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EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
GDP mannose-undecaprenyl phosphate mannosyltransferase, GDP-D-mannose:lipid phosphate transmannosylase, guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase, mannosyl-1-phosphoryl-undecaprenol synthetase, mannosylphosphorylundecaprenol synthase, mannosyltransferase, guanosine diphosphomannose-undecaprenyl phosphate, MPU synthetase,
more
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GDP mannose-undecaprenyl phosphate mannosyltransferase
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GDP-D-mannose:lipid phosphate transmannosylase
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guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase
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mannosyl-1-phosphoryl-undecaprenol synthetase
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mannosylphosphorylundecaprenol synthase
mannosyltransferase, guanosine diphosphomannose-undecaprenyl phosphate
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mannosylphosphorylundecaprenol synthase
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mannosylphosphorylundecaprenol synthase
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GDP-alpha-D-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol
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hexosyl group transfer
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GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase
Requires phosphatidylglycerol.
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GDPmannose + citronellyl phosphate
GDP + mannosyl-phosphorylcitronellol
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beta-isomer as product
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GDPmannose + dolichyl phosphate
GDP + mannosyl-phosphoryldolichol
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beta-isomer as product
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GDPmannose + ficaprenyl phosphate
GDP + mannosyl-1-phosphorylficaprenol
GDPmannose + phospholipid
GDP + mannosyl-1-phospholipid
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polyprenol type, involved in glycophospholipid biosynthesis
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GDPmannose + phytanol phosphate
GDP + D-mannosyl-1-phosphophytanol
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reaction is reversed by GDP, but not by GMP, enzyme is relatively specific for GDPmannose, phytanol phosphate is a poorer glycosyl acceptor than the unidentified endogenous lipid phosphate substrate
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r
GDPmannose + phytol phosphate
GDP + D-mannosyl-1-phosphophytol
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poor substrate
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r
GDPmannose + polyisoprenyl phosphate
GDP + mannosyl-phosphorylpolyisoprenol
GDPmannose + undecaprenyl phosphate
GDP + D-mannosyl-1-phosphoundecaprenol
UDPglucose + ficaprenyl phosphate
GDP + glucosyl-1-phosphorylficaprenol
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in the reverse reaction UMP is no substrate
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r
additional information
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GDPmannose + ficaprenyl phosphate
GDP + mannosyl-1-phosphorylficaprenol
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effective substrate
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GDPmannose + ficaprenyl phosphate
GDP + mannosyl-1-phosphorylficaprenol
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effective substrate
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GDPmannose + polyisoprenyl phosphate
GDP + mannosyl-phosphorylpolyisoprenol
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endogenous lipid moiety of the glycolipid is a polyprenol and similar to undecaprenyl phosphate, but probably not identical with it, reaction is reversed by GDP, but not by GMP
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GDPmannose + polyisoprenyl phosphate
GDP + mannosyl-phosphorylpolyisoprenol
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mannosylates a wide range of isoprenyl monophosphate substrates
beta-isomer as product
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GDPmannose + undecaprenyl phosphate
GDP + D-mannosyl-1-phosphoundecaprenol
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GDPmannose + undecaprenyl phosphate
GDP + D-mannosyl-1-phosphoundecaprenol
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r
GDPmannose + undecaprenyl phosphate
GDP + D-mannosyl-1-phosphoundecaprenol
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Man-P-Undec is an activated mannosyl donor in micrococcal mannan biosynthesis
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GDPmannose + undecaprenyl phosphate
GDP + D-mannosyl-1-phosphoundecaprenol
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reaction is reversed by GDP
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r
additional information
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no substrates: phosphatidylglycerol, phosphatidylethanolamine, phosphatidylserine, Triton X-100
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additional information
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involved in biosynthesis of mannan
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additional information
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no substrates: lauryl sulfate, myristyl sulfate, phytol, phytanol, GDPglucose, UDPxylose
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GDPmannose + phospholipid
GDP + mannosyl-1-phospholipid
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polyprenol type, involved in glycophospholipid biosynthesis
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GDPmannose + undecaprenyl phosphate
GDP + D-mannosyl-1-phosphoundecaprenol
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Man-P-Undec is an activated mannosyl donor in micrococcal mannan biosynthesis
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additional information
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involved in biosynthesis of mannan
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Ca2+
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activation, can replace Mg2+ to some extent
Mn2+
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activation, can replace Mg2+ to some extent
additional information
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not activated by Co2+
Mg2+
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requirement
Mg2+
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optimal concentration: 15 mM, facilitates interaction of lipid and enzyme
Mg2+
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optimal concentration: 67 mM
Mg2+
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optimal concentration: 15 mM, facilitates interaction of lipid and enzyme
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phosphatidylglycerol
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inhibits in excess amount
Triton X-100
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at high concentrations
undecaprenyl phosphate
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inhibits in excess amount
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phosphatidylethanolamine
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activates
phosphatidylglycerol
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requirement
Phytanol phosphate
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stimulates
sodium lauryl sulfate
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activates
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0.02 - 0.04
ficaprenyl phosphate
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6.9 - 7.5
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0.06 M Tris-maleate buffer
7.5
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Tris-maleate buffer
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6.2 - 8.6
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about half-maximal activity at pH 6.2 and 8.6
6.2 - 9
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Tris buffer, about half-maximal activity at pH 6.2 and 63% of maximal activity at pH 9.0
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additional information
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assay at room temperature
additional information
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assay at room temperature
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12-15 days after anthesis
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brenda
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brenda
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brenda
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brenda
formerly Micrococcus lysodeikticus
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brenda
Micrococcus lysodeikticus
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brenda
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brenda
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brenda
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membrane-bound
brenda
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brenda
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membrane-bound
brenda
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membrane-bound
brenda
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30700
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x * 30700, SDS-PAGE
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50
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above, rapid inactivation
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-20°C, at least 1 year, stable
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synthesis
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useful for enzymatic synthesis of a wide variety of mannosylphosphopolyisoprenyl products
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Lahav, M.; Chiu, T.H.; Lennarz, W.J.
Studies on the biosynthesis of mannan in Micrococcus lysodeikticus. II. The enzymatic synthesis of mannosyl-l-phosphoryl-undecaprenol
J. Biol. Chem.
244
5890-5898
1969
Micrococcus luteus
brenda
Clark, A.F.; Villemez, C.L.
An artificial mannosyl acceptor for GDP-D-mannose: lipid phosphate transmannosylase from Phaseolus aureus
FEBS Lett.
32
84-86
1973
Vigna radiata var. radiata
brenda
Forsee, W.T.; Elbein, A.D.
Biosynthesis of mannosyl- and glucosyl-phosphoryl-polyprenols in cotton fibers
J. Biol. Chem.
248
2858-2867
1973
Gossypium hirsutum, Mycolicibacterium smegmatis
brenda
Rush, J.S.; Shelling, J.G.; Zingg, N.S.; Ray, P.H.; Waechter, C.J.
Mannosylphosphoryldolichol-mediated reactions in oligosaccharide-P-P-dolichol biosynthesis. Recognition of the saturated alpha-isoprene unit of the mannosyl donor by pig brain mannosyltransferases
J. Biol. Chem.
268
13110-13117
1993
Micrococcus luteus
brenda
Rush, J.S.; Waechter, C.J.
Partial purification of mannosylphosphorylundecaprenol synthase from Micrococcus luteus: a useful enzyme for the biosynthesis of a variety of mannosylphosphorylpolyisoprenol products
Methods Mol. Biol.
347
13-30
2006
Micrococcus luteus
brenda
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