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IUBMB Comments Isolated from the plant Catharanthus roseus (Madagascar periwinkle). Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetin. cf . EC 2.4.1.324 7-deoxyloganetin glucosyltransferase.
Synonyms
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UDP-alpha-D-glucose + 7-deoxyloganetate = UDP + 7-deoxyloganate
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MetaCyc
secologanin and strictosidine biosynthesis
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UDP-alpha-D-glucose:7-deoxyloganetate O-D-glucosyltransferase
Isolated from the plant Catharanthus roseus (Madagascar periwinkle). Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetin. cf. EC 2.4.1.324 7-deoxyloganetin glucosyltransferase.
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UDP-alpha-D-glucose + 7-deoxyloganetate
UDP + 7-deoxyloganate
UDP-alpha-D-glucose + 7-deoxyloganetate
UDP + 7-deoxyloganate
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Substrates: -
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UDP-alpha-D-glucose + 7-deoxyloganetate
UDP + 7-deoxyloganate
Substrates: the enzyme is involved in loganin and secologanin biosynthesis
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UDP-alpha-D-glucose + 7-deoxyloganetate
UDP + 7-deoxyloganate
Substrates: does not react with 7-deoxyloganetin
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UDP-alpha-D-glucose + 7-deoxyloganetate
UDP + 7-deoxyloganate
UDP-alpha-D-glucose + 7-deoxyloganetate
UDP + 7-deoxyloganate
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Substrates: -
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UDP-alpha-D-glucose + 7-deoxyloganetate
UDP + 7-deoxyloganate
Substrates: the enzyme is involved in loganin and secologanin biosynthesis
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5.38
7-deoxyloganetate
pH 8.0, 30°C
0.088
UDP-alpha-D-glucose
pH 8.0, 30°C
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0.325
7-deoxyloganetate
pH 8.0, 30°C
0.13
UDP-alpha-D-glucose
pH 8.0, 30°C
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0.064
7-deoxyloganetate
pH 8.0, 30°C
1.5
UDP-alpha-D-glucose
pH 8.0, 30°C
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UniProt
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preferentially expressed in internal phloem associated parenchyma cells
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preferentially expressed in internal phloem associated parenchyma cells
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preferentially expressed in internal phloem associated parenchyma cells
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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physiological function
the enzyme is involved in loganin and secologanin biosynthesis
metabolism
the enzyme is involved in vindoline biosynthetic pathway
metabolism
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crucial catalytic enzyme in monoterpene indole alkaloid biosynthesis
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recombinant enzyme, purified by nickel nitrilotriacetic acid affinity chromatography
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expression in Escherichia coli
expression in Escherichia coli BL21(DE3) and in Saccharomyces cerevisiae. Ca7DLS2 (7-deoxyloganeticacid synthase, cf. EC 1.14.14.161) and Ca7DLGT1 (7-deoxyloganetic acid glucosyltransferase) are inserted into the dual expression vector pESC-URA and the resulting construct is transformed into the competent cells of Saccharomyces cerevisiae WAT11 to give the recombinant yeast strain
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downregulated after endophyte treatment
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synthesis
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thes study provides two cytochrome P450 enzymes as Ca7DLS1 (7-deoxyloganetic acid synthase, cf. EC 1.14.14.161) and Ca7DLS1 (7-deoxyloganetic acid synthase, cf. EC 1.14.14.161) and two uridine 5'-diphosphate glycosyltransferases as Ca7DLGT1 (7-deoxyloganetic acid glucosyltransferase) and Ca7DLGT2 (7-deoxyloganetic acid glucosyltransferase), offering potential applications biosynthesis of monoterpene indole alkaloid
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Asada, K.; Salim, V.; Masada-Atsumi, S.; Edmunds, E.; Nagatoshi, M.; Terasaka, K.; Mizukami, H.; de Luca, V.
A 7-deoxyloganetic acid glucosyltransferase contributes a key step in secologanin biosynthesis in madagascar periwinkle
Plant Cell
25
4123-4134
2013
Catharanthus roseus (U3U992), Catharanthus roseus
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Pandey, S.S.; Singh, S.; Babu, C.S.; Shanker, K.; Srivastava, N.K.; Shukla, A.K.; Kalra, A.
Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis
Sci. Rep.
6
26583
2016
Catharanthus roseus (U3U992)
brenda
Li, Y.; Wang, X.; Jiang, H.; Xu, S.; Xu, Y.; Liu, Z.; Luo, Y.
Functional characterization of Camptotheca acuminata 7-deoxyloganetic acid synthases and 7-deoxyloganetic acid glucosyltransferases involved in camptothecin biosynthesis
Plant Physiol. Biochem.
218
109305
2025
Camptotheca acuminata
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