show all | hide all No of entries

Information on EC 2.4.1.255 - protein O-GlcNAc transferase

for references in articles please use BRENDA:EC2.4.1.255
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.255 protein O-GlcNAc transferase
IUBMB Comments
Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins.
Specify your search results
Select one or more organisms in this record:
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
o-linked n-acetylglucosamine transferase, o-glcnac protein, n-acetylglucosamine transferase, ogt protein, o-glcnac-transferase, ncogt, human ogt, o-linked glcnac transferase, secret agent, ogtase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
show the reaction diagram
The N-acetyl-D-glucosaminyl residue is transferred to threonine or serine hydroxy groups on the polypeptide.
-
-
-
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
show the reaction diagram
-
-
-
-