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EC Tree
IUBMB Comments The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of protopanaxatriol and ginsenoside F1.
The expected taxonomic range for this enzyme is: Panax ginseng
Synonyms
UGTPg100 ,
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UGTPg100
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UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1
(2)
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UDP-alpha-D-glucose + protopanaxatriol = UDP + ginsenoside Rh1
(1)
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UDP-alpha-D-glucose:ginsenoside 6-O-glucosyltransferase
The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of protopanaxatriol and ginsenoside F1.
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UDP-alpha-D-glucose + (20S)-protopanaxatriol
UDP + ginsenoside Rh1
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UDP-alpha-D-glucose + ginsenoside F1
UDP + (20S)-ginsenoside Rg1
UDP-alpha-D-glucose + protopanaxatriol
UDP + ginsenoside Rh1
UDP-alpha-D-glucose + ginsenoside F1
UDP + (20S)-ginsenoside Rg1
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?
UDP-alpha-D-glucose + ginsenoside F1
UDP + (20S)-ginsenoside Rg1
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UDP-alpha-D-glucose + protopanaxatriol
UDP + ginsenoside Rh1
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UDP-alpha-D-glucose + protopanaxatriol
UDP + ginsenoside Rh1
the enzyme specifically catalyzes the glycosylation of protopanaxatriol at C-6
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UDP-alpha-D-glucose + (20S)-protopanaxatriol
UDP + ginsenoside Rh1
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?
UDP-alpha-D-glucose + ginsenoside F1
UDP + (20S)-ginsenoside Rg1
UDP-alpha-D-glucose + protopanaxatriol
UDP + ginsenoside Rh1
UDP-alpha-D-glucose + ginsenoside F1
UDP + (20S)-ginsenoside Rg1
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?
UDP-alpha-D-glucose + ginsenoside F1
UDP + (20S)-ginsenoside Rg1
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?
UDP-alpha-D-glucose + protopanaxatriol
UDP + ginsenoside Rh1
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?
UDP-alpha-D-glucose + protopanaxatriol
UDP + ginsenoside Rh1
the enzyme specifically catalyzes the glycosylation of protopanaxatriol at C-6
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?
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0.153
(20S)-protopanaxatriol
at pH 8.0 and 35°C
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9.1
(20S)-protopanaxatriol
at pH 8.0 and 35°C
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60
(20S)-protopanaxatriol
at pH 8.0 and 35°C
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UniProt
brenda
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adventitious root
brenda
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UGT10_PANGI
472
0
53131
Swiss-Prot
Secretory Pathway (Reliability: 5 )
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A142T
the mutant of isoform UGTPg100 is inactive towards (20S)-protopanaxatriol
G338R
the mutant of isoform UGTPg100 is inactive towards (20S)-protopanaxatriol
L186S
the mutant of isoform UGTPg100 is inactive towards (20S)-protopanaxatriol
W205R
the mutant of isoform UGTPg100 remains active with (20S)-protopanaxatriol
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treatment with 0.2 mg/l elicitors of the mycelium of Aspergillus niger significantly up-regulates the gene expression of the enzyme
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Lu, J.; Li, J.; Wang, S.; Yao, L.; Liang, W.; Wang, J.; Gao, W.
Advances in ginsenoside biosynthesis and metabolic regulation
Biotechnol. Appl. Biochem.
65
514-522
2018
Panax ginseng (A0A0K0PVW1)
brenda
Li, J.; Liu, S.; Wang, J.; Li, J.; Liu, D.; Li, J.; Gao, W.
Fungal elicitors enhance ginsenosides biosynthesis, expression of functional genes as well as signal molecules accumulation in adventitious roots of Panax ginseng C. A. Mey
J. Biotechnol.
239
106-114
2016
Panax ginseng (A0A0K0PVW1)
brenda
Wei, W.; Wang, P.; Wei, Y.; Liu, Q.; Yang, C.; Zhao, G.; Yue, J.; Yan, X.; Zhou, Z.
Characterization of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts
Mol. Plant
8
1412-1424
2015
Panax ginseng (A0A0K0PVW1), Panax ginseng
brenda
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