Disease on EC 2.5.1.16 - spermidine synthase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Brain Neoplasms
Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells.
Breast Neoplasms
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
Carcinoma
Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine, synthase.
Carcinoma, Hepatocellular
Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.
Carcinoma, Hepatocellular
Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells.
Carcinoma, Hepatocellular
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.
Chagas Disease
An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi.
Chagas Disease
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.
Cysts
Arabidopsis spermidine synthase is targeted by an effector protein of the cyst nematode Heterodera schachtii.
Dehydration
Genome-wide identification of genes involved in polyamine biosynthesis and the role of exogenous polyamines in Malus hupehensis Rehd. under alkaline stress.
Hypersensitivity
Engineering a spermidine biosynthetic pathway in Clostridium thermocellum results in increased resistance to furans and increased ethanol production.
Infections
Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes.
Infections
Transcriptomic Analysis of Resistant and Susceptible Responses in a New Model Root-Knot Nematode Infection System Using Solanum torvum and Meloidogyne arenaria.
Leishmaniasis
A leishmaniasis study: Structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase.
Leishmaniasis
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Leukemia
2-Mercaptoethylamine, a competitive inhibitor of spermidine synthase in mammalian cells.
Leukemia
Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine synthase against P388 leukemia.
Leukemia
Synthesis of N-chlorosulfonyl dicyclohexylamine as a potent inhibitor for spermidine synthase and its effects on human leukemia Molt4B cells.
Leukemia, Lymphoid
Inhibition by polyamines of methylthiopropylamine-induced ornithine decarboxylase in human lymphoid leukemia Molt 4B cells.
Leukemia, Lymphoid
Methylthiopropylamine, a potent inhibitor of spermidine synthase and its antiproliferative effect on human lymphoid leukemia Molt 4B cells.
Lymphoma, B-Cell
Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase.
Malaria
Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing.
Malaria
Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening.
Malaria
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.
Malaria
The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme.
Nematode Infections
Arabidopsis spermidine synthase is targeted by an effector protein of the cyst nematode Heterodera schachtii.
Neoplasms
Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing.
Neoplasms
Chain-fluorinated polyamines as tumor markers--IV. Comparison of 2-fluoroputrescine and 2,2-difluoroputrescine as substrates of spermidine synthase in vitro and in vivo.
Neoplasms
Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase.
Osteoporosis
Modeling Snyder-Robinson Syndrome in multipotent stromal cells reveals impaired mitochondrial function as a potential cause for deficient osteogenesis.
Potassium Deficiency
Polyamine Metabolism in Scots Pine Embryogenic Cells under Potassium Deficiency.
Trypanosomiasis, African
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.
html completed