Reference on EC 2.4.2.9 - uracil phosphoribosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Flaks, J.G.
Nucleotide synthesis from 5-phosphoribosylpyrophosphate
Methods Enzymol.
6
136-158
1963
Escherichia coli, Lactobacillus bifidus, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. bulgaricus 09X
-
Asai, T.; Lee, C.S.; Chandler, A.; O'Sullivan, W.J.
Purification and characterization of uracil phosphoribosyltransferase from Crithidia luciliae
Comp. Biochem. Physiol. B
95
159-163
1990
Crithidia luciliae
Plunkett, W.; Moner, J.G.
UMP pyrophosphorylase of Tetrahymena pyriformis. Partial purification and properties
Arch. Biochem. Biophys.
187
264-271
1978
Tetrahymena pyriformis, Tetrahymena pyriformis GL-7
Andersen, P.S.; Smith, J.M.; Mygind, B.
Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12
Eur. J. Biochem.
204
51-56
1992
Escherichia coli
Rasmussen, U.B.; Mygind, B.; Nygaard, P.
Purification and some properties of uracil phosphoribosyltransferase from Escherichia coli K12
Biochim. Biophys. Acta
881
268-275
1986
Escherichia coli, Escherichia coli SO 1344
McIvor, R.S.; Wohlhueter, R.M.; Plagemann, P.G.W.
Uracil phosphoribosyltransferase from Acholeplasma laidlawii: partial purification and kinetic properties
J. Bacteriol.
156
192-197
1983
Acholeplasma laidlawii
Lindsay, R.H.; Tillery, C.R.; Yu, M.Y.W.
Conversion of the antithyroid drug 2-thiouracil to 2-thio-5-UMP by UMP pyrophosphorylase
Arch. Biochem. Biophys.
148
466-474
1972
Lactobacillus leichmannii
Natalini, P.; Ruggieri, S.; Santarelli, I.; Vita, A.; Magni, G.
Bakers yeast UMP:pyrophosphate phosphoribosyltransferase. Purification, enzymatic and kinetic properties
J. Biol. Chem.
254
1558-1563
1979
Saccharomyces cerevisiae
Alloush, H.M.; Kerridge, D.
Characterization of a partially purified uracil phosphoribosyltransferase from the opportunistic pathogen Candida albicans
Mycopathologia
125
129-141
1994
Candida albicans
Carter, D.; Donald, R.G.K.; Roos, D.; Ullman, B.
Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii
Mol. Biochem. Parasitol.
87
137-144
1997
Toxoplasma gondii
Dai, Y.P.; Lee, C.S.; O'Sullivan, W.J.
Properties of uracil phosphoribosyltransferase from Giardia intestinalis
Int. J. Parasitol.
25
207-214
1995
Giardia intestinalis, Giardia intestinalis Portland
Jensen, K.F.; Mygind, B.
Different oligomeric states are involved in the allosteric behavior of uracil phosphoribosyltransferase from Escherichia coli
Eur. J. Biochem.
240
637-645
1996
Escherichia coli
Jensen, H.K.; Mikkelsen, N.; Neuhard, J.
Recombinant uracil phosphoribosyltransferase from the thermophile Bacillus caldolyticus: expression, purification, and partial characterization
Protein Expr. Purif.
10
356-364
1997
Bacillus subtilis, Bacillus subtilis 168, [Bacillus] caldolyticus (P70881), [Bacillus] caldolyticus
Grabner, G.K.; Switzer, R.L.
Kinetic studies of the uracil phosphoribosyltransferase reaction catalyzed by the Bacillus subtilis pyrimidine attenuation regulatory protein PyrR
J. Biol. Chem.
278
6921-6927
2003
Bacillus subtilis
Lundegaard, C.; Jensen, K.F.
Kinetic mechanism of uracil phosphoribosyltransferase from Escherichia coli and catalytic importance of the conserved proline in the PRPP binding site
Biochemistry
38
3327-3334
1999
Escherichia coli
Barchue, J.; Symersky, J.; Narayana, S.V.; Moore, J.K.; DeLucas, L.J.; Chattopadhyay, D.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of uracil phosphoribosyltransferase of Toxoplasma gondii
Acta Crystallogr. Sect. D
55
347-349
1999
Toxoplasma gondii (Q26998)
-
Schumacher, M.A.; Bashor, C.J.; Song, M.H.; Otsu, K.; Zhu, S.; Parry, R.J.; Ullman, B.; Brennan, R.G.
The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase
Proc. Natl. Acad. Sci. USA
99
78-83
2002
Toxoplasma gondii (Q26998), Toxoplasma gondii
Kadziola, A.; Neuhard, J.; Larsen, S.
Structure of product-bound Bacillus caldolyticus uracil phosphoribosyltransferase confirms ordered sequential substrate binding
Acta Crystallogr. Sect. D
58
936-945
2002
[Bacillus] caldolyticus (P70881), [Bacillus] caldolyticus
Arent, S.; Harris, P.; Jensen, K.F.; Larsen, S.
Allosteric regulation and communication between subunits in uracil phosphoribosyltransferase from Sulfolobus solfataricus
Biochemistry
44
883-892
2005
Saccharolobus solfataricus (Q980Q4), Saccharolobus solfataricus
Jensen, K.F.; Arent, S.; Larsen, S.; Schack, L.
Allosteric properties of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermoacidophilic archaeon Sulfolobus solfataricus
FEBS J.
272
1440-1453
2005
Saccharolobus solfataricus
Cleary, M.D.; Meiering, C.D.; Jan, E.; Guymon, R.; Boothroyd, J.C.
Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay
Nat. Biotechnol.
23
232-237
2005
Toxoplasma gondii
O'Brien, T.A.; Tuong, D.T.; Basso, L.M.; McIvor, R.S.; Orchard, P.J.
Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine
Hum. Gene Ther.
17
518-530
2006
Saccharomyces cerevisiae
Arsene-Ploetze, F.; Nicoloff, H.; Kammerer, B.; Martinussen, J.; Bringel, F.
Uracil salvage pathway in Lactobacillus plantarum: transcription and genetic studies
J. Bacteriol.
188
4777-4786
2006
Lactiplantibacillus plantarum (Q9RE01), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum BM604 (Q9RE01)
Khatri, A.; Zhang, B.; Doherty, E.; Chapman, J.; Ow, K.; Pwint, H.; Martiniello-Wilks, R.; Russell, P.J.
Combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice
J. Gene Med.
8
1086-1096
2006
Mus musculus
Li, J.; Huang, S.; Chen, J.; Yang, Z.; Fei, X.; Zheng, M.; Ji, C.; Xie, Y.; Mao, Y.
Identification and characterization of human uracil phosphoribosyltransferase (UPRTase)
J. Hum. Genet.
52
415-422
2007
Homo sapiens, Homo sapiens (Q96BW1)
Islam, M.R.; Kim, H.; Kang, S.W.; Kim, J.S.; Jeong, Y.M.; Hwang, H.J.; Lee, S.Y.; Woo, J.C.; Kim, S.G.
Functional characterization of a gene encoding a dual domain for uridine kinase and uracil phosphoribosyltransferase in Arabidopsis thaliana
Plant Mol. Biol.
63
465-477
2007
Arabidopsis thaliana (Q9FKS0), Arabidopsis thaliana
Linde, L.; Jensen, K.F.
Uracil phosphoribosyltransferase from the extreme thermoacidophilic archaebacterium Sulfolobus shibatae is an allosteric enzyme, activated by GTP and inhibited by CTP.
Biochim. Biophys. Acta
1296
16-22
1996
Saccharolobus shibatae
Xing, L.; Deng, X.; Kotedia, K.; Ackerstaff, E.; Ponomarev, V.; Clifton Ling, C.; Koutcher, J.A.; Li, G.C.
Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein
Acta Oncol.
47
1211-1220
2008
Homo sapiens (Q96BW1)
Perez-Zuniga, F.J.; Guenther Sillero, M.A.; Sillero, A.
Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments
Biochem. Pharmacol.
76
825-830
2008
Saccharomyces cerevisiae
Lu, S.; Wang, X.; Xiao, L.; Cai, L.; Zhang, Y.; Wang, H.; Wang, Z.
Gene therapy for ovarian cancer using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene directed by MDR1 promoter
Cancer Biol. Ther.
6
397-404
2007
Homo sapiens (Q96BW1)
Zeiner, G.M.; Cleary, M.D.; Fouts, A.E.; Meiring, C.D.; Mocarski, E.S.; Boothroyd, J.C.
RNA analysis by biosynthetic tagging using 4-thiouracil and uracil phosphoribosyltransferase
Methods Mol. Biol.
419
135-146
2008
Toxoplasma gondii (Q26998), Toxoplasma gondii
Gopinath, P.; Ghosh, S.S.
Apoptotic induction with bifunctional E.coli cytosine deaminase-uracil phosphoribosyltransferase mediated suicide gene therapy is synergized by curcumin treatment in vitro
Mol. Biotechnol.
39
39-48
2008
Escherichia coli
Fogar, P.; Navaglia, F.; Basso, D.; Greco, E.; Zambon, C.F.; Fadi, E.; Falda, A.; Stranges, A.; Vannozzi, F.; Danesi, R.; Pedrazzoli, S.; Plebani, M.
Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer
Pancreas
35
224-231
2007
Saccharomyces cerevisiae
Zhao, F.J.; Zhang, S.; Yu, Z.M.; Xia, S.J.; Li, H.
Specific targeting of prostate cancer cells in vitro by the suicide gene/prodrug system, uracil phosphoribosyltransferase/5-fluorouracil, under the control of prostate-specific membrane antigen promoter/enhancer
Prostate Cancer Prostatic. Dis.
12
166-171
2008
Escherichia coli
Tanaka, T.; Duflot-Dancer, A.; Tiraby, M.; Piccoli, C.; Tiraby, G.; Yamasaki, H.; Mesnil, M.
Bystander effect from cytosine deaminase and uracil phosphoribosyl transferase genes in vitro: a partial contribution of gap junctions
Cancer Lett.
282
43-47
2009
Homo sapiens
Christoffersen, S.; Kadziola, A.; Johansson, E.; Rasmussen, M.; Willemoes, M.; Jensen, K.F.
Structural and kinetic studies of the allosteric transition in Sulfolobus solfataricus uracil phosphoribosyltransferase: Permanent activation by engineering of the C-terminus
J. Mol. Biol.
393
464-477
2009
Saccharolobus solfataricus (Q980Q4), Saccharolobus solfataricus
Mainguet, S.E.; Gakiere, B.; Majira, A.; Pelletier, S.; Bringel, F.; Guerard, F.; Caboche, M.; Berthome, R.; Renou, J.P.
Uracil salvage is necessary for early Arabidopsis development
Plant J.
60
280-291
2009
Arabidopsis thaliana (Q9M336)
Altanerova, V.; Cihova, M.; Babic, M.; Rychly, B.; Ondicova, K.; Mravec, B.; Altaner, C.
Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase:uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma
Int. J. Cancer
130
2455-2463
2012
Saccharomyces cerevisiae
Yata, V.; Sen, K.; Kumar, M.; Ghosh, S.
Interaction studies of E. coli uracil phosphoribosyltransferase with 5-fluorouracil for potent anti cancer activity
Med. Chem. Res.
21
1149-1155
2012
Escherichia coli
-
Ghode, P.; Jobichen, C.; Ramachandran, S.; Bifani, P.; Sivaraman, J.
Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
467
577-582
2015
Mycobacterium tuberculosis (P9WFF3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WFF3)
Narayanan, S.; Sanpui, P.; Sahoo, L.; Ghosh, S.S.
Unravelling the potential of a new uracil phosphoribosyltransferase (UPRT) from Arabidopsis thaliana in sensitizing HeLa cells towards 5-fluorouracil
Int. J. Biol. Macromol.
91
310-316
2016
Arabidopsis thaliana
Hasegawa, N.; Abei, M.; Yokoyama, K.K.; Fukuda, K.; Seo, E.; Kawashima, R.; Nakano, Y.; Yamada, T.; Nakade, K.; Hamada, H.; Obata, Y.; Hyodo, I.
Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters
Int. J. Cancer
133
1479-1488
2013
Syrian hamster adenovirus
Soysa, R.; Wilson, Z.N.; Elferich, J.; Forquer, I.; Shinde, U.; Riscoe, M.K.; Yates, P.A.; Ullman, B.
Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs
J. Biol. Chem.
288
29954-29964
2013
Leishmania donovani
Villela, A.D.; Ducati, R.G.; Rosado, L.A.; Bloch, C.J.; Prates, M.V.; Goncalves, D.C.; Ramos, C.H.; Basso, L.A.; Santos, D.S.
Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis
PLoS ONE
8
e56445
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Leonhardt, N.; Divol, F.; Chiarenza, S.; Deschamps, S.; Renaud, J.; Giacalone, C.; Laurent, N.; Berthome, R.; Peret, B.
Tissue-specific inactivation by cytosine deaminase/uracil phosphoribosyl transferase as a tool to study plant biology
Plant J.
101
731-741
2019
Escherichia coli (P0A8F0)
Del Arco, J.; Galindo, J.; Clemente-Suarez, V.J.; Corrales, A.; Fernandez-Lucas, J.
Sustainable synthesis of uridine-5-monophosphate analogues by immobilized uracil phosphoribosyltransferase from Thermus thermophilus
Biochim. Biophys. Acta
1868
140251
2020
Thermus thermophilus (Q5SIQ7), Thermus thermophilus
Villela, A.D.; Pham, H.; Jones, V.; Grzegorzewicz, A.E.; Rodrigues-Junior, V.D.; Campos, M.M.; Basso, L.A.; Jackson, M.; Santos, D.S.
Analysis of uracil phosphoribosyltransferase expression in Mycobacterium tuberculosis and evaluation of upp knockout strain in infected mice
FEMS Microbiol. Lett.
364
gnx023
2017
Mycobacterium tuberculosis (P9WFF3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WFF3), Mycobacterium tuberculosis ATCC 25618 (P9WFF3)
Silva, R.; Aguiar, T.Q.; Oliveira, C.; Domingues, L.
Physiological characterization of a pyrimidine auxotroph exposes link between uracil phosphoribosyltransferase regulation and riboflavin production in Ashbya gossypii
New Biotechnol.
50
1-8
2019
Eremothecium gossypii (Q754M0), Eremothecium gossypii, Eremothecium gossypii CBS 109.51 (Q754M0), Eremothecium gossypii FGSC 9923 (Q754M0), Eremothecium gossypii ATCC 10895 (Q754M0), Eremothecium gossypii NRRL Y-1056 (Q754M0)
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