Reference on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, Y.; Lee, G.F.; Kelley, R.F.; Spellman, M.W.
Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymic addition of O-linked fucose to EGF domains
Glycobiology
6
837-842
1996
Cricetulus griseus, Rattus norvegicus
Wang, Y.; Spellman, M.W.
Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells
J. Biol. Chem.
273
8112-8118
1998
Cricetulus griseus
Voynow, J.A.; Scanlin, T.F.; Glick, M.C.
A quantitative method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1-6fucosyltransferase activity with lectin affinity chromatography
Anal. Biochem.
168
367-373
1988
Homo sapiens
Altmann, F.; Kornfeld, G.; Dalik, T.; Staudacher, E.; Glossl, J.
Processing of asparagine-linked oligosaccharides in insect cells. N-acetylglucosaminyltransferase I and II activities in cultured lepidopteran cells
Glycobiology
3
619-625
1993
Bombyx mori, Mamestra brassicae, Spodoptera frugiperda
Shao, M.C.; Sokolik, C.W.; Wold, F.
Specificity studies of the GDP-[L]-fucose:2-acetamido-2-deoxy-beta-[D]-glucoside (Fuc-Asn-linked GlcNAc) 6-alpha-[L]-fucosyltransferase from rat-liver Golgi membranes
Carbohydr. Res.
251
163-173
1994
Rattus norvegicus
Kaminska, J.; Musielak, M.; Nowicka, A.; Wozniewicz, B.; Koscielak, J.
Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase
Biochimie
83
739-742
2001
Homo sapiens
Uozumi, N.; Teshima, T.; Yamamoto, T.; Nishikawa, A.; Gao, Y.E.; Miyoshi, E.; Gao, C.X.; Noda, K.; Islam, K.N.; et al.
A fluorescent assay method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-6fucosyltransferase activity, involving high performance liquid chromatography
J. Biochem.
120
385-392
1996
Homo sapiens, Rattus norvegicus, Sus scrofa
Uozumi, N.; Yanagidani, S.; Miyoshi, E.; Ihara, Y.; Sakuma, T.; Gao, C.X.; Teshima, T.; Fujii, S.; Shiba, T.; Taniguchi, N.
Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase
J. Biol. Chem.
271
27810-27817
1996
Rattus norvegicus, Sus scrofa
Yanagidani, S.; Uozumi, N.; Ihara, Y.; Miyoshi, E.; Yamaguchi, N.; Taniguchi, N.
Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells
J. Biochem.
121
626-632
1997
Homo sapiens, Homo sapiens (Q9BYC5), Sus scrofa
Struppe, E.; Staudacher, E.
Occurrence of GDP-L-fucose:beta-N-acetylglucosamine (Fuc to Asn-linked GlcNAc) alpha1,6-fucosyltransferases in porcine, sheep, bovine, rabbit and chicken tissues
Biochim. Biophys. Acta
1475
360-368
2000
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Ovis aries, Sus scrofa
Breton, C.; Oriol, R.; Imberty, A.
Conserved structural features in eukaryotic and prokaryotic fucosyltransferases
Glycobiology
8
87-94
1998
Sus scrofa (P79282), Azorhizobium caulinodans (Q43966), Bradyrhizobium japonicum (Q45271), Homo sapiens (Q9BYC5)
Kaminska, J.; Glick, M.C.; Koscielak, J.
Purification and characterization of GDP-L-Fuc:N-acetyl beta-D-glucosaminide alpha1->6 fucosyltransferase from human blood platelets
Glycoconjugate J.
15
783-788
1998
Homo sapiens
Miyoshi, E.; Noda, K.; Yamaguchi, Y.; Inoue, S.; Ikeda, Y.; Wang, W.; Ko, J.H.; Uozumi, N.; Li, W.; Taniguchi, N.
The alpha1-6-fucosyltransferase gene and its biological significance
Biochim. Biophys. Acta
1473
9-20
1999
Homo sapiens, Homo sapiens (Q9BYC5), Rattus norvegicus, Sus scrofa, Sus scrofa (P79282)
Kaminska, J.; Wisniewska, A.; Koscielak, J.
Chemical modifications of alpha1,6-fucosyltransferase define amino acid residues of catalytic importance
Biochimie
85
303-310
2003
Homo sapiens
Bany-Laszewicz, U.; Kaminska, J.; Klimczak-Jajor, E.; Koscielak, J.
The activity of alpha1,6-fucosyltransferase during human megakaryocytic differentiation
Cell. Mol. Biol. Lett.
9
145-152
2004
Homo sapiens
Martinez-Duncker, I.; Michalski, J.C.; Bauvy, C.; Candelier, J.J.; Mennesson, B.; Codogno, P.; Oriol, R.; Mollicone, R.
Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis
Glycobiology
14
13-25
2004
Homo sapiens
Ihara, H.; Ikeda, Y.; Taniguchi, N.
Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1,6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8
Glycobiology
16
333-342
2006
Homo sapiens
Ihara, H.; Ikeda, Y.; Toma, S.; Wang, X.; Suzuki, T.; Gu, J.; Miyoshi, E.; Tsukihara, T.; Honke, K.; Matsumoto, A.; Nakagawa, A.; Taniguchi, N.
Crystal structure of mammalian {alpha}1,6-fucosyltransferase, FUT8
Glycobiology
17
455-466
2007
Homo sapiens (Q9BYC5), Homo sapiens
Brzezinski, K.; Stepkowski, T.; Panjikar, S.; Bujacz, G.; Jaskolski, M.
High-resolution structure of NodZ fucosyltransferase involved in the biosynthesis of the nodulation factor
Acta Biochim. Pol.
54
537-549
2007
Bradyrhizobium sp. WM9 (Q9AQ17)
Muinelo-Romay, L.; Vazquez-Martin, C.; Villar-Portela, S.; Cuevas, E.; Gil-Martin, E.; Fernandez-Briera, A.
Expression and enzyme activity of alpha(1,6)fucosyltransferase in human colorectal cancer
Int. J. Cancer
123
641-646
2008
Homo sapiens
Matsumoto, K.; Shimizu, C.; Arao, T.; Andoh, M.; Katsumata, N.; Kohno, T.; Yonemori, K.; Koizumi, F.; Yokote, H.; Aogi, K.; Tamura, K.; Nishio, K.; Fujiwara, Y.
Identification of predictive biomarkers for response to trastuzumab using plasma FUCA activity and N-glycan identified by MALDI-TOF-MS
J. Proteome Res.
8
457-462
2009
Homo sapiens (Q9BYC5)
Beuger, V.; Kuenkele, K.P.; Koll, H.; Gaertner, A.; Baehner, M.; Burtscher, H.; Klein, C.
Short-hairpin-RNA-mediated silencing of fucosyltransferase 8 in Chinese-hamster ovary cells for the production of antibodies with enhanced antibody immune effector function
Biotechnol. Appl. Biochem.
53
31-37
2009
Cricetulus griseus
Matsumoto, K.; Yokote, H.; Arao, T.; Maegawa, M.; Tanaka, K.; Fujita, Y.; Shimizu, C.; Hanafusa, T.; Fujiwara, Y.; Nishio, K.
N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor
Cancer Sci.
99
1611-1617
2008
Homo sapiens
Brzezinski, K.; Dauter, Z.; Jaskolski, M.
Structures of NodZ alpha1,6-fucosyltransferase in complex with GDP and GDP-fucose
Acta Crystallogr. Sect. D
68
160-168
2012
Bradyrhizobium sp. (Q9AQ17)
Koetzler, M.P.; Blank, S.; Bantleon, F.I.; Spillner, E.; Meyer, B.
Donor substrate binding and enzymatic mechanism of human core alpha1,6-fucosyltransferase (FUT8)
Biochim. Biophys. Acta
1820
1915-1925
2012
Homo sapiens (Q9BYC5)
Muinelo-Romay, L.; Villar-Portela, S.; Cuevas, E.; Gil-Martin, E.; Fernandez-Briera, A.
Identification of alpha(1,6)fucosylated proteins differentially expressed in human colorectal cancer
BMC Cancer
11
508
2011
Homo sapiens
Ihara, H.; Hanashima, S.; Okada, T.; Ito, R.; Yamaguchi, Y.; Taniguchi, N.; Ikeda, Y.
Fucosylation of chitooligosaccharides by human alpha1,6-fucosyltransferase requires a nonreducing terminal chitotriose unit as a minimal structure
Glycobiology
20
1021-1033
2010
Homo sapiens
Ihara, H.; Okada, T.; Ikeda, Y.
Cloning, expression and characterization of Bombyx mori alpha1,6-fucosyltransferase
Biochem. Biophys. Res. Commun.
450
953-960
2014
Bombyx mori (A0A060PLD2)
Sasaki, H.; Toda, T.; Furukawa, T.; Mawatari, Y.; Takaesu, R.; Shimizu, M.; Wada, R.; Kato, D.; Utsugi, T.; Ohtsu, M.; Murakami, Y.
alpha-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells
J. Biol. Chem.
288
16839-16847
2013
Homo sapiens (Q9BYC5), Mus musculus (Q9WTS2)
Juliant, S.; Harduin-Lepers, A.; Monjaret, F.; Catieau, B.; Violet, M.L.; Cerutti, P.; Ozil, A.; Duonor-Cerutti, M.
The alpha1,6-fucosyltransferase gene (fut8) from the Sf9 lepidopteran insect cell line: Insights into fut8 evolution
PLoS ONE
9
e110422
2014
Spodoptera frugiperda
Ohashi, H.; Ohashi, T.; Kajiura, H.; Misaki, R.; Kitamura, S.; Fujiyama, K.
Fucosyltransferases produce N-glycans containing core l-galactose
Biochem. Biophys. Res. Commun.
483
658-663
2017
Mus musculus (Q9WTS2)
Ihara, H.; Okada, T.; Taniguchi, N.; Ikeda, Y.
Involvement of the alpha-helical and Src homology 3 domains in the molecular assembly and enzymatic activity of human alpha1,6-fucosyltransferase, FUT8
Biochim. Biophys. Acta
1864
129596
2020
Homo sapiens (Q9BYC5)
Manabe, Y.; Kasahara, S.; Takakura, Y.; Yang, X.; Takamatsu, S.; Kamada, Y.; Miyoshi, E.; Yoshidome, D.; Fukase, K.
Development of alpha1,6-fucosyltransferase inhibitors through the diversity-oriented syntheses of GDP-fucose mimics using the coupling between alkyne and sulfonyl azide
Bioorg. Med. Chem.
25
2844-2850
2017
Homo sapiens (Q9BYC5)
Li, C.; Zhu, S.; Ma, C.; Wang, L.X.
Designer alpha1,6-fucosidase mutants enable direct core fucosylation of intact N-glycopeptides and N-glycoproteins
J. Am. Chem. Soc.
139
15074-15087
2017
Lacticaseibacillus casei, Lacticaseibacillus casei W56
Yang, Q.; Wang, L.X.
Mammalian alpha-1,6-fucosyltransferase (FUT8) is the sole enzyme responsible for the N-acetylglucosaminyltransferase I-independent core fucosylation of high-mannose N-glycans
J. Biol. Chem.
291
11064-11071
2016
Homo sapiens (Q9BYC5)
Yang, Q.; Zhang, R.; Cai, H.; Wang, L.X.
Revisiting the substrate specificity of mammalian alpha1,6-fucosyltransferase reveals that it catalyzes core fucosylation of N-glycans lacking alpha1,3-arm GlcNAc
J. Biol. Chem.
292
14796-14803
2017
Homo sapiens (Q9BYC5)
Tomida, S.; Takata, M.; Hirata, T.; Nagae, M.; Nakano, M.; Kizuka, Y.
The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation
J. Biol. Chem.
295
7992-8004
2020
Homo sapiens (Q9BYC5)
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