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Disease on EC 2.4.2.31 - NAD+-protein-arginine ADP-ribosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation.
Bicarbonate transport along the loop of Henle. II. Effects of acid-base, dietary, and neurohumoral determinants.
Effect of ANG II on pHi, [Ca2+]i, and contraction in rabbit ventricular myocytes from infarcted hearts.
Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia.
The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis.
Acute Coronary Syndrome
Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-?B Pathway.
Acute Kidney Injury
Acute kidney injury: AT1 receptors modulate AKI.
Acute renal failure in 2K2C Goldblatt hypertensive rats during antihypertensive therapy: comparison of an angiotensin AT1 receptor antagonist and clonidine analogues.
Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion.
AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease.
Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
Protection of kidney function and tissue integrity by pharmacologic use of natriuretic peptides and neprilysin inhibitors.
Role of angiotensin II in treatment of refractory distributive shock.
Valsartan and the kidney: present and future.
Variance of ACE and AT1 receptor gene does not influence the risk of neonatal acute renal failure.
[Acute kidney failure and losartan: a recently observed event of antagonists of angiotensin II AT1 receptors]
Acute Lung Injury
Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury.
Angiotensin II type-1 receptor antagonist attenuates LPS-induced acute lung injury.
Apoptosis-dependent acute pulmonary injury after intratracheal instillation of angiotensin II.
Losartan, an antagonist of AT1 receptor for angiotensin II, attenuates lipopolysaccharide-induced acute lung injury in rat.
Adenocarcinoma
Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer.
Alveolar progenitor cells and the origin of lung cancer.
Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase.
Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas.
Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2.
Expression of transforming growth factor-beta 1 in prostate cancer.
GdDO3NI, a nitroimidazole-based T1 MRI contrast agent for imaging tumor hypoxia in vivo.
Intracellular visualization of prostate cancer using magnetic resonance imaging.
Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer.
Real-time impedance assay to follow the invasive activities of metastatic cells in culture.
Synergistic inhibitory effect of high-intensity focused ultrasound combined with chemotherapy on Dunning adenocarcinoma.
Adenocarcinoma of Lung
Angiotensin II elevates cytosolic free calcium in human lung adenocarcinoma cells via activation of AT1 receptors.
Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation.
Identification of Sca-1+Abcg1+ bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.
Adenoma
Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors.
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes.
Alveolar progenitor and stem cells in lung development, renewal and cancer.
Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism.
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
PCR-SSCP analysis of the angiotensin II type 1 receptor gene in patients with aldosterone-producing adenomas.
Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma.
Type 1 angiotensin II receptors of adrenal tumors.
[Angiotensin II receptor subtype in human adrenal glands]
Adrenal Gland Neoplasms
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Adrenocortical Adenoma
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Albuminuria
Angiotensin II increases glomerular permeability by ?-arrestin mediated nephrin endocytosis.
Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders.
Deterioration of Kidney Function by the (Pro)renin Receptor Blocker Handle Region Peptide in Aliskiren-treated Diabetic Transgenic (mRen2)27 Rats.
Differential effects of enalapril and irbesartan in experimental papillary necrosis.
Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension.
Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats.
Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.
Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure.
Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin.
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
Alkalosis
Bicarbonate transport along the loop of Henle. II. Effects of acid-base, dietary, and neurohumoral determinants.
Alveolar Bone Loss
Protective effects of the angiotensin type 1 receptor antagonist losartan in infection-induced and arthritis-associated alveolar bone loss.
Alveolitis, Extrinsic Allergic
Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease.
Alzheimer Disease
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease.
Renin-angiotensin system gene expression and neurodegenerative diseases.
Transient Mild Cerebral Ischemia Significantly Deteriorated Cognitive Impairment in a Mouse Model of Alzheimer's Disease via Angiotensin AT1 Receptor.
Amnesia
Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function.
Anemia
Effects of an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitors on burst forming units-erythroid in chronic hemodialysis patients.
Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways.
Aneurysm
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.
Angina Pectoris
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.
Angina, Unstable
Agonistic autoantibodies against the angiotensin AT1 receptor increase in unstable angina patients after stent implantation.
Angioedema
Angioedema and AT1 receptor blockers: proceed with caution.
Angioedema associated with angiotensin II receptor antagonists: challenging our knowledge of angioedema and its etiology.
Angiotensin II Receptor Blocker Neprilysin Inhibitor (ARNI): New Avenues in Cardiovascular Therapy.
Angiotensin II receptor blockers are safe in patients with prior angioedema related to angiotensin-converting enzyme inhibitors - a nationwide registry-based cohort study.
Antagonizing the angiotensin II subtype 1 receptor: a focus on olmesartan medoxomil.
Antihypertensive efficacy and tolerability of once daily losartan potassium compared with captopril in patients with mild to moderate essential hypertension.
Are patients who develop angioedema with ACE inhibition at risk of the same problem with AT1 receptor blockers?
Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-Like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation In The Rat.
Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
Losartan increases bradykinin levels in hypertensive humans.
Olmesartan medoxomil-induced angioedema.
[Are AT1 receptor antagonists an alternative to ACE inhibitors in angioedema?]
[AT1 angiotensin receptor inhibition as a new therapeutic possibility]
Anthrax
Immunological and functional comparison between Clostridium perfringens iota toxin, C. spiroforme toxin, and anthrax toxins.
Interactions of high-affinity cationic blockers with the translocation pores of B. anthracis, C. botulinum, and C. perfringens binary toxins.
Aortic Aneurysm
Angiotensin II induces an increase in MMP-2 expression in idiopathic ascending aortic aneurysm via AT1 receptor and JNK pathway.
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Aortic Aneurysm, Abdominal
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat.
Cartilage oligomeric matrix protein is an endogenous ?-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Aortic Aneurysm, Thoracic
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Aortic Coarctation
Decreased perfusion pressure modulates renin and ANG II type 1 receptor gene expression in the rat kidney.
Effects of des-aspartate-angiotensin I on the expression of angiotensin AT1 and AT2 receptors in ventricles of hypertrophic rat hearts.
Aortic Valve Stenosis
Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis.
Role of angiotensin AT1, and AT2 receptors in cardiac hypertrophy and disease.
[Blockade of renin-angiotensin system attenuates cardiac remodeling in rats undergoing aortic stenosis]
Apnea
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Arrhythmias, Cardiac
On the local cardiac renin angiotensin system. Basic and clinical implications.
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
[New strategies in the treatment of atrial fibrillation]
Arteriosclerosis
Candesartan cilexetil reduces graft arteriosclerosis in aortic transplantation model in rat.
Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms.
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Regulation of the angiotensin AT1 receptor expression by hypercholesterolemia.
[Significance of the angiotensin-II receptor AT1 in the pathogenesis of arterial hypertension and arteriosclerosis]
Arteriovenous Fistula
Arteriovenous fistula patency associated with angiotensin-converting enzyme I/D polymorphism and ACE inhibition or AT1 receptor blockade.
Arthritis
AT1 receptor characteristics of angiotensin analogue binding in human synovium.
Effects of adjuvant-induced arthritis on the ventral prostate of rats treated with angiotensin AT1 receptor blocker.
Arthritis, Rheumatoid
Effects of adjuvant-induced arthritis on the ventral prostate of rats treated with angiotensin AT1 receptor blocker.
Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis.
Asthma
Effect of losartan, a type 1 angiotensin II receptor antagonist, on bronchial hyperresponsiveness to methacholine in patients with bronchial asthma.
Role of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in airway reactivity and inflammation in an allergic mouse model of asthma.
Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma.
The involvement of type 1a angiotensin II receptors in the regulation of airway inflammation in a murine model of allergic asthma.
Type II alveolar epithelial cell-specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4.
[Differential therapy with calcium antagonists]
Astrocytoma
Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis.
Ataxia Telangiectasia
Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines.
Atherosclerosis
A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study.
Alpha1-adrenergic plus angiotensin receptor blockade reduces atherosclerosis in apolipoprotein E-deficient mice.
Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice.
Angiotensin AT1 receptor over-expression in hypercholesterolaemia.
Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice.
Angiotensin II and serotonin potentiate endothelin-1-induced vascular smooth muscle cell proliferation.
Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis.
Angiotensin II type 1 (AT1) receptor deficiency halts the progression of age-related atherosclerosis in hypercholesterolemia: molecular link between the AT1 receptor and hypercholesterolemia.
Angiotensin II type 1 receptor expression in human coronary arteries with variable degrees of atherosclerosis.
Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice.
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis.
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
Blood pressure is the major driving force for plaque formation in aortic-constricted ApoE-/- mice.
Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions.
BR 08-3 MANAGEMENT OF DYSLIPIDEMIA IN HYPERTENSION.
Comparison of the effects of AT1 receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis.
Compound 21 prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo.
Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice.
Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells.
Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species.
Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC.
Effect of a common X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) on the occurrence of premature myocardial infarction and stenotic atherosclerosis requiring revascularization.
Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice.
Effect of long-term angiotensin II type I receptor antagonism on peripheral and coronary vasomotion.
Effects of angiotensin II type 1 receptor blockade in ApoE-deficient mice with post-ischemic heart failure.
Estrogen modulates AT1 receptor gene expression in vitro and in vivo.
Factor XIIIA (cross)links AT1 receptors to atherosclerosis.
Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.
Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor.
Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits.
Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys.
Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice.
Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress.
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Irbesartan but not amlodipine suppresses diabetes-associated atherosclerosis.
Irbesartan, an angiotensin type 1 receptor inhibitor, regulates markers of inflammation in patients with premature atherosclerosis.
Local angiotensin II-generating system in vascular tissues: the roles of chymase.
Low-sodium diet induces atherogenesis regardless of lowering blood pressure in hypertensive hyperlipidemic mice.
Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality.
Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Pharmacology of ACE inhibitors versus AT1 blockers.
Potential of renin inhibition in cardiovascular disease.
Prevention of accelerated atherosclerosis by AT1 receptor blockade in experimental renal failure.
Renin Angiotensin blockers and cardiac protection. From basis to clinical trials.
Rosuvastatin attenuates atherosclerosis in rats via activation of scavenger receptor class B type I.
Stimulation of the AT2 receptor reduced atherogenesis in ApoE(-/-)/AT1A(-/-) double knock out mice.
The angiotensin II type 2 receptor and the kidney.
The angiotensin II type 2 receptor in cardiovascular disease.
The antiatherogenic potential of blocking the renin-angiotensin system.
The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms.
The potential role of the angiotensin subtype 2 receptor in cardiovascular protection.
Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-gamma in vascular smooth muscle cells.
Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components.
[Genes in rennin-angiotensin system]
[Signal transduction systems of angiotensin II receptors]
[The effect of losartan on the intima-media thickness of carotid artery]
Atrial Fibrillation
Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes.
AT1 mutations and risk of atrial fibrillation based on genotypes from 71,000 individuals from the general population.
Direct action of an angiotensin II receptor blocker on angiotensin II-induced left atrial conduction delay in spontaneously hypertensive rats.
Does treatment of hypertension decrease the incidence of atrial fibrillation and cardioembolic stroke?
Rationale and design of the GISSI-Atrial Fibrillation Trial: a randomized, prospective, multicentre study on the use of valsartan, an angiotensin II AT1-receptor blocker, in the prevention of atrial fibrillation recurrence.
[Atrial fibrillation as end point of hypertension. Can antihypertensive therapy prevent it?]
Azotemia
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Bacterial Infections
Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome.
Bartter Syndrome
Angiotensin II type 1 receptor gene abnormality in a patient with Bartter's syndrome.
Blister
Involvement of the angiotensin II type 2 receptor in apoptosis during human fetal adrenal gland development.
Bradycardia
AT2 and MAS (but not AT1) angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats.
Brain angiotensin receptors and sympathoadrenal regulation during insulin-induced hypoglycemia.
Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.
Cardiovascular effects after the intracerebroventricular administration of peptide and nonpeptide angiotensin antagonists in Dahl salt-sensitive rats.
Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat.
Early Training-Induced Reduction of Angiotensinogen in Autonomic Areas-The Main Effect of Exercise on Brain Renin-Angiotensin System in Hypertensive Rats.
[Angiotensin II Regulates Excitability and Contractile Functions of Myocardium and Smooth Muscles through Autonomic Nervous Transmission].
Brain Diseases
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders.
Beneficial effects of Angiotensin II receptor blockers in brain disorders.
Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis.
Brain Edema
AT1 receptor antagonist prevents brain edema without lowering blood pressure.
Candesartan attenuates ischemic brain edema and protects the blood-brain barrier integrity from ischemia/reperfusion injury in rats.
Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.
Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor.
Brain Infarction
Ischemic injury in experimental stroke depends on angiotensin II.
Brain Injuries
Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury.
Angiotensin II Receptor 1 Blockage Limits Brain Damage and Improves Functional Outcome After Brain Injury in Aged Animals Despite Age-Dependent Reduction in AT1 Expression.
Are angiotensin receptor blockers neuroprotective?
AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion.
Attenuation of stroke damage by angiotensin II type 2 receptor stimulation via peroxisome proliferator-activated receptor-gamma activation.
Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats.
Excess salt causes cerebral neuronal apoptosis and inflammation in stroke-prone hypertensive rats through angiotensin II-induced NADPH oxidase activation.
Losartan inhibits development of spontaneous recurrent seizures by preventing astrocyte activation and attenuating blood-brain barrier permeability following pilocarpine-induced status epilepticus.
Neuroprotective potential of azilsartan against cerebral ischemic injury: Possible involvement of mitochondrial mechanisms.
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
Selective blockade of AT1 receptor attenuates impairment of hypotensive autoregulation and improves cerebral blood flow after brain injury in the newborn pig.
Brain Injuries, Traumatic
Angiotensin II Type 1 receptor deficiency protects against the impairment of blood-brain barrier in a mouse model of traumatic brain injury.
Brain Ischemia
Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury.
Are angiotensin receptor blockers neuroprotective?
Associations of renin-angiotensin system genetic polymorphisms and clinical course after aneurysmal subarachnoid hemorrhage.
AT(2) receptor and tissue injury: therapeutic implications.
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats.
Blockade of Central Angiotensin II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats.
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats.
Cerebral ischemia induced inflammatory response and altered glutaminergic function mediated through brain AT1 and not AT2 receptor.
Cerebrovascular angiotensin AT1 receptor regulation in cerebral ischemia.
Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive rats.
Ischemic injury in experimental stroke depends on angiotensin II.
Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor.
Neuroprotective potential of azilsartan against cerebral ischemic injury: Possible involvement of mitochondrial mechanisms.
Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition.
Platelet-endothelial cell interaction in brain microvessels of angiotensin II type-2 receptor knockout mice following transient bilateral common carotid artery occlusion.
Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models.
Protective effect of candesartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors.
Protective effect of irbesartan, an angiotensin II receptor antagonist, alone and in combination with aspirin on middle cerebral artery occlusion model of focal cerebral ischemia in rats.
Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies.
Stroke prevention with losartan in the context of other antihypertensive drugs.
Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat.
Synergistic protective effects of erythropoietin and olmesartan on ischemic stroke survival and post-stroke memory dysfunctions in the gerbil.
The calcium-channel blocker, azelnidipine, enhances the inhibitory action of AT1 receptor blockade on ischemic brain damage.
The pathophysiologic role of the brain renin-angiotensin system in stroke protection: clinical implications.
The Promyelocytic Leukemia Zinc Finger (PLZF) Protein Exerts Neuroprotective Effects in Neuronal Cells and is Dysregulated in Experimental Stroke.
Transient Mild Cerebral Ischemia Significantly Deteriorated Cognitive Impairment in a Mouse Model of Alzheimer's Disease via Angiotensin AT1 Receptor.
[Effect of irbesartan on focal cerebral ischemia in rats].
Breast Neoplasms
A Novel Cellular Model to Study Angiotensin II AT2 Receptor Function in Breast Cancer Cells.
Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells.
Angiotensin II stimulation of Na+/K+ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells.
Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor.
Association between AT1 and AT2 angiotensin II receptor expression with cell proliferation and angiogenesis in operable breast cancer.
Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer.
Correction to: Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1.
Effects of Angiotensin, vasopressin and aldosterone on proliferation of mcf-7 cells and their sensitivity to Doxorubicin.
G-protein coupled receptors of the renin-angiotensin system: new targets against breast cancer?
Glutamyl- but not aspartyl-aminopeptidase activity is modified in serum of N-methyl nitrosourea-induced rat mammary tumours.
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1.
The renin-angiotensin system in the breast and breast cancer.
Bronchopulmonary Dysplasia
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
Carcinogenesis
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes.
Alveolar progenitor and stem cells in lung development, renewal and cancer.
Analysis of the biological function of ELDF15 using an antisense recombinant expression vector.
Angiotensin 1-7 inhibits angiotensin II-stimulated head and neck cancer progression.
Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to tobacco-specific nitrosamine-induced lung tumorigenesis: involvement of transforming growth factor-beta-dependent cell growth attenuation.
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
The angiotensin II type 2 receptor and the gastrointestinal tract.
Carcinoma
Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors.
Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells.
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
Angiotensin II receptor subtypes in the human renal cortex and renal cell carcinoma.
Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.
Assessing p-Glycoprotein (Pgp) Activity In Vivo Utilizing (68)Ga-Schiff Base Complexes.
AT1 angiotensin II receptor subtype in the human larynx and squamous laryngeal carcinoma.
AT1 receptor and ACE mRNA are increased in chemically induced carcinoma of rat mammary gland.
Decreasing the thresholds for electroporation by sensitizing cells with local cationic anesthetics and substances that decrease the surface negative electric charge.
Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression.
Direct determination of intracellular daunorubicin in intact confluent monolayers of AT1 prostate carcinoma cells using a multiwell-multilabel counter.
Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells.
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
Immunohistochemical study of angiotensin receptors in human anagen hair follicles and basal cell carcinoma.
Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo.
Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma.
Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.
Localisation of renin-angiotensin system (RAS) components in breast.
Measurement of Protein Synthesis: In Vitro Comparison of (68)Ga-DOTA-Puromycin, [ (3)H]Tyrosine, and 2-Fluoro-[ (3)H]tyrosine.
Regulation of the RhoA/ROCK/AKT/?-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma.
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.
The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis.
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells.
Carcinoma, Basal Cell
Immunohistochemical study of angiotensin receptors in human anagen hair follicles and basal cell carcinoma.
Carcinoma, Ductal
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.
Carcinoma, Hepatocellular
Glucocorticoids regulate the expression of angiotensin AT1 receptors, in the human hepatoma cell line, PLC-PRF-5.
Carcinoma, Intraductal, Noninfiltrating
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.
Carcinoma, Lewis Lung
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.
Carcinoma, Non-Small-Cell Lung
Angiotensin II elevates cytosolic free calcium in human lung adenocarcinoma cells via activation of AT1 receptors.
Carcinoma, Pancreatic Ductal
Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.
Carcinoma, Renal Cell
Angiotensin II receptor subtypes in the human renal cortex and renal cell carcinoma.
Carcinoma, Squamous Cell
Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression.
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Cardiomegaly
A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expression.
A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.
Alterations of angiotensin II receptor contents in hypertrophied hearts.
Anabolic Steroid Associated To Physical Training Induces Deleterious Cardiac Effects.
Ang-(1-7) is an endogenous ?-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy.
Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage.
Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep.
Angiotensin AT1 receptor-mediated attenuation of cardiac hypertrophy due to volume overload: involvement of endothelin.
Angiotensin blocking drugs and the heart beyond 2000.
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload.
Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung.
Angiotensin II receptor subtypes and cardiac function.
Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor.
Angiotensin II type 2 receptor blockade partially negates antihypertrophic effects of type 1 receptor blockade on pressure-overload rat cardiac hypertrophy.
Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats.
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy.
AT1 receptor antagonist, TCV 116, does not prevent cardiac hypertrophy in salt-loaded Dahl salt-sensitive rats.
AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension.
AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats.
AT1 receptor density changes during development of hypertension in hyperinsulinemic rats.
AT1 receptor participates in the cardiac hypertrophy induced by resistance training in rats.
Attenuation of Angiotensin II-Induced Hypertension and Cardiac Hypertrophy in Transgenic Mice Overexpressing a Type 1 Receptor Mutant.
Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.
Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats.
Cardiac angiotensin II receptor populations during aortocaval fistulae, AII and beta adrenergic receptor blockade.
Cardiac AT1 receptor-dependent and IGF1 receptor-independent signaling is activated by a single bout of resistance exercise.
Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan.
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice.
Cardiac hypertrophy is associated with decreased eNOS expression in angiotensin AT2 receptor-deficient mice.
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
Cardiac senescence is associated with enhanced expression of angiotensin II receptor subtypes.
Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate-salt hypertension in rats.
Chronic AT1 receptor blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival.
Comparative effects of chronic ACE inhibition and AT1 receptor blocked losartan on cardiac hypertrophy and renal function in hypertensive patients.
Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat.
Comparison of the angiotensin II type 1-receptor antagonist YM358 and the angiotensin-converting enzyme inhibitor enalapril in rats with cardiac volume overload.
Contribution of local renin-angiotensin system to cardiac hypertrophy, phenotypic modulation, and remodeling in TGR (mRen2)27 transgenic rats.
Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.
Effect of an ACE inhibitor and an AT1 receptor antagonist on cardiac hypertrophy.
Effect of an angiotensin II receptor antagonist, TCV-116, on cardiac hypertrophy and coronary circulation in spontaneously hypertensive rats.
Effect of an AT1 receptor antagonist (CV-11974) on angiotensin II-induced cardiomyocyte hypertrophy in vitro.
Effect of AT2 blockade on cardiac hypertrophy as induced by high dietary salt in the proatrial natriuretic peptide (ANP) gene-disrupted mouse.
Effects of an AT1 receptor antagonist, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats.
Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats.
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Effects of AT1 receptor blockade on blood pressure and the renin-angiotensin system in spontaneously hypertensive rats of the stroke prone strain.
Effects of des-aspartate-angiotensin I on the expression of angiotensin AT1 and AT2 receptors in ventricles of hypertrophic rat hearts.
Effects of the new angiotensin receptor antagonist dipotassium (Z)-2-[[5-ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1,3,4-thiadiazoline-2-ylidene]aminocarbonyl]-1-cy clopentencarbox ylate on experimental cardiac hypertrophy and acute left ventricular failure.
Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation.
Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy.
Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure.
Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart.
High-density lipoprotein inhibits mechanical stress-induced cardiomyocyte autophagy and cardiac hypertrophy through angiotensin II type 1 receptor-mediated PI3K/Akt pathway.
In hypertension, the kidney rules.
Isosorbide dinitrate inhibits mechanical stress-induced cardiac hypertrophy and autophagy through downregulation of angiotensin II type 1 receptor.
Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system.
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Myocardial angiotensin receptors in human hearts.
New perspectives in angiotensin system control.
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Overexpression of insulin-like growth factor-I in hearts of rats with isoproterenol-induced cardiac hypertrophy.
Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy.
Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy.
Regulation of atrial contraction by PKA and PKC during development and regression of eccentric cardiac hypertrophy.
Renin, angiotensin, sodium and organ damage.
Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and cardiac remodelling.
Role of angiotensin AT1, and AT2 receptors in cardiac hypertrophy and disease.
Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice.
Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy.
Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection.
Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by ?-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue.
The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?
The angiotensin II type 2 receptor in cardiovascular disease.
The role of the AT1 angiotensin receptor in cardiac hypertrophy: angiotensin II receptor or stretch sensor?
[Blockade of renin-angiotensin system attenuates cardiac remodeling in rats undergoing aortic stenosis]
[Mechanisms underlying angiotensin II-independent activation of angiotensin II type 1 receptor].
[Renin-angiotensin system and heart failure]
Cardiomyopathies
Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy.
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure.
Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression.
Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan.
Impact of early life AT1 blockade on adult cardiac morpho-functional changes and the renin-angiotensin system in a model of neonatal high oxygen-induced cardiomyopathy.
Subtype 2 and atypical angiotensin receptors in the human heart.
Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression.
Cardiomyopathy, Dilated
Angiotensin deficiency in mice leads to dilated cardiomyopathy.
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure.
Angiotensin-converting enzyme inhibitors improve coronary flow reserve in dilated cardiomyopathy by a bradykinin-mediated, nitric oxide-dependent mechanism.
AT1 and AT2 angiotensin receptor gene expression in human heart failure.
Differential distribution of angiotensin AT2 receptors in the normal and failing human heart.
Effects of losartan on the collagen degradative enzymes in hypertrophic and congestive types of cardiomyopathic hamsters.
Impact of repeated intravenous bone marrow mesenchymal stem cells infusion on myocardial collagen network remodeling in a rat model of doxorubicin-induced dilated cardiomyopathy.
Up-regulated expression of angiotensin II type 1 receptor gene in human pathologic hearts.
Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice.
Cardiomyopathy, Hypertrophic
AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1.
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy.
Cardiotoxicity
Mitochondrial ROS-induced ERK1/2 Activation and HSF2-mediated AT1 R Upregulation Are Required for Doxorubicin-induced Cardiotoxicity.
Cardiovascular Diseases
A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.
Angiotensin II and coronary artery disease, congestive heart failure, and sudden cardiac death.
Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in San Luis.
Angiotensin II type 2 receptor gene polymorphisms in cardiovascular disease.
Angiotensin receptors in the cardiovascular system.
Antibodies against AT1 receptors are associated with vascular endothelial and smooth muscle function impairment: protective effects of hydroxysafflor yellow A.
Apoptosis induction and inhibition of cellular proliferation by angiotensin II: possible implication and perspectives.
Are reactive oxygen species important mediators of vascular dysfunction?
Association between AT C573T polymorphism and cardiovascular risk factors in myocardial infarction.
AT2 receptors: functional relevance in cardiovascular disease.
Biphasic effects of angiotensin II and receptor antagonism on aggregability and protein kinase C phosphorylation in human platelets.
Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.
Cartilage oligomeric matrix protein is an endogenous ?-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.
Cells on a chip--the use of electric properties for highly sensitive monitoring of blood-derived factors involved in angiotensin II type 1 receptor signalling.
Central inhibition of AT1receptors by eprosartan--in vitro autoradiography in the brain.
Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials.
Characterization of polymorphisms in the promoter of the human angiotensin II subtype 1 (AT1) receptor gene.
Des-aspartate-angiotensin I causes specific release of PGE2 and PGI2 in HUVEC via the angiotensin AT1 receptor and biased agonism.
In vitro pharmacology of a novel non-peptide angiotensin II-receptor antagonist, E4177.
Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cell proliferation.
Kinins and cardiovascular diseases.
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Management of hypertension: the advent of a new angiotensin II receptor antagonist.
Modulation by bradykinin and nitric oxide of angiotensin II-induced apoptosis in a vascular smooth muscle cell phenotype.
Molecular biology of angiotensin receptors and their role in human cardiovascular disease.
Multiple templates-based homology modeling enhances structure quality of AT1 receptor: validation by molecular dynamics and antagonist docking.
Negative feedback regulation of reactive oxygen species on AT1 receptor gene expression.
Neuroendocrine mechanisms of acupuncture in the treatment of hypertension.
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
Renin-angiotensin system in thyroid dysfunction in rats.
Renin-angiotensin system revisited.
Role of angiotensin II AT1 receptor activation in cardiovascular diseases.
Running Exercise and Angiotensin II Type I Receptor Blocker Telmisartan Are Equally Effective in Preventing Angiotensin II-Mediated Vulnerable Atherosclerotic Lesions.
Safety and efficacy of eprosartan, a new angiotensin II receptor blocker.
Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes.
The angiotensin II type 2 receptor and the kidney.
The angiotensin II type 2 receptor for pain control.
The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition.
The role of tyrosine phosphorylation in angiotensin II mediated intracellular signaling and cell growth.
Vasopressor meets vasodepressor: The AT1-B2 receptor heterodimer.
[6]-Gingerol: A Novel AT1 Antagonist for the Treatment of Cardiovascular Disease.
[Angiotensin II receptor and oxidative stress]
[Angiotensin II receptor]
[AT1 angiotensin receptor inhibition as a new therapeutic possibility]
[Candesartan cilexetil: pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist]
[Mechanisms underlying angiotensin II-independent activation of angiotensin II type 1 receptor].
[Prevention of progression and regression of target organ damage. Future strategies].
[Renin-angiotensin system modulation: instructions for use]
[Selective knockdown of Angiotensin II receptor subtype 1a in rat vascular smooth muscle cells by RNA interference]
[Tendency and prospect of the development of new ARBs]
Carotid Stenosis
Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia.
Catalepsy
Effects of losartan on neuroleptic-induced catalepsy in mice.
Cerebral Hemorrhage
Blockade of AT1 receptor reduces apoptosis, inflammation, and oxidative stress in normotensive rats with intracerebral hemorrhage.
Cerebral Infarction
Cerebroprotective effects of angiotensin II (AT 1) receptor antagonists?
Cerebrovascular Disorders
Angiotensin AT2 receptors regulate cerebral blood flow in rats.
Effect of compound EXP-2528 on angiotensin II-induced E-selectin and VCAM-1 expression in rat brain microvascular endothelial cells in vitro.
Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes.
The angiotensin II type 2 receptor in the brain.
[Stroke and renin-angiotensin system]
Cholera
DeoxyNAD and deoxyADP-ribosylation of proteins.
Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities.
Intracellular inhibition of mono(ADP-ribosylation) by meta-iodobenzylguanidine: specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis.
Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells.
Vibrio fischeri genes hvnA and hvnB encode secreted NAD(+)-glycohydrolases.
Choriocarcinoma
Angiotensin II augmented migration and invasion of choriocarcinoma cells involves PI3K activation through the AT1 receptor.
Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.
Colitis
Implication of Clostridium difficile and Clostridium perfringens iota toxins in experimental lincomycin-associated colitis of rabbits.
PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2, 4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility.
Colorectal Neoplasms
Angiotensin II receptors on colorectal carcinoma cells.
Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
Congenital Abnormalities
AT2 R deficiency mediated podocyte loss via activation of ectopic hedgehog interacting protein (Hhip) gene expression.
Coronary Artery Disease
Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts.
Angiotensin II type 1 receptor expression in human coronary arteries with variable degrees of atherosclerosis.
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism in coronary disease and malignant ventricular arrhythmias.
Dose-dependent regulation of NAD(P)H oxidase expression by angiotensin II in human endothelial cells: protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease.
Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension and coronary artery disease.
Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial.
Expression of Renin-Angiotensin System on Dendritic Cells of Patients with Coronary Artery Disease.
Growth response of human coronary smooth muscle cells to angiotensin II and influence of angiotensin AT1 receptor blockade.
Impact of kinins in the treatment of cardiovascular diseases.
Localization of the angiotensin II receptor subtypes in the human atrium.
Subtype 2 and atypical angiotensin receptors in the human heart.
The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease.
Coronary Disease
[Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease]
[Screening, prevention and early therapy of type 2 diabetics]
[The involvement of the renin-angiotensin system gene polymorphisms in coronary heart disease]
Coronary Occlusion
Early and chronic captopril or Losartan therapy reduces infarct size and avoids congestive heart failure after myocardial infarction in rats.
Role of augmented expression of intermediate-conductance Ca2+-activated K+ channels in postischaemic heart.
Cough
ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group.
Angiotensin II receptor antagonists - antihypertensive agents.
Antagonizing the angiotensin II subtype 1 receptor: a focus on olmesartan medoxomil.
Antihypertensive efficacy and tolerability of once daily losartan potassium compared with captopril in patients with mild to moderate essential hypertension.
Antihypertensive therapy targeted to the needs of the patient: focus on the renin-angiotensin system; older and newer agents.
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Experience with angiotensin II antagonists in hypertensive patients.
Increase in AT1 Receptors as a Mechanism of ACE Inhibition-induced Cough.
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism.
The clinical profile of the angiotensin II receptor blocker eprosartan.
The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit.
The management of heart failure--an overview.
Therapeutic advantages of AT1 blockers in hypertension.
[AT1 angiotensin receptor inhibition as a new therapeutic possibility]
COVID-19
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.
Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19.
Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model.
Hypothesis for renin-angiotensin inhibitor mitigation of COVID-19.
In silico studies on therapeutic agents for COVID-19: Drug repurposing approach.
RAAS Blockade and COVID-19: Mechanistic Modeling of Mas and AT1 Receptor Occupancy as Indicators of Pro-Inflammatory and Anti-Inflammatory Balance.
Renin-angiotensin-system inhibitors and all-cause mortality in patients with COVID-19: a systematic review and meta-analysis of observational studies.
Role of the Backbenchers of the Renin-Angiotensin System ACE2 and AT2 Receptors in COVID-19: Lessons From SARS.
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
Cushing Syndrome
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
[Angiotensin II receptor subtype in human adrenal glands]
Cystic Fibrosis
Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling.
Cysts
Expression of Angiotensin II Types 1 and 2 Receptors in Endometriotic Lesions.
FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.
Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.
Dehydration
Differential regulation of angiotensinogen and AT1A receptor mRNA within the rat subfornical organ during dehydration.
Effects of dehydration and blockade of angiotensin II AT1 receptor on stress hormones and anti-oxidants in the one-humped camel.
Inhibitory effect of DUP-753 on the drinking responses of rats to central administration of noradrenaline and angiotensin II and to dehydration.
Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.
Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system.
Type 1A angiotensin II receptor is regulated differently in proximal and distal nephron segments.
Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary.
Dementia
Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia.
Evaluating the relationship of blood pressure, plasma angiotensin peptides and aldosterone with cognitive functions in patients with hypertension.
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Dementia, Vascular
Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia.
Diabetes Complications
Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO-mediated mechanisms.
Diabetes Insipidus
Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone.
Diabetes Mellitus
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Deletion of AT2 Receptor Prevents SHP-1-Induced VEGF Inhibition and Improves Blood Flow Reperfusion in Diabetic Ischemic Hindlimb.
Effects of candesartan cilexetil on glucose homeostasis. Multicenter Study Group.
Elevation of [Ca2+]i of renal proximal tubular cells and down-regulation of mRNA of PTH-PTHrP, V1a and AT1 receptors in kidney of diabetic rats.
Expression of Angiotensin II Type 1 Receptor in Rat Bladder Smooth Muscle Cells in Response to a Streptzotocin Induced Diabetes Mellitus Model.
Management of hypertension.
Potential of renin inhibition in cardiovascular disease.
Renal AT1 receptor protein expression during the early stage of diabetes mellitus.
Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus.
Role of renin angiotensin system inhibitors in cardiovascular and renal protection: a lesson from clinical trials.
The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects.
[ACE inhibitor or AT1 antagonist. Is there a differential therapy?]
[Are beta blockers no longer the medicines of choice for the treatment of hypertension?]
Diabetes Mellitus, Experimental
Kinins or nitric oxide, or both, are involved in the antitrophic effects of angiotensin converting enzyme inhibitors on diabetes-associated mesenteric vascular hypertrophy in the rat.
Diabetes Mellitus, Type 1
DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity.
Elevation of [Ca2+]i of renal proximal tubular cells and down-regulation of mRNA of PTH-PTHrP, V1a and AT1 receptors in kidney of diabetic rats.
Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2.
Importance of donor-derived lymphocytes in the protection of pancreaticoduodenal or islet grafts from recurrent autoimmunity: a role for RT6+NKR-P1+ T cells.
Mono(ADP-ribosyl)transferase genes and diabetes in NOD mice. Is there a relationship?
Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus.
The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.
The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes.
[Efficacy of valsartan in the treatment of persistent microalbuminuria in normotensive patients with type 1 diabetes]
Diabetes Mellitus, Type 2
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
Autoantibodies against ?1 receptor and AT1 receptor in type 2 diabetes patients with left ventricular dilatation.
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes.
Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus.
Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist.
Inhibiting angiotensin type 1 receptors as a target for diabetes.
Inhibition of cellular transdifferentiation by losartan minimizes but does not reverse type 2 diabetes-induced renal fibrosis.
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Regional variation in the prescribing for diabetes and use of secondary preventative therapies in Ireland.
Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 2. Overview of physiological and biochemical mechanisms.
Renoprotective effects of blockade of angiotensin II AT1 receptors in an animal model of type 2 diabetes.
Role of renin angiotensin system inhibitors in cardiovascular and renal protection: a lesson from clinical trials.
The angiotensin II receptor antagonist valsartan enhances lipoprotein lipase mass in preheparin serum in type 2 diabetes with hypertension.
The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology.
The role of angiotensin II antagonism in type 2 diabetes mellitus: a review of renoprotection studies.
[NAVIGATOR: A trial of prevention of cardiovascular complications and type 2 diabetes with valsartan and/or nateglinide]
[THE ROLE OF MARKER FIBROSIS ST2 AND ANGIOTENZINOGEN GENE POLYMORPHISM IN HEART FAILURE PROGRESSING IN PATIENTS WITH TYPE 2 DIABETES MELLITUS].
Diabetic Cardiomyopathies
Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression.
AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase.
Exposure of cardiomyocytes to angiotensin II induces over-activation of monoamine oxidase type A: Implications in heart failure.
Significance of AT1 Receptor Independent Activation of Mineralocorticoid Receptor in Murine Diabetic Cardiomyopathy.
Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression.
[Research progress in relations between renin angiotensin system and diabetic cardiomyopathy].
Diabetic Nephropathies
Additive hypotensive and anti-albuminuric effects of angiotensin-converting enzyme inhibition and angiotensin receptor antagonism in diabetic spontaneously hypertensive rats.
Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus.
AT1 receptor antagonists: a challenge for ACE inhibitors in diabetic nephropathy.
AT2 receptor agonist Compound 21: A silver lining for diabetic nephropathy.
Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase.
Differential regulation of angiotensin converting enzyme 2 and nuclear factor-?B by angiotensin II receptor subtypes in type 2 diabetic kidney.
Early streptozotocin-diabetes mellitus downregulates rat kidney AT2 receptors.
KRH-594, a new angiotensin AT1 receptor antagonist, ameliorates nephropathy and hyperlipidaemia in diabetic spontaneously hypertensive rats.
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist.
Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice.
Major role for ACE-independent intrarenal ANGII formation in type II diabetes.
Podocytes of AT2 Receptor Knockout Mice Are Protected from Angiotensin II-Mediated RAGE Induction.
Possible involvement of intracellular angiotensin II receptor in high-glucose-induced damage in renal proximal tubular cells.
Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats.
Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.
Renoprotective effects of Vitamin D and renin-angiotensin system.
The angiotensin II type 2 receptor and the kidney.
The angiotensin type 2 receptor and the kidney.
The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy.
Time course of the antiproteinuric and antihypertensive effect of losartan in diabetic nephropathy.
Valsartan inhibited HIF-1? pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats.
[Efficacy of valsartan in the treatment of persistent microalbuminuria in normotensive patients with type 1 diabetes]
[Renoprotective effects of ACE inhibitors and AT1 antagonists on diabetic nephropathy beyond blood pressure control]
[Threatened diabetic nephropathy. Early administration of ACE inhibitors and AT1 blockers]
Diabetic Retinopathy
Diabetes and retinal vascular disorders: role of the reninangiotensin system.
Pharmacological and pharmacokinetic study of olmesartan medoxomil in animal diabetic retinopathy models.
Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors.
Diphtheria
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells.
Dupuytren Contracture
Angiotensin receptors in Dupuytren's disease: a target for pharmacological treatment?
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Dysautonomia, Familial
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Dyskinesias
Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia.
Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias: a retrospective case-control study.
Embolism, Fat
Evidence for angiotensin mediation of the late histopathological effects of pulmonary fat embolism: Protection by losartan in a rat model.
Encephalitis
Chronic Brain Inflammation: The Neurochemical Basis for Drugs to Reduce Inflammation.
Endometriosis
Expression of angiotensin II type 1 (AT1) and angiotensin II type 2 (AT2) receptors in human granulosa-lutein (GL) cells: correlation with infertility diagnoses.
The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients.
Endotoxemia
Involvement of central angiotensin II type 1 receptors in LPS-induced systemic vasopressin release and blood pressure regulation in rats.
Enteritis
Clostridium perfringens type E animal enteritis isolates with highly conserved, silent enterotoxin gene sequences.
Effects of Clostridium perfringens iota toxin in the small intestine of mice.
Enterotoxemia in rabbits.
Enterotoxemia
Two Clostridiumperfringens Type E Isolates in France.
Epidermolysis Bullosa Dystrophica
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Epilepsy
Effect of Combined Treatment with AT1 Receptor Antagonists and Tiagabine on Seizures, Memory and Motor Coordination in Mice.
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy.
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
The amygdala and intractable temporal lobe epilepsy: a quantitative magnetic resonance imaging study.
The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
The Potential Therapeutic Capacity of Inhibiting the Brain Renin-Angiotensin System in the Treatment of Co-Morbid Conditions in Epilepsy.
The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis.
Epilepsy, Temporal Lobe
The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis.
Essential Hypertension
825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension.
A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene.
Angiotensin II AT1 receptor gene polymorphism and microalbuminuria in essential hypertension.
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension.
Angiotensin-converting enzyme inhibitors.
Comparison of angiotensin II receptor antagonists.
Effect of AT1 receptor blockade on endothelial function in essential hypertension.
Effect of losartan on haematology and haemorheology in elderly patients with essential hypertension: a pilot study.
Effects of losartan on renal function in patients with essential hypertension.
Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: comparison with enalapril.
Eprosartan provides safe and effective long-term maintenance of blood pressure control in patients with mild to moderate essential hypertension.
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension.
Favourable effects on arterial wave reflection and pulse pressure amplification of adding angiotensin II receptor blockade in resistant hypertension.
Genetic polymorphism of the renin-angiotensin system and organ damage in essential hypertension.
Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings.
Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1 R and ecNOS.
Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: results from the study of optimal treatment in hypertensive patients with anti-AT1-receptor autoantibodies trial.
Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin-converting enzyme inhibitor therapy?
Lack of association between angiotensin II type 1 receptor gene polymorphism and hypertension in Japanese.
Pharmacokinetics and blood pressure response of losartan in end-stage renal disease.
Prolonged treatment with the AT1 receptor blocker, valsartan, increases small and large artery compliance in uncomplicated essential hypertension.
Protection against ischemia: a physiological function of the renin-angiotensin system.
Regression of left ventricular hypertrophy by AT1 receptor blockade in renal transplant recipients.
Role of angiotensin II and endogenous vasodilators in the control of glomerular hemodynamics.
The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension.
The renal profile of eprosartan.
[Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease]
[AT1 receptor autoantibodies and essential hypertension]
[The usefulness of a new class antihypertensive drug, angiotensin II receptor antagonist, for essential hypertension]
Fatty Liver
ACE Inhibition and AT1 Receptor Blockade Prevent Fatty Liver and Fibrosis in Obese Zucker Rats.
Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice.
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Fetal Growth Retardation
Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature.
Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants.
Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia.
Influence of aerobic training on the reduced vasoconstriction to angiotensin II in rats exposed to intrauterine growth restriction: possible role of oxidative stress and AT2 receptor of angiotensin II.
Maternal treatment with agonistic autoantibodies against type-1 angiotensin II receptor in late pregnancy increases apoptosis of myocardial cells and myocardial susceptibility to ischemia-reperfusion injury in offspring rats.
Fibrosarcoma
[Effect of expression of exogenous PDGF-A chain on growth and transformation of CHO cells]
Foodborne Diseases
Two Clostridiumperfringens Type E Isolates in France.
Gastroschisis
Does a large abdominal wall defect affect lung growth?
Genetic Diseases, Inborn
Alveolar injury and regeneration following deletion of ABCA3.
Glaucoma
Changes in Corneal Biomechanical Properties after Long-Term Topical Prostaglandin Therapy.
Effect of CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure in glaucomatous monkey eyes.
Glioma
Angiotensin II type-2 (AT2) receptor-mediated inhibition of NMDA receptor signalling in neuronal cells.
AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma.
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma.
Induction of the angiotensin AT2 receptor subtype expression by differentiation of the neuroblastoma x glioma hybrid, NG-108-15.
Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.
Transcriptional network analysis reveals that AT1 and AT2 angiotensin II receptors are both involved in the regulation of genes essential for glioma progression.
Glomerulonephritis
Nature and Mediators of Parietal Epithelial Cell Activation in Glomerulonephritides of Human and Rat.
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
Glomerulonephritis, IGA
Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol.
Glomerulosclerosis, Focal Segmental
Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats.
Glucose Intolerance
Angiotensin receptor and tumor necrosis factor-? activation contributes to glucose intolerance independent of systolic blood pressure in obese rats.
Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.
Epigenetic repression of AT2 receptor is involved in ? cell dysfunction and glucose intolerance of adult female offspring rats exposed to dexamethasone prenatally.
TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation.
Granuloma
Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma.
Hallucinations
The amygdala and temporal lobe simple partial seizures: a prospective and quantitative MRI study.
Hartnup Disease
Accurate discrimination of Hartnup disorder from other aminoacidurias using a diagnostic ratio.
The molecular basis of neutral aminoacidurias.
[Hartnup disease is related to a mutation in the SL C6A19 gene coding for the B degrees AT1 aminoacid transporter]
Heart Block
Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
Heart Diseases
Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and 'overdrive' of the endothelin system.
Nitric oxide synthases and heart failure - lessons from genetically manipulated mice.
The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives.
The angiotensin II type 2 receptor and the kidney.
Up-regulated expression of angiotensin II type 1 receptor gene in human pathologic hearts.
[Study of autoantibodies against the G-protein-coupled beta 2- and alpha 1-adrenergic and AT1 receptors in patients with primary hypertension]
[The role of DNA polymorphism in the renin-angiotensin system and the pathogenesis of cardiovascular diseases]
Heart Failure
A case series about the favorable effects of sacubitril/valsartan on anthracycline cardiomyopathy.
ACE-inhibition and angiotensin II receptor blockers in chronic heart failure: pathophysiological consideration of the unresolved battle.
ACE2 gene expression is up-regulated in the human failing heart.
ACE2-Ang (1-7) axis is induced in pressure overloaded rat model.
Acute effects of E-3174, a human active metabolite of losartan, on the cardiovascular system in tachycardia-induced canine heart failure.
Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.
ADEPT: Addition of the AT1 receptor antagonist eprosartan to ACE inhibitor therapy in chronic heart failure trial: hemodynamic and neurohormonal effects.
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Angiotensin AT1 receptor inhibition in pacing induced heart failure: effects on left ventricular myocardial collagen content and composition.
Angiotensin AT1 receptor inhibition, angiotensin-converting enzyme inhibition, and combination therapy with developing heart failure: cellular mechanisms of action.
Angiotensin converting enzyme inhibition, AT1 receptor inhibition, and combination therapy with pacing induced heart failure: effects on left ventricular performance and regional blood flow patterns.
Angiotensin deficiency in mice leads to dilated cardiomyopathy.
Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure.
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders.
Angiotensin II blockade [corrected] enhances baroreflex control of sympathetic outflow in heart failure.
Angiotensin II in the Failing Heart. Short Communication.
Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes.
Angiotensin II receptor antagonist treatment during pregnancy.
Angiotensin II receptor antagonists - antihypertensive agents.
Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics.
Angiotensin II receptor blockade prevents acute renal sodium retention induced by low levels of orthostatic stress.
Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice.
Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice.
Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure.
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Angiotensin subtype 1 rReceptor (AT1) blockade improves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor.
Apoptosis induction and inhibition of cellular proliferation by angiotensin II: possible implication and perspectives.
AT1 and AT2 angiotensin receptor gene expression in human heart failure.
AT1 angiotensin II receptor inhibition in pacing-induced heart failure: effects on left ventricular performance and regional blood flow patterns.
AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model.
AT1 receptor blocker, but not an ACE inhibitor, prevents kidneys from hypoperfusion during congestive heart failure in normotensive and hypertensive rats.
AT1 receptor in paraventricular nucleus mediates the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
BLAST-AHF: insights into biased AT1 ligands and heart failure. Beginning of the end or end of the beginning?
Blockade of AT1 receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure.
Blockade of the renin-angiotensin system in heart failure in conscious dogs.
Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone.
Brain AT1 Receptor Activates the Sympathetic Nervous System through Toll-like Receptor 4 in Mice with Heart Failure.
Captopril and angiotensin II receptor antagonist therapy in a pacing model of heart failure.
Central AT1 receptors are involved in the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
Central inhibition of AT1receptors by eprosartan--in vitro autoradiography in the brain.
Changes of renal AQP2, ENaC, and NHE3 in experimentally induced heart failure: response to angiotensin II AT1 receptor blockade.
Chronic administration of angiotensin II receptor antagonist, TCV-116, in cardiomyopathic hamsters.
Chronic AT1 receptor blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival.
Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure.
Combined effects of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism in conscious pigs with congestive heart failure.
Comparison between angiotensin receptor antagonism and converting enzyme inhibition in heart failure. Differential acute effects according to the renin-angiotensin system activation.
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Difficult cases in heart failure: Raison d'Être behind ACE inhibitors and AT1 receptor combinations in chronic heart failure: chemical nuances or clinical significance?
Diverse effects of AT1 receptor antagonists on normal blood pressure and regulatory system.
Dose-related beneficial long-term hemodynamic and clinical efficacy of irbesartan in heart failure.
Effects of ACE inhibitor, AT1 antagonist, and combined treatment in mice with heart failure.
Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure.
Effects of angiotensin II type 1 receptor blockade in ApoE-deficient mice with post-ischemic heart failure.
Effects of angiotensin receptor antagonists in heart failure: clinical and experimental aspects.
Effects of AT1 receptor antagonist therapy in patients with severe heart failure pretreated with angiotensin-converting enzyme inhibitors.
Effects of long-term angiotensin II AT1 receptor blockade on survival, hemodynamics and cardiac remodeling in chronic heart failure in rats.
From bedside to bench--meeting report of the 7th International Conference on cGMP "cGMP: generators, effectors and therapeutic implications" in Trier, Germany, from June 19th to 21st 2015.
Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation.
Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure.
Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.
In heart failure with reduced ejection fraction patients' left ventricular global longitudinal strain is enhanced after 1-year therapy with sacubitril/valsartan compared with conventional therapy with angiotensin-converting enzyme-inhibitors or AT1 blockers: results from a retrospective cohort study.
Initial white blood cell count is an independent risk factor for survival in patients with dilated cardiomyopathy.
Interaction between AT1 and alpha1-adrenergic receptors in cardiomyopathic hamsters.
Interaction Between AT1 Receptor and NF-?B in Hypothalamic Paraventricular Nucleus Contributes to Oxidative Stress and Sympathoexcitation by Modulating Neurotransmitters in Heart Failure.
Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure.
Leptin, Galectin-3 and Angiotensin II Type 1 Receptor Polymorphism in Overweight and Obese Patients with Heart Failure - Role and Functional Interplay.
Long-term combined therapy with an angiotensin type I receptor blocker and an angiotensin converting enzyme inhibitor prolongs survival in dilated cardiomyopathy.
Losartan corrects abnormal frequency response of renal vasculature in congestive heart failure.
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Management of hypertension and heart failure with AT1 receptor blockade.
Managing hypertension in patients with heart failure: an ongoing quandary.
Mechanism of beta-adrenergic receptor upregulation induced by ACE inhibition in cultured neonatal rat cardiac myocytes: roles of bradykinin and protein kinase C.
Mitochondrial ROS-induced ERK1/2 Activation and HSF2-mediated AT1 R Upregulation Are Required for Doxorubicin-induced Cardiotoxicity.
Modulation of oxidative stress by a selective inhibition of angiotensin II type 1 receptors in MI rats.
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems.
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes.
Molecular biology of angiotensin receptors and their role in human cardiovascular disease.
Molecular signaling mediated by angiotensin II type 1A receptor blockade leading to attenuation of renal dysfunction-associated heart failure.
Myocardial angiotensin receptors in human hearts.
Myocardial bradykinin following acute angiotensin-converting enzyme inhibition, AT1 receptor blockade, or combined inhibition in congestive heart failure.
Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.
New perspectives in angiotensin system control.
Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF.
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Olmesartan, a novel AT1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure.
Potential of renin inhibition in cardiovascular disease.
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism.
Reduced atrial angiotensin receptor type 1 mRNA content in end-stage human heart failure: assessment by a novel quantitative PCR-ELISA technique.
Regulation of the angiotensin receptor subtypes in cell cultures, animal models and human diseases.
Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 2. Overview of physiological and biochemical mechanisms.
Role of angiotensin II receptors in the regulation of vasomotor neurons in the ventrolateral medulla.
Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons.
Sacubitril and valsartan fixed combination to reduce heart failure events in post-acute myocardial infarction patients.
Sacubitril/valsartan: from a large clinical trial to clinical practice.
Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure.
Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction-induced heart failure.
Subtype 2 and atypical angiotensin receptors in the human heart.
Sympatho-inhibitory properties of various AT1 receptor antagonists.
The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?
The angiotensin II type 2 receptor and the kidney.
The central vasopressinergic system in experimental left ventricular hypertrophy and dysfunction.
The preclinical basis of the therapeutic evaluation of losartan.
The Protective Effects of Compound 21 and Valsartan in Isoproterenol-Induced Myocardial Injury in Rats.
The Regulation of Central Angiotensin Type 1 Receptors and Sympathetic Outflow in Heart Failure.
The role of angiotensin II AT1 receptor in the maintenance of hemodynamics in a canine model of coronary microembolization-induced heart failure.
TNF-? in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters.
Use of angiotensin II antagonists in human heart failure: function of the subtype 1 receptor.
Valsartan and coronary haemodynamics in early post-myocardial infarction in rats.
Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice.
[Angiotensin receptor antagonist for therapy of patients with hypertension]
[AT1 blockers against heart failure. The charm of polypharmacy]
[Bradykinin and ventricular function]
[Candesartan cilexetil: pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist]
[Distribution and function of angiotensin receptor subtypes in cardiovascular system]
[ESC guidelines for therapy of heart failure. AT1 blockers are now also included]
[Heart failure. Who benefits from an AT1 blocker?]
[Irbesartan in the treatment of arterial hypertension]
[Levosimendan: a new option in the pharmacologic management of cardiac insufficiency]
[Options in drug combinations]
[Tendency and prospect of the development of new ARBs]
[The ACE inhibitor, captopril, in the light of new clinical studies]
[Therapy of heart failure. Which patients does the AT1 blocker help?]
Heart Failure, Diastolic
AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure.
Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and 'overdrive' of the endothelin system.
[Diastolic heart failure: AT1 blocker without effect]
[Differential therapy with calcium antagonists]
Heart Failure, Systolic
Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension.
Hepatitis B
A bivalent antihypertensive vaccine targeting L-type calcium channels and angiotensin AT1 receptors.
Hepatitis C
Angiotensin II Activates IkappaB Kinase Phosphorylation of RelA at Ser(536) to Promote Myofibroblast Survival and Liver Fibrosis.
Hermanski-Pudlak Syndrome
AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells.
Gene-edited MLE-15 Cells as a Model for the Hermansky Pudlak Syndromes.
In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.
Herpes Simplex
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
[Anti-idiotypic antibodies to the herpes simplex type-1 virus neutralize the virus' infectious activity]
Herpes Zoster
Agonist-induced phosphorylation of the endogenous AT1 angiotensin receptor in bovine adrenal glomerulosa cells.
Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide.
Angiotensin II receptor subtypes in the adrenals of pregnant rats.
Angiotensin II receptors in the human adrenal gland.
Angiotensin II stimulates both aldosterone secretion and DNA synthesis via type 1 but not type 2 receptors in bovine adrenocortical cells.
Angiotensin II stimulates growth and steroidogenesis in zona fasciculata/reticularis cells from bovine adrenal cortex via the AT1 receptor subtype.
Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor.
Characterization of a specific antibody to the rat angiotensin II AT1 receptor.
Differential regulation of angiotensin II receptor subtypes in the adrenal gland: role of aldosterone.
Distribution and functional significance of angiotensin-II AT1- and AT2-receptor subtypes in the rat adrenal gland.
Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice.
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats.
Gene expression of the type-1 angiotensin II receptor in rat adrenal gland.
Immunocytochemical localization of angiotensin II receptor subtypes 1 and 2 in the porcine fetal, prepubertal and postpubertal ovary.
Immunohistochemical Localization of AT1a, AT1b, and AT2 Angiotensin II Receptor Subtypes in the Rat Adrenal, Pituitary, and Brain with a Perspective Commentary.
Influence of dietary sodium restriction on angiotensin II receptors in rat adrenals.
Internalization of the type I angiotensin II receptor (AT1) is required for protein kinase C activation but not for inositol trisphosphate release in the angiotensin II stimulated rat adrenal zona glomerulosa cell.
Localization of a novel non-peptide angiotensin II type 1 receptor antagonist, E4177, in rat adrenal glomerulosa.
Locally generated angiotensin II in the adrenal gland regulates basal, corticotropin-, and potassium-stimulated aldosterone secretion.
Multiple signal transduction systems regulate angiotensin II type 1 (AT1) receptor mRNA expression in bovine adrenocortical cells.
Ontogeny and regulation of the AT1 and AT2 receptors in the ovine fetal adrenal gland.
Role of angiotensin II receptor subtypes on the regulation of aldosterone secretion in the adrenal glomerulosa zone in the rat.
The angiotensin AT2 receptor is present in the human fetal adrenal gland throughout the second trimester of gestation.
Hodgkin Disease
The Reed-Steinberg cell: molecular characterization by proteomic analysis with therapeutic implications.
Huntington Disease
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
Hydronephrosis
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract.
Hyperaldosteronism
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism.
Influence of antihypertensive medication on aldosterone and renin concentration in the differential diagnosis of essential hypertension and primary aldosteronism.
Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma.
Hyperalgesia
A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception.
Effect of subpressor dose of angiotensin II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells in the rat dorsal root ganglia.
Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice.
Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting.
Hypercalcemia
Hypercalcemia stimulates expression of intrarenal phospholipase A2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors.
Hypercholesterolemia
Angiotensin II AT1 receptor blockade improves renal perfusion in hypercholesterolemia.
Angiotensin II type 1 (AT1) receptor deficiency halts the progression of age-related atherosclerosis in hypercholesterolemia: molecular link between the AT1 receptor and hypercholesterolemia.
Angiotensin II type 1 receptor antagonism improves hypercholesterolemia-associated endothelial dysfunction.
Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression.
Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits.
Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system.
Regulation of the angiotensin AT1 receptor expression by hypercholesterolemia.
Renin-angiotensin system at the crossroad of hypertension and hypercholesterolemia.
Role of blood cell-associated AT1 receptors in the microvascular responses to hypercholesterolemia.
Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men.
Hyperemia
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
Hyperglycemia
Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2).
Baseline glucose and left ventricular remodeling after acute myocardial infarction.
Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.
Elevation of [Ca2+]i of renal proximal tubular cells and down-regulation of mRNA of PTH-PTHrP, V1a and AT1 receptors in kidney of diabetic rats.
Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor.
The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors.
Hyperhomocysteinemia
Synergism between AT1 receptor and hyperhomocysteinemia during vascular remodeling.
Hyperinsulinism
Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats.
Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms.
Insulin treatment enhances AT1 receptor function in OK cells.
Hyperlipidemias
AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia.
Combined effect of ACE inhibitor and exercise training on insulin resistance in type 2 diabetic rats.
Hyperphosphatemia
Measurement of serum electrolytes and phosphate after sodium phosphate colonoscopy bowel preparation: an evaluation.
Hypersensitivity
A Local Inflammatory Renin-Angiotensin System Drives Sensory Axon Sprouting in Provoked Vestibulodynia.
Angiotensin II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats.
Angiotensin II pressor response in the L-NAME-induced hypertensive pithed rat: role of the AT1 receptor.
Angiotensin II Receptor Type 2 Activation Is Required for Cutaneous Sensory Hyperinnervation and Hypersensitivity in a Rat Hind Paw Model of Inflammatory Pain.
Efficacy and tolerability of angiotensin II type 1 receptor antagonists in dialysis patients using AN69 dialysis membranes.
Nitric oxide: a physiological mediator of the type 2 (AT2) angiotensin receptor.
Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor.
The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women: early- versus late-onset pre-eclampsia.
Update: role of the angiotensin type-2 (AT(2)) receptor in blood pressure regulation.
Upregulation of angiotensin II type 1 receptor gene expression in chronic renovascular hypertension.
[Behavioral and Molecular Pharmacological Study of the Role of Angiotensin II in Spinal Pain Transmission].
Hypertension
(Pro)renin receptor knockdown in the paraventricular nucleus of the hypothalamus attenuates hypertension development and AT1 receptor-mediated calcium events.
A case of lithium intoxication induced by an antihypertensive angiotensin 1 subtype-specific angiotensin II receptor blocker in an elderly patient with bipolar disorder and hypertension.
A new class of therapeutic agents: the angiotensin II receptor antagonists.
A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension.
A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study.
ABPM comparison of the antihypertensive profiles of the selective angiotensin II receptor antagonists telmisartan and losartan in patients with mild-to-moderate hypertension.
Absence of a pharmacokinetic interaction between losartan and hydrochlorothiazide.
ACE inhibitors versus AT1 blockers in the treatment of hypertension and syndrome X.
Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats.
Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats.
Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells.
Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension.
Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.
Acute hypertension after nitric oxide synthase inhibition is mediated primarily by increased endothelin vasoconstriction.
Acute myocardial and vascular responses to specific angiotensin II antagonism in the spontaneously hypertensive rat.
Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.
Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide.
Agonistic autoantibodies against the angiotensin AT1 receptor increase in unstable angina patients after stent implantation.
Alpha-adrenergic systems mediate chronic central AII hypertension in rats fed high sodium chloride diet from weaning.
Alterations in sarcoplasmic reticulum and angiotensin II receptor type 1 gene expression in spontaneously hypertensive rat hearts.
Altered AT1 receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats.
Altered expression of vascular natriuretic peptide receptors in experimental hypertensive rats.
An ab initio study of AT2 antagonists.
An effort to understand the molecular basis of hypertension through the study of conformational analysis of losartan and sarmesin using a combination of nuclear magnetic resonance spectroscopy and theoretical calculations.
An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation.
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Angiotensin AT1 receptor over-expression in hypercholesterolaemia.
Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats.
Angiotensin AT2 receptor as a potential therapeutic target in hypertension.
Angiotensin blocking drugs and the heart beyond 2000.
Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension.
Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice.
Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension.
Angiotensin II and serotonin potentiate endothelin-1-induced vascular smooth muscle cell proliferation.
Angiotensin II AT1 receptor alters ACE2 activity, eNOS expression and CD44-hyaluronan interaction in rats with hypertension and myocardial fibrosis.
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders.
Angiotensin II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats.
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism.
Angiotensin II pressor response in the L-NAME-induced hypertensive pithed rat: role of the AT1 receptor.
Angiotensin II receptor antagonist treatment during pregnancy.
Angiotensin II receptor antagonists - antihypertensive agents.
Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.
Angiotensin II receptor blockade in TGR(mREN2)27: effects of renin-angiotensin-system gene expression and cardiovascular functions.
Angiotensin II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR.
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats.
Angiotensin II type 1 autoantibody induced hypertension during pregnancy is associated with renal endothelial dysfunction.
Angiotensin II type 1 receptor antagonist and angiotensin-converting enzyme inhibitor altered the activation of Cu/Zn-containing superoxide dismutase in the heart of stroke-prone spontaneously hypertensive rats.
Angiotensin II type 1 receptor antibodies in childhood kidney transplantation.
Angiotensin II type 1 receptor blockade by telmisartan prevents stress-induced impairment of memory via HPA axis deactivation and up-regulation of brain-derived neurotrophic factor gene expression.
Angiotensin II type 1 receptor blocker irbesartan ameliorates vascular function in spontaneously hypertensive rats regardless of oestrogen status.
Angiotensin II type 1 receptor gene A1166C polymorphism and essential hypertension in Chinese: a meta-analysis.
Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension.
Angiotensin II type 1 receptor is involved in hypertension and vascular alterations caused by environmental toxicant hexachlorobenzene.
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.
Angiotensin II type 2 receptor agonists--where should they be applied?
Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension.
Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium.
Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide.
Angiotensin II-Mediated Microvascular Thrombosis.
Angiotensin in the kidney: a key to understanding hypertension?
Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats.
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Angiotensin type 1 receptor blockade prevents cardiac remodeling in mice with pregnancy-associated hypertension.
Angiotensin type 2 receptor-mediated phosphorylation of eNOS in the aortas of mice with 2-kidney, 1-clip hypertension.
Angiotensin Type-2 (AT-2)-Receptor activation reduces renal fibrosis in cyclosporine nephropathy: Evidence for blood-pressure independent effect.
Antagonizing the angiotensin II subtype 1 receptor: a focus on olmesartan medoxomil.
Antihypertensive effects of a mixed endothelin-A- and -B-receptor antagonist, J-104132, were augmented in the presence of an AT1 -receptor antagonist, MK-954.
Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin.
Antisense oligonucleotide to AT1 receptor mRNA inhibits central angiotensin induced thirst and vasopressin.
Aortic collagen, aortic stiffness, and AT1 receptors in experimental and human hypertension.
Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study.
Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects.
Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade.
AT(2) receptor and tissue injury: therapeutic implications.
AT1 and TxA2/PGH2 receptors maintain hypertension throughout 2K,1C Goldblatt hypertension in the rat.
AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.
AT1 antagonists: a patent review (2008 - 2012).
AT1 receptor agonistic antibodies, hypertension, and preeclampsia.
AT1 receptor antagonist prevents brain edema without lowering blood pressure.
AT1 receptor antagonist treatment caused persistent arterial functional changes in young spontaneously hypertensive rats.
AT1 receptor antisense therapy transiently lowers blood pressure in Ren-2 transgenic rats.
AT1 receptor blockade in experimental myocardial ischemia/reperfusion.
AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension.
AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats.
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats.
AT1 receptor blockers--cost-effectiveness within the South African context.
AT1 receptor density changes during development of hypertension in hyperinsulinemic rats.
AT1 receptor expression in glomeruli from NO-deficient rats.
AT1 receptor mediated augmentation of intrarenal angiotensinogen in angiotensin II-dependent hypertension.
AT1 receptor signaling pathways in the cardiovascular system.
AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension.
AT1 receptors mediate chronic central nervous system AII hypertension in rats fed high sodium chloride diet from weaning.
AT1 receptors mediate pressor responses induced by angiotensin II in the periaqueductal gray area of rats.
AT2 Receptor Activation Prevents Sodium Retention and Reduces Blood Pressure in Angiotensin II-Dependent Hypertension.
AT2 receptor agonists: hypertension and beyond.
AT2 receptor: Its role in obesity associated hypertension.
AT2 Receptors: Potential Therapeutic Targets for Hypertension.
Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats.
Beraprost Sodium, a Stable Analogue of PGI2, Inhibits the Renin-Angiotensin System in the Renal Tissues of Rats with Chronic Renal Failure.
Biphasic effects of angiotensin II and receptor antagonism on aggregability and protein kinase C phosphorylation in human platelets.
Blockade of AT1 receptor reduces apoptosis, inflammation, and oxidative stress in normotensive rats with intracerebral hemorrhage.
Blockade of AT1 receptors by specific antibody attenuated hypertension development in young spontaneously hypertensive rats.
Blood pressure and proteinuria after cessation of a brief renin-angiotensin system blockade in young and adult Lyon hypertensive rats.
Blood pressure lowering and renin-angiotensin system blockade.
BR 08-3 MANAGEMENT OF DYSLIPIDEMIA IN HYPERTENSION.
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities.
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice.
C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice.
Candesartan cilexetil on regular hemodialysis: inability to reduce excessive thirst, but good tolerance and efficacy in hypertensive patients.
Candesartan: a new-generation angiotensin II AT1 receptor blocker: pharmacology, antihypertensive efficacy, renal function, and renoprotection.
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice.
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension.
Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate-salt hypertension in rats.
Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla: the push-pull hypothesis.
Cardiovascular effects of GR117289, a novel angiotensin AT1 receptor antagonist.
Caspase-dependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats.
Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.
Central inhibition of AT1receptors by eprosartan--in vitro autoradiography in the brain.
Central Mineralocorticoid Receptors and the Role of Angiotensin II and Glutamate in the Paraventricular Nucleus of Rats With Angiotensin II-Induced Hypertension.
Cerebroventricular injection of angiotensin II antagonist: effects on blood pressure responses to central and systemic angiotensin II.
Changes in angiotensin AT1 receptor density during hypertension in fructose-fed rats.
Changes in endothelium-derived hyperpolarizing factor in hypertension and ageing: response to chronic treatment with renin-angiotensin system inhibitors.
Changes in protein and gene expression of angiotensin II receptors (AT1 and AT2) in aorta of diabetic and hypertensive rats.
Characterization of polymorphisms in the promoter of the human angiotensin II subtype 1 (AT1) receptor gene.
Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.
Chronic AT1 receptor blockade alters aortic nerve activity in hypertension.
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.
Chronic effects of central and systemic administration of losartan on blood pressure and baroreceptor reflex in spontaneously hypertensive rats.
Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat.
Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist.
Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.
Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension.
Combined treatment with ibuprofen and the AT1 receptor antagonist candesartan in young spontaneously hypertensive rats.
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. AT1 receptors in the kidney mediate the chronic hypertensive response to angiotensin II.
Comparison between chronic converting enzyme inhibition and AT1 blockade in mRen2 transgenic rats.
Comparison of angiotensin II receptor antagonists.
Comparison of circulating and local adipose tissue renin-angiotensin system in normotensive and hypertensive obese subjects.
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Conformation and bioactivity. Design and discovery of novel antihypertensive drugs.
Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury.
Control of renal sympathetic nerve activity by neurotransmitters in the spinal cord in Goldblatt hypertension.
Coordinate regulation of canine glomeruli and adrenal angiotensin receptors by dietary sodium manipulation.
Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Curcumin Exerts its Anti-hypertensive Effect by Down-regulating the AT1 Receptor in Vascular Smooth Muscle Cells.
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue.
Design and synthesis of novel antihypertensive drugs.
Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition.
Differential expression of AT1 receptors in the pituitary and adrenal gland of SHR and WKY.
Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC.
Differential regulation of renal angiotensin subtype AT1A and AT2 receptor protein in rats with angiotensin-dependent hypertension.
Direct analysis of valsartan or candesartan in human plasma and urines by on-line solid phase extraction coupled to electrospray tandem mass spectrometry.
Direct Renin Inhibition With Aliskiren Normalizes Blood Pressure in Cyp1a1-Ren2 Transgenic Rats With Inducible Angiotensin II-Dependent Malignant Hypertension.
Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
Distinct mechanisms of modulation of angiotensin II type I receptor gene expression in heart and aorta.
Does blockade of angiotensin II receptors offer clinical benefits over inhibition of angiotensin-converting enzyme?
Early and late haemodynamic and morphological effects of angiotensin II subtype 1 receptor blockade during genetic hypertension development.
Effect of an angiotensin II receptor antagonist, TCV-116, on cardiac hypertrophy and coronary circulation in spontaneously hypertensive rats.
Effect of AT1 receptor blockade on hepatic redox status in SHR: possible relevance for endothelial function?
Effect of chronic treatment with ME3221 on blood pressure and mortality in aged stroke-prone spontaneously hypertensive rats.
Effect of Combined Treatment with AT1 Receptor Antagonists and Tiagabine on Seizures, Memory and Motor Coordination in Mice.
Effect of sodium on blood pressure, cardiac hypertrophy, and angiotensin receptor expression in rats.
Effect of sodium on vasoconstriction and angiotensin II type 1 receptor mRNA expression in cold-induced hypertensive rats.
Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats.
Effects and mechanism of irbesartan on tubulointerstitial fibrosis in 5/6 nephrectomized rats.
Effects of angiotensin type 2 receptor on secretion of the locus coeruleus in stress-induced hypertension rats.
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension and coronary artery disease.
Effects of candesartan cilexetil in patients with systemic hypertension. Candesartan Cilexetil Study Investigators.
Effects of candesartan cilexetil on glucose homeostasis. Multicenter Study Group.
Effects of centrally administered losartan on deoxycorticosterone-salt hypertension rats.
Effects of changes in sodium balance on plasma and kidney angiotensin II levels in anesthetized and conscious Ren-2 transgenic rats.
Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat.
Effects of high salt intake on brain AT1 receptor densities in Dahl rats.
Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat.
Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats.
Effects of quinapril on expression of eNOS, ACE, and AT1 receptor in deoxycorticosterone acetate-salt hypertensive rats.
Efficacy and safety of telmisartan, a selective AT1 receptor antagonist, compared with enalapril in elderly patients with primary hypertension. TEES Study Group.
Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation.
Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension.
Enhanced Angiotensin II type 1 receptor expression in leukocytes of patients with chronic kidney disease.
Enhanced platelet release of superoxide anion in systemic hypertension: role of AT1 receptors.
Enhanced pressor response to angiotensin III in spontaneously hypertensive rats: effects of losartan.
Eprosartan provides safe and effective long-term maintenance of blood pressure control in patients with mild to moderate essential hypertension.
Estrogen modulates AT1 receptor gene expression in vitro and in vivo.
Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2.Lewis rat.
Evaluation of three polymorphisms in the promoter region of the angiotensin II type I receptor gene.
Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension.
Exaggerated tubuloglomerular feedback activity in genetic hypertension is mediated by ANG II and AT1 receptors.
Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats.
Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.
Favourable effects on arterial wave reflection and pulse pressure amplification of adding angiotensin II receptor blockade in resistant hypertension.
Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats.
Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant.
Gene therapy for hypertension: sense and antisense strategies.
Gene therapy for hypertension: the preclinical data.
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor.
Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus.
Haemodynamic effects of AT1 inhibition and Ca(2+)-channel blockade in hypertensive patients during isometric stress.
Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension.
High-salt intake accelerates functional and histological renal damage associated with renal tissue overexpression of (pro)renin receptors and AT1 receptors in spontaneously hypertensive rats.
Homology modeling, binding site identification and docking study of human angiotensin II type I (Ang II-AT1) receptor.
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
Hypercholesterolemia blunts the oxidative stress elicited by hypertension in venules through angiotensin II type-2 receptors.
Hypersensitivity of the adrenal cortex to trophic and secretory effects of angiotensin II in Lyon genetically-hypertensive rats.
Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1 R and ecNOS.
Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage.
Hypertension study in anesthetized rabbits: protocol proposal for AT1 antagonists screening.
Hypertension: AT1 autoantibodies and response to therapy.
Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.
Identification of a cis-acting glucocorticoid responsive element in the rat angiotensin II type 1A promoter.
Identification of AT1 receptors on human platelets and decreased angiotensin II binding in hypertension.
Identification of reference genes for quantitative RT-PCR in ascending aortic aneurysms.
Identifying structural features related to the biological activity of a series of AT1 antagonists from fragment-based drug design.
IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy.
Immunohistochemical localization of angiotensin II receptor types 1 and 2 in the mesenteric artery from spontaneously hypertensive rats.
Immunologic Effects of the Renin-Angiotensin System.
Impact of kinins in the treatment of cardiovascular diseases.
In hypertension, the kidney rules.
In silico identification of novel lead compounds with AT1 receptor antagonist activity: successful application of chemical database screening protocol.
In vitro pharmacology of a novel non-peptide angiotensin II-receptor antagonist, E4177.
In vivo and in vitro characterization of the novel antiarrhythmic agent SSR149744C: electrophysiological, anti-adrenergic, and anti-angiotensin II effects.
In vivo pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for AT2 receptors.
Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1-/- mice.
Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension.
Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats.
Influence of active immunization against angiotensin AT1 or AT2 receptor on hypertension development in young and adult SHR.
Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat.
Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: results from the study of optimal treatment in hypertensive patients with anti-AT1-receptor autoantibodies trial.
Influence of irbesartan and enalapril on changes of renal function associated with the established phase of l-NAME hypertension.
INFLUENCE OF POLYMORPHISM OF GENES INVOLVED IN ARTERIAL HYPERTENSION: ANGIOTENSIN I CONVERTING ENZYME (ACE); ANGIOTENSINOGEN (AGT); AT1 RECEPTOR OF ANGIOTENSIN II (AT1-R); AND ENDOTHELIAL CONSTITUTIVE NO SYNTHASE (ecNOS); ON LONG TERM RESULTS AFTER RENAL TRANSPLANTATION.
Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats.
Inhibition of pressure natriuresis in mice lacking the AT2 receptor.
Insights into angiotensin II receptor function through AT2 receptor knockout mice.
Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms.
Insulin treatment enhances AT1 receptor function in OK cells.
Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cell proliferation.
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells.
Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats.
Intrarenal angiotensin II and hypertension.
Intrarenal angiotensin II augmentation in angiotensin II dependent hypertension.
Intrarenal angiotensin II generation and renal effects of AT1 receptor blockade.
Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury.
Investigation of angiotensin II/AT1 receptors with carbon-11-L-159,884: a selective AT1 antagonist.
Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin-converting enzyme inhibitor therapy?
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.
Lack of association between angiotensin II type 1 receptor gene polymorphism and hypertension in Japanese.
Localization and functional properties of angiotensin II AT1 receptors in the kidney: focus on renomedullary interstitial cells.
Long-term blood pressure telemetry in AT2 receptor-disrupted mice.
Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT1 receptor blockade.
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
Losartan and atenolol on hypertension induced by adenosine receptor blockade.
Losartan reduces the increased participation of cyclooxygenase-2-derived products in vascular responses of hypertensive rats.
Losartan renography for the detection of renal artery stenosis: comparison with captopril renography and evaluation of dose and timing.
Losartan, a selective inhibitor of subtype AT1 receptors for angiotensin II, inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors.
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
MALDI-TOF/MS-based label-free binding assay for angiotensin II type 1 receptor: application for novel angiotensin peptides.
Management of hypertension and heart failure with AT1 receptor blockade.
Management of hypertension: the advent of a new angiotensin II receptor antagonist.
Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension.
Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertension.
Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.
Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure.
Moderate-intensity exercise and renin angiotensin system blockade improve the renovascular hypertension (2K1C)-induced gastric dysmotility in rats.
Modulating Role of Ang1-7 in Control of Blood Pressure and Renal Function in AngII-infused Hypertensive Rats.
Modulation of haemodynamics, endogeneous antioxidant enzymes, and pathophysiological changes by selective inhibition of angiotensin II type 1 receptors in pressureoverload rats.
Molecular biology of angiotensin receptors and their role in human cardiovascular disease.
Molecular mechanism of angiotensin II type I and type II receptors in cardiac hypertrophy of spontaneously hypertensive rats.
Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockade.
Neuroendocrine mechanisms of acupuncture in the treatment of hypertension.
New perspectives in angiotensin system control.
Nitric oxide: a physiological mediator of the type 2 (AT2) angiotensin receptor.
Non-peptide angiotensin type 1 receptor antagonists in the treatment of hypertension.
Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition.
Normalizing the expression of nitric oxide synthase by low-dose AT1 receptor antagonism parallels improved vascular morphology in hypertensive rats.
Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension.
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Olmesartan improves endothelin-induced hypertension and oxidative stress in rats.
Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats.
Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy.
Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension.
Participation of 5-HT and AT1 Receptors within the Rostral Ventrolateral Medulla in the Maintenance of Hypertension in the Goldblatt 1 Kidney-1 Clip Model.
Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin II and sodium.
Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats.
Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats.
Pharmacokinetic and pharmacodynamic interaction of single doses of valsartan and atenolol.
Pharmacologic profiles of KRH-594, a novel nonpeptide angiotensin II-receptor antagonist.
Pharmacological Potential of Exercise and RAS Vasoactive Peptides for Prevention of Diseases.
Physiopathological implications of P2X1 and P2X7 receptors in regulation of glomerular hemodynamics in angiotensin II-induced hypertension.
Position Paper of the Department of Hypertension of the Brazilian Society of Nephrology: Use of renin-angiotensin system blockers during the course of Covid-19 infection.
Postovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity.
Potential of renin inhibition in cardiovascular disease.
Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects.
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Prevention of diabetes and left ventricular hypertrophy with AT1 receptor blockade for hypertension.
Prolonged angiotensin II antagonism in spontaneously hypertensive rats. Hemodynamic and biochemical consequences.
Prolonged reduction of high blood pressure with an in vivo, nonpathogenic, adeno-associated viral vector delivery of AT1-R mRNA antisense.
Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model.
Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice.
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
Quantitative localization of angiotensin II receptor subtypes in spontaneously hypertensive rats.
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism.
Recent progress in molecular and cell biological studies of angiotensin receptors.
Recent Updates on the Proximal Tubule Renin-Angiotensin System in Angiotensin II-Dependent Hypertension.
Redox-sensitive regulation of lox-1 gene expression in vascular endothelium.
Regulation of ANG II receptor in hypertension: role of ANG II.
Regulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension.
Regulation of growth of the adrenal gland in DOC-salt hypertension. Role of angiotensin II receptor subtypes.
Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone.
Regulation of the angiotensin AT1 receptor expression by hypercholesterolemia.
Regulation of the angiotensin receptor subtypes in cell cultures, animal models and human diseases.
Regulation of the gene-encoding angiotensin II receptor in vascular tissue.
Relation of renin-angiotensin system gene polymorphisms and expressions with the efficacy of antihypertensive drugs.
Renal angiotensin II receptors, hyperinsulinemia, and obesity.
Renal AT1 receptor: computerized quantification in spontaneously hypertensive rats and DOCA-salt rats.
Renal responses to AT1 receptor blockade.
Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor.
Renin-angiotensin system and fibronectin gene expression in Dahl Iwai salt-sensitive and salt-resistant rats.
Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 2. Overview of physiological and biochemical mechanisms.
Renin-angiotensin system: upgrade of recent knowledge and perspectives.
Resistance to oxidative stress by chronic infusion of angiotensin II in mouse kidney is not mediated by the AT2 receptor.
Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats.
Role of angiotensin AT1, and AT2 receptors in cardiac hypertrophy and disease.
Role of angiotensin II and bradykinin on aortic collagen following converting enzyme inhibition in spontaneously hypertensive rats.
Role of angiotensin II and endogenous vasodilators in the control of glomerular hemodynamics.
Role of angiotensin II AT1 receptor blockers in the treatment of arterial hypertension.
Role of anterior hypothalamic angiotensin II in the pathogenesis of salt sensitive hypertension in the spontaneously hypertensive rat.
Role of AT1 and AT2 receptor subtypes in salt-sensitive hypertension induced by sensory nerve degeneration.
Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR.
Role of bradykinin in renoprotective effects by angiotensin II type 1 receptor antagonist in salt-sensitive hypertension.
Role of central angiotensin II receptors in cold-induced hypertension.
Role of GRK4 in the regulation of arterial AT1 receptor in hypertension.
Role of GRK4 in the Regulation of Arterial AT1 Receptor in Hypertension.
Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat.
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Role of paraventricular angiotensin AT1 receptors in salt-sensitive hypertension in mRen-2 transgenic rats.
Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implications.
Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats.
Role of vascular smooth muscle PPAR? in regulating AT1 receptor signaling and angiotensin II-dependent hypertension.
Roles of angiotensin type 1 and 2 receptors in pregnancy-associated blood pressure change.
Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney.
Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension.
Safety and efficacy of eprosartan, a new angiotensin II receptor blocker.
Salt induces vascular AT1 receptor overexpression in vitro and in vivo.
Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan.
Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat.
Sex Differences in the Renal Vascular Responses of AT1 and Mas Receptors in Two-Kidney-One-Clip Hypertension.
Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.
Stress and angiotensin II: novel therapeutic opportunities.
Structural adaptation to ischemia in skeletal muscle: effects of blockers of the renin-angiotensin system.
Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor.
Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats.
Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor.
Sympatho-inhibitory properties of various AT1 receptor antagonists.
Target organ protection from a novel angiotensin II receptor (AT1) vaccine ATR12181 in spontaneously hypertensive rats.
Targeting of the renin-angiotensin system by antisense gene therapy: a possible strategy for the long-term control of hypertension.
Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers.
Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-? agonism via SARM and MyD88 signaling.
The angiotensin AT2 receptor in left ventricular hypertrophy.
The angiotensin II AT1 receptor antagonist irbesartan prevents thromboxane A2-induced vasoconstriction in the rat hind-limb vascular bed in vivo.
The angiotensin II receptor antagonist valsartan enhances lipoprotein lipase mass in preheparin serum in type 2 diabetes with hypertension.
The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?
The angiotensin II type 2 receptor and the kidney.
The angiotensin II type 2 receptor in cardiovascular disease.
The angiotensin II type 2 receptor in the brain.
The angiotensin receptor antagonist, irbesartan, reduces renal injury in experimental chronic renal failure.
The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease.
The compensatory renin-angiotensin system in the central regulation of arterial pressure: new avenues and new challenges.
The effects of novokinin, an AT2 agonist, on blood pressure, vascular responses, and levels of ADMA, NADPH oxidase, and Rho kinase in hypertension induced by NOS inhibition and salt.
The immune system and hypertension.
The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension.
The neurogenic origin of hypertension in SHR may be mediated by angiotensin II through a receptor different from AT1 and AT2.
The potential role of angiotensin II in the vasculature.
The preclinical basis of the therapeutic evaluation of losartan.
The Role of AT1 Receptor-Mediated Salt Retention in Angiotensin II-Dependent Hypertension.
The Role of Endothelial Dysfunction in Aortic Aneurysms.
The role of macrophages in hypertension and its complications.
The role of the AT2 receptor in hypertension.
The tissue renin-angiotensin system in rats with fructose-induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue.
The use of ultralow doses of antibodies to C-terminal fragment of angiotensin II AT1 receptor (kardos) in the therapy of arterial hypertension.
Therapeutic advantages of AT1 blockers in hypertension.
Thiazide diuretics, endothelial function, and vascular oxidative stress.
Time course of inhibition of hypertension by antisense oligonucleotides targeted to AT1 angiotensin receptor mRNA in spontaneously hypertensive rats.
Time course of losartan blockade of angiotensin II hypertension versus blockade of angiotensin II fast pressor effects.
Tissue transglutaminase-mediated AT1 receptor sensitization underlies pro-inflammatory cytokine LIGHT-induced hypertension.
Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-gamma in vascular smooth muscle cells.
Understanding electrostatic and steric requirements related to hypertensive action of AT(1) antagonists using molecular modeling techniques.
Up-regulation of Akt and eNOS induces vascular smooth muscle cell differentiation in hypertension in vivo.
Update: role of the angiotensin type-2 (AT(2)) receptor in blood pressure regulation.
Upregulation of angiotensin II type 1 receptor gene expression in chronic renovascular hypertension.
Upregulation of AT1 Receptor Mediates a Pressor Effect Through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats With Stress-Induced Hypertension.
Upregulation of AT2 receptor and iNOS impairs angiotensin II-induced contraction without endothelium influence in young normotensive diabetic rats.
Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy.
Vascular angiotensin AT1 receptor neuromodulation in fetal programming of hypertension.
Vascular angiotensin AT2 receptors in hypertension and ageing.
Vasodilation mediated by angiotensin II type 2 receptor is impaired in afferent arterioles of young spontaneously hypertensive rats.
Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.
Vulnerability to stress consequences induced by repeated social defeat in rats: Contribution of the angiotensin II type 1 receptor in cardiovascular alterations associated to low brain derived neurotrophic factor.
[Angiotensin receptor antagonist for therapy of patients with hypertension]
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
[AT1 angiotensin receptor inhibition as a new therapeutic possibility]
[AT1 blocker or calcium antagonist in treatment of hypertension. What protects the heart better?]
[AT1 blocker therapy of hypertension in seniors. Added protection for cerebral blood vessels?]
[AT1 blockers - comparability with ACE inhibitors].
[AT1 receptor antagonist lorsartan and organ protection. Managing hypertension a different way]
[AT1 receptor antagonists in treatment of hypertension]
[Candesartan cilexetil: pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist]
[Clinical study of the month. The LIFE study: cardiovascular protection of hypertensive patients by losartan]
[Concurrence to ACE inhibitors? AT1 receptor blockers and hypertension]
[Converting enzyme inhibitors or AT1 receptor blockers]
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
[Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]
[Effects of angiotensin II receptor antagonist on insulin sensitivity and sympathetic activity in spontaneously hypertensive rats]
[Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension]
[Fixed combination of AT1 blocker and diuretic. Stroke preventive combination for hypertension]
[Genetic predisposition to systemic complications of arterial hypertension in maintenance haemodialysis patients]
[German Hypertension League on the LIFE Study. New evaluation of AT1 receptor antagonists]
[Hypertrophy and ventricular remodeling in systemic arterial hypertension: role of AT1 receptors]
[Irbesartan--antihypertensive treatment in patients with heart failure and diabetes mellitus]
[Pathophysiological roles of angiotensin in the pathogenesis of hypertension and cardiovascular remodeling]
[Pharmacological properties and its significance in clinical practice]
[Signal transduction systems of angiotensin II receptors]
[Significance of the angiotensin-II receptor AT1 in the pathogenesis of arterial hypertension and arteriosclerosis]
[Study of autoantibodies against the G-protein-coupled beta 2- and alpha 1-adrenergic and AT1 receptors in patients with primary hypertension]
[Tendency and prospect of the development of new ARBs]
[The role of DNA polymorphism in the renin-angiotensin system and the pathogenesis of cardiovascular diseases]
[The usefulness of a new class antihypertensive drug, angiotensin II receptor antagonist, for essential hypertension]
[Therapy of hypertension. A new rapidly effective AT1 blocker]
[Therapy of hypertension. AT1 blockers soon to be the first choice?]
Hypertension, Malignant
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.
AT1 receptor blockade prevents the increase in blood pressure and the augmentation of intrarenal ANG II levels in hypertensive Cyp1a1-Ren2 transgenic rats fed with a high-salt diet.
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension.
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension.
Hypertension, Portal
Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension.
Hypertension, Pregnancy-Induced
Expression of angiotensin II receptor-like 1 in the placentas of pregnancy-induced hypertension.
Roles of angiotensin type 1 and 2 receptors in pregnancy-associated blood pressure change.
Hypertension, Pulmonary
Angiotensin II and monocrotaline-induced pulmonary hypertension: effect of losartan (DuP 753), a nonpeptide angiotensin type 1 receptor antagonist.
Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung.
Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats.
Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.
Lung angiotensin receptor binding characteristics during the development of monocrotaline-induced pulmonary hypertension.
Modification of the pulmonary renin-angiotensin system and lung structural remodelling in congestive heart failure.
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Selective Activation of At2 Receptor Attenuates Progression of Pulmonary Hypertension and Inhibits Cardiopulmonary Fibrosis.
[Angiotensin receptor in the lung]
[Effects of estrogen on ACE-Ang II-AT1 axis in ovariectomy and hypoxic pulmonary hypertension rats].
[Losartan prevents pulmonary hypertension induced by a thromboxane A2 analog]
Hypertension, Renal
Acute AT1 receptor blockade does not improve the depressed baroreflex in rats with chronic renal hypertension.
Angiotensin AT1 receptor blockade by specific antibody prevented two-kidney, one-clip renal hypertension in the rat.
Differential regulation of renal angiotensin subtype AT1A and AT2 receptor protein in rats with angiotensin-dependent hypertension.
Hypertension, Renovascular
ACE inhibition is superior to angiotensin receptor blockade for renography in renal artery stenosis.
Angiotensin II and the adrenal.
Angiotensin II receptors in cardiac left ventricles of Dahl rats.
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension.
Angiotensin type 2 receptor-mediated phosphorylation of eNOS in the aortas of mice with 2-kidney, 1-clip hypertension.
AT1 and TxA2/PGH2 receptors maintain hypertension throughout 2K,1C Goldblatt hypertension in the rat.
Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor.
Reliability of captopril renography in patients under chronic therapy with angiotensin II (AT1) receptor antagonists.
The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats.
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
Hyperthyroidism
Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem and propranolol.
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
Involvement of renin-angiotensin system in the reduced pressure natriuresis response of hyperthyroid rats.
Hypertriglyceridemia
Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats.
Hypertrophy, Left Ventricular
Angiotensin AT1/AT2 receptors: regulation, signalling and function.
Angiotensin II receptor gene expression in hypertrophied left ventricles of rat hearts.
Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor.
Angiotensin in the kidney: a key to understanding hypertension?
AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1.
Blockade of Angiotensin II Type 1 Receptor Improves the Arrhythmia Morbidity in Mice With Left Ventricular Hypertrophy.
Blood pressure lowering and renin-angiotensin system blockade.
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice.
Development of pressure overload induced cardiac hypertrophy is unaffected by long-term treatment with losartan.
Effect of combination of valsartan with benazepril on blood pressure and left ventricular hypertrophy in SHR.
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Experimental evidence for effects of ramipril on cardiac and vascular hypertrophy beyond blood pressure reduction.
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
Hypertension and angiogenesis.
Intronic ANG II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein expression but not mRNA splicing.
Prevention of diabetes and left ventricular hypertrophy with AT1 receptor blockade for hypertension.
Regression of left ventricular hypertrophy by AT1 receptor blockade in renal transplant recipients.
The angiotensin AT2 receptor in left ventricular hypertrophy.
[Clinical study of the month. The LIFE study: cardiovascular protection of hypertensive patients by losartan]
[Differential therapy with calcium antagonists]
Hypertrophy, Right Ventricular
Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep.
Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung.
Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.
Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27.
[Angiotensin receptor in the lung]
Hypoalbuminemia
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Hypoglycemia
AT1 and AT2 receptor blockade and epinephrine release during insulin-induced hypoglycemia.
AT1 receptor blockade and the sympathoadrenal response to insulin-induced hypoglycemia in humans.
Brain angiotensin receptors and sympathoadrenal regulation during insulin-induced hypoglycemia.
The AT1 receptor autoantibody causes hypoglycemia in fetal rats via promoting the STT3A-GLUT1-glucose uptake axis in liver.
Hypokalemia
Low-dose angiotensin AT1 receptor ?-arrestin-biased ligand, TRV027, protects against cisplatin-induced nephrotoxicity.
Hypophosphatemia
Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.
Hypophosphatemia, Familial
Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.
Hypotension
Angiotensin II AT2 receptor stimulation increases cerebrovascular resistance during hemorrhagic hypotension in rats.
Anomalous effects of losartan on aminopeptidase-induced reductions of blood pressure in SHR.
Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: an in vivo approach to the hypotensive mechanism.
CNS pathways mediating cardiovascular regulation of vasopressin.
Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats.
Endogenous angiotensin II in the paraventricular nucleus regulates arterial pressure during hypotension in rat, a single-unit study.
Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.
Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan.
Role of bradykinins and nitric oxide in the AT2 receptor-mediated hypotension.
Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implications.
Selective blockade of AT1 receptor attenuates impairment of hypotensive autoregulation and improves cerebral blood flow after brain injury in the newborn pig.
The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.
[Renal effects of AT1 angiotensin receptor antagonists (AT1ra)]
Hypoxia, Brain
Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats.
Idiopathic Pulmonary Fibrosis
Culture of human alveolar epithelial type II cells by sprouting.
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease.
Infarction, Middle Cerebral Artery
Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2.
Ischemic injury in experimental stroke depends on angiotensin II.
Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat.
Infections
Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.
Clostridium perfringens type E virulence traits involved in gut colonization.
Detection of angiotensin ii type i-receptor antibodies in transplant glomerulopathy.
G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.
Plant eR genes that encode photorespiratory enzymes confer resistance against disease.
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system.
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection.
The expression of human brain vascular smooth muscle cell AT receptor after the UL83 gene of HCMV inhibition by small interfering RNAs.
Infertility, Male
Angiotensin II regulates testicular peritubular cell function via AT1 receptor: a specific situation in male infertility.
Decreased angiotensin receptor 1 expression in?±?AT1 Knockout mice testis results in male infertility and GnRH reduction.
Influenza, Human
Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics.
Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.
N-linked glycosylation is required for optimal AT1a angiotensin receptor expression in COS-7 cells.
Insulin Resistance
ACE inhibitors versus AT1 blockers in the treatment of hypertension and syndrome X.
Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO-mediated mechanisms.
Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity.
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue.
Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice.
Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPAR?.
Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice.
Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats.
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Anti-inflammatory and metabolic effects of candesartan in hypertensive patients.
AT1 Receptor Blockade Attenuates Insulin Resistance and Myocardial Remodeling in Rats with Diet-Induced Obesity.
BLOCKADE OF THE RENIN-ANGIOTENSIN SYSTEM IMPROVES INSULIN RECEPTOR SIGNALING AND INSULIN-STIMULATED SKELETAL MUSCLE GLUCOSE TRANSPORT IN BURN INJURY.
Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.
Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders.
Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension.
Differential effects of ACE-inhibition and angiotensin II antagonism on fibrinolysis and insulin sensitivity in hypertensive postmenopausal women.
Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat.
Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.
Evidence for functional expression of vascular angiotensin II type 2 receptors in patients with insulin resistance.
Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats.
Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade.
Improved Insulin Sensitivity after Long-Term Treatment with AT1 Blockers Is Not Associated with PPAR? Target Gene Regulation.
Insulin resistance induces a segmental difference in thoracic and abdominal aorta: differential expression of AT1 and AT2 receptors.
Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin-converting enzyme inhibitor therapy?
Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats.
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle.
Valsartan, independently of AT1 receptor or PPAR?, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.
[Effects of angiotensin II receptor antagonist on insulin sensitivity and sympathetic activity in spontaneously hypertensive rats]
[RAAS and insulin resistance].
[Treatment of hypertension in patients with diabetes mellitus and lower limb ischemia]
Intellectual Disability
AT2 Receptor-Interacting Proteins ATIPs in the Brain.
Intermittent Claudication
Structural adaptation to ischemia in skeletal muscle: effects of blockers of the renin-angiotensin system.
Iron Overload
Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats.
[Effect of iron overload on experimental immunological liver injury in rats and the role of angiotensin]
Ischemic Attack, Transient
Deterioration of cognitive function after transient cerebral ischemia with amyloid-? infusion-possible amelioration of cognitive function by AT2 receptor activation.
Ischemic Contracture
Angiotensin II subtype 1 (AT1) receptors contribute to ischemic contracture and regulate chemomechanical energy transduction in isolated transgenic rat (alphaMHC-hAT1)594-17 hearts.
Ischemic Stroke
Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats.
Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant.
Ischemia Induced Brain Damage Is Enhanced in Human Renin and Angiotensinogen Double Transgenic Mice.
Neuroprotection via AT2 receptor agonists in ischemic stroke.
Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important?
Protective effect of candesartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors.
The angiotensin II type 2 receptor in the brain.
Keloid
Detection of Angiotensin II and AT1 Receptor Concentrations in Keloid and Hypertrophic Scar.
Losartan ointment relieves hypertrophic scars and keloid: A pilot study.
Keratoacanthoma
Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression.
Kidney Diseases
Angiotensin II receptor blockade and renal protection.
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes.
Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.
The angiotensin type 2 receptor and the kidney.
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
[The significance of angiotensin-converting enzyme inhibitors genotype for ACEi response in patients with chronic allograft nephropathy]
Kidney Failure, Chronic
Angiotensin II AT1 receptor blockade changes expression of renal sodium transporters in rats with chronic renal failure.
AT1 receptor up-regulation in intestine in chronic renal failure is segment specific.
Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass.
Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism.
Metabolic reprogramming by N-acetyl-seryl-aspartyl-lysyl-proline protects against diabetic kidney disease.
The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology.
[ACE and AT1 inhibitors in used in the progression of chronic renal failure]
[Different effect of angiotensin convertase inhibitors and AT1 receptor blockers on renal function in patients with chronic renal failure: report of two cases]
Leiomyoma
Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy.
Leiomyosarcoma
Activation of intracellular angiotensin AT2 receptors induces rapid cell death in human uterine leiomyosarcoma cells.
Activation of the cell membrane angiotensin AT2 receptors in human leiomyosarcoma cells induces differentiation and apoptosis by a PPAR? - dependent mechanism.
Leukemia
Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction.
[Expression of angiotensin-II type 1 receptor at1 mRNA in myeloid leukemia].
Liddle Syndrome
Quantitative trait loci for blood pressure exist near the IGF-1, the Liddle syndrome, the angiotensin II-receptor gene and the renin loci in man.
Liver Cirrhosis
Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis.
AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers.
AT1 receptor-mediated Janus-kinase-2 activation induces liver fibrosis.
Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension.
Potential antifibrotic effects of at1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by schistosoma mansoni.
Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.
Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection.
Liver Diseases
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Pharmacokinetics and safety of candesartan cilexetil in subjects with normal and impaired liver function.
Liver Failure
Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet.
Lung Diseases
A SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
Alveolar injury and regeneration following deletion of ABCA3.
Alveolar type 2 progenitor cells for lung injury repair.
Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.
Early lung injury contributes to lung fibrosis via AT1 receptor in rats.
Gene-edited MLE-15 Cells as a Model for the Hermansky Pudlak Syndromes.
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair.
In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.
Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.
Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells.
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration.
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
The development and plasticity of alveolar type 1 cells.
Lung Diseases, Interstitial
A SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
Alveolar injury and regeneration following deletion of ABCA3.
Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice.
Lung Injury
A Cellular Pathway Involved in Clara Cell to Alveolar Type II Cell Differentiation after Severe Lung Injury.
Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration.
Alveolar type 2 progenitor cells for lung injury repair.
Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair.
Angiotensin II is related to the acute aortic dissection complicated with lung injury through mediating the release of MMP9 from macrophages.
Angiotensin II receptor antagonists in the treatment and prevention of radiation nephropathy.
Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury.
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung Injury.
Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.
Early lung injury contributes to lung fibrosis via AT1 receptor in rats.
Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis.
FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.
Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation.
Impact of Regulatory T Cells on Type 2 Alveolar Epithelial Cell Transcriptomes during Resolution of Acute Lung Injury and Contributions of IFN-?.
Losartan attenuated lipopolysaccharide-induced lung injury by suppression of lectin-like oxidized low-density lipoprotein receptor-1.
Losartan, a selective antagonist of AT1 receptor, attenuates seawater inhalation induced lung injury via modulating JAK2/STATs and apoptosis in rat.
Protein Expression Profile of Rat Type Two Alveolar Epithelial Cells During Hyperoxic Stress and Recovery.
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration.
Serum-Free Differentiation of Murine Embryonic Stem Cells into Alveolar Type II Epithelial Cells.
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling.
The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.
Lung Neoplasms
A precision-guided MWNT mediated reawakening the sunk synergy in RAS for anti-angiogenesis lung cancer therapy.
Angiotensin II elevates cytosolic free calcium in human lung adenocarcinoma cells via activation of AT1 receptors.
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Mutationally-activated PI3'-kinase-? promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase.
Lymphoma
A role of intracellular mono-ADP-ribosylation in cancer biology.
An 18-kDa domain of a glycosylphosphatidylinositol-linked NAD:arginine ADP-ribosyltransferase possesses NAD glycohydrolase activity.
Lymphopenia
Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2.
Macular Degeneration
Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy).
Marfan Syndrome
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
AT1 receptor antagonism to reduce aortic expansion in Marfan syndrome: lost in translation or in need of different interpretation?
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Melanoma
AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells.
Diagnostic accuracy of whole slide imaging for cutaneous, soft tissue, and melanoma sentinel lymph node biopsies with and without immunohistochemistry.
Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma.
The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior.
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Memory Disorders
A Comparative Study on the Memory-Enhancing Actions of Oral Renin-Angiotensin System Altering Drugs in Scopolamine-Treated Mice.
Angiotensin-(1-7)/Mas axis modulates fear memory and extinction in mice.
Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin.
Metabolic Diseases
Characterization in mice of the resident mesenchymal niche maintaining AT2 stem cell proliferation in homeostasis and disease.
Metabolic Syndrome
A mechanism underlying hypertensive occurrence in the metabolic syndrome: cooperative effect of oxidative stress and calcium accumulation in vascular smooth muscle cells.
Angiotensin II and 1-7 during aging in Metabolic Syndrome rats. Expression of AT1, AT2 and Mas receptors in abdominal white adipose tissue.
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue.
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Coronary arteriolar vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors.
Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis.
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Migraine Disorders
Botulinum toxin and other new approaches to migraine therapy.
Muscle Weakness
Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Muscular Disorders, Atrophic
Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia.
Muscular Dystrophies, Limb-Girdle
In dystrophic hamsters losartan affects control of ventilation and dopamine D1 receptor density.
Mydriasis
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Myocardial Infarction
ACE inhibitor suppresses cardiac remodeling after myocardial infarction by regulating dendritic cells and AT2 receptor-mediated mechanism in mice.
Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats.
Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice.
Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus.
Angiotensin blockade inhibits SIF DNA binding activities via STAT3 after myocardial infarction.
Angiotensin II receptor binding following myocardial infarction in the rat.
Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart.
Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats.
Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus.
Angiotensin-converting enzyme inhibitors.
Antagonism of the renin-angiotensin-aldosterone system and collagen metabolism in cardiac fibroblasts.
Antioxidant effect of valsartan in experimental model of myocardial infarction.
Association between AT C573T polymorphism and cardiovascular risk factors in myocardial infarction.
AT(2) receptor and tissue injury: therapeutic implications.
AT1 receptor blockade alters metabolic, functional and structural proteins after reperfused myocardial infarction: detection using proteomics.
AT1 receptor blockade for the prevention of cardiovascular events after myocardial infarction.
AT1 receptor blockade in experimental myocardial ischemia/reperfusion.
AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats.
AT1 receptor blockade limits myocardial injury and upregulates AT2 receptors during reperfused myocardial infarction.
AT1 receptor blockade prevents cardiac dysfunction after myocardial infarction in rats.
AT2 receptor and apoptosis during AT1 receptor blockade in reperfused myocardial infarction in the rat.
AT2 receptor blockade reduces cardiac interstitial cell DNA synthesis and cardiac function after rat myocardial infarction.
Atrial expression of the CCN1 and CCN2 proteins in chronic heart failure.
Blood pressure lowering and renin-angiotensin system blockade.
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Cardiac c-kit+AT2+ Cell Population is Increased in Response to Ischemic Injury and Supports Cardiomyocyte Performance.
Cardiac hypertrophy is associated with decreased eNOS expression in angiotensin AT2 receptor-deficient mice.
Cardioprotection after angiotensin II type 1 blockade involves angiotensin II type 2 receptor expression and activation of protein kinase C-epsilon in acutely reperfused myocardial infarction in the dog. Effect of UP269-6 and losartan on AT1 and AT2-receptor expression and IP3 receptor and PKCepsilon proteins.
Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling.
CCN1 expression in interleukin-6 deficient mouse kidney in experimental model of heart failure.
Combination therapy with angiotensin converting enzyme inhibition and AT1 receptor inhibitor on ventricular remodeling after myocardial infarction in rats.
Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat.
Differential effects of angiotensin AT1 and AT2 receptors on the expression, translation and function of the Na+-H+ exchanger and Na+-HCO3- symporter in the rat heart after myocardial infarction.
Dual ACE-inhibition and angiotensin II AT1 receptor antagonism with curcumin attenuate maladaptive cardiac repair and improve ventricular systolic function after myocardial infarctionin rat heart.
Effect of ANG II on pHi, [Ca2+]i, and contraction in rabbit ventricular myocytes from infarcted hearts.
Effect of AT1 receptor blockade on cardiac collagen remodeling after myocardial infarction.
Effect of chronic blockade of angiotensin II-receptor subtypes on aortic compliance in rats with myocardial infarction.
Effect of Early vs Late AT1 Receptor Blockade with Losartan on Post-Myocardial Infarction Ventricular Remodeling in Rabbits.
Effect of losartan and captopril on expression of cardiac angiotensin II AT1 receptor mRNA in rats following myocardial infarction.
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial Infarction in rabbits: reversal of altered expression of beta-adrenoceptor kinase and G i alpha.
Effects of AT1 receptor blockade after myocardial infarct on myocardial fibrosis, stiffness, and contractility.
Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction.
Efficacy of angiotensin-converting enzyme inhibition and AT1 receptor blockade on cardiac pump performance after myocardial infarction in rats.
Expression of Renin-Angiotensin System on Dendritic Cells of Patients with Coronary Artery Disease.
Impact of kinins in the treatment of cardiovascular diseases.
Increased expression of glomerular AT1 receptors in rats with myocardial infarction.
Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats.
Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate.
Influence of the angiotensin II AT1 receptor antagonist irbesartan on ischemia/reperfusion injury in the dog heart.
Inhibition by angiotensin II type 1 receptor antagonist of cardiac phenotypic modulation after myocardial infarction.
Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state.
Mineralocorticoid and AT1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarct.
Myocardial angiotensin II receptor expression and ischemia-reperfusion injury.
Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone.
Relationship between remodeling and function of left ventricle and angiotensin II AT1 receptor expression after myocardial infarction in rats.
Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians.
Retraction notice to “Dual ACE-inhibition and angiotensin II AT1 receptor antagonism with curcumin attenuate maladaptive cardiac repair and improve ventricular systolic function after myocardial infarction in rat heart” [Eur.J.Pharmacol.January(2015)22–30].
Role of ACE inhibition or AT1 blockade in the remodeling following myocardial infarction.
Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and cardiac remodelling.
Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice.
Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling.
Suppression of Ventricular Arrhythmias After Myocardial Infarction by AT1 Receptor Blockade: Role of the AT2 Receptor and Casein Kinase 2/Kir2.1 Pathway. Editorial to: "Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction Via Casein Kinase 2" by Xinran Li et al.
Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction.
The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction.
The angiotensin II type 2 receptor and the kidney.
The angiotensin II type 2 receptor in cardiovascular disease.
The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction.
The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction.
The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction.
The potential role of the angiotensin subtype 2 receptor in cardiovascular protection.
The Protective Role of AT2 and B1 Receptors in Kinin B2 Receptor Knockout Mice with Myocardial Infarction.
The scar neovasculature after myocardial infarction in rats.
Up-regulated expression of angiotensin II type 1 receptor gene in human pathologic hearts.
[AT1 blockers - comparability with ACE inhibitors].
[Changes in expression of angiotensin subtype AT1A and AT2 receptors in rats during cardiac remodeling following myocardial infarction]
[Distribution and function of angiotensin receptor subtypes in cardiovascular system]
[Effects of combination therapy with angiotensin I-converting enzyme inhibitor and angiotensin 1 receptor antagonist on ventricular remodeling and expression of endothelial nitric oxide synthase]
[The ACE inhibitor, captopril, in the light of new clinical studies]
[The role of DNA polymorphism in the renin-angiotensin system and the pathogenesis of cardiovascular diseases]
Myocardial Ischemia
Angiotensin II type 1 receptor blockade abolishes specific K(ATP)channel gene expression in rats with myocardial ischemia.
AT1 receptor blockade in experimental myocardial ischemia/reperfusion.
Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia.
Differential distribution of angiotensin AT2 receptors in the normal and failing human heart.
Effects of acute and chronic angiotensin receptor blockade on myocardial vascular blood volume and perfusion in a pig model of coronary microembolization.
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.
Myocardial Stunning
Attenuation of myocardial stunning by the AT1 receptor antagonist candesartan.
nad+-protein-arginine adp-ribosyltransferase deficiency
AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARgamma.
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue.
Neoplasm Metastasis
Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.
Expression of transforming growth factor-beta 1 in prostate cancer.
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
Neoplasms
A precision-guided MWNT mediated reawakening the sunk synergy in RAS for anti-angiogenesis lung cancer therapy.
A role of intracellular mono-ADP-ribosylation in cancer biology.
Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors.
ACE2/Angiotensin-(1-7)/Mas receptor axis in human cancer: Potential role for pediatric tumors.
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
Actin filament organization of the Dunning R3327 rat prostatic adenocarcinoma system: correlation with metastatic potential.
Activation of the cell membrane angiotensin AT2 receptors in human leiomyosarcoma cells induces differentiation and apoptosis by a PPAR? - dependent mechanism.
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes.
Altered TGF-?/? signaling drives cooperation between breast cancer cell populations.
Alveolar progenitor and stem cells in lung development, renewal and cancer.
An ATIPical family of angiotensin II AT2 receptor-interacting proteins.
Angiotensin II and the adrenal.
Angiotensin II receptor blocker: possibility of antitumor agent for prostate cancer.
Angiotensin II receptor subtypes on adrenal adenoma in primary hyperaldosteronism.
Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus.
Angiotensin II Type 1 Receptor (AT1) Knockdown Impairs Interleukin (IL)-1?-Induced Cytokines in Human Periodontal Fibroblasts.
Angiotensin II type 1 receptor expression in two cases of juxtaglomerular cell tumor: correlation to negative feedback of renin secretion by angiotensin II.
Angiotensin II type 1 receptor messenger RNA levels in human blood cells of patients with primary and secondary hypertension: reference to renin profile.
Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.
Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury.
Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to tobacco-specific nitrosamine-induced lung tumorigenesis: involvement of transforming growth factor-beta-dependent cell growth attenuation.
Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPAR?.
Angiotensin receptors in hormone-independent prostate cancer cell line DU145: presence of two variants of angiotensin type 1 receptor.
Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth.
Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor.
ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma.
Association between AT1 and AT2 angiotensin II receptor expression with cell proliferation and angiogenesis in operable breast cancer.
AT1 angiotensin II receptor subtype in the human larynx and squamous laryngeal carcinoma.
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.
AT2 receptor stimulation may halt progression of pheochromocytoma.
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma.
Cancer, inflammation and the AT1 and AT2 receptors.
Cardiovascular Drug Use and Risk of Actinic Keratosis: A Case-Control Study.
Chronic ethanol ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances tumor necrosis factor-alpha- and angiotensin II-induced cytotoxicity via AT2 signaling in rat alveolar epithelial cells.
Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor.
Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumour and human gastric cancer using quantitative in vitro autoradiography.
Dermatan carriers for neovascular transport targeting, deep tumor penetration and improved therapy.
Differential sensitivity of three sublines of the rat Dunning prostate tumor system R3327 to radiation and/or local tumor hyperthermia.
Differentiation-stage specific expression of oncoprotein 18 in human and rat prostatic adenocarcinoma.
Dynamic oxygen challenge evaluated by NMR T1 and T2*--insights into tumor oxygenation.
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.
Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study.
Exercise training as a modulator of epigenetic events in prostate tumors.
Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis.
Expression of ras proto-oncogenes in the Dunning R3327 rat prostatic adenocarcinoma system.
Expression of transforming growth factor-beta 1 in prostate cancer.
Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4.
Feasibility study of cavitation-induced liposomal doxorubicin release in an AT2 Dunning rat tumor model.
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
GdDO3NI, a nitroimidazole-based T1 MRI contrast agent for imaging tumor hypoxia in vivo.
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
High-grade tumours promote growth of other less-malignant tumours in the same prostate.
Highly aggressive rat prostate tumors rapidly precondition regional lymph nodes for subsequent metastatic growth.
Identification of Sca-1+Abcg1+ bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
Immunohistochemical study of angiotensin receptors in human anagen hair follicles and basal cell carcinoma.
Immunohistochemical study of angiotensin receptors in normal human sweat glands and eccrine poroma.
Impact of stroma on the growth, microcirculation, and metabolism of experimental prostate tumors.
Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells.
Intracellular visualization of prostate cancer using magnetic resonance imaging.
Losartan and Vitamin D Inhibit Colonic Tumor Development in a Conditional Apc-Deleted Mouse Model of Sporadic Colon Cancer.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality.
Measurement of hypoxia-related parameters in three sublines of a rat prostate carcinoma using dynamic (18)F-FMISO-Pet-Ct and quantitative histology.
Measurement of Protein Synthesis: In Vitro Comparison of (68)Ga-DOTA-Puromycin, [ (3)H]Tyrosine, and 2-Fluoro-[ (3)H]tyrosine.
Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma.
Mutationally-activated PI3'-kinase-? promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase.
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Novel 18F-Labeled PET Imaging Agent FV45 Targeting the Renin-Angiotensin System.
PAK1-cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin-13.
PCR-SSCP analysis of the angiotensin II type 1 receptor gene in patients with aldosterone-producing adenomas.
Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment.
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Possible roles of tumor necrosis factor-? and angiotensin II type 1 receptor on high glucose-induced damage in renal proximal tubular cells.
Pre-treatment with angiotensin-(1-7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts.
Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells.
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration.
Regulation of vascular type 1 angiotensin receptors by cytokines.
Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth.
Role of the Renin-Angiotensin System in Prostate Cancer.
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.
Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP.
The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior.
The effects of angiotensin peptides and angiotensin receptor antagonists on the cell growth and angiogenic activity of GH3 lactosomatotroph cells in vitro.
The renin-angiotensin system in the breast and breast cancer.
The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis.
The scar neovasculature after myocardial infarction in rats.
The transport of glutamine into mammalian cells.
Therapeutic efficacy of the combination of doxorubicin-loaded liposomes with inertial cavitation generated by confocal ultrasound in AT2 Dunning rat tumour model.
Transcription of the prorenin gene in normal and diseased breast.
Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells.
Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis.
Tumor oxygen dynamics: correlation of in vivo MRI with histological findings.
Whole slide imaging equivalency and efficiency study: experience at a large academic center.
[Application of angiotensin II receptor blocker in prostate cancer]
[Cancer and renin-angiotensin system].
[Role of AT2 receptors on angiotensin II-induced tumor necrosis factor alpha and interleukin 1 beta secretion in adult rat cardiac fibroblasts]
[Role of renin-angiotensin system in prostate cancer]
Nephritis
Angiotensin II type I receptor antagonist suppresses proteinuria and glomerular lesions in experimental nephritis.
Local actions of endogenous angiotensin II in injured glomeruli.
Mesangial AT1 receptors: expression, signaling, and regulation.
Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure.
Nephrosclerosis
Angiotensin AT1/AT2 receptors: regulation, signalling and function.
Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats.
Effects of angiotensin inhibitors on renal injury and angiotensin receptor expression in early hypertensive nephrosclerosis.
Kidney angiotensin receptors and their role in renal pathophysiology.
Nephrosis
Addition of AT1 blocker fails to overcome resistance to ACE inhibition in adriamycin nephrosis.
Involvement of angiotensin II in development of spontaneous nephrosis in Dahl salt-sensitive rats.
Nervous System Diseases
What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?
Neuralgia
Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain.
AT2 R Antagonists as Novel Analgesics for Relief of Neuropathic Pain.
Effect of subpressor dose of angiotensin II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells in the rat dorsal root ganglia.
Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats.
Propofol inhibits expression of angiotensin II receptor type 2 in dorsal root ganglion neurons.
Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.
Small Molecule Angiotensin II Type 2 Receptor (AT2 R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats.
The Characterization of AT1 Expression in the Dorsal Root Ganglia After Chronic Constriction Injury.
Neuralgia, Postherpetic
Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain.
Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.
Neuroblastoma
Angiotensin II AT2 receptors are functionally coupled to protein tyrosine dephosphorylation in N1E-115 neuroblastoma cells.
Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase.
Angiotensin II type-2 (AT2) receptor-mediated inhibition of NMDA receptor signalling in neuronal cells.
AT1 angiotensin receptors mobilize intracellular calcium in a subclone of NG108-15 neuroblastoma cells.
Biochemical characterization of two distinct angiotensin AT2 receptor populations in murine neuroblastoma N1E-115 cells.
Cloning and expression of angiotensin II type 2 (AT2) receptors from murine neuroblastoma N1E-115 cells: evidence for AT2 receptor heterogeneity.
Differentiation of NG108-15 neuroblastoma cells by serum starvation or dimethyl sulfoxide results in marked differences in angiotensin II receptor subtype expression.
Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells.
Induction of the angiotensin AT2 receptor subtype expression by differentiation of the neuroblastoma x glioma hybrid, NG-108-15.
Intracerebroventricular administration of AT1 receptor antisense oligonucleotides inhibits the behavioral actions of angiotensin II.
Molecular and functional characterization of angiotensin II AT2 receptor in neuroblastoma N1E-115 cells.
Neurodegenerative Diseases
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
The Renin-Angiotensin System and the Neurodegenerative Diseases: a brief review.
Neuroinflammatory Diseases
Angiotensin Receptor Blockade Modulates NF?B and STAT3 Signaling and Inhibits Glial Activation and Neuroinflammation Better than Angiotensin-Converting Enzyme Inhibition.
Neurologic Manifestations
Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat.
Neuromyelitis Optica
Angiotensin AT2 receptor-induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology.
Non-alcoholic Fatty Liver Disease
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Obesity
ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance.
Angiotensin II impairs glucose utilization in obese Zucker rats by increasing HPA activity via an adrenal-dependent mechanism.
Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice.
AT1 Receptor Blockade Attenuates Insulin Resistance and Myocardial Remodeling in Rats with Diet-Induced Obesity.
AT2 receptor: Its role in obesity associated hypertension.
Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue.
Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System.
Effects of 17?-estradiol on cardiac Na(+)/K(+)-ATPase in high fat diet fed rats.
Elevated AT1 receptor protein but lower angiotensin II-binding in adipose tissue of rats with monosodium glutamate-induced obesity.
Evidence of changes in alpha-1/AT1 receptor function generated by diet-induced obesity.
Genetic Contributions to Childhood Obesity: Association of Candidate Gene Polymorphisms and Overweight/Obesity in Korean Preschool Children.
Influence of AT1 blockers on obesity and stress induced eating of cafeteria diet.
Lack of weight gain after angiotensin AT1 receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway.
Low number of insulin receptors but high receptor protein content in adipose tissue of rats with monosodium glutamate-induced obesity.
Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition.
Obesity and aging affects skeletal muscle renin-angiotensin system and myosin heavy chain proportions in pre-diabetic Zucker rats.
Prevention of metabolic disorders and reproductive performance deficits by the blockade of Angiotensin II AT1 receptor in female rats fed with cafeteria diet.
Renal angiotensin II receptors, hyperinsulinemia, and obesity.
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats.
Suppression of Inflammatory Cardiac Cytokine Network in Rats with Untreated Obesity and Pre-Diabetes by AT2 Receptor Agonist NP-6A4.
Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets.
[Blockade of AT1 receptor of Angiotensin II reduces the number of antral follicles in female rats with obesity induced by cafeteria diet].
Obesity, Abdominal
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue.
Osteoporosis
Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension.
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Osteoporosis, Postmenopausal
Chronic treatment with angiotensin AT1 receptor antagonists reduced serum but not bone TGF-beta1 levels in ovariectomized rats.
Overnutrition
Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats.
Overweight
Association of angiotensin II type 1 receptor polymorphism with resistant essential hypertension.
Genetic Contributions to Childhood Obesity: Association of Candidate Gene Polymorphisms and Overweight/Obesity in Korean Preschool Children.
Leptin, Galectin-3 and Angiotensin II Type 1 Receptor Polymorphism in Overweight and Obese Patients with Heart Failure - Role and Functional Interplay.
Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects.
Pancreatic Neoplasms
Angiotensin II activates MAP kinase and NF-kappaB through angiotensin II type I receptor in human pancreatic cancer cells.
Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist.
Angiotensin II type 1 receptor mRNA and its protein expression in human pancreatic cancer cell lines.
Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.
Pancreatitis
Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein induced chronic pancreatitis in the mouse.
The effect of anti-hypertensive drugs on the obstructive pancreatitis in rats.
The role of the pancreatic renin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis.
Parkinson Disease
Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders.
Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia.
Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson's disease in CATH.a cells.
Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage.
Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors.
Renin-angiotensin system gene expression and neurodegenerative diseases.
Parkinsonian Disorders
Effects of Telmisartan, an AT1 receptor antagonist, on mitochondria-specific genes expression in a mouse MPTP model of Parkinsonism.
The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism.
Peptic Ulcer
Upper gastrointestinal ulcer in Japanese patients taking low-dose aspirin.
peptidyl-dipeptidase a deficiency
Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice.
Periodontitis
AT1 receptor antagonism promotes bone loss attenuation in experimental periodontitis, block inflammatory mediators, upregulate antioxidant enzymes and bone formation markers.
Peripheral Nervous System Diseases
The Characterization of AT1 Expression in the Dorsal Root Ganglia After Chronic Constriction Injury.
Peritoneal Fibrosis
Angiotensin II induces fibronectin expression in human peritoneal mesothelial cells via ERK1/2 and p38 MAPK.
Peritoneal Neoplasms
Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivin.
Pheochromocytoma
Analysis of the role of N-glycosylation in cell-surface expression and binding properties of angiotensin II type-2 receptor of rat pheochromocytoma cells.
Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation.
Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells.
Angiotensin II type 2 receptor mediates programmed cell death.
Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20.
Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis.
AT2 receptor stimulation may halt progression of pheochromocytoma.
Characterization of biochemical responses of angiotensin II (AT2) binding sites in the rat pheochromocytoma PC12W cells.
Cloning, expression and regulation of angiotensin II receptors.
Effect of angiotensin II on protein phosphorylation in PC12 cell line.
Effects of growth factors on cell proliferation and angiotensin II type 2 receptor number and mRNA in PC12W and R3T3 cells.
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals.
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
Molecular structure and function of angiotensin type 2 receptor.
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2.
Recognition of tissue- and subtype-specific modulation of angiotensin II receptors using antibodies against AT1 and AT2 receptors.
Repression of c-fos and c-jun gene expression is not part of AT2 receptor coupled signal transduction.
The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells.
[Angiotensin II receptor subtype in human adrenal glands]
Pituitary Neoplasms
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
Plant Diseases
Plant eR genes that encode photorespiratory enzymes confer resistance against disease.
Pneumonia
Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury.
Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury.
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics.
Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.
Polycystic Kidney Diseases
AT1 Receptor Antagonism Improves Structural, Functional and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model.
Polycystic Kidney, Autosomal Dominant
[Progression of autosomic dominant polycystic kidney disease. Influence of endothelial NO synthase (ecNOS) and renin angiotensin system gene polymorphisms]
Polycystic Ovary Syndrome
Expression of angiotensin II type 1 (AT1) and angiotensin II type 2 (AT2) receptors in human granulosa-lutein (GL) cells: correlation with infertility diagnoses.
Polycythemia
Losartan, an angiotensin II type 1 receptor antagonist, lowers hematocrit in posttransplant erythrocytosis.
Polyuria
Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction.
Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone.
Porphyria, Acute Intermittent
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Pre-Eclampsia
1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia.
Activating auto-antibodies against the AT1 receptor in preeclampsia.
Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders.
Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia.
Agonistic autoantibodies against the angiotensin AT1 receptor increase in unstable angina patients after stent implantation.
Agonistic autoantibodies directed against the angiotensin II AT1 receptor in patients with preeclampsia.
Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia.
Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature.
Angiotensin receptors, autoimmunity, and preeclampsia.
Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction.
Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activation.
Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression.
AT1 receptor agonistic antibodies, hypertension, and preeclampsia.
AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia.
Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers.
Contractility of placental vascular smooth muscle cells in response to stimuli produced by the placenta: roles of ACE vs. non-ACE and AT1 vs. AT2 in placental vessel cells.
Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia.
Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia.
Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia.
Exposure to AT1 receptor autoantibodies during pregnancy increases susceptibility of the maternal heart to postpartum ischemia-reperfusion injury in rats.
High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.
Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.
Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients.
Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?
Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia.
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells.
Murine pre-eclampsia induced by unspecific activation of the immune system correlates with alterations in the eNOS and AT1 receptor expression in the kidneys and placenta.
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Renal vascular responses in an experimental model of preeclampsia.
The angiotensin II type I receptor contributes to impaired cerebral blood flow autoregulation caused by placental ischemia in pregnant rats.
The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension.
The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad.
The role of AT1 angiotensin receptor activation in the pathogenesis of preeclampsia.
Vascular Contraction and Preeclampsia. Downregulation of the Angiotensin Receptor 1 by Hemopexin In Vitro.
Pregnancy Complications
High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.
Premature Birth
Extremely preterm infants in Tunisia: Where are we now?
The development and plasticity of alveolar type 1 cells.
Primary Ovarian Insufficiency
Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.
Prostatic Hyperplasia
Autoantibodies Directed Against the Endothelin A Receptor in Patients With Benign Prostatic Hyperplasia.
Prostatic Neoplasms
A comparison of the effects of Angiotensin IV on androgen-dependent and androgen-independent prostate cancer cell lines.
Albendazole exerts antiproliferative effects on prostate cancer cells by inducing reactive oxygen species generation.
Angiotensin II receptor blocker: possibility of antitumor agent for prostate cancer.
Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study.
Expression and role of the angiotensin II AT2 receptor in human prostate tissue: In search of a new therapeutic option for prostate cancer.
Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4.
Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.
High-grade tumours promote growth of other less-malignant tumours in the same prostate.
Immunohistochemical detection of angiotensin AT 1 and AT 2 receptors in prostate cancer.
Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells.
Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.
Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment.
Role of the Renin-Angiotensin System in Prostate Cancer.
Synergistic inhibitory effect of high-intensity focused ultrasound combined with chemotherapy on Dunning adenocarcinoma.
Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer.
[Renin-angiotensin system (RAS) as new molecular therapeutic targets in prostate cancer].
[Role of renin-angiotensin system in prostate cancer]
Proteinuria
A new class of therapeutic agents: the angiotensin II receptor antagonists.
Aldosterone, mineralocorticoid receptors, and vascular inflammation.
Angiotensin II receptor blockade and renal protection.
Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria.
Anti-inflammatory effects of AT1 receptor blockade provide end-organ protection in stroke-prone rats independently from blood pressure fall.
ARB protects podocytes from HIV-1 nephropathy independently of podocyte AT1.
AT1 receptor antagonists: a challenge for ACE inhibitors in diabetic nephropathy.
Blood pressure and proteinuria after cessation of a brief renin-angiotensin system blockade in young and adult Lyon hypertensive rats.
Chronic angiotensin II infusion but not bradykinin blockade abolishes the antiproteinuric response to angiotensin-converting enzyme inhibition in established adriamycin nephrosis.
Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.
Deterioration of Kidney Function by the (Pro)renin Receptor Blocker Handle Region Peptide in Aliskiren-treated Diabetic Transgenic (mRen2)27 Rats.
Differential effects of angiotensin II type-1 receptor antisense oligonucleotides on renal function in spontaneously hypertensive rats.
Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli.
Enhanced Urinary Angiotensinogen Excretion in Cyp1a1-Ren2 Transgenic Rats With Inducible ANG II-Dependent Malignant Hypertension.
Kidney angiotensin receptors and their role in renal pathophysiology.
Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.
Persistent proteinuria up-regulates angiotensin II type 2 receptor and induces apoptosis in proximal tubular cells.
Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.
Renal expression of angiotensin type 2 (AT2) receptors during kidney damage.
Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats.
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol.
Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria.
Thiazide diuretics, endothelial function, and vascular oxidative stress.
Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy.
Valsartan and the kidney: present and future.
[Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
[IgA nephropathy. Significance of immunoglobulin A glycosylation in pathogenesis and clinical presentation]
[Irbesartan--antihypertensive treatment in patients with heart failure and diabetes mellitus]
[Present opinions on use of ketoanalog essential aminoacids in a conservative treatment of chronic renal insufficiency]
Psoriasis
Candesartan cilexetil induced pustular psoriasis.
Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation.
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Pulmonary Disease, Chronic Obstructive
Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease.
Testosterone replacement therapy and hospitalization rates in men with COPD.
Treating systemic effects of COPD.
[Differential therapy with calcium antagonists]
Pulmonary Fibrosis
Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice.
AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells.
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Early lung injury contributes to lung fibrosis via AT1 receptor in rats.
Genetics and animal models of familial pulmonary fibrosis.
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Impact of Olmesartan Medoxomil on Amiodarone- Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor-ßeta-1.
LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis.
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist.
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis.
Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.
Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease.
Renal Artery Obstruction
Reliability of captopril renography in patients under chronic therapy with angiotensin II (AT1) receptor antagonists.
Renal Insufficiency
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats.
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
AT1 receptor blockade improves vasorelaxation in experimental renal failure.
Does blockade of angiotensin II receptors offer clinical benefits over inhibition of angiotensin-converting enzyme?
Effect of angiotensin II type 1 receptor blockade on conduit artery tone in subtotally nephrectomized rats.
Fetal toxic effects of angiotensin II receptor antagonists: case report and follow-up after birth.
Impact of kinins in the treatment of cardiovascular diseases.
KRH-594, a new angiotensin AT1 receptor antagonist, prevents end-organ damage in stroke-prone spontaneously hypertensive/Izm rats.
Pharmacological inhibition of TRPV4 channels protects against ischemia-reperfusion-induced renal insufficiency in neonatal pigs.
Prevention of accelerated atherosclerosis by AT1 receptor blockade in experimental renal failure.
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Renoprotection and renin-angiotensin system blockade in diabetes mellitus.
The effect of different antihypertensive drugs on cavernous tissue in experimental chronic renal insufficiency.
[Effects of Jianpi Qinghua Recipe on angiotensin II/NADPH oxidase pathway in 5/6 nephrectomized rats].
Renal Insufficiency, Chronic
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy.
Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus.
Angiotensin II stimulates MCP-1 production in rat glomerular endothelial cells via NAD(P)H oxidase-dependent nuclear factor-kappa B signaling.
Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion.
Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.
Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis.
AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease.
AT1 Receptor Antagonism Improves Structural, Functional and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model.
Effect of Shenxinning decoction on ventricular remodeling in AT1 receptor-knockout mice with chronic renal insufficiency.
Enhanced Angiotensin II type 1 receptor expression in leukocytes of patients with chronic kidney disease.
Heme oxygenase-1 inducer hemin attenuates the progression of remnant kidney model.
Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging.
Protection of kidney function and tissue integrity by pharmacologic use of natriuretic peptides and neprilysin inhibitors.
The angiotensin II type 2 receptor in renal disease.
Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging.
Tubular apoptosis in the pathophysiology of renal disease.
Reperfusion Injury
Aliskiren Reduces Myocardial Ischemia-Reperfusion Injury by a Bradykinin B2 Receptor- and Angiotensin AT2 Receptor-Mediated Mechanism.
Angiotensin II in paraventricular nucleus contributes to sympathoexcitation in renal ischemia-reperfusion injury by AT1 receptor and oxidative stress.
Angiotensin II type 1 receptor antagonist protects ventricular and coronary endothelial function after 24-hour heart preservation.
Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK.
Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts.
Exposure to AT1 receptor autoantibodies during pregnancy increases susceptibility of the maternal heart to postpartum ischemia-reperfusion injury in rats.
Microvascular responses to aldosterone in hamster cheek pouch microcirculation.
Myocardial angiotensin II receptor expression and ischemia-reperfusion injury.
The preventive effect of captopril or enalapril on reperfusion injury of the kidney of rats is independent of angiotensin II AT1 receptors.
Therapeutic modulation of tissue kallikrein expression.
Tissue kallikrein is involved in the cardioprotective effect of AT1-receptor blockade in acute myocardial ischemia.
Respiratory Distress Syndrome
Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome.
Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome.
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.
Retinal Diseases
Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors.
Retinal Neovascularization
Angiotensin II induces expression of the Tie2 receptor ligand, angiopoietin-2, in bovine retinal endothelial cells.
Dual effect of angiotensin-converting enzyme inhibition on angiogenesis in type 1 diabetic mice.
Retinopathy of Prematurity
The vasoneuronal effects of AT1 receptor blockade in a rat model of retinopathy of prematurity.
Sarcoma, Avian
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Schistosomiasis mansoni
Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection.
Scoliosis
Does a large abdominal wall defect affect lung growth?
Seizures
Adenosine-angiotensin II interactions in pentylenetetrazol seizure threshold in mice.
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy.
Combined treatment with gabapentin and drugs affecting the renin-angiotensin system against electroconvulsions in mice.
Effect of ACE inhibitors and AT1 receptor antagonists on pentylenetetrazole-induced convulsions in mice.
Effect of Combined Treatment with AT1 Receptor Antagonists and Tiagabine on Seizures, Memory and Motor Coordination in Mice.
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Effects of non-peptide angiotensin II-receptor antagonists on pentylenetetrazol kindling in mice.
Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy.
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
The amygdala and temporal lobe simple partial seizures: a prospective and quantitative MRI study.
The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis.
Seizures, Febrile
The amygdala and intractable temporal lobe epilepsy: a quantitative magnetic resonance imaging study.
Sepsis
Angiotensin II receptor type 1 blockade improves hyporesponsiveness to vasopressors in septic shock.
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Shock, Septic
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Silicosis
Influence of the interaction between Ac?SDKP and Ang II on the pathogenesis and development of silicotic fibrosis.
Skin Diseases
Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation.
The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.
Sleep Apnea Syndromes
Up-regulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia.
Spasm
[Could the understanding of racial differences prevent idiosyncratic anesthetic reactions?]
Squamous Cell Carcinoma of Head and Neck
Angiotensin 1-7 inhibits angiotensin II-stimulated head and neck cancer progression.
Starvation
Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study.
Differentiation of NG108-15 neuroblastoma cells by serum starvation or dimethyl sulfoxide results in marked differences in angiotensin II receptor subtype expression.
Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis.
Status Epilepticus
Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus.
Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy.
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.
Stomach Neoplasms
Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivin.
Stomach Ulcer
Angiotensin II AT1 receptor blockade prevents gastric ulcers during cold-restraint stress.
Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury.
Stroke
Acute effects of E-3174, a human active metabolite of losartan, on the cardiovascular system in tachycardia-induced canine heart failure.
Age-adjusted stroke incidence increase: could angiotensin AT1 receptor antagonists enhance stroke prevention?
Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage.
Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke.
Angiotensin AT2 receptor stimulation increases survival in gerbils with abrupt unilateral carotid ligation.
Angiotensin AT2 receptor-mediated neuroprotection and nitric oxide-bioavailability in stroke.
Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats.
Are angiotensin receptor blockers neuroprotective?
AT2 Receptor-Interacting Proteins ATIPs in the Brain.
Biphasic effects of angiotensin II and receptor antagonism on aggregability and protein kinase C phosphorylation in human platelets.
Blood pressure lowering and renin-angiotensin system blockade.
Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities.
Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials.
Clinical experience with the use of angiotensin receptor blockers in patients with cardiovascular, cerebrovascular and renal diseases.
Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain.
Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats.
Direct Stimulation of Angiotensin II Type 2 Receptor Initiated After Stroke Ameliorates Ischemic Brain Damage.
Does treatment of hypertension decrease the incidence of atrial fibrillation and cardioembolic stroke?
Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy.
Effects of AT1 receptor blockade on blood pressure and the renin-angiotensin system in spontaneously hypertensive rats of the stroke prone strain.
Expression of angiotensin II AT2 receptor in the acute phase of stroke in rats.
Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients.
Inhibiting renin-angiotensin in the brain: the possible therapeutic implications.
Ischemic injury in experimental stroke depends on angiotensin II.
Left ventricular function in mice lacking the AT2 receptor.
Losartan's protective effects in stroke-prone spontaneously hypertensive rats persist durably after treatment withdrawal.
Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice.
Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension.
Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive rats.
Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition.
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
Possible pathophysiologic mechanisms supporting the superior stroke protection of angiotensin receptor blockers compared to angiotensin-converting enzyme inhibitors: clinical and experimental evidence.
Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models.
Protective arms of the renin-angiotensin-system in neurological disease.
Revisiting the Brain Renin-Angiotensin System-Focus on Novel Therapies.
Stroke prevention with losartan in the context of other antihypertensive drugs.
Synergistic protective effects of erythropoietin and olmesartan on ischemic stroke survival and post-stroke memory dysfunctions in the gerbil.
The protective arms of the renin-angiontensin system in stroke.
The Renin-Angiotensin System and the Cerebrovascular Diseases: Experimental and Clinical Evidence.
[Atrial fibrillation as end point of hypertension. Can antihypertensive therapy prevent it?]
[Effect of RAAS inhibition on stroke prevention].
[Fixed combination of AT1 blocker and diuretic. Stroke preventive combination for hypertension]
Stroke, Lacunar
Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study.
Subarachnoid Hemorrhage
Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage.
Sunburn
Cardiovascular Drug Use and Risk of Actinic Keratosis: A Case-Control Study.
Tachycardia
AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats.
AT2 and MAS (but not AT1) angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats.
Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.
In vivo and in vitro characterization of the novel antiarrhythmic agent SSR149744C: electrophysiological, anti-adrenergic, and anti-angiotensin II effects.
Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.
Tachycardia, Sinus
Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.
Tachycardia, Ventricular
Angiotensin II Effects on Ischemic Focal Ventricular Tachycardia are Predominantly Mediated Through Myocardial AT2 Receptor.
Thromboembolism
Novel Vasopressors in the Treatment of Vasodilatory Shock: A Systematic Review of Angiotensin II, Selepressin, and Terlipressin.
Thrombosis
Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats.
Angiotensin II-Mediated Microvascular Thrombosis.
Imidapril, an angiotensin-converting enzyme inhibitor, inhibits thrombosis via reduction in aortic plasminogen activator inhibitor type-1 levels in spontaneously hypertensive rats.
Inhibition of arterial thrombogenesis by quinapril but not losartan.
Studies on the antithrombotic action of AT1 receptor antagonists.
The acute prothrombotic effect of aldosterone in rats is partially mediated via angiotensin II receptor type 1.
The pivotal link between ACE2 deficiency and SARS-CoV-2 infection.
Ureteral Obstruction
Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction.
Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase.
AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction.
Effect of AT2 receptor blockade on the pathogenesis of renal fibrosis.
Effect of losartan pretreatment on kidney lipid content after unilateral obstruction in rats.
Regulation of angiotensin II AT1 and AT2 receptors in neonatal ureteral obstruction.
Regulation of renal growth factors and clusterin by AT1 receptors during neonatal ureteral obstruction.
Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis.
Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.
Urethral Obstruction
Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility.
Urinary Bladder Neck Obstruction
Effect of the Renin-Angiotensin System on the Obstructed Bladder.
Uveitis
Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats.
Vascular Calcification
AT2 receptor stimulation inhibits phosphate-induced vascular calcification.
Roles and possible mechanisms of autoantibodies against the angiotensin AT1 receptor in vascular calcification of rats.
Vascular Diseases
Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice.
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.
Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan.
Effects of valsartan and valeryl 4-hydroxy valsartan on human platelets: a possible additional mechanism for clinical benefits.
Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation.
Influence of oxidized low-density lipoprotein on vascular angiotensin II receptor expression.
Vascular Ring
Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide.
Autoantibodies isolated from preeclamptic patients induce endothelial dysfunction via interaction with the angiotensin II AT1 receptor.
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Vascular System Injuries
Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery.
AT(2) receptor and tissue injury: therapeutic implications.
BR 09-3 AT2R STIMULATION AND ITS EFFECT ON TARGET ORGAN DAMAGE: THERAPEUTIC IMPLICATIONS.
Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan.
Cartilage oligomeric matrix protein is an endogenous ?-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.
CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells.
Deletion of angiotensin II type 1 receptor gene or scavenge of superoxide prevents chronic alcohol-induced aortic damage and remodeling.
Effects of subtype-selective and balanced angiotensin II receptor antagonists in a porcine coronary artery model of vascular restenosis.
Interferon regulatory factor-1 exerts inhibitory effect on neointimal formation after vascular injury.
New perspectives in angiotensin system control.
Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects.
Prevention of vascular injury by combination of an AT1 receptor blocker, olmesartan, with various calcium antagonists.
Renal and vascular injury induced by exogenous angiotensin II is AT1 receptor-dependent.
Renin-angiotensin system modulates oxidative stress-induced endothelial cell apoptosis in rats.
Role of angiotensin II-regulated apoptosis through distinct AT1 and AT2 receptors in neointimal formation.
Role of the angiotensin II type 2 receptor in arterial remodeling after wire injury in mice.
Sex difference in vascular injury and the vasoprotective effect of valsartan are related to differential AT2 receptor expression.
The angiotensin II type 2 receptor in cardiovascular disease.
[Distribution and function of angiotensin receptor subtypes in cardiovascular system]
[Recent progress in AT1 and AT2 receptor research]
Venous Thrombosis
Antithrombotic activity of losartan in two kidney, one clip hypertensive rats. A study on the mechanism of action.
Effects of drugs affecting the renin-angiotensin system on venous thrombosis in normotensive rats.
Losartan inhibits experimental venous thrombosis in spontaneously hypertensive rats.
Studies on the antithrombotic action of AT1 receptor antagonists.
Ventricular Dysfunction
Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart.
Angiotensin-converting enzyme inhibitors.
Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium.
Ventricular Dysfunction, Left
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism in coronary disease and malignant ventricular arrhythmias.
Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts.
[Renin-angiotensin system modulation: instructions for use]
Vesico-Ureteral Reflux
Angiotensin II AT2 receptor regulates ureteric bud morphogenesis.
Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux.
Vulvodynia
A Local Inflammatory Renin-Angiotensin System Drives Sensory Axon Sprouting in Provoked Vestibulodynia.
Whooping Cough
Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis.
Angiotensin AT1 receptors in Clone 9 rat liver cells: Ca2+ signaling and c-fos expression.
Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins.
Angiotensin II receptor coupling to phospholipase D is mediated by the betagamma subunits of heterotrimeric G proteins in vascular smooth muscle cells.
Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells.
Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.
Angiotensin II type 2 receptor stimulation increases the rate of NG108-15 cell migration via actin depolymerization.
Characterization of PD 121981- and CGP 42112-induced unmasking of low concentration effects of angiotensin II in rabbit abdominal aorta.
Cloning, expression and regulation of angiotensin II receptors.
Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons.
Expression and regulation of G alpha q and G alpha 11 mRNAs and proteins in bovine adrenal cells.
Growth responses to angiotensin II in bovine adrenal glomerulosa cells.
Heterogeneity of angiotensin II AT2 receptors in the rat brain.
Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways.
Hydrophobicity and subunit interactions of rod outer segment proteins investigated using Triton X-114 phase partitioning.
Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells.
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
Molecular structure and function of angiotensin type 2 receptor.
Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of Gq and G11 in bovine adrenal cells.
Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors.
Selective antagonism of the AT1 receptor inhibits the effect of angiotensin II on DNA and protein synthesis of rat proximal tubular cells.
Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells.
Subcellular mechanisms of angiotensin II and arginine vasopressin activation of area postrema neurons.
The bradykinin B2 receptor couples less efficiently than the angiotensin AT1 receptor to the G protein Gq in transiently transfected COS-7 cells.