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IUBMB CommentsThe enzyme, which has been studied in the archaeon Methanocaldococcus jannaschii, is involved in the biosynthesis of tetrahydromethanopterin.
The expected taxonomic range for this enzyme is: Methanocaldococcus jannaschii
Synonyms
dihydropteroate synthase, MJ0301, more
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dihydropteroate synthase
ambiguous
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(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
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MetaCyc
tetrahydromethanopterin biosynthesis
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(7,8-dihydropterin-6-yl)methyl diphosphate:4-(beta-D-ribofuranosyl)aniline 5'-phosphate 6-hydroxymethyl-7,8-dihydropterintransferase
The enzyme, which has been studied in the archaeon Methanocaldococcus jannaschii, is involved in the biosynthesis of tetrahydromethanopterin.
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(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate
N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
6-hydroxymethyl-7,8-dihydropterin diphosphate + 1-(4-aminophenyl)-1-deoxy-D-ribitol
7,8-dihydropterin-6-methyl-1-(4-aminophenyl)-1-deoxy-D-ribitol + diphosphate
Substrates: about 25% of the activity compared to 4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate
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additional information
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Substrates: no activity with 4-(beta-D-ribofuranosyl)-aminobenzene
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(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate

N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
Substrates: the enzyme is involved in the biosynthesis of methanopterin
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(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate
N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
Substrates: -
Products: -
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(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate
N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
Substrates: the enzyme is involved in the biosynthesis of methanopterin
Products: -
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UniProt
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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DHPSL_METJA
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
294
0
33076
Swiss-Prot
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33076
x * 33076, calculated from sequence
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x * 33076, calculated from sequence
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expression in Escherichia coli
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Xu, H.; Aurora, R.; Rose, G.D.; White, R.H.
Identifying two ancient enzymes in Archaea using predicted secondary structure alignment
Nat. Struct. Biol.
6
750-754
1999
Methanocaldococcus jannaschii (Q57749)
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