show all | hide all No of entries

Information on EC 2.4.99.22 - N-acetylglucosaminide alpha-(2,6)-sialyltransferase

for references in articles please use BRENDA:EC2.4.99.22
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-beta-D-glucosamine. The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl residues, but more slowly.
Specify your search results
Select one or more organisms in this record: ?
The expected taxonomic range for this enzyme is: Rattus norvegicus
Reaction Schemes
+
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
=
+
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-R
Synonyms
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylglucosaminide 6-alpha-sialyltransferase, CMP-N-acetylneuraminate : N-acetylglucosaminide (alpha2->6)-sialyltransferase, Galbeta1->4GlcNAcalpha2->6 sialyltransferase, N-acetylglucosaminide (alpha 2->6)-sialyltransferas, N-acetylglucosaminide (alpha2->6)-sialyltransferase, ST6GlcNAc, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-R
show the reaction diagram
-
-
-
-
Select items on the left to see more content.