 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
dimethylallyl diphosphate shows 28% of the activity with farnesyl diphosphate
large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate
-
?
dimethylallyl diphosphate + 4 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
-
dimethylallyl diphosphate shows 51% of the activity with farnesyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate
-
?
farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis
-
-
?
farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
the enzyme prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate is the main product, a considerable amount of geranylgeranyl diphosphate as an intermediate is also observed
-
?
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
geranyl diphosphate shows 72% of the activity with farnesyl diphosphate
-
-
?
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
slight activity
-
-
?
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
-
geranyl diphosphate shows 81% of the activity with farnesyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
geranylgeranyl diphosphate shows 65% of the activity with farnesyl diphosphate
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
among mutants, in which the bulky residues that constitute the bottom of the product-accommodating cavity is replaced with alanine, those having mutations on an alpha-helix existing at the subunit interface yield longer products
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
the enzyme prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
the enzyme may synthesize a precursor for the C25 moiety of C20,C25 diether lipids
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
geranylgeranyl diphosphate is the allylic substrate with the highest activity. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
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-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
dimethylally diphosphate is not accepted as substrate
-
-
?
additional information
?
-
-
dimethylally diphosphate is not accepted as substrate
-
-
?
additional information
?
-
the residues in chain length determination region III are the predominant factor in the determination of the product specificity
-
-
?
additional information
?
-
-
the residues in chain length determination region III are the predominant factor in the determination of the product specificity
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids
-
-
?
farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
additional information
?
-
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
the enzyme may synthesize a precursor for the C25 moiety of C20,C25 diether lipids
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Tachibana, A.; Yano, Y.; Otani, S.; Nomura, N.; Sako, Y.; Taniguchi, M.
Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon,Aeropyrum pernix. Molecular evolution with alteration in product specificity
Eur. J. Biochem.
267
321-328
2000
Aeropyrum pernix (Q9UWR6), Aeropyrum pernix
brenda
Tachibana, A.
A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis
FEBS Lett.
341
291-294
1994
Natronomonas pharaonis
brenda
Lee, P.C.; Mijts, B.N.; Petri, R.; Watts, K.T.; Schmidt-Dannert, C.
Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution
Protein Eng. Des. Sel.
17
771-777
2004
Aeropyrum pernix (Q9UWR6), Aeropyrum pernix
brenda
Ogawa, T.; Yoshimura, T.; Hemmi, H.
Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution
Biochem. Biophys. Res. Commun.
393
16-20
2010
Methanosarcina mazei (Q8PYS1), Methanosarcina mazei
brenda
Ogawa, T.; Yoshimura, T.; Hemmi, H.
Connected cavity structure enables prenyl elongation across the dimer interface in mutated geranylfarnesyl diphosphate synthase from Methanosarcina mazei
Biochem. Biophys. Res. Commun.
409
333-337
2011
Methanosarcina mazei (Q8PYS1), Methanosarcina mazei
brenda
Liu, Y.; Luo, S.H.; Schmidt, A.; Wang, G.D.; Sun, G.L.; Grant, M.; Kuang, C.; Yang, M.J.; Jing, S.X.; Li, C.H.; Schneider, B.; Gershenzon, J.; Li, S.H.
A geranylfarnesyl diphosphate synthase provides the precursor for sesterterpenoid (C25) formation in the glandular trichomes of the mint species Leucosceptrum canum
Plant Cell
28
804-822
2016
Leucosceptrum canum
brenda
Nagel, R.; Bernholz, C.; Vranova, E.; Kosuth, J.; Bergau, N.; Ludwig, S.; Wessjohann, L.; Gershenzon, J.; Tissier, A.; Schmidt, A.
Arabidopsis thaliana isoprenyl diphosphate synthases produce the C25 intermediate geranylfarnesyl diphosphate
Plant J.
84
847-859
2015
Arabidopsis thaliana, Arabidopsis thaliana (Q9LIA0), Arabidopsis thaliana (Q9LUD9), Arabidopsis thaliana (Q9LUE1), Arabidopsis thaliana Col-0, Arabidopsis thaliana Col-0 (Q9LIA0), Arabidopsis thaliana Col-0 (Q9LUD9), Arabidopsis thaliana Col-0 (Q9LUE1)
brenda