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Information on EC 2.5.1.147 - 5-amino-6-(D-ribitylamino)uracil-L-tyrosine 4-hydroxyphenyl transferase

for references in articles please use BRENDA:EC2.5.1.147
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IUBMB Comments
The enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 4.3.1.32, 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to initiate the reaction.
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
CbiF, cofH, fbiC, FO synthase, MjCofH, MSMEG_5126, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
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