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IUBMB Comments The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
The enzyme appears in viruses and cellular organisms
Synonyms
mycarosyltransferase,
tylC5 ,
tylCV ,
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tylC5
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tylCV
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dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin
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dTDP-beta-L-mycarose:demethyllactenocin 4'-O-alpha-L-mycarosyltransferase
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
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dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
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-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
dTDP-beta-L-mycarose i.e. dTDP-2,6-dideoxy-3-C-methyl-beta-L-ribo-hexose. demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside
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-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
dTDP-beta-L-mycarose i.e. dTDP-2,6-dideoxy-3-C-methyl-beta-L-ribo-hexose. demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside
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-
?
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dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
-
?
dTDP-beta-L-mycarose + demethyllactenocin
dTDP + demethylmacrocin
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
wild-type strain also known as C373.1
UniProt
brenda
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UniProt
brenda
wild-type strain also known as C373.1
UniProt
brenda
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physiological function
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
physiological function
the disruption of the tylCV gene results in the accumulation of desmycosin, the direct precursor of tilmicosin
physiological function
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the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
-
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TYLCV_STRFR
461
0
50120
Swiss-Prot
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A0A5C0WJB4_BACIA
389
0
44106
TrEMBL
-
A0A2H5Z4H1_9BACT
432
0
48877
TrEMBL
-
A0A2N8NW32_STREU
404
0
44036
TrEMBL
-
A0A7H2CEC0_9BACI
397
0
44581
TrEMBL
-
A0A1S6IRZ0_9LACT
435
0
49334
TrEMBL
-
A0A509DUU3_9RHIZ
392
0
43839
TrEMBL
-
A0A509G642_PAEPO
395
0
43921
TrEMBL
-
A0A7U9SZ42_9FIRM
398
1
45928
TrEMBL
-
A0A2C2DH28_BACCE
395
0
44577
TrEMBL
-
A0A509G4M6_PAEPO
405
0
45288
TrEMBL
-
A0A411A2Z4_9BACI
397
0
44583
TrEMBL
-
A0A498U671_BACIA
389
0
44127
TrEMBL
-
A0A645DAN2_9ZZZZ
357
0
40890
TrEMBL
other Location (Reliability: 1 )
E0RF21_PAEP6
Paenibacillus polymyxa (strain E681)
399
0
44548
TrEMBL
-
A0A2H5WCG2_9BACT
436
0
50204
TrEMBL
-
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30120
x * 30120, calculated from sequence
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?
x * 30120, calculated from sequence
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x * 30120, calculated from sequence
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synthesis
the disruption of the tylCV gene results in the accumulation of desmycosin, the direct precursor of tilmicosin. After optimization of the culture conditions, the yield of desmycosin reaches 7.3 g/l in a 5 l jar fermentor
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Bate, N.; Butler, A.R.; Smith, I.P.; Cundliffe, E.
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin
Microbiology
146
139-146
2000
Streptomyces fradiae (Q9XC67), Streptomyces fradiae, Streptomyces fradiae T59235 (Q9XC67)
brenda
Min, Y.; Lv, H.; Zheng, Y.
Fusion PCR-targeted tylCV gene deletion of Streptomyces fradiae for producing desmycosin, the direct precursor of tilmicosin
Process Biochem.
42
729-733
2007
Streptomyces fradiae (Q9XC67)
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brenda
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History
Enzyme Nomenclature
2.4.1.318 demethyllactenocin mycarosyltransferase
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