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Information on EC 2.5.1.45 - homospermidine synthase (spermidine-specific)

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IUBMB Comments
The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of spermidine, (b) transfer of the 4-aminobutylidene group from dehydrospermidine to putrescine and (c) reduction of the imine intermediate to form homospermidine. This enzyme is more specific than EC 2.5.1.44, homospermidine synthase, which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group. Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts (Senecio).
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The enzyme appears in viruses and cellular organisms
Synonyms
homospermidine synthase, HSS, synthase, homospermidine, synthase, homospermidine (Senecio vernalis root gene HSS1), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
spermidine + putrescine = sym-homospermidine + propane-1,3-diamine
show the reaction diagram
the reaction of this enzyme occurs in three steps: i. NAD-dependent dehydrogenation of spermidine, ii. transfer of the 4-aminobutylidene group from dehydrospermidine to putrescine, iii. reduction of the imine intermediate to form homospermidine. Hence the overall reaction is transfer of a 4-aminobutyl group. This enzyme is more specific than EC 2.5.1.44, homospermidine synthase, which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group. Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts, Senecio
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PATHWAY SOURCE
PATHWAYS
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