Reference on EC 2.5.1.22 - spermine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pegg, A.E.; Shuttleworth, K.; Hibasami, H.
Specificity of mammalian spermidine synthase and spermine synthase
Biochem. J.
197
315-320
1981
Rattus norvegicus
Hannonen, P.; Jnne, J.; Raina, A.
Partial purification and characterization of spermine synthase from rat brain
Biochim. Biophys. Acta
289
225-231
1972
Rattus norvegicus, Rattus norvegicus Wistar
Pajula, R.L.; Raina, A.; Eloranta, T.
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain
Eur. J. Biochem.
101
619-626
1979
Bos taurus
Raina, A.; Pajula, R.L.; Eloranta, T.
Purification of spermidine aminopropyltransferase (spermine synthase) from bovine brain
Methods Enzymol.
94
276-279
1983
Bos taurus
Eloranta, T.; Khomutov, A.R.; Khomutov, R.M.; Hyvnen, T.
Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity
J. Biochem.
108
593-598
1990
Bos taurus
Coward, J.K.; Anderson, G.L.; Tang, K.C.
Aminopropyltransferase substrates and inhibitors
Methods Enzymol.
94
286-294
1983
Bos taurus, Rattus norvegicus
-
Pegg, A.E.
Inhibition of aminopropyltransferases
Methods Enzymol.
94
294-297
1983
Bos taurus, Rattus norvegicus
Kajander, E.O.; Kauppinen, L.I.; Pajula, R.L.; Karkola, K.; Eloranta, T.O.
Purification and partial characterization of human polyamine synthases
Biochem. J.
259
879-886
1989
Homo sapiens
Baillon, J.G.; Mamont, P.S.; Wagner, J.; Gerhart, F.; Lux, P.
Fluorinated analogues of spermidine as substrates of spermine synthase
Eur. J. Biochem.
176
237-242
1988
Bos taurus, Rattus norvegicus
Hibasami, H.; Borchardt, R.T.; Chen, S.Y.; Coward, J.K.; Pegg, A.E.
Studies of inhibition of rat spermidine synthase and spermine synthase
Biochem. J.
187
419-428
1980
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Sindhu, R.K.; Cohen, S.S.
Propylaminetransferases in chinese cabbage leaves
Plant Physiol.
74
645-649
1984
Brassica rapa subsp. pekinensis
Raina, A.; Pajula, R.L.; Eloranta, T.
A rapid assay method for spermidine and spermine synthases. Distribution of polyamine-synthesizing enzymes and methionine adenosyltransferase in rat tissues
FEBS Lett.
67
252-255
1976
Rattus norvegicus, Rattus norvegicus Wistar
Pajula, R.L.
Kinetic properties of spermine synthase from bovine brain
Biochem. J.
215
669-676
1983
Bos taurus
Pajula, R.L.; Raina, A.; Kekoni, J.
Purification of spermine synthase from bovine brain by spermine-Sepharose affinity chromatography
FEBS Lett.
90
153-156
1978
Bos taurus
Pajula, R.L.; Raina, A.
Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain
FEBS Lett.
99
343-345
1979
Bos taurus
Shirahata, A.; Takahashi, N.; Beppu, T.; Hosoda, H.; Samejima, K.
Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues
Biochem. Pharmacol.
45
1897-1903
1993
Rattus norvegicus
Ikeguchi, Y.; Mackintosh, C.A.; McCloskey, D.E.; Pegg, A.E.
Effect of spermine synthase on the sensitivity of cells to anti-tumour agents
Biochem. J.
373
885-892
2003
Mus musculus
Lee, S.H.; Cho, Y.D.
A new assay method for spermidine and spermine synthases using antibody against MTA
J. Biochem. Mol. Biol.
30
443-447
1997
Rattus norvegicus
-
Korhonen, V.P.; Halmekyto, M.; Kauppinen, L.; Myohanen, S.; Wahlfors, J.; Keinanen, T.; Hyvonen, T.; Alhonen, L.; Eloranta, T.; Janne, J.
Molecular cloning of a cDNA encoding human spermine synthase
DNA Cell Biol.
14
841-847
1995
Homo sapiens
Ikeguchi, Y.; Wang, X.; McCloskey, D.E.; Coleman, C.S.; Nelson, P.; Hu, G.; Shantz, L.M.; Pegg, A.E.
Characterization of transgenic mice with widespread overexpression of spermine synthase
Biochem. J.
381
701-707
2004
Homo sapiens
Imai, A.; Akiyama, T.; Kato, T.; Sato, S.; Tabata, S.; Yamamoto, K.T.; Takahashi, T.
Spermine is not essential for survival of Arabidopsis
FEBS Lett.
556
148-152
2004
Arabidopsis thaliana
Kitashiba, H.; Hao, Y.J.; Honda, C.; Moriguchi, T.
Two types of spermine synthase gene: MdACL5 and MdSPMS are differentially involved in apple fruit development and cell growth
Gene
361
101-111
2005
Malus sylvestris
Ikeguchi, Y.; Bewley, M.C.; Pegg, A.E.
Aminopropyltransferases: function, structure and genetics
J. Biochem.
139
1-9
2006
Mus musculus
Liu, J.; Nada, K.; Pang, X.; Honda, C.; Kitashiba, H.; Moriguchi, T.
Role of polyamines in peach fruit development and storage
Tree Physiol.
26
791-798
2006
Prunus persica
Wu, H.; Min, J.; Zeng, H.; McCloskey, D.E.; Ikeguchi, Y.; Loppnau, P.; Michael, A.J.; Pegg, A.E.; Plotnikov, A.N.
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism
J. Biol. Chem.
283
16135-16146
2008
Homo sapiens (P52788), Homo sapiens
de Alencastro, G.; McCloskey, D.E.; Kliemann, S.E.; Maranduba, C.M.; Pegg, A.E.; Wang, X.; Bertola, D.R.; Schwartz, C.E.; Passos-Bueno, M.R.; Sertie, A.L.
New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder-Robinson X-linked recessive mental retardation syndrome
J. Med. Genet.
45
539-543
2008
Homo sapiens
Efrose, R.C.; Flemetakis, E.; Sfichi, L.; Stedel, C.; Kouri, E.D.; Udvardi, M.K.; Kotzabasis, K.; Katinakis, P.
Characterization of spermidine and spermine synthases in Lotus japonicus: induction and spatial organization of polyamine biosynthesis in nitrogen fixing nodules
Planta
228
37-49
2008
Lotus japonicus (A2VC29), Lotus japonicus
MacLean, H.E.; Chiu, W.S.; Notini, A.J.; Axell, A.; Davey, R.A.; McManus, J.F.; Ma, C.; Plant, D.R.; Lynch, G.S.; Zajac, J.D.
Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice
FASEB J.
22
2676-2689
2008
Homo sapiens (P52788)
Wu, X.B.; Wang, J.; Liu, J.H.; Deng, X.X.
Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol
J. Plant Physiol.
166
52-62
2009
Citrus sinensis
Pegg, A.E.; Michael, A.J.
Spermine synthase
Cell. Mol. Life Sci.
67
113-121
2010
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, no activity in Caenorhabditis elegans, Monosiga brevicollis, no activity in Hydra magnipapillata
Pegg, A.E.; Wang, X.; Schwartz, C.E.; McCloskey, D.E.
Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine
Biochem. J.
433
139-144
2011
Homo sapiens, Mus musculus
Alet, A.I.; Sanchez, D.H.; Cuevas, J.C.; Marina, M.; Carrasco, P.; Altabella, T.; Tiburcio, A.F.; Ruiz, O.A.
New insights into the role of spermine in Arabidopsis thaliana under long-term salt stress
Plant Sci.
182
94-100
2012
Arabidopsis thaliana
Zhang, Z.; Norris, J.; Schwartz, C.; Alexov, E.
In silico and in vitro investigations of the mutability of disease-causing missense mutation sites in spermine synthase
PLoS ONE
6
e20373
2011
Homo sapiens (P52788)
Zhu, X.; Li, Q.; Hu, J.; Wang, M.; Li, X.
Molecular cloning and characterization of spermine synthesis gene associated with cold tolerance in tea plant (Camellia sinensis)
Appl. Biochem. Biotechnol.
177
1055-1068
2015
Camellia sinensis (A0A0E3DGE7), Camellia sinensis
Imamura, T.; Fujita, K.; Tasaki, K.; Higuchi, A.; Takahashi, H.
Characterization of spermidine synthase and spermine synthase - The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora
Biochem. Biophys. Res. Commun.
463
781-786
2015
Gentiana triflora (A0A0K2S254), Gentiana triflora
Peng, Y.; Norris, J.; Schwartz, C.; Alexov, E.
Revealing the effects of missense mutations causing Snyder-Robinson syndrome on the stability and dimerization of spermine synthase
Int. J. Mol. Sci.
17
77
2016
Homo sapiens (P52788)
Maruri-Lopez, I.; Hernandez-Sanchez, I.E.; Ferrando, A.; Carbonell, J.; Jimenez-Bremont, J.F.
Characterization of maize spermine synthase 1 (ZmSPMS1): Evidence for dimerization and intracellular location
Plant Physiol. Biochem.
97
264-271
2015
Zea mays
Zhang, Z.; Zheng, Y.; Petukh, M.; Pegg, A.; Ikeguchi, Y.; Alexov, E.
Enhancing human spermine synthase activity by engineered mutations
PLoS Comput. Biol.
9
e1002924
2013
Homo sapiens
Zhang, Z.; Martiny, V.; Lagorce, D.; Ikeguchi, Y.; Alexov, E.; Miteva, M.A.
Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach
PLoS ONE
9
e110884
2014
Homo sapiens (P52788), Homo sapiens
Dolce, L.G.; Silva-Junior, R.M.P.; Assis, L.H.P.; Nascimento, A.F.Z.; Araujo, J.S.; Meschede, I.P.; Espreafico, E.M.; de Giuseppe, P.O.; Murakami, M.T.
Myosin Va interacts with the exosomal protein spermine synthase
Biosci. Rep.
39
BSR20182189
2019
Homo sapiens (P52788)
Timson, D.J.
Myosin Va and spermine synthase partners in exosome transport
Biosci. Rep.
39
BSR20190326
2019
Homo sapiens (P52788)
Peng, Y.; Michonova, E.
Long-range effect of a single mutation in spermine synthase
J. Theor. Comput. Chem.
17
16135-16146
2018
Homo sapiens (P52788)
-
Guo, Y.; Ye, Q.; Deng, P.; Cao, Y.; He, D.; Zhou, Z.; Wang, C.; Zaytseva, Y.Y.; Schwartz, C.E.; Lee, E.Y.; Mark Evers, B.; Morris, A.J.; Liu, S.; She, Q.B.
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
Nat. Commun.
11
3243
2020
Homo sapiens (P52788)
Tao, Y.; Wang, J.; Miao, J.; Chen, J.; Wu, S.; Zhu, J.; Zhang, D.; Gu, H.; Cui, H.; Shi, S.; Xu, M.; Yao, Y.; Gong, Z.; Yang, Z.; Gu, M.; Zhou, Y.; Liang, G.
The spermine synthase OsSPMS1 regulates seed germination, grain size, and yield
Plant Physiol.
178
1522-1536
2018
Oryza sativa
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