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Information on EC 2.4.2.42 - UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase

for references in articles please use BRENDA:EC2.4.2.42
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IUBMB Comments
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains [2,3]. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
[protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine
=
+
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Synonyms
alpha-xyloside alpha-1,3-xylosyltransferase, beta-glucoside alpha-1,3-xylosyltransferase, UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase, UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosytransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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