Information on EC 2.5.1.113 - [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

for references in articles please use BRENDA:EC2.5.1.113
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IUBMB Comments
A pyridoxal-phosphate protein. The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O3-acetyl-L-serine (cf. EC 2.5.1.65, O-phosphoserine sulfhydrylase).
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Word Map
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  • 2.5.1.113
  • tubulin
  • microtubule
  • polyglutamylation
  • glutamylation
  • ligase-like
  • deglutamylated
  • cilia
  • purkinje
  • carboxypeptidase
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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O-phospho-L-serine
+
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH
=
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine
+
phosphate
+
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH
=
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine
+
Synonyms
CysM, Cysteine synthase, O-phosphoserine sulfhydrylase, O-phosphoserine-specific cysteine synthase, Rv1336, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + phosphate
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PATHWAY SOURCE
PATHWAYS
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