The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains [2,3]. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
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The enzyme appears in viruses and cellular organisms
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SYSTEMATIC NAME
IUBMB Comments
UDP-alpha-D-xylose:[protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining)
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains [2,3]. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
activity is 12fold lower with reduced and alkylated Glc-EGF. This enzyme recognizes not only the glucose portion but also the tertiary structure of the EGF-like domain even though it transfers xylose to a glucose residue and not to peptide
the enzyme is appears to be involved in the biosynthesis of the Xylalpha(1-3)Glcbeta-Ser structure of glycoproteins such as human blood coagulation factors VII and IX
the enzyme is appears to be involved in the biosynthesis of the Xylalpha(1-3)Glcbeta-Ser structure of glycoproteins such as human blood coagulation factors VII and IX
Presence of UDP-D-xylose: beta-D-glucoside alpha-1,3-D-xylosyltransferase involved in the biosynthesis of the Xylalpha1-3Glcbeta-Ser structure of glycoproteins in the human hepatoma cell line HepG2
Purification and substrate specificity of UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase involved in the biosynthesis of the Xylalpha1-3Xylalpha1-3Glcbeta1-O-Ser on epidermal growth factor-like domains