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Reference on EC 2.5.1.46 - deoxyhypusine synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wolff, E.C.; Park, M.H.; Folk, J.E.
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD+
J. Biol. Chem.
265
4793-4799
1990
Rattus norvegicus
Manually annotated by BRENDA team
Wolff, E.C.; Folk, J.E.; Park, M.H.
Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
J. Biol. Chem.
272
15865-15871
1997
Homo sapiens
Manually annotated by BRENDA team
Chen, K.Y.; Liu, A.Y.C.
Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A
Biol. Signals
6
105-109
1997
Homo sapiens, Neurospora crassa
Manually annotated by BRENDA team
Ober, D.; Hartmann, T.
Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity
J. Biol. Chem.
274
32040-32047
1999
Nicotiana tabacum (Q9SC80), Nicotiana tabacum
Manually annotated by BRENDA team
Ober, D.; Hartmann, T.
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved form deoxyhypusine synthase
Proc. Natl. Acad. Sci. USA
96
14777-14782
1999
Senecio vernalis (Q9SC14), Senecio vernalis
Manually annotated by BRENDA team
Wolff, E.C.; Park, M.H.
Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation
Yeast
15
43-50
1999
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wolff, E.C.; Wolff.J.; Park, M.H.
Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism
J. Biol. Chem.
275
9170-9177
2000
Homo sapiens
Manually annotated by BRENDA team
Joe, Y.A.; Wolff, E.C.; Park, M.H.
Cloning and expression of human deoxyhypusine synthase cDNA: structure-function studies with the recombinant enzyme and mutant proteins
J. Biol. Chem.
270
22386-22392
1995
Homo sapiens (P49366), Homo sapiens
Manually annotated by BRENDA team
Tao, Y.; Chen, K.Y.
Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast deoxyhypusine synthase cDNA
J. Biol. Chem.
270
23984-23987
1995
Saccharomyces cerevisiae, Neurospora crassa (P49365), Neurospora crassa
Manually annotated by BRENDA team
Wang, T.W.; Lu, L.; Wang, D.; Thompson, J.E.
Isolation and characterization of senescence-induced cDNAs encoding deoxyhypusine synthase and eucaryotic translation initiation factor 5A from tomato
J. Biol. Chem.
276
17541-17549
2001
Solanum lycopersicum (Q9AXR0), Solanum lycopersicum
Manually annotated by BRENDA team
Lee, C.H.; Um, P.Y.; Park, M.H.
Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD
Biochem. J.
355
841-849
2001
Homo sapiens
Manually annotated by BRENDA team
Lee, C.H.; Park, M.H.
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates
Biochem. J.
352
851-857
2000
Homo sapiens
-
Manually annotated by BRENDA team
Lee, Y.B.; Joe, Y.A.; Wolff, E.C.; Dimitriadis, E.K.; Park, M.H.
Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor
Biochem. J.
340
273-281
1999
Homo sapiens
-
Manually annotated by BRENDA team
Liao, D.I.; Wolff, E.C.; Park, M.H.; Davies, D.R.
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site
Structure
6(1)
23-32
1998
Homo sapiens
-
Manually annotated by BRENDA team
Park, M.H.; Joe, Y.A.; Kang, K.R.
Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae
J. Biol. Chem.
273
1677-1683
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Joe, Y.A.; Wolff, E.C.; Lee, Y.B.; Park, M.H.
Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase
J. Biol. Chem.
272
32679-32685
1997
Homo sapiens
Manually annotated by BRENDA team
Kang, K.R.; Wolff, E.C.; Park, M.H.; Folk, J.E.; Chung, S.I.
Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme
J. Biol. Chem.
270
18408-18412
1995
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wolff, E.C.; Lee, Y.B.; Chung, S.I.; Folk, J.E.; Park, M.H.
Deoxyhypusine synthase from rat testis: purification and characterization
J. Biol. Chem.
270
8660-8666
1995
Rattus norvegicus
Manually annotated by BRENDA team
Jakus, J.; Wolff, E.C.; Park, M.H.; Folk, J.E.
Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines
J. Biol. Chem.
268
13151-13159
1993
Rattus norvegicus
Manually annotated by BRENDA team
Abid, M.R.; Sasaki, K.; Titani, K.; Miyazaki, M.
Biochemical and immunological characterization of deoxyhypusine synthase purified from the yeast Saccharomyces carlsbergensis
J. Biochem.
121
769-778
1997
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Abid, R.; Ueda, K.; Miyazaki, M.
Novel features of the functional site and expression of the yeast deoxyhypusine synthase
Biol. Signals
6
157-165
1997
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Klier, H.; Csonga, R.; Steinkasserer, A.; Woehl, T.; Lottspeich, F.; Eder, J.
Purification and characterization of human deoxyhypusine synthase from HeLa cells
FEBS Lett.
364
207-210
1995
Homo sapiens
Manually annotated by BRENDA team
Ober, D.; Harms, R.; Witte, L.; Hartmann, T.
Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retains all properties of deoxyhypusine synthase except binding the eIF5A precursor protein
J. Biol. Chem.
278
12805-12812
2003
Senecio vernalis (Q9SC14), Senecio vernalis
Manually annotated by BRENDA team
Kang, K.R.; Kim, J.S.; Chang, S.II; Park, M.H.; Kim, Y.W.; Lim, D.; Lee, S.Y.
Deoxyhypusine synthase is phosphorylated by protein kinase C in vivo as well as in vitro
Exp. Mol. Med.
34
489-495
2002
Saccharomyces cerevisiae, Gallus gallus, Cricetulus griseus, Homo sapiens
Manually annotated by BRENDA team
Lee, Y.; Kim, H.K.; Park, H.E.
Park, M.H.; Joe, Y.A.: Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis
Mol. Cell. Biochem.
237
69-76
2002
Homo sapiens
Manually annotated by BRENDA team
Park, J.H.; Wolff, E.C.; Folk, E.C.; Park, M.H.
Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase
J. Biol. Chem.
278
32683-32691
2003
Homo sapiens
Manually annotated by BRENDA team
Moll, S.; Anke, S.; Kahmann, U.; Hnsch, R.; Hartmann, T.; Ober, D.
Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase
Plant Physiol.
130
47-57
2002
Nicotiana tabacum, Senecio vernalis
Manually annotated by BRENDA team
Huang, J.K.; Tsai, S.; Huang, G.H.; Sershon, V.C.; Alley, A.M.; Wen, L.
Molecular cloning of bovine eIF5A and deoxyhypusine synthase cDNA
DNA Seq.
15
26-32
2004
Bos taurus (Q6EWQ6), Bos taurus
Manually annotated by BRENDA team
Clement, P.M.; Henderson, C.A.; Jenkins, Z.A.; Smit-McBride, Z.; Wolff, E.C.; Hershey, J.W.; Park, M.H.; Johansson, H.E.
Identification and characterization of eukaryotic initiation factor 5A-2
Eur. J. Biochem.
270
4254-4263
2003
Homo sapiens
Manually annotated by BRENDA team
Umland, T.C.; Wolff, E.C.; Park, M.H.; Davies, D.R.
A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme-NAD-inhibitor ternary complex
J. Biol. Chem.
279
28697-28705
2004
Homo sapiens (P49366), Homo sapiens
Manually annotated by BRENDA team
Wang, T.W.; Wu, W.; Zhang, C.G.; Nowack, L.M.; Liu, Z.; Thompson, J.E.
Antisense suppression of deoxyhypusine synthase by vacuum-infiltration of Agrobacterium enhances growth and seed yield of canola
Physiol. Plant.
124
493-503
2005
Brassica napus
-
Manually annotated by BRENDA team
Nurhayati, N.; Ober, D.
Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity?
Phytochemistry
66
1346-1357
2005
Crotalaria juncea, Crotalaria scassellatii (Q4QZB4), Crotalaria scassellatii
Manually annotated by BRENDA team
Huang, J.K.; Tsai, S.; Huang, G.H.; Gowda, P.G.; Walzer, A.M.; Wen, L.
Higher activity of recombinant bovine deoxyhypusine synthase vs. human deoxyhypusine synthase
Protein Expr. Purif.
35
32-38
2004
Homo sapiens, Bos taurus (Q6EWQ6), Bos taurus
Manually annotated by BRENDA team
Jao, D.L.; Chen, K.Y.
Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex
J. Cell. Biochem.
97
583-598
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae KCY307
Manually annotated by BRENDA team
Duguay, J.; Jamal, S.; Liu, Z.; Wang, T.W.; Thompson, J.E.
Leaf-specific suppression of deoxyhypusine synthase in Arabidopsis thaliana enhances growth without negative pleiotropic effects
J. Plant Physiol.
164
408-420
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Cano, V.S.; Jeon, G.A.; Johansson, H.E.; Henderson, C.A.; Park, J.H.; Valentini, S.R.; Hershey, J.W.; Park, M.H.
Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification
FEBS J.
275
44-58
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Park, M.H.; Nishimura, K.; Zanelli, C.F.; Valentini, S.R.
Functional significance of eIF5A and its hypusine modification in eukaryotes
Amino Acids
38
491-500
2010
Saccharomyces cerevisiae, Mus musculus
Manually annotated by BRENDA team
Chawla, B.; Jhingran, A.; Singh, S.; Tyagi, N.; Park, M.H.; Srinivasan, N.; Roberts, S.C.; Madhubala, R.
Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani
J. Biol. Chem.
285
453-463
2010
Leishmania donovani, Leishmania donovani (B5APK2), Leishmania donovani MHOM/IN/1983/AG83 (B5APK2)
Manually annotated by BRENDA team
Ober, D.; Kaltenegger, E.
Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism
Phytochemistry
70
1687-1695
2009
Leishmania donovani
Manually annotated by BRENDA team
Nurhayati, N.; Gonde, D.; Ober, D.
Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes
Phytochemistry
70
508-516
2009
Phalaenopsis sp., Zea mays (B7FBH2), Zea mays
Manually annotated by BRENDA team
Park, J.; Dias, C.; Lee, S.; Valentini, S.; Sokabe, M.; Fraser, C.; Park, M.
Production of active recombinant eIF5A: Reconstitution in E. coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes
Protein Eng. Des. Sel.
24
301-309
2011
Homo sapiens
Manually annotated by BRENDA team
Hyvoenen, M.T.; Keinaenen, T.A.; Khomutov, M.; Simonian, A.; Vepsaelaeinen, J.; Park, J.H.; Khomutov, A.R.; Alhonen, L.; Park, M.H.
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A
Amino Acids
42
685-695
2012
Homo sapiens
Manually annotated by BRENDA team
Nishimura, K.; Lee, S.B.; Park, J.H.; Park, M.H.
Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development
Amino Acids
42
703-710
2012
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Templin, A.T.; Maier, B.; Nishiki, Y.; Tersey, S.A.; Mirmira, R.G.
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling
Cell Cycle
10
1043-1049
2011
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Ziegler, P.; Chahoud, T.; Wilhelm, T.; Paellman, N.; Braig, M.; Wiehle, V.; Ziegler, S.; Schroeder, M.; Meier, C.; Kolodzik, A.; Rarey, M.; Panse, J.; Hauber, J.; Balabanov, S.; Bruemmendorf, T.H.
Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias
Invest. New Drugs
30
2274-2283
2012
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wolff, E.C.; Lee, S.B.; Park, M.H.
Assay of deoxyhypusine synthase activity
Methods Mol. Biol.
720
195-205
2011
Homo sapiens
Manually annotated by BRENDA team
Woriedh, M.; Hauber, I.; Martinez-Rocha, A.L.; Voigt, C.; Maier, F.J.; Schroeder, M.; Meier, C.; Hauber, J.; Schaefer, W.
Preventing Fusarium head blight of wheat and cob rot of maize by inhibition of fungal deoxyhypusine synthase
Mol. Plant Microbe Interact.
24
619-627
2011
Fusarium graminearum, Triticum aestivum, Zea mays, Fusarium graminearum FG00323.1
Manually annotated by BRENDA team
Preukschas, M.; Hagel, C.; Schulte, A.; Weber, K.; Lamszus, K.; Sievert, H.; Paellmann, N.; Bokemeyer, C.; Hauber, J.; Braig, M.; Balabanov, S.
Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies
PLoS ONE
7
e43468
2012
Homo sapiens
Manually annotated by BRENDA team
Hyvoenen, M.T.; Khomutov, M.; Petit, M.; Weisell, J.; Kochetkov, S.N.; Alhonen, L.; Vepsaelaeinen, J.; Khomutov, A.R.; Keinaenen, T.A.
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport
ACS Chem. Biol.
10
1417-1424
2015
Homo sapiens (P49366)
Manually annotated by BRENDA team
Prunetti, L.; Graf, M.; Blaby, I.K.; Peil, L.; Makkay, A.M.; Starosta, A.L.; Papke, R.T.; Oshima, T., Wilson, D.N.; de Crcy-Lagard, V.
Deciphering the translation initiation factor 5A modification pathway in halophilic Archaea
Archaea
2016
7316725
2016
Haloferax volcanii, Haloferax volcanii LSP5021, Saccharomyces cerevisiae, Thermococcus kodakarensis
Manually annotated by BRENDA team
Quintas-Granados, L.I.; Carvajal Gamez, B.I.; Villalpando, J.L.; Ortega-Lopez, J.; Arroyo, R.; Azuara-Liceaga, E.; Alvarez-Sanchez, M.E.
Bifunctional activity of deoxyhypusine synthase/hydroxylase from Trichomonas vaginalis
Biochimie
123
37-51
2016
Trichomonas vaginalis (F1AQF9), Trichomonas vaginalis, Trichomonas vaginalis CNCD 147 (F1AQF9)
Manually annotated by BRENDA team
Njuguna, J.T.; von Koschitzky, I.; Gerhardt, H.; Laemmerhofer, M.; Choucry, A.; Pink, M.; Schmitz-Spahnke, S.; Bakheit, M.A.; Strube, C.; Kaiser, A.
Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium
Bioorg. Med. Chem.
22
4338-4346
2014
Theileria parva (Q4UDC3), Theileria parva, Theileria parva Muguga (Q4UDC3)
Manually annotated by BRENDA team
Belda-Palazon, B.; Nohales, M.A.; Rambla, J.L.; Acena, J.L.; Delgado, O.; Fustero, S.; Martinez, M.C.; Granell, A.; Carbonell, J.; Ferrando, A.
Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation
Front. Plant Sci.
5
202
2014
Arabidopsis thaliana (Q9FI94), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9FI94)
Manually annotated by BRENDA team
Belda-Palazon, B.; Almendariz, C.; Marti, E.; Carbonell, J.; Ferrando, A.
Relevance of the axis spermidine/eIF5A for plant growth and development
Front. Plant Sci.
7
245
2016
Arabidopsis thaliana (Q9FI94), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9FI94)
Manually annotated by BRENDA team
Nguyen, S.; Jones, D.C.; Wyllie, S.; Fairlamb, A.H.; Phillips, M.A.
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog
J. Biol. Chem.
288
15256-15267
2013
Trypanosoma brucei brucei (Q38BX0), Trypanosoma brucei brucei (Q4GZD1), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q38BX0), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q4GZD1)
Manually annotated by BRENDA team
Mittal, N.; Morada, M.; Tripathi, P.; Gowri, V.S.; Mandal, S.; Quirch, A.; Park, M.H.; Yarlett, N.; Madhubala, R.
Cryptosporidium parvum has an active hypusine biosynthesis pathway
Mol. Biochem. Parasitol.
195
14-22
2014
Cryptosporidium parvum (A3FQA5), Cryptosporidium parvum
Manually annotated by BRENDA team
Muramatsu, T.; Kozaki, K.I.; Imoto, S.; Yamaguchi, R.; Tsuda, H.; Kawano, T.; Fujiwara, N.; Morishita, M.; Miyano, S.; Inazawa, J.
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma
Oncogene
35
5304-5316
2016
Homo sapiens (P49366), Homo sapiens
Manually annotated by BRENDA team
Kaltenegger, E.; Eich, E.; Ober, D.
Evolution of homospermidine synthase in the convolvulaceae: a story of gene duplication, gene loss, and periods of various selection pressures
Plant Cell
25
1213-1227
2013
Convolvulus arvensis, Ipomoea neei, Ipomoea hederifolia, Ipomoea alba, Ipomoea meyeri, Distimake quinquefolius, Convolvulus tricolor
Manually annotated by BRENDA team
Galvao, F.C.; Rossi, D.; Silveira, W.d.a..S.; Valentini, S.R.; Zanelli, C.F.
The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity
PLoS ONE
8
e60140
2013
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Khomutov, M.; Keinanen, T.; Hyvonen, M.; Weisell, J.; Vepsalainen, J.; Alhonen, L.; Kochetkov, S.; Khomutov, A.
Enantioselective synthesis of (R)- and (S)-3-methylspermidines
Russ. J. Bioorg. Chem.
41
548-553
2015
Homo sapiens (P49366)
-
Manually annotated by BRENDA team
Martinez-Rocha, A.L.; Woriedh, M.; Chemnitz, J.; Willingmann, P.; Kroeger, C.; Hadeler, B.; Hauber, J.; Schaefer, W.
Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence
Sci. Rep.
6
24698
2016
Fusarium graminearum (D5L6Z2), Fusarium graminearum
Manually annotated by BRENDA team
Bassani, F.; Romagnoli, A.; Cacciamani, T.; Amici, A.; Benelli, D.; Londei, P.; Maertens, B.; Blaesi, U.; La Teana, A.
Modification of translation factor aIF5A from Sulfolobus solfataricus
Extremophiles
22
769-780
2018
Saccharolobus solfataricus (Q97ZF1), Saccharolobus solfataricus, Saccharolobus solfataricus DSM 1617 (Q97ZF1)
Manually annotated by BRENDA team
Burnat, M.; Li, B.; Kim, S.; Michael, A.; Flores, E.
Homospermidine biosynthesis in the cyanobacterium Anabaena requires a deoxyhypusine synthase homologue and is essential for normal diazotrophic growth
Mol. Microbiol.
109
763-780
2018
Nostoc sp. PCC 7120 = FACHB-418 (Q8YQL7)
Manually annotated by BRENDA team
Ganapathi, M.; Padgett, L.R.; Yamada, K.; Devinsky, O.; Willaert, R.; Person, R.; Au, P.B.; Tagoe, J.; McDonald, M.; Karlowicz, D.; Wolf, B.; Lee, J.; Shen, Y.; Okur, V.; Deng, L.; LeDuc, C.A.; Wang, J.; Hanner, A.; Mirmira, R.G.; Park, M.H.; Mastracci, T.L.; Chung, W.K.
Recessive rare variants in deoxyhypusine synthase, an enzyme involved in the synthesis of hypusine, are associated with a neurodevelopmental disorder
Am. J. Hum. Genet.
104
287-298
2019
Homo sapiens (P49366)
Manually annotated by BRENDA team
Park, M.H.; Mandal, A.; Mandal, S.; Wolff, E.C.
A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening
Amino Acids
49
1793-1804
2017
Homo sapiens (P49366), Homo sapiens
Manually annotated by BRENDA team
Schultz, C.R.; Geerts, D.; Mooney, M.; El-Khawaja, R.; Koster, J.; Bachmann, A.S.
Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma
Biochem. J.
475
531-545
2018
Homo sapiens (P49366)
Manually annotated by BRENDA team
Wator, E.; Wilk, P.; Grudnik, P.
Half way to hypusine-structural basis for substrate recognition by human deoxyhypusine synthase
Biomolecules
10
522
2020
Homo sapiens (P49366), Homo sapiens
Manually annotated by BRENDA team
Liu, J.; Chang, X.; Ding, B.; Zhong, S.; Peng, L.; Wei, Q.; Meng, J.; Yu, Y.
PhDHS is involved in chloroplast development in petunia
Front. Plant Sci.
10
284
2019
Petunia x hybrida
Manually annotated by BRENDA team
Tanaka, Y.; Kurasawa, O.; Yokota, A.; Klein, M.G.; Ono, K.; Saito, B.; Matsumoto, S.; Okaniwa, M.; Ambrus-Aikelin, G.; Morishita, D.; Kitazawa, S.; Uchiyama, N.; Ogawa, K.; Kimura, H.; Imamura, S.
Discovery of novel allosteric inhibitors of deoxyhypusine synthase
J. Med. Chem.
63
3215-3226
2020
Homo sapiens (P49366)
Manually annotated by BRENDA team
Aroonsri, A.; Posayapisit, N.; Kongsee, J.; Siripan, O.; Vitsupakorn, D.; Utaida, S.; Uthaipibull, C.; Kamchonwongpaisan, S.; Shaw, P.J.
Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target
PeerJ
7
e6713
2019
Plasmodium falciparum (Q8ILW8), Plasmodium falciparum
Manually annotated by BRENDA team
Imam, S.; Prathibha, R.; Dar, P.; Almotah, K.; Al-Khudhair, A.; Hasan, S.A.; Salim, N.; Jilani, T.N.; Mirmira, R.G.; Jaume, J.C.
eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of type 1 diabetes
Sci. Rep.
9
1533
2019
Mus musculus (Q3TXU5), Mus musculus
Manually annotated by BRENDA team
Levasseur, E.M.; Yamada, K.; Pineros, A.R.; Wu, W.; Syed, F.; Orr, K.S.; Anderson-Baucum, E.; Mastracci, T.L.; Maier, B.; Mosley, A.L.; Liu, Y.; Bernal-Mizrachi, E.; Alonso, L.C.; Scott, D.; Garcia-Ocana, A.; Tersey, S.A.; Mirmira, R.G.
Hypusine biosynthesis in beta cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
Sci. Signal.
12
eaax0715
2019
Mus musculus (Q3TXU5), Mus musculus
Manually annotated by BRENDA team
Afanador, G.A.; Tomchick, D.R.; Phillips, M.A.
Trypanosomatid deoxyhypusine synthase activity is dependent on shared active-site complementation between pseudoenzyme paralogs
Structure
26
1499-1512
2018
Trypanosoma brucei brucei (Q38BX0 and Q4GZD1), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q38BX0 and Q4GZD1)
Manually annotated by BRENDA team