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Information on EC 2.4.99.12 - lipid IVA 3-deoxy-D-manno-octulosonic acid transferase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC2.4.99.12

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IUBMB Comments

The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) . The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-oct-2-ulosonate residue from CMP-3-deoxy-D-manno-oct-2-ulosonate to lipid IVA [2-4]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes .

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
hide
CMP-beta-Kdo
+
a lipid IVA
=
CMP
+
an alpha-Kdo-(2->6)-lipid IVA
+
=
+
an alpha-Kdo-(2->6)-lipid IVA

Synonyms
kdo transferase, 3-deoxy-d-manno-oct-2-ulosonic acid transferase, monofunctional kdo transferase, 3-deoxy-manno-octulosonic acid transferase, multi-functional kdo-transferase, 3-deoxy-d-manno-octulosonic acid transferase, mono-functional kdo transferase, more

PATHWAY SOURCE
PATHWAYS
MetaCyc
Kdo transfer to lipid IVA (Brucella), Kdo transfer to lipid IVA (E. coli), Kdo transfer to lipid IVA (generic), Kdo transfer to lipid IVA (H. pylori), Kdo transfer to lipid IVA (Haemophilus), Kdo transfer to lipid IVA (P. gingivalis), Kdo transfer to lipid IVA (P. putida), Kdo transfer to lipid IVA (Vibrio cholerae serogroup O1 El Tor)
SYSTEMATIC NAME
IUBMB Comments
CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase
The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-oct-2-ulosonate residue from CMP-3-deoxy-D-manno-oct-2-ulosonate to lipid IVA [2-4]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [5].
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A0D6ISR5_PSEAI
425
0
46487
TrEMBL
-
A0A367MD76_PSEAI
373
0
41116
TrEMBL
-
A0A3M5DEC3_PSEAI
390
0
42208
TrEMBL
-
A0A3M5DDH2_PSEAI
161
0
16979
TrEMBL
-
A0A509JHP2_PSEAI
425
0
46489
TrEMBL
other Location (Reliability: 3)
A0A5N3Z7F9_PSEAI
425
0
46515
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6A9JZ73_PSEAI
425
0
46466
TrEMBL
-
A0A6B0J1F6_PSEAI
425
0
46515
TrEMBL
Secretory Pathway (Reliability: 1)
A0AAQ3LJW6_PSEAI
425
0
46604
TrEMBL
Secretory Pathway (Reliability: 3)
A0ABD7K1P0_PSEAI
425
0
46196
TrEMBL
Secretory Pathway (Reliability: 2)