Reference on EC 2.5.1.46 - deoxyhypusine synthase
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Wolff, E.C.; Park, M.H.; Folk, J.E.
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD+
J. Biol. Chem.
265
4793-4799
1990
Rattus norvegicus
Wolff, E.C.; Folk, J.E.; Park, M.H.
Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
J. Biol. Chem.
272
15865-15871
1997
Homo sapiens
Chen, K.Y.; Liu, A.Y.C.
Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A
Biol. Signals
6
105-109
1997
Homo sapiens, Neurospora crassa
Ober, D.; Hartmann, T.
Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity
J. Biol. Chem.
274
32040-32047
1999
Nicotiana tabacum (Q9SC80), Nicotiana tabacum
Ober, D.; Hartmann, T.
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved form deoxyhypusine synthase
Proc. Natl. Acad. Sci. USA
96
14777-14782
1999
Senecio vernalis (Q9SC14), Senecio vernalis
Wolff, E.C.; Park, M.H.
Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation
Yeast
15
43-50
1999
Saccharomyces cerevisiae
Wolff, E.C.; Wolff.J.; Park, M.H.
Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism
J. Biol. Chem.
275
9170-9177
2000
Homo sapiens
Joe, Y.A.; Wolff, E.C.; Park, M.H.
Cloning and expression of human deoxyhypusine synthase cDNA: structure-function studies with the recombinant enzyme and mutant proteins
J. Biol. Chem.
270
22386-22392
1995
Homo sapiens (P49366), Homo sapiens
Tao, Y.; Chen, K.Y.
Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast deoxyhypusine synthase cDNA
J. Biol. Chem.
270
23984-23987
1995
Saccharomyces cerevisiae, Neurospora crassa (P49365), Neurospora crassa
Wang, T.W.; Lu, L.; Wang, D.; Thompson, J.E.
Isolation and characterization of senescence-induced cDNAs encoding deoxyhypusine synthase and eucaryotic translation initiation factor 5A from tomato
J. Biol. Chem.
276
17541-17549
2001
Solanum lycopersicum (Q9AXR0), Solanum lycopersicum
Lee, C.H.; Um, P.Y.; Park, M.H.
Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD
Biochem. J.
355
841-849
2001
Homo sapiens
Lee, C.H.; Park, M.H.
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates
Biochem. J.
352
851-857
2000
Homo sapiens
-
Lee, Y.B.; Joe, Y.A.; Wolff, E.C.; Dimitriadis, E.K.; Park, M.H.
Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor
Biochem. J.
340
273-281
1999
Homo sapiens
-
Liao, D.I.; Wolff, E.C.; Park, M.H.; Davies, D.R.
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site
Structure
6(1)
23-32
1998
Homo sapiens
-
Park, M.H.; Joe, Y.A.; Kang, K.R.
Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae
J. Biol. Chem.
273
1677-1683
1998
Saccharomyces cerevisiae
Joe, Y.A.; Wolff, E.C.; Lee, Y.B.; Park, M.H.
Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase
J. Biol. Chem.
272
32679-32685
1997
Homo sapiens
Kang, K.R.; Wolff, E.C.; Park, M.H.; Folk, J.E.; Chung, S.I.
Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme
J. Biol. Chem.
270
18408-18412
1995
Saccharomyces cerevisiae
Wolff, E.C.; Lee, Y.B.; Chung, S.I.; Folk, J.E.; Park, M.H.
Deoxyhypusine synthase from rat testis: purification and characterization
J. Biol. Chem.
270
8660-8666
1995
Rattus norvegicus
Jakus, J.; Wolff, E.C.; Park, M.H.; Folk, J.E.
Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines
J. Biol. Chem.
268
13151-13159
1993
Rattus norvegicus
Abid, M.R.; Sasaki, K.; Titani, K.; Miyazaki, M.
Biochemical and immunological characterization of deoxyhypusine synthase purified from the yeast Saccharomyces carlsbergensis
J. Biochem.
121
769-778
1997
Saccharomyces cerevisiae
Abid, R.; Ueda, K.; Miyazaki, M.
Novel features of the functional site and expression of the yeast deoxyhypusine synthase
Biol. Signals
6
157-165
1997
Saccharomyces cerevisiae
Klier, H.; Csonga, R.; Steinkasserer, A.; Woehl, T.; Lottspeich, F.; Eder, J.
Purification and characterization of human deoxyhypusine synthase from HeLa cells
FEBS Lett.
364
207-210
1995
Homo sapiens
Ober, D.; Harms, R.; Witte, L.; Hartmann, T.
Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retains all properties of deoxyhypusine synthase except binding the eIF5A precursor protein
J. Biol. Chem.
278
12805-12812
2003
Senecio vernalis (Q9SC14), Senecio vernalis
Kang, K.R.; Kim, J.S.; Chang, S.II; Park, M.H.; Kim, Y.W.; Lim, D.; Lee, S.Y.
Deoxyhypusine synthase is phosphorylated by protein kinase C in vivo as well as in vitro
Exp. Mol. Med.
34
489-495
2002
Saccharomyces cerevisiae, Gallus gallus, Cricetulus griseus, Homo sapiens
Lee, Y.; Kim, H.K.; Park, H.E.
Park, M.H.; Joe, Y.A.: Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis
Mol. Cell. Biochem.
237
69-76
2002
Homo sapiens
Park, J.H.; Wolff, E.C.; Folk, E.C.; Park, M.H.
Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase
J. Biol. Chem.
278
32683-32691
2003
Homo sapiens
Moll, S.; Anke, S.; Kahmann, U.; Hnsch, R.; Hartmann, T.; Ober, D.
Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase
Plant Physiol.
130
47-57
2002
Nicotiana tabacum, Senecio vernalis
Huang, J.K.; Tsai, S.; Huang, G.H.; Sershon, V.C.; Alley, A.M.; Wen, L.
Molecular cloning of bovine eIF5A and deoxyhypusine synthase cDNA
DNA Seq.
15
26-32
2004
Bos taurus (Q6EWQ6), Bos taurus
Clement, P.M.; Henderson, C.A.; Jenkins, Z.A.; Smit-McBride, Z.; Wolff, E.C.; Hershey, J.W.; Park, M.H.; Johansson, H.E.
Identification and characterization of eukaryotic initiation factor 5A-2
Eur. J. Biochem.
270
4254-4263
2003
Homo sapiens
Umland, T.C.; Wolff, E.C.; Park, M.H.; Davies, D.R.
A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme-NAD-inhibitor ternary complex
J. Biol. Chem.
279
28697-28705
2004
Homo sapiens (P49366), Homo sapiens
Wang, T.W.; Wu, W.; Zhang, C.G.; Nowack, L.M.; Liu, Z.; Thompson, J.E.
Antisense suppression of deoxyhypusine synthase by vacuum-infiltration of Agrobacterium enhances growth and seed yield of canola
Physiol. Plant.
124
493-503
2005
Brassica napus
-
Nurhayati, N.; Ober, D.
Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity?
Phytochemistry
66
1346-1357
2005
Crotalaria juncea, Crotalaria scassellatii (Q4QZB4), Crotalaria scassellatii
Huang, J.K.; Tsai, S.; Huang, G.H.; Gowda, P.G.; Walzer, A.M.; Wen, L.
Higher activity of recombinant bovine deoxyhypusine synthase vs. human deoxyhypusine synthase
Protein Expr. Purif.
35
32-38
2004
Homo sapiens, Bos taurus (Q6EWQ6), Bos taurus
Jao, D.L.; Chen, K.Y.
Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex
J. Cell. Biochem.
97
583-598
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae KCY307
Duguay, J.; Jamal, S.; Liu, Z.; Wang, T.W.; Thompson, J.E.
Leaf-specific suppression of deoxyhypusine synthase in Arabidopsis thaliana enhances growth without negative pleiotropic effects
J. Plant Physiol.
164
408-420
2007
Arabidopsis thaliana
Cano, V.S.; Jeon, G.A.; Johansson, H.E.; Henderson, C.A.; Park, J.H.; Valentini, S.R.; Hershey, J.W.; Park, M.H.
Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification
FEBS J.
275
44-58
2008
Saccharomyces cerevisiae
Park, M.H.; Nishimura, K.; Zanelli, C.F.; Valentini, S.R.
Functional significance of eIF5A and its hypusine modification in eukaryotes
Amino Acids
38
491-500
2010
Saccharomyces cerevisiae, Mus musculus
Chawla, B.; Jhingran, A.; Singh, S.; Tyagi, N.; Park, M.H.; Srinivasan, N.; Roberts, S.C.; Madhubala, R.
Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani
J. Biol. Chem.
285
453-463
2010
Leishmania donovani, Leishmania donovani (B5APK2), Leishmania donovani MHOM/IN/1983/AG83 (B5APK2)
Ober, D.; Kaltenegger, E.
Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism
Phytochemistry
70
1687-1695
2009
Leishmania donovani
Nurhayati, N.; Gonde, D.; Ober, D.
Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes
Phytochemistry
70
508-516
2009
Phalaenopsis sp., Zea mays (B7FBH2), Zea mays
Park, J.; Dias, C.; Lee, S.; Valentini, S.; Sokabe, M.; Fraser, C.; Park, M.
Production of active recombinant eIF5A: Reconstitution in E. coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes
Protein Eng. Des. Sel.
24
301-309
2011
Homo sapiens
Hyvoenen, M.T.; Keinaenen, T.A.; Khomutov, M.; Simonian, A.; Vepsaelaeinen, J.; Park, J.H.; Khomutov, A.R.; Alhonen, L.; Park, M.H.
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A
Amino Acids
42
685-695
2012
Homo sapiens
Nishimura, K.; Lee, S.B.; Park, J.H.; Park, M.H.
Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development
Amino Acids
42
703-710
2012
Mus musculus, Mus musculus C57/BL6J
Templin, A.T.; Maier, B.; Nishiki, Y.; Tersey, S.A.; Mirmira, R.G.
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling
Cell Cycle
10
1043-1049
2011
Mus musculus, Mus musculus C57/BL6J
Ziegler, P.; Chahoud, T.; Wilhelm, T.; Paellman, N.; Braig, M.; Wiehle, V.; Ziegler, S.; Schroeder, M.; Meier, C.; Kolodzik, A.; Rarey, M.; Panse, J.; Hauber, J.; Balabanov, S.; Bruemmendorf, T.H.
Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias
Invest. New Drugs
30
2274-2283
2012
Homo sapiens, Mus musculus
Wolff, E.C.; Lee, S.B.; Park, M.H.
Assay of deoxyhypusine synthase activity
Methods Mol. Biol.
720
195-205
2011
Homo sapiens
Woriedh, M.; Hauber, I.; Martinez-Rocha, A.L.; Voigt, C.; Maier, F.J.; Schroeder, M.; Meier, C.; Hauber, J.; Schaefer, W.
Preventing Fusarium head blight of wheat and cob rot of maize by inhibition of fungal deoxyhypusine synthase
Mol. Plant Microbe Interact.
24
619-627
2011
Fusarium graminearum, Triticum aestivum, Zea mays, Fusarium graminearum FG00323.1
Preukschas, M.; Hagel, C.; Schulte, A.; Weber, K.; Lamszus, K.; Sievert, H.; Paellmann, N.; Bokemeyer, C.; Hauber, J.; Braig, M.; Balabanov, S.
Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies
PLoS ONE
7
e43468
2012
Homo sapiens
Hyvoenen, M.T.; Khomutov, M.; Petit, M.; Weisell, J.; Kochetkov, S.N.; Alhonen, L.; Vepsaelaeinen, J.; Khomutov, A.R.; Keinaenen, T.A.
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport
ACS Chem. Biol.
10
1417-1424
2015
Homo sapiens (P49366)
Prunetti, L.; Graf, M.; Blaby, I.K.; Peil, L.; Makkay, A.M.; Starosta, A.L.; Papke, R.T.; Oshima, T., Wilson, D.N.; de Crcy-Lagard, V.
Deciphering the translation initiation factor 5A modification pathway in halophilic Archaea
Archaea
2016
7316725
2016
Haloferax volcanii, Haloferax volcanii LSP5021, Saccharomyces cerevisiae, Thermococcus kodakarensis
Quintas-Granados, L.I.; Carvajal Gamez, B.I.; Villalpando, J.L.; Ortega-Lopez, J.; Arroyo, R.; Azuara-Liceaga, E.; Alvarez-Sanchez, M.E.
Bifunctional activity of deoxyhypusine synthase/hydroxylase from Trichomonas vaginalis
Biochimie
123
37-51
2016
Trichomonas vaginalis (F1AQF9), Trichomonas vaginalis, Trichomonas vaginalis CNCD 147 (F1AQF9)
Njuguna, J.T.; von Koschitzky, I.; Gerhardt, H.; Laemmerhofer, M.; Choucry, A.; Pink, M.; Schmitz-Spahnke, S.; Bakheit, M.A.; Strube, C.; Kaiser, A.
Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium
Bioorg. Med. Chem.
22
4338-4346
2014
Theileria parva (Q4UDC3), Theileria parva, Theileria parva Muguga (Q4UDC3)
Belda-Palazon, B.; Nohales, M.A.; Rambla, J.L.; Acena, J.L.; Delgado, O.; Fustero, S.; Martinez, M.C.; Granell, A.; Carbonell, J.; Ferrando, A.
Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation
Front. Plant Sci.
5
202
2014
Arabidopsis thaliana (Q9FI94), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9FI94)
Belda-Palazon, B.; Almendariz, C.; Marti, E.; Carbonell, J.; Ferrando, A.
Relevance of the axis spermidine/eIF5A for plant growth and development
Front. Plant Sci.
7
245
2016
Arabidopsis thaliana (Q9FI94), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9FI94)
Nguyen, S.; Jones, D.C.; Wyllie, S.; Fairlamb, A.H.; Phillips, M.A.
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog
J. Biol. Chem.
288
15256-15267
2013
Trypanosoma brucei brucei (Q38BX0), Trypanosoma brucei brucei (Q4GZD1), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q38BX0), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q4GZD1)
Mittal, N.; Morada, M.; Tripathi, P.; Gowri, V.S.; Mandal, S.; Quirch, A.; Park, M.H.; Yarlett, N.; Madhubala, R.
Cryptosporidium parvum has an active hypusine biosynthesis pathway
Mol. Biochem. Parasitol.
195
14-22
2014
Cryptosporidium parvum (A3FQA5), Cryptosporidium parvum
Muramatsu, T.; Kozaki, K.I.; Imoto, S.; Yamaguchi, R.; Tsuda, H.; Kawano, T.; Fujiwara, N.; Morishita, M.; Miyano, S.; Inazawa, J.
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma
Oncogene
35
5304-5316
2016
Homo sapiens (P49366), Homo sapiens
Kaltenegger, E.; Eich, E.; Ober, D.
Evolution of homospermidine synthase in the convolvulaceae: a story of gene duplication, gene loss, and periods of various selection pressures
Plant Cell
25
1213-1227
2013
Convolvulus arvensis, Ipomoea neei, Ipomoea hederifolia, Ipomoea alba, Ipomoea meyeri, Distimake quinquefolius, Convolvulus tricolor
Galvao, F.C.; Rossi, D.; Silveira, W.d.a..S.; Valentini, S.R.; Zanelli, C.F.
The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity
PLoS ONE
8
e60140
2013
Saccharomyces cerevisiae
Khomutov, M.; Keinanen, T.; Hyvonen, M.; Weisell, J.; Vepsalainen, J.; Alhonen, L.; Kochetkov, S.; Khomutov, A.
Enantioselective synthesis of (R)- and (S)-3-methylspermidines
Russ. J. Bioorg. Chem.
41
548-553
2015
Homo sapiens (P49366)
-
Martinez-Rocha, A.L.; Woriedh, M.; Chemnitz, J.; Willingmann, P.; Kroeger, C.; Hadeler, B.; Hauber, J.; Schaefer, W.
Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence
Sci. Rep.
6
24698
2016
Fusarium graminearum (D5L6Z2), Fusarium graminearum
Bassani, F.; Romagnoli, A.; Cacciamani, T.; Amici, A.; Benelli, D.; Londei, P.; Maertens, B.; Blaesi, U.; La Teana, A.
Modification of translation factor aIF5A from Sulfolobus solfataricus
Extremophiles
22
769-780
2018
Saccharolobus solfataricus (Q97ZF1), Saccharolobus solfataricus, Saccharolobus solfataricus DSM 1617 (Q97ZF1)
Burnat, M.; Li, B.; Kim, S.; Michael, A.; Flores, E.
Homospermidine biosynthesis in the cyanobacterium Anabaena requires a deoxyhypusine synthase homologue and is essential for normal diazotrophic growth
Mol. Microbiol.
109
763-780
2018
Nostoc sp. PCC 7120 = FACHB-418 (Q8YQL7)
Ganapathi, M.; Padgett, L.R.; Yamada, K.; Devinsky, O.; Willaert, R.; Person, R.; Au, P.B.; Tagoe, J.; McDonald, M.; Karlowicz, D.; Wolf, B.; Lee, J.; Shen, Y.; Okur, V.; Deng, L.; LeDuc, C.A.; Wang, J.; Hanner, A.; Mirmira, R.G.; Park, M.H.; Mastracci, T.L.; Chung, W.K.
Recessive rare variants in deoxyhypusine synthase, an enzyme involved in the synthesis of hypusine, are associated with a neurodevelopmental disorder
Am. J. Hum. Genet.
104
287-298
2019
Homo sapiens (P49366)
Park, M.H.; Mandal, A.; Mandal, S.; Wolff, E.C.
A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening
Amino Acids
49
1793-1804
2017
Homo sapiens (P49366), Homo sapiens
Schultz, C.R.; Geerts, D.; Mooney, M.; El-Khawaja, R.; Koster, J.; Bachmann, A.S.
Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma
Biochem. J.
475
531-545
2018
Homo sapiens (P49366)
Wator, E.; Wilk, P.; Grudnik, P.
Half way to hypusine-structural basis for substrate recognition by human deoxyhypusine synthase
Biomolecules
10
522
2020
Homo sapiens (P49366), Homo sapiens
Liu, J.; Chang, X.; Ding, B.; Zhong, S.; Peng, L.; Wei, Q.; Meng, J.; Yu, Y.
PhDHS is involved in chloroplast development in petunia
Front. Plant Sci.
10
284
2019
Petunia x hybrida
Tanaka, Y.; Kurasawa, O.; Yokota, A.; Klein, M.G.; Ono, K.; Saito, B.; Matsumoto, S.; Okaniwa, M.; Ambrus-Aikelin, G.; Morishita, D.; Kitazawa, S.; Uchiyama, N.; Ogawa, K.; Kimura, H.; Imamura, S.
Discovery of novel allosteric inhibitors of deoxyhypusine synthase
J. Med. Chem.
63
3215-3226
2020
Homo sapiens (P49366)
Aroonsri, A.; Posayapisit, N.; Kongsee, J.; Siripan, O.; Vitsupakorn, D.; Utaida, S.; Uthaipibull, C.; Kamchonwongpaisan, S.; Shaw, P.J.
Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target
PeerJ
7
e6713
2019
Plasmodium falciparum (Q8ILW8), Plasmodium falciparum
Imam, S.; Prathibha, R.; Dar, P.; Almotah, K.; Al-Khudhair, A.; Hasan, S.A.; Salim, N.; Jilani, T.N.; Mirmira, R.G.; Jaume, J.C.
eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of type 1 diabetes
Sci. Rep.
9
1533
2019
Mus musculus (Q3TXU5), Mus musculus
Levasseur, E.M.; Yamada, K.; Pineros, A.R.; Wu, W.; Syed, F.; Orr, K.S.; Anderson-Baucum, E.; Mastracci, T.L.; Maier, B.; Mosley, A.L.; Liu, Y.; Bernal-Mizrachi, E.; Alonso, L.C.; Scott, D.; Garcia-Ocana, A.; Tersey, S.A.; Mirmira, R.G.
Hypusine biosynthesis in beta cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
Sci. Signal.
12
eaax0715
2019
Mus musculus (Q3TXU5), Mus musculus
Afanador, G.A.; Tomchick, D.R.; Phillips, M.A.
Trypanosomatid deoxyhypusine synthase activity is dependent on shared active-site complementation between pseudoenzyme paralogs
Structure
26
1499-1512
2018
Trypanosoma brucei brucei (Q38BX0 and Q4GZD1), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q38BX0 and Q4GZD1)
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